Metabolism of steroids

Proteins (109)

Protein	Synonyms	Taxonomy
Glycoprotein hormones alpha chain	Anterior pituitary glycoprotein hormones common subunit alpha; Choriogonadotropin alpha chain; Chorionic gonadotrophin subunit alpha; CG-alpha; Follicle-stimulating hormone alpha chain; FSH-alpha; Follitropin alpha chain; Luteinizing hormone alpha chain;	Homo sapiens (human)
Peripheral-type benzodiazepine receptor-associated protein 1	PRAX-1; Peripheral benzodiazepine receptor-interacting protein; PBR-IP; RIMS-binding protein 1; RIM-BP1; TSPO-associated protein 1	Homo sapiens (human)
Small ubiquitin-related modifier 2	SUMO-2; HSMT3; SMT3 homolog 2; SUMO-3; Sentrin-2; Ubiquitin-like protein SMT3B; Smt3B	Homo sapiens (human)
Vitamin D 25-hydroxylase	EC 1.14.14.24; Cytochrome P450 2R1	Homo sapiens (human)
Cholesterol 24-hydroxylase	CH24H; EC 1.14.14.25; Cholesterol 24-monooxygenase; Cholesterol 24S-hydroxylase; Cytochrome P450 46A1	Homo sapiens (human)
Very long-chain acyl-CoA synthetase	VLACS; VLCS; EC 6.2.1.-; Arachidonate--CoA ligase; 6.2.1.15; Fatty acid transport protein 2; FATP-2; Fatty-acid-coenzyme A ligase, very long-chain 1; Long-chain-fatty-acid--CoA ligase; 6.2.1.3; Phytanate--CoA ligase; 6.2.1.24; Solute carrier family 27 mem	Homo sapiens (human)
Steroid 21-hydroxylase	EC 1.14.14.16; 21-OHase; Cytochrome P-450c21; Cytochrome P450 21; Cytochrome P450 XXI; Cytochrome P450-C21; Cytochrome P450-C21B	Homo sapiens (human)
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1	3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type I; 3-beta-HSD I; 3-beta-hydroxy-5-ene steroid dehydrogenase; 3-beta-hydroxy-Delta(5)-steroid dehydrogenase; 1.1.1.145; 3-beta-hydroxysteroid 3-dehydrogenase; 1.1.1.270; Delta-5-3-ketosteroid i	Homo sapiens (human)
Bile acyl-CoA synthetase	BACS; EC 6.2.1.7; Bile acid-CoA ligase; BA-CoA ligase; BAL; Cholate--CoA ligase; Fatty acid transport protein 5; FATP-5; Fatty-acid-coenzyme A ligase, very long-chain 3; Solute carrier family 27 member 5; Very long-chain acyl-CoA synthetase homolog 2; VLC	Homo sapiens (human)
ATP-binding cassette sub-family C member 3	EC 7.6.2.-; EC 7.6.2.2; EC 7.6.2.3; Canalicular multispecific organic anion transporter 2; Multi-specific organic anion transporter D; MOAT-D; Multidrug resistance-associated protein 3	Homo sapiens (human)
Vitamin D3 receptor	VDR; 1,25-dihydroxyvitamin D3 receptor; Nuclear receptor subfamily 1 group I member 1	Homo sapiens (human)
17-beta-hydroxysteroid dehydrogenase type 1	17-beta-HSD 1; EC 1.1.1.51; 20 alpha-hydroxysteroid dehydrogenase; 20-alpha-HSD; E2DH; Estradiol 17-beta-dehydrogenase 1; 1.1.1.62; Placental 17-beta-hydroxysteroid dehydrogenase; Short chain dehydrogenase/reductase family 28C member 1	Homo sapiens (human)
Fatty acid synthase	EC 2.3.1.85; Type I fatty acid synthase	Homo sapiens (human)
Delta(24)-sterol reductase	EC 1.3.1.72; 24-dehydrocholesterol reductase; 3-beta-hydroxysterol Delta-24-reductase; Diminuto/dwarf1 homolog; Seladin-1	Homo sapiens (human)
Bile acid receptor	Farnesoid X-activated receptor; Farnesol receptor HRR-1; Nuclear receptor subfamily 1 group H member 4; Retinoid X receptor-interacting protein 14; RXR-interacting protein 14	Homo sapiens (human)
Solute carrier organic anion transporter family member 1B1	Liver-specific organic anion transporter 1; LST-1; OATP-C; Sodium-independent organic anion-transporting polypeptide 2; OATP-2; Solute carrier family 21 member 6	Homo sapiens (human)
Squalene monooxygenase	EC 1.14.14.17; Squalene epoxidase; SE	Homo sapiens (human)
F-box-like/WD repeat-containing protein TBL1XR1	Nuclear receptor corepressor/HDAC3 complex subunit TBLR1; TBL1-related protein 1; Transducin beta-like 1X-related protein 1	Homo sapiens (human)
Delta(14)-sterol reductase TM7SF2	Delta-14-SR; EC 1.3.1.70; 3-beta-hydroxysterol Delta (14)-reductase; Another new gene 1 protein; C-14 sterol reductase; C14SR; Putative sterol reductase SR-1; Sterol C14-reductase; Transmembrane 7 superfamily member 2	Homo sapiens (human)
Stearoyl-CoA desaturase	hSCD1; EC 1.14.19.1; Acyl-CoA desaturase; Delta(9)-desaturase; Delta-9 desaturase; Fatty acid desaturase	Homo sapiens (human)
25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial	EC 1.14.15.18; 25-OHD-1 alpha-hydroxylase; 25-hydroxyvitamin D(3) 1-alpha-hydroxylase; VD3 1A hydroxylase; Calcidiol 1-monooxygenase; Cytochrome P450 subfamily XXVIIB polypeptide 1; Cytochrome P450C1 alpha; Cytochrome P450VD1-alpha; Cytochrome p450 27B1	Homo sapiens (human)
Geranylgeranyl pyrophosphate synthase	GGPP synthase; GGPPSase; EC 2.5.1.-; (2E,6E)-farnesyl diphosphate synthase; Dimethylallyltranstransferase; 2.5.1.1; Farnesyl diphosphate synthase; Farnesyltranstransferase; 2.5.1.29; Geranylgeranyl diphosphate synthase; Geranyltranstransferase; 2.5.1.10	Homo sapiens (human)
Albumin		Homo sapiens (human)
Steryl-sulfatase	EC 3.1.6.2; Arylsulfatase C; ASC; Estrone sulfatase; Steroid sulfatase; Steryl-sulfate sulfohydrolase	Homo sapiens (human)
Aromatase	EC 1.14.14.14; CYPXIX; Cytochrome P-450AROM; Cytochrome P450 19A1; Estrogen synthase	Homo sapiens (human)
Farnesyl pyrophosphate synthase	FPP synthase; FPS; EC 2.5.1.10; (2E,6E)-farnesyl diphosphate synthase; Dimethylallyltranstransferase; 2.5.1.1; Farnesyl diphosphate synthase; Geranyltranstransferase	Homo sapiens (human)
Aldo-keto reductase family 1 member B1	EC 1.1.1.300; EC 1.1.1.372; EC 1.1.1.54; Aldehyde reductase; Aldose reductase; AR; 1.1.1.21	Homo sapiens (human)
Cytochrome P450 11B2, mitochondrial	Aldosterone synthase; ALDOS; Aldosterone-synthesizing enzyme; CYPXIB2; Corticosterone 18-monooxygenase, CYP11B2; 1.14.15.5; Cytochrome P-450Aldo; Cytochrome P-450C18; Steroid 11-beta-hydroxylase, CYP11B2; 1.14.15.4; Steroid 18-hydroxylase	Homo sapiens (human)
Retinoic acid receptor RXR-alpha	Nuclear receptor subfamily 2 group B member 1; Retinoid X receptor alpha	Homo sapiens (human)
Translocator protein	Mitochondrial benzodiazepine receptor; PKBS; Peripheral-type benzodiazepine receptor; PBR	Homo sapiens (human)
17-beta-hydroxysteroid dehydrogenase type 2	17-beta-HSD 2; 20 alpha-hydroxysteroid dehydrogenase; 20-alpha-HSD; E2DH; Estradiol 17-beta-dehydrogenase 2; 1.1.1.62; Microsomal 17-beta-hydroxysteroid dehydrogenase; Short chain dehydrogenase/reductase family 9C member 2; Testosterone 17-beta-dehydrogen	Homo sapiens (human)
Low-density lipoprotein receptor-related protein 2	LRP-2; Glycoprotein 330; gp330; Megalin	Homo sapiens (human)
1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial	24-OHase; Vitamin D(3) 24-hydroxylase; EC 1.14.15.16; Cytochrome P450 24A1; Cytochrome P450-CC24	Homo sapiens (human)
Acetyl-CoA carboxylase 1	ACC1; EC 6.4.1.2; Acetyl-Coenzyme A carboxylase alpha; ACC-alpha	Homo sapiens (human)
Lanosterol 14-alpha demethylase	LDM; EC 1.14.14.154; CYPLI; Cytochrome P450 51A1; Cytochrome P450-14DM; Cytochrome P45014DM; Cytochrome P450LI; Sterol 14-alpha demethylase	Homo sapiens (human)
Protein transport protein Sec23A	hSec23A; SEC23-related protein A	Homo sapiens (human)
17-beta-hydroxysteroid dehydrogenase 14	17-beta-HSD 14; EC 1.1.1.62; 17-beta-hydroxysteroid dehydrogenase DHRS10; Dehydrogenase/reductase SDR family member 10; Retinal short-chain dehydrogenase/reductase retSDR3; Short chain dehydrogenase/reductase family 47C member 1	Homo sapiens (human)
Vitamin D-binding protein	DBP; VDB; Gc protein-derived macrophage activating factor; Gc-MAF; GcMAF; Gc-globulin; Group-specific component; Gc; Vitamin D-binding protein-macrophage activating factor; DBP-maf	Homo sapiens (human)
Squalene synthase	SQS; SS; EC 2.5.1.21; FPP:FPP farnesyltransferase; Farnesyl-diphosphate farnesyltransferase; Farnesyl-diphosphate farnesyltransferase 1	Homo sapiens (human)
Lanosterol synthase	EC 5.4.99.7; 2,3-epoxysqualene--lanosterol cyclase; Oxidosqualene--lanosterol cyclase; OSC; hOSC	Homo sapiens (human)
Sterol 26-hydroxylase, mitochondrial	EC 1.14.15.15; 5-beta-cholestane-3-alpha,7-alpha,12-alpha-triol 26-hydroxylase; Cytochrome P-450C27/25; Cytochrome P450 27; Sterol 27-hydroxylase; Vitamin D(3) 25-hydroxylase	Homo sapiens (human)
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase	EC 5.3.3.5; Cholestenol Delta-isomerase; Delta(8)-Delta(7) sterol isomerase; D8-D7 sterol isomerase; Emopamil-binding protein	Homo sapiens (human)
Legumain	EC 3.4.22.34; Asparaginyl endopeptidase; Protease, cysteine 1	Homo sapiens (human)
Elongation of very long chain fatty acids protein 6	EC 2.3.1.199; 3-keto acyl-CoA synthase ELOVL6; ELOVL fatty acid elongase 6; ELOVL FA elongase 6; Fatty acid elongase 2; hELO2; Fatty acyl-CoA elongase; Long-chain fatty-acyl elongase; Very long chain 3-ketoacyl-CoA synthase 6; Very long chain 3-oxoacyl-Co	Homo sapiens (human)
Nuclear receptor coactivator 1	NCoA-1; EC 2.3.1.48; Class E basic helix-loop-helix protein 74; bHLHe74; Protein Hin-2; RIP160; Renal carcinoma antigen NY-REN-52; Steroid receptor coactivator 1; SRC-1	Homo sapiens (human)
Alpha-methylacyl-CoA racemase	EC 5.1.99.4; 2-methylacyl-CoA racemase	Homo sapiens (human)
StAR-related lipid transfer protein 5	START domain-containing protein 5; StARD5	Homo sapiens (human)
Oxysterol-binding protein 1		Homo sapiens (human)
Gastrotropin	GT; Fatty acid-binding protein 6; Ileal lipid-binding protein; ILBP; Intestinal 15 kDa protein; I-15P; Intestinal bile acid-binding protein; I-BABP	Homo sapiens (human)
Sterol regulatory element-binding protein cleavage-activating protein	SCAP; SREBP cleavage-activating protein	Homo sapiens (human)
Nuclear receptor coactivator 2	NCoA-2; Class E basic helix-loop-helix protein 75; bHLHe75; Transcriptional intermediary factor 2; hTIF2	Homo sapiens (human)
Acetyl-CoA carboxylase 2	EC 6.4.1.2; ACC-beta	Homo sapiens (human)
Bile salt export pump	EC 7.6.2.-; ATP-binding cassette sub-family B member 11	Homo sapiens (human)
Steroid 17-alpha-hydroxylase/17,20 lyase	EC 1.14.14.19; 17-alpha-hydroxyprogesterone aldolase; 1.14.14.32; CYPXVII; Cytochrome P450 17A1; Cytochrome P450-C17; Cytochrome P450c17; Steroid 17-alpha-monooxygenase	Homo sapiens (human)
3-oxo-5-alpha-steroid 4-dehydrogenase 1	EC 1.3.1.22; SR type 1; Steroid 5-alpha-reductase 1; S5AR 1	Homo sapiens (human)
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2	3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II; 3-beta-HSD II; 3-beta-HSD adrenal and gonadal type	Homo sapiens (human)
3-oxo-5-alpha-steroid 4-dehydrogenase 2	EC 1.3.1.22; 5 alpha-SR2; SR type 2; Steroid 5-alpha-reductase 2; S5AR 2; Type II 5-alpha reductase	Homo sapiens (human)
Solute carrier organic anion transporter family member 1A2	OATP-A; Organic anion-transporting polypeptide 1; OATP-1; Sodium-independent organic anion transporter; Solute carrier family 21 member 3	Homo sapiens (human)
Ileal sodium/bile acid cotransporter	Apical sodium-dependent bile acid transporter; ASBT; Ileal Na(+)/bile acid cotransporter; Ileal sodium-dependent bile acid transporter; IBAT; ISBT; Na(+)-dependent ileal bile acid transporter; Sodium/taurocholate cotransporting polypeptide, ileal; Solute	Homo sapiens (human)
Sodium/bile acid cotransporter	Cell growth-inhibiting gene 29 protein; Na(+)/bile acid cotransporter; Na(+)/taurocholate transport protein; Sodium/taurocholate cotransporting polypeptide; Solute carrier family 10 member 1	Homo sapiens (human)
Organic solute transporter subunit alpha	OST-alpha; Solute carrier family 51 subunit alpha	Homo sapiens (human)
Solute carrier organic anion transporter family member 1B3	Liver-specific organic anion transporter 2; LST-2; Organic anion transporter 8; Organic anion-transporting polypeptide 8; OATP-8; Solute carrier family 21 member 8	Homo sapiens (human)
7-dehydrocholesterol reductase	7-DHC reductase; EC 1.3.1.21; Delta7-sterol reductase; Sterol Delta(7)-reductase; Sterol reductase SR-2	Homo sapiens (human)
Transcription factor Sp1		Homo sapiens (human)
Cholesterol side-chain cleavage enzyme, mitochondrial	EC 1.14.15.6; CYPXIA1; Cholesterol desmolase; Cytochrome P450 11A1; Cytochrome P450(scc)	Homo sapiens (human)
Corticosteroid-binding globulin	CBG; Serpin A6; Transcortin	Homo sapiens (human)
Diphosphomevalonate decarboxylase	EC 4.1.1.33; Mevalonate (diphospho)decarboxylase; MDDase; Mevalonate pyrophosphate decarboxylase	Homo sapiens (human)
Importin subunit beta-1	Importin-90; Karyopherin subunit beta-1; Nuclear factor p97; Pore targeting complex 97 kDa subunit; PTAC97	Homo sapiens (human)
Polyprenol reductase	EC 1.3.1.94; 3-oxo-5-alpha-steroid 4-dehydrogenase 3; 1.3.1.22; Steroid 5-alpha-reductase 2-like; Steroid 5-alpha-reductase 3; S5AR 3; SR type 3	Homo sapiens (human)
Hydroxymethylglutaryl-CoA synthase, cytoplasmic	HMG-CoA synthase; EC 2.3.3.10; 3-hydroxy-3-methylglutaryl coenzyme A synthase	Homo sapiens (human)
Peroxisomal multifunctional enzyme type 2	MFE-2; 17-beta-hydroxysteroid dehydrogenase 4; 17-beta-HSD 4; D-bifunctional protein; DBP; Multifunctional protein 2; MFP-2; Short chain dehydrogenase/reductase family 8C member 1	Homo sapiens (human)
3-keto-steroid reductase/17-beta-hydroxysteroid dehydrogenase 7	17-beta-hydroxysteroid dehydrogenase 7; 17-beta-HSD 7; 3-keto-steroid reductase; 1.1.1.270; Dihydrotestosterone oxidoreductase; 1.1.1.210; Estradiol 17-beta-dehydrogenase 7; 1.1.1.62; Short chain dehydrogenase/reductase family 37C member 1	Homo sapiens (human)
SUMO-conjugating enzyme UBC9	EC 2.3.2.-; RING-type E3 SUMO transferase UBC9; SUMO-protein ligase; Ubiquitin carrier protein 9; Ubiquitin carrier protein I; Ubiquitin-conjugating enzyme E2 I; Ubiquitin-protein ligase I; p18	Homo sapiens (human)
Lathosterol oxidase	EC 1.14.19.20; C-5 sterol desaturase; Delta(7)-sterol 5-desaturase; Delta(7)-sterol C5(6)-desaturase; Lathosterol 5-desaturase; Sterol-C5-desaturase	Homo sapiens (human)
GTP-binding nuclear protein Ran	Androgen receptor-associated protein 24; GTPase Ran; Ras-like protein TC4; Ras-related nuclear protein	Homo sapiens (human)
Glycerol-3-phosphate acyltransferase 1, mitochondrial	GPAT-1; EC 2.3.1.15	Homo sapiens (human)
Delta(14)-sterol reductase LBR	Delta-14-SR; EC 1.3.1.70; 3-beta-hydroxysterol Delta (14)-reductase; C-14 sterol reductase; C14SR; Integral nuclear envelope inner membrane protein; LMN2R; Lamin-B receptor; Sterol C14-reductase	Homo sapiens (human)
Peroxisomal acyl-coenzyme A oxidase 2	EC 1.17.99.3; 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanoyl-CoA 24-hydroxylase; 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanoyl-CoA oxidase; Trihydroxycoprostanoyl-CoA oxidase; THCA-CoA oxidase; THCCox	Homo sapiens (human)
Membrane-bound transcription factor site-1 protease	EC 3.4.21.112; Endopeptidase S1P; Subtilisin/kexin-isozyme 1; SKI-1	Homo sapiens (human)
Cubilin	460 kDa receptor; Intestinal intrinsic factor receptor; Intrinsic factor-cobalamin receptor; Intrinsic factor-vitamin B12 receptor	Homo sapiens (human)
Aldo-keto reductase family 1 member B15	EC 1.1.1.-; EC 1.1.1.300; EC 1.1.1.54; Estradiol 17-beta-dehydrogenase AKR1B15; Farnesol dehydrogenase; 1.1.1.216; Testosterone 17beta-dehydrogenase; 1.1.1.64	Homo sapiens (human)
Pro-opiomelanocortin	POMC; Corticotropin-lipotropin	Homo sapiens (human)
NADPH:adrenodoxin oxidoreductase, mitochondrial	AR; Adrenodoxin reductase; EC 1.18.1.6; Ferredoxin--NADP(+) reductase; Ferredoxin reductase	Homo sapiens (human)
Bile acid-CoA:amino acid N-acyltransferase	BACAT; BAT; EC 2.3.1.65; Bile acid-CoA thioesterase; Choloyl-CoA hydrolase; 3.1.2.27; Glycine N-choloyltransferase; Long-chain fatty-acyl-CoA hydrolase; 3.1.2.2	Homo sapiens (human)
Isopentenyl-diphosphate Delta-isomerase 1	EC 5.3.3.2; Isopentenyl pyrophosphate isomerase 1; IPP isomerase 1; IPPI1	Homo sapiens (human)
Acyl-coenzyme A thioesterase 8	Acyl-CoA thioesterase 8; EC 3.1.2.1; EC 3.1.2.11; EC 3.1.2.2; EC 3.1.2.3; EC 3.1.2.5; Choloyl-coenzyme A thioesterase; 3.1.2.27; HIV-Nef-associated acyl-CoA thioesterase; Peroxisomal acyl-CoA thioesterase 2; PTE-2; Peroxisomal acyl-coenzyme A thioester hy	Homo sapiens (human)
Cholesterol 25-hydroxylase	EC 1.14.99.38; Cholesterol 25-monooxygenase; h25OH	Homo sapiens (human)
Acetyl-CoA acetyltransferase, cytosolic	EC 2.3.1.9; Acetyl-CoA transferase-like protein; Cytosolic acetoacetyl-CoA thiolase	Homo sapiens (human)
Steroidogenic acute regulatory protein, mitochondrial	StAR; START domain-containing protein 1; StARD1	Homo sapiens (human)
24-hydroxycholesterol 7-alpha-hydroxylase	EC 1.14.14.26; Cytochrome P450 39A1; hCYP39A1; Oxysterol 7-alpha-hydroxylase	Homo sapiens (human)
Membrane-bound transcription factor site-2 protease	EC 3.4.24.85; Endopeptidase S2P; Sterol regulatory element-binding proteins intramembrane protease; SREBPs intramembrane protease	Homo sapiens (human)
Low density lipoprotein receptor adapter protein 1	Autosomal recessive hypercholesterolemia protein	Homo sapiens (human)
F-box-like/WD repeat-containing protein TBL1X	SMAP55; Transducin beta-like protein 1X; Transducin-beta-like protein 1, X-linked	Homo sapiens (human)
Lutropin subunit beta	Lutropin beta chain; Luteinizing hormone subunit beta; LH-B; LSH-B; LSH-beta	Homo sapiens (human)
Nuclear transcription factor Y subunit alpha	CAAT box DNA-binding protein subunit A; Nuclear transcription factor Y subunit A; NF-YA	Homo sapiens (human)
Nuclear transcription factor Y subunit beta	CAAT box DNA-binding protein subunit B; Nuclear transcription factor Y subunit B; NF-YB	Homo sapiens (human)
Aldo-keto reductase family 1 member D1	EC 1.3.1.3; 3-oxo-5-beta-steroid 4-dehydrogenase; Delta(4)-3-ketosteroid 5-beta-reductase; Delta(4)-3-oxosteroid 5-beta-reductase	Homo sapiens (human)
Mevalonate kinase	MK; EC 2.7.1.36	Homo sapiens (human)
Nuclear transcription factor Y subunit gamma	CAAT box DNA-binding protein subunit C; Nuclear transcription factor Y subunit C; NF-YC; Transactivator HSM-1/2	Homo sapiens (human)
Phosphomevalonate kinase	PMKase; hPMK; EC 2.7.4.2	Homo sapiens (human)
Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating	EC 1.1.1.170; Protein H105e3	Homo sapiens (human)
Methylsterol monooxygenase 1	EC 1.14.18.9; C-4 methylsterol oxidase; Sterol-C4-methyl oxidase	Homo sapiens (human)
Organic solute transporter subunit beta	OST-beta; Solute carrier family 51 subunit beta	Homo sapiens (human)
Phospholipid phosphatase 6	EC 3.1.3.-; Phosphatidic acid phosphatase type 2 domain-containing protein 2; PPAP2 domain-containing protein 2; Presqualene diphosphate phosphatase	Homo sapiens (human)
E3 SUMO-protein ligase PIAS4	EC 2.3.2.27; PIASy; Protein inhibitor of activated STAT protein 4; Protein inhibitor of activated STAT protein gamma; PIAS-gamma; RING-type E3 ubiquitin transferase PIAS4	Homo sapiens (human)
Estradiol 17-beta-dehydrogenase 11	EC 1.1.1.62; 17-beta-hydroxysteroid dehydrogenase 11; 17-beta-HSD 11; 17bHSD11; 17betaHSD11; 17-beta-hydroxysteroid dehydrogenase XI; 17-beta-HSD XI; 17betaHSDXI; Cutaneous T-cell lymphoma-associated antigen HD-CL-03; CTCL-associated antigen HD-CL-03; Deh	Homo sapiens (human)
Protein ARV1	hARV1	Homo sapiens (human)
3 beta-hydroxysteroid dehydrogenase type 7	3 beta-hydroxysteroid dehydrogenase type VII; 3-beta-HSD VII; 3-beta-hydroxy-Delta(5)-C27 steroid oxidoreductase; C(27) 3-beta-HSD; 1.1.1.-; Cholest-5-ene-3-beta,7-alpha-diol 3-beta-dehydrogenase; 1.1.1.181	Homo sapiens (human)
GTP-binding protein SAR1b	GTP-binding protein B; GTBPB	Homo sapiens (human)

Compounds (92)

Compound	Description
hydronium ion
NADH
deoxycholic acid	A bile acid formed by bacterial action from cholate. It is usually conjugated with glycine or taurine. Deoxycholic acid acts as a detergent to solubilize fats for intestinal absorption, is reabsorbed itself, and is used as a choleretic and detergent.
cortisone	A naturally occurring glucocorticoid that has been used in replacement therapy for ADRENAL INSUFFICIENCY and as an anti-inflammatory agent. Cortisone itself is inactive; it is converted in the liver to the active metabolite HYDROCORTISONE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p726)
Calcium	A basic element found in nearly all tissues. It is a member of the alkaline earth family of metals with the atomic symbol Ca, atomic number 20, and atomic weight 40. Calcium is the most abundant mineral in the body and combines with phosphorus to form calcium phosphate in the bones and teeth. It is essential for the normal functioning of nerves and muscles and plays a role in blood coagulation (as factor IV) and in many enzymatic processes.
iron	A metallic element with atomic symbol Fe, atomic number 26, and atomic weight 55.85. It is an essential constituent of HEMOGLOBINS; CYTOCHROMES; and IRON-BINDING PROTEINS. It plays a role in cellular redox reactions and in the transport of OXYGEN.
Carbon Dioxide	A colorless, odorless gas that can be formed by the body and is necessary for the respiration cycle of plants and animals.
Orthophosphate
calcitriol	The physiologically active form of vitamin D. It is formed primarily in the kidney by enzymatic hydroxylation of 25-hydroxycholecalciferol (CALCIFEDIOL). Its production is stimulated by low blood calcium levels and parathyroid hormone. Calcitriol increases intestinal absorption of calcium and phosphorus, and in concert with parathyroid hormone increases bone resorption.
cholecalciferol	Derivative of 7-dehydroxycholesterol formed by ULTRAVIOLET RAYS breaking of the C9-C10 bond. It differs from ERGOCALCIFEROL in having a single bond between C22 and C23 and lacking a methyl group at C24.
calcifediol	The major circulating metabolite of VITAMIN D3. It is produced in the LIVER and is the best indicator of the body's vitamin D stores. It is effective in the treatment of RICKETS and OSTEOMALACIA, both in azotemic and non-azotemic patients. Calcifediol also has mineralizing properties.
Hydrocortisone	The main glucocorticoid secreted by the ADRENAL CORTEX. Its synthetic counterpart is used, either as an injection or topically, in the treatment of inflammation, allergy, collagen diseases, asthma, adrenocortical deficiency, shock, and some neoplastic conditions.
Estradiol	The 17-beta-isomer of estradiol, an aromatized C18 steroid with hydroxyl group at 3-beta- and 17-beta-position. Estradiol-17-beta is the most potent form of mammalian estrogenic steroids.
estrone	An aromatized C18 steroid with a 3-hydroxyl group and a 17-ketone, a major mammalian estrogen. It is converted from ANDROSTENEDIONE directly, or from TESTOSTERONE via ESTRADIOL. In humans, it is produced primarily by the cyclic ovaries, PLACENTA, and the ADIPOSE TISSUE of men and postmenopausal women.
dehydroepiandrosterone	A major C19 steroid produced by the ADRENAL CORTEX. It is also produced in small quantities in the TESTIS and the OVARY. Dehydroepiandrosterone (DHEA) can be converted to TESTOSTERONE; ANDROSTENEDIONE; ESTRADIOL; and ESTRONE. Most of DHEA is sulfated (DEHYDROEPIANDROSTERONE SULFATE) before secretion.
Progesterone	The major progestational steroid that is secreted primarily by the CORPUS LUTEUM and the PLACENTA. Progesterone acts on the UTERUS, the MAMMARY GLANDS and the BRAIN. It is required in EMBRYO IMPLANTATION; PREGNANCY maintenance, and the development of mammary tissue for MILK production. Progesterone, converted from PREGNENOLONE, also serves as an intermediate in the biosynthesis of GONADAL STEROID HORMONES and adrenal CORTICOSTEROIDS.
Cholesterol	The principal sterol of all higher animals, distributed in body tissues, especially the brain and spinal cord, and in animal fats and oils.
Testosterone	A potent androgenic steroid and major product secreted by the LEYDIG CELLS of the TESTIS. Its production is stimulated by LUTEINIZING HORMONE from the PITUITARY GLAND. In turn, testosterone exerts feedback control of the pituitary LH and FSH secretion. Depending on the tissues, testosterone can be further converted to DIHYDROTESTOSTERONE or ESTRADIOL.
desoxycorticosterone	A steroid metabolite that is the 11-deoxy derivative of CORTICOSTERONE and the 21-hydroxy derivative of PROGESTERONE
squalene	A natural 30-carbon triterpene.
adenosine diphosphate	Adenosine 5'-(trihydrogen diphosphate). An adenine nucleotide containing two phosphate groups esterified to the sugar moiety at the 5'-position.
Hydrogen Peroxide	A strong oxidizing agent used in aqueous solution as a ripening agent, bleach, and topical anti-infective. It is relatively unstable and solutions deteriorate over time unless stabilized by the addition of acetanilide or similar organic materials.
Magnesium	A metallic element that has the atomic symbol Mg, atomic number 12, and atomic weight 24.31. It is important for the activity of many enzymes, especially those involved in OXIDATIVE PHOSPHORYLATION.
pregnenolone	A 21-carbon steroid, derived from CHOLESTEROL and found in steroid hormone-producing tissues. Pregnenolone is the precursor to GONADAL STEROID HORMONES and the adrenal CORTICOSTEROIDS.
Sodium	A member of the alkali group of metals. It has the atomic symbol Na, atomic number 11, and atomic weight 23.
Water	A clear, odorless, tasteless liquid that is essential for most animal and plant life and is an excellent solvent for many substances. The chemical formula is hydrogen oxide (H2O). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
Oxygen	An element with atomic symbol O, atomic number 8, and atomic weight [15.99903; 15.99977]. It is the most abundant element on earth and essential for respiration.
presqualene monophosphate	structure in first source
Guanosine Monophosphate	A guanine nucleotide containing one phosphate group esterified to the sugar moiety and found widely in nature.
zymostenol	RN given refers to (3beta,5alpha)-isomer; RN for cpd without isomeric designation not available 9/88
dihydrotestosterone	A potent androgenic metabolite of TESTOSTERONE. It is produced by the action of the enzyme 3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE.
18-hydroxycorticosterone	11 beta,18,21-Trihydroxypregn-4-ene-3,20-dione.
isopentenyl pyrophosphate	substrate for isopentenyl pyrophosphate isomerase; RN given refers to unlabeled cpd; a nonpeptide mycobacterial antigen that stimulates gamma delta T cells
7,25-dihydroxycholesterol	has various immunosupressive effects; RN given refers to (3beta)-isomer; RN for cpd without isomeric designation not available 12/88
24-hydroxycholesterol
3,7,12-trihydroxycholestan-26-oic acid	RN given refers to (3alpha,5beta,7alpha,12alpha)-isomer
7 alpha-hydroxy-4-cholesten-3-one	structure
isocaproaldehyde	produced from side-chain cleavage of 20,22-dihydroxycholesterol
adenosine monophosphate	Adenine nucleotide containing one phosphate group esterified to the sugar moiety in the 2'-, 3'-, or 5'-position.
nad	A coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage. It is found widely in nature and is involved in numerous enzymatic reactions in which it serves as an electron carrier by being alternately oxidized (NAD+) and reduced (NADH). (Dorland, 27th ed)
NADP	Nicotinamide adenine dinucleotide phosphate. A coenzyme composed of ribosylnicotinamide 5'-phosphate (NMN) coupled by pyrophosphate linkage to the 5'-phosphate adenosine 2',5'-bisphosphate. It serves as an electron carrier in a number of reactions, being alternately oxidized (NADP+) and reduced (NADPH). (Dorland, 27th ed)
NADP	Nicotinamide adenine dinucleotide phosphate. A coenzyme composed of ribosylnicotinamide 5'-phosphate (NMN) coupled by pyrophosphate linkage to the 5'-phosphate adenosine 2',5'-bisphosphate. It serves as an electron carrier in a number of reactions, being alternately oxidized (NADP+) and reduced (NADPH). (Dorland, 27th ed)
3,7,12-trihydroxycoprostane	intermediate in bile acid synthesis in liver; enhances rate of porphyrin synthesis in cultured liver cells by induction of delta-aminolevulinic acid synthetase; RN given refers to (3alpha,5beta,7alpha,12alpha)-isomer; structure
acetaldehyde	A colorless, flammable liquid used in the manufacture of acetic acid, perfumes, and flavors. It is also an intermediate in the metabolism of alcohol. It has a general narcotic action and also causes irritation of mucous membranes. Large doses may cause death from respiratory paralysis.
cholestane-3,7,12,26-tetrol	precursor of cholic acid biosyn in man; RN given refers to (3alpha,5beta,7alpha,12alpha)-isomer
7 alpha,12 alpha,26-trihydroxy-5 beta-cholestan-3-one	structure in first source
formate
dihydroxycoprostane	intermediate in bile acid synthesis in the liver; enhance rate of prophyrin synthesis in cultured liver cells by induction of delta-aminolevulinic acid synthetase; RN given refers to (3alpha,5beta,7alpha)-isomer; structure
7 alpha,12 alpha-dihydroxy-5-cholesten-3-one	inermediate in bile acid biosynthesis
cholestane-3,7,26-triol
5-diphosphomevalonic acid	RN given refers to ion(1-)
7-dehydrocholesterol	RN given refers to (3beta)-isomer; structure; main provitamin in skin that is converted by sunlight to cholecalciferol (vitamin D3)
3,7,12-trihydroxycholestan-26-al	structure in first source
desmosterol	An intermediate in the synthesis of cholesterol.
24-dehydroprovitamin D3
24,25-dihydrolanosterol
cortodoxone	17,21-Dihydroxypregn-4-ene-3,20-dione. A 17-hydroxycorticosteroid with glucocorticoid and anti-inflammatory activities.
cholest-5-ene-3,7,27-triol
4,4-dimethylcholesta-8,14,24-trienol	a meiosis activating sterol; RN given refers to (5alpha,3beta)-isomer
farnesyl pyrophosphate	a sesquiterpene that dimerizes to SQUALENE; RN given refers to cpd without isomeric designation
geranyl pyrophosphate	RN given refers to (E)-isomer
presqualene pyrophosphate
Mevalonate
2,3-oxidosqualene	an oxidized derivative of SQUALENE that can fold in several ways: chair-boat-chair-boat to LANOSTEROL; chair-chair-chair-boat to dammarane; or all chair to hopane and on to cycloartenol; RN given refers to (all-Z)-isomer
cholesta-7,24-dien-3-ol	minor metabolite of in vitro incubation of mevalonic acid with yeast; structure; RN given refers to (3beta,5alpha)-isomer; RN for cpd without isomeric designation not avail 10/89
adenosine triphosphate	An adenine nucleotide containing three phosphate groups esterified to the sugar moiety. In addition to its crucial roles in metabolism adenosine triphosphate is a neurotransmitter.
aldosterone	A hormone secreted by the ADRENAL CORTEX that regulates electrolyte and water balance by increasing the renal retention of sodium and the excretion of potassium.
17-alpha-hydroxyprogesterone	A metabolite of PROGESTERONE with a hydroxyl group at the 17-alpha position. It serves as an intermediate in the biosynthesis of HYDROCORTISONE and GONADAL STEROID HORMONES.
20,22-dihydroxycholesterol	RN given refers to (3beta,22R)-isomer
lathosterol	RN given refers to (3beta,5alpha)-isomer
calcitroic acid	structure
cholest-5-en-3 beta,7 alpha-diol	substrate for hydroxysteroid dehydrogenase; RN given refers to (3beta,7alpha)-isomer
pregn-5-ene-3,20-dione
4,4-dimethyl-5-alpha-cholesta-(8,24)-dien-3-beta-ol	RN given refers to (3beta,5alpha)-isomer
22s-hydroxycholesterol
17-hydroxypregnenedione	structure
7 alpha,26-dihydroxy-4-cholesten-3-one
lanosterol	A triterpene that derives from the chair-boat-chair-boat folding of 2,3-oxidosqualene. It is metabolized to CHOLESTEROL and CUCURBITACINS.
Coenzyme A
acetoacetyl CoA
Acetyl Coenzyme A	Acetyl CoA participates in the biosynthesis of fatty acids and sterols, in the oxidation of fatty acids and in the metabolism of many amino acids. It also acts as a biological acetylating agent.
Dicyclomine	A muscarinic antagonist used as an antispasmodic and in urinary incontinence. It has little effect on glandular secretion or the cardiovascular system. It does have some local anesthetic properties and is used in gastrointestinal, biliary, and urinary tract spasms.
Flavin-Adenine Dinucleotide	A condensation product of riboflavin and adenosine diphosphate. The coenzyme of various aerobic dehydrogenases, e.g., D-amino acid oxidase and L-amino acid oxidase. (Lehninger, Principles of Biochemistry, 1982, p972)
corticosterone	An adrenocortical steroid that has modest but significant activities as a mineralocorticoid and a glucocorticoid. (From Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed, p1437)
creolin	from refined coal tar oils
androstenedione	A delta-4 C19 steroid that is produced not only in the TESTIS, but also in the OVARY and the ADRENAL CORTEX. Depending on the tissue type, androstenedione can serve as a precursor to TESTOSTERONE as well as ESTRONE and ESTRADIOL.
3,3-dimethylallyl pyrophosphate	isomeric with isopentenyl pyrophosphate
25-hydroxycholesterol
17-alpha-hydroxypregnenolone	A 21-carbon steroid that is converted from PREGNENOLONE by STEROID 17-ALPHA-HYDROXYLASE. It is an intermediate in the delta-5 pathway of biosynthesis of GONADAL STEROID HORMONES and the adrenal CORTICOSTEROIDS.
zymosterol	a 4,14-desmethyl intermediate between LANOSTEROL and CHOLESTEROL
propionyl-coenzyme a	RN given refers to parent cpd
cholest-5-ene-3 beta,26-diol	isolated from human brain

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Metabolism of steroids

Proteins (109)

Compounds (92)