Page last updated: 2024-10-06
Peroxisomal lipid metabolism
Proteins (20)
| Protein | Synonyms | Taxonomy |
|---|---|---|
| Very long-chain acyl-CoA synthetase | VLACS; VLCS; EC 6.2.1.-; Arachidonate--CoA ligase; 6.2.1.15; Fatty acid transport protein 2; FATP-2; Fatty-acid-coenzyme A ligase, very long-chain 1; Long-chain-fatty-acid--CoA ligase; 6.2.1.3; Phytanate--CoA ligase; 6.2.1.24; Solute carrier family 27 mem | Homo sapiens (human) |
| Peroxisomal carnitine O-octanoyltransferase | COT; EC 2.3.1.137 | Homo sapiens (human) |
| Alpha-methylacyl-CoA racemase | EC 5.1.99.4; 2-methylacyl-CoA racemase | Homo sapiens (human) |
| Hydroxyacid oxidase 2 | HAOX2; EC 1.1.3.15; (S)-2-hydroxy-acid oxidase, peroxisomal; Cell growth-inhibiting gene 16 protein; Long chain alpha-hydroxy acid oxidase; Long-chain L-2-hydroxy acid oxidase | Homo sapiens (human) |
| Carnitine O-acetyltransferase | Carnitine acetylase; EC 2.3.1.137; EC 2.3.1.7; Carnitine acetyltransferase; CAT; CrAT | Homo sapiens (human) |
| Phytanoyl-CoA dioxygenase, peroxisomal | EC 1.14.11.18; Phytanic acid oxidase; Phytanoyl-CoA alpha-hydroxylase; PhyH | Homo sapiens (human) |
| Peroxisomal bifunctional enzyme | PBE; PBFE; L-bifunctional protein; LBP; Multifunctional enzyme 1; MFE1 | Homo sapiens (human) |
| Peroxisomal multifunctional enzyme type 2 | MFE-2; 17-beta-hydroxysteroid dehydrogenase 4; 17-beta-HSD 4; D-bifunctional protein; DBP; Multifunctional protein 2; MFP-2; Short chain dehydrogenase/reductase family 8C member 1 | Homo sapiens (human) |
| Peroxisomal acyl-coenzyme A oxidase 2 | EC 1.17.99.3; 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanoyl-CoA 24-hydroxylase; 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanoyl-CoA oxidase; Trihydroxycoprostanoyl-CoA oxidase; THCA-CoA oxidase; THCCox | Homo sapiens (human) |
| Peroxisomal acyl-coenzyme A oxidase 3 | EC 1.3.3.6; Branched-chain acyl-CoA oxidase; BRCACox; Pristanoyl-CoA oxidase | Homo sapiens (human) |
| Acyl-coenzyme A thioesterase 8 | Acyl-CoA thioesterase 8; EC 3.1.2.1; EC 3.1.2.11; EC 3.1.2.2; EC 3.1.2.3; EC 3.1.2.5; Choloyl-coenzyme A thioesterase; 3.1.2.27; HIV-Nef-associated acyl-CoA thioesterase; Peroxisomal acyl-CoA thioesterase 2; PTE-2; Peroxisomal acyl-coenzyme A thioester hy | Homo sapiens (human) |
| ATP-binding cassette sub-family D member 1 | EC 7.6.2.4; Adrenoleukodystrophy protein; ALDP | Homo sapiens (human) |
| Nucleoside diphosphate-linked moiety X motif 19 | Nudix motif 19; EC 3.6.1.- | Homo sapiens (human) |
| Peroxisomal membrane protein PMP34 | 34 kDa peroxisomal membrane protein; Solute carrier family 25 member 17 | Homo sapiens (human) |
| 3-ketoacyl-CoA thiolase, peroxisomal | EC 2.3.1.16; Acetyl-CoA C-myristoyltransferase; 2.3.1.155; Acetyl-CoA acyltransferase; 2.3.1.9; Beta-ketothiolase; Peroxisomal 3-oxoacyl-CoA thiolase | Homo sapiens (human) |
| Peroxisomal coenzyme A diphosphatase NUDT7 | EC 3.6.1.-; Nucleoside diphosphate-linked moiety X motif 7; Nudix motif 7 | Homo sapiens (human) |
| Peroxisomal trans-2-enoyl-CoA reductase | TERP; EC 1.3.1.38; 2,4-dienoyl-CoA reductase-related protein; DCR-RP; HPDHase; Short chain dehydrogenase/reductase family 29C member 1; pVI-ARL | Homo sapiens (human) |
| Peroxisomal 2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing] | pDCR; EC 1.3.1.124; 2,4-dienoyl-CoA reductase 2; Short chain dehydrogenase/reductase family 17C member 1 | Homo sapiens (human) |
| Acyl-coenzyme A oxidase-like protein | Acyl-CoA oxidase-like protein; EC 1.3.3.- | Homo sapiens (human) |
| 2-hydroxyacyl-CoA lyase 1 | EC 4.1.2.n2; 2-hydroxyphytanoyl-CoA lyase; 2-HPCL; Phytanoyl-CoA 2-hydroxylase 2 | Homo sapiens (human) |
Compounds (34)
| Compound | Description |
|---|---|
| hydronium ion | |
| Thiamine Pyrophosphate | The coenzyme form of Vitamin B1 present in many animal tissues. It is a required intermediate in the PYRUVATE DEHYDROGENASE COMPLEX and the KETOGLUTARATE DEHYDROGENASE COMPLEX. |
| Succinate | |
| acetic acid | Product of the oxidation of ethanol and of the destructive distillation of wood. It is used locally, occasionally internally, as a counterirritant and also as a reagent. (Stedman, 26th ed) |
| NADH | |
| iron | A metallic element with atomic symbol Fe, atomic number 26, and atomic weight 55.85. It is an essential constituent of HEMOGLOBINS; CYTOCHROMES; and IRON-BINDING PROTEINS. It plays a role in cellular redox reactions and in the transport of OXYGEN. |
| Carbon Dioxide | A colorless, odorless gas that can be formed by the body and is necessary for the respiration cycle of plants and animals. |
| Hydrogen Peroxide | A strong oxidizing agent used in aqueous solution as a ripening agent, bleach, and topical anti-infective. It is relatively unstable and solutions deteriorate over time unless stabilized by the addition of acetanilide or similar organic materials. |
| Magnesium | A metallic element that has the atomic symbol Mg, atomic number 12, and atomic weight 24.31. It is important for the activity of many enzymes, especially those involved in OXIDATIVE PHOSPHORYLATION. |
| Water | A clear, odorless, tasteless liquid that is essential for most animal and plant life and is an excellent solvent for many substances. The chemical formula is hydrogen oxide (H2O). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed) |
| Oxygen | An element with atomic symbol O, atomic number 8, and atomic weight [15.99903; 15.99977]. It is the most abundant element on earth and essential for respiration. |
| propionylcarnitine | RN given refers to cpd without isomeric designation |
| 3-oxopristanoyl-coenzyme A | |
| phytanoyl-coenzyme A | |
| hydroxyphytanoyl-coenzyme A | an intermediate in the alpha-oxidation of phytanic acid in rat liver peroxisomes; its formation is enhanced by dioxygenase cofactors |
| pristanal | structure given in first source |
| adenosine monophosphate | Adenine nucleotide containing one phosphate group esterified to the sugar moiety in the 2'-, 3'-, or 5'-position. |
| nad | A coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage. It is found widely in nature and is involved in numerous enzymatic reactions in which it serves as an electron carrier by being alternately oxidized (NAD+) and reduced (NADH). (Dorland, 27th ed) |
| alpha-Ketoglutarate | |
| formate | |
| carnitine | A constituent of STRIATED MUSCLE and LIVER. It is an amino acid derivative and an essential cofactor for fatty acid metabolism. |
| formyl-coenzyme a | |
| octanoyl-coenzyme A | |
| adenosine triphosphate | An adenine nucleotide containing three phosphate groups esterified to the sugar moiety. In addition to its crucial roles in metabolism adenosine triphosphate is a neurotransmitter. |
| 2-hydroxyhexadecanoic acid | RN given refers to cpd without isomeric designation |
| pristanic acid | |
| Coenzyme A | |
| lignoceroyl-coenzyme A | |
| phytanic acid | A 20-carbon branched chain fatty acid. In phytanic acid storage disease (REFSUM DISEASE) this lipid may comprise as much as 30% of the total fatty acids of the plasma. This is due to a phytanic acid alpha-hydroxylase deficiency. |
| Acetyl Coenzyme A | Acetyl CoA participates in the biosynthesis of fatty acids and sterols, in the oxidation of fatty acids and in the metabolism of many amino acids. It also acts as a biological acetylating agent. |
| Malonyl Coenzyme A | A coenzyme A derivative which plays a key role in the fatty acid synthesis in the cytoplasmic and microsomal systems. |
| Flavin-Adenine Dinucleotide | A condensation product of riboflavin and adenosine diphosphate. The coenzyme of various aerobic dehydrogenases, e.g., D-amino acid oxidase and L-amino acid oxidase. (Lehninger, Principles of Biochemistry, 1982, p972) |
| creolin | from refined coal tar oils |
| propionyl-coenzyme a | RN given refers to parent cpd |