Compounds > vanicoside b
Page last updated: 2024-11-11

vanicoside b

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth

Description

vanicoside B: isolated from Polygonum pensylvanicum; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

FloraRankFlora DefinitionFamilyFamily Definition
PolygonumgenusA plant genus of the family POLYGONACEAE that is an ingredient of Shou-Wu-Pian, a Chinese herbal preparation (DRUGS, CHINESE HERBAL). The common name of black bindweed also refers to TAMUS or Fallopia (use POLYGONACEAE).[MeSH]PolygonaceaeThe only family of the buckwheat order (Polygonales) of dicotyledonous flowering plants. It has 40 genera of herbs, shrubs, and trees.[MeSH]

Cross-References

ID SourceID
PubMed CID10033855
CHEMBL ID492323
SCHEMBL ID3366349
MeSH IDM0230777

Synonyms (9)

Synonym
155179-21-8
vanicoside b
SCHEMBL3366349
CHEMBL492323
[(2r,3r,4s,5s)-3-hydroxy-4-[(e)-3-(4-hydroxyphenyl)prop-2-enoyl]oxy-5-[[(e)-3-(4-hydroxyphenyl)prop-2-enoyl]oxymethyl]-5-[(2r,3r,4s,5s,6r)-3,4,5-trihydroxy-6-[[(e)-3-(4-hydroxy-3-methoxyphenyl)prop-2-enoyl]oxymethyl]oxan-2-yl]oxyoxolan-2-yl]methyl (e)-3-(
DTXSID401317941
HY-N9561
CS-0201356
AKOS040763269
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (56)

Assay IDTitleYearJournalArticle
AID1541027Inhibition of epithelial-mesenchymal transition in human MDA-MB-231 cells increase in E-cadherin expression at 5 uM after 24 hrs by RT-PCR analysis2019Journal of natural products, 11-22, Volume: 82, Issue:11
Antitumor Activity of Vanicoside B Isolated from
AID1540998Cell cycle arrest in human HCC38 cells assessed as increase in accumulation of cells at sub-G1 phase at 2.5 to 10 uM by PI/RNase staining based flow cytometric analysis2019Journal of natural products, 11-22, Volume: 82, Issue:11
Antitumor Activity of Vanicoside B Isolated from
AID1541021Inhibition of epithelial-mesenchymal transition in human MDA-MB-231 cells reduction in beta catenin protein expression after 24 hrs by Western blot analysis2019Journal of natural products, 11-22, Volume: 82, Issue:11
Antitumor Activity of Vanicoside B Isolated from
AID358233Inhibition of 12-O-tetradecanoylphorbol-13-acetate-induced EBV-early antigen activation in human Raji cells at 10 molar ratio relative to TPA2001Journal of natural products, Oct, Volume: 64, Issue:10
New phenylpropanoid esters of sucrose from Polygonum lapathifolium.
AID1541035Downregulation of phosphorylated STAT1 expression at ser727 residue in Balb/c mouse xenografted with human MDA-MB-231 cells at 5 to 20 mg/kg, ip administered 3 times per week for 29 days by DAB staining based immunohistochemical analysis2019Journal of natural products, 11-22, Volume: 82, Issue:11
Antitumor Activity of Vanicoside B Isolated from
AID1541007Inhibition of CDK8 in human MDA-MB-231 cells assessed as reduction in HK1 expression at 10 uM after 24 hrs by RT-PCR analysis2019Journal of natural products, 11-22, Volume: 82, Issue:11
Antitumor Activity of Vanicoside B Isolated from
AID1540991Antiproliferative activity against human MDA-MB-231 cells assessed as reduction in cell viability after 72 hrs by SRB assay2019Journal of natural products, 11-22, Volume: 82, Issue:11
Antitumor Activity of Vanicoside B Isolated from
AID1540999Induction of apoptosis in human MDA-MB-231 cells at 2.5 to 20 uM after 48 hrs by Annexin-V/PI staining based flow cytometric analysis2019Journal of natural products, 11-22, Volume: 82, Issue:11
Antitumor Activity of Vanicoside B Isolated from
AID1541012Inhibition of CDK8 in human MDA-MB-231 cells assessed as reduction in AXL expression after 24 hrs by Western blot analysis2019Journal of natural products, 11-22, Volume: 82, Issue:11
Antitumor Activity of Vanicoside B Isolated from
AID1541031Antitumour activity against human MDA-MB-231 cells xenografted in Balb/c mouse assessed as reduction in tumour volume at 5 mg/kg, ip administered 3 times per week and measured 2 times per week for 29 days relative to control2019Journal of natural products, 11-22, Volume: 82, Issue:11
Antitumor Activity of Vanicoside B Isolated from
AID1541024Inhibition of epithelial-mesenchymal transition in human HCC38 cells reduction in beta catenin protein expression after 24 hrs by Western blot analysis2019Journal of natural products, 11-22, Volume: 82, Issue:11
Antitumor Activity of Vanicoside B Isolated from
AID1540994Inhibition of colony formation in human HCC38 cells assessed as reduction in number of colonies at 2.5 to 20 uM after 14 days by crystal violet staining based light microscopic analysis2019Journal of natural products, 11-22, Volume: 82, Issue:11
Antitumor Activity of Vanicoside B Isolated from
AID1540996Inhibition of colony formation in human HCC38 cells assessed as reduction in colony size at 20 uM after 14 days by crystal violet staining based light microscopic analysis2019Journal of natural products, 11-22, Volume: 82, Issue:11
Antitumor Activity of Vanicoside B Isolated from
AID1541018Inhibition of CDK8 in human HCC38 cells assessed as reduction in S6 phosphorylation after 24 hrs by Western blot analysis2019Journal of natural products, 11-22, Volume: 82, Issue:11
Antitumor Activity of Vanicoside B Isolated from
AID1540993Inhibition of colony formation in human MDA-MB-231 cells assessed as reduction in number of colonies at 2.5 to 20 uM after 14 days by crystal violet staining based light microscopic analysis2019Journal of natural products, 11-22, Volume: 82, Issue:11
Antitumor Activity of Vanicoside B Isolated from
AID1541034Toxicity in Balb/c mouse xenografted with human MDA-MB-231 cells assessed as effect on body weight at 5 to 20 mg/kg, ip ip administered 3 times per week and measured 2 times per week for 29 days2019Journal of natural products, 11-22, Volume: 82, Issue:11
Antitumor Activity of Vanicoside B Isolated from
AID1541020Antimigratory activity against human HCC38 cells at 1.25 to 5 uM after 24 hrs by scratch wound healing based microscopic analysis2019Journal of natural products, 11-22, Volume: 82, Issue:11
Antitumor Activity of Vanicoside B Isolated from
AID358236Cytotoxicity against human Raji cells assessed as cell viability at 100 molar ratio by Trypan blue method2001Journal of natural products, Oct, Volume: 64, Issue:10
New phenylpropanoid esters of sucrose from Polygonum lapathifolium.
AID1541014Inhibition of CDK8 in human MDA-MB-231 cells assessed as reduction in S6 phosphorylation after 24 hrs by Western blot analysis2019Journal of natural products, 11-22, Volume: 82, Issue:11
Antitumor Activity of Vanicoside B Isolated from
AID1541010Inhibition of CDK8 in human HCC38 cells assessed as increase in P27 expression at 10 uM after 24 hrs by RT-PCR analysis2019Journal of natural products, 11-22, Volume: 82, Issue:11
Antitumor Activity of Vanicoside B Isolated from
AID1541015Inhibition of CDK8 in human HCC38 cells assessed as reduction in STAT1 phosphorylation at Ser727 residue after 24 hrs by Western blot analysis2019Journal of natural products, 11-22, Volume: 82, Issue:11
Antitumor Activity of Vanicoside B Isolated from
AID1541000Induction of apoptosis in human HCC38 cells at 2.5 to 20 uM after 48 hrs by Annexin-V/PI staining based flow cytometric analysis2019Journal of natural products, 11-22, Volume: 82, Issue:11
Antitumor Activity of Vanicoside B Isolated from
AID1541026Inhibition of epithelial-mesenchymal transition in human HCC38 cells reduction in vimentin protein expression after 24 hrs by Western blot analysis2019Journal of natural products, 11-22, Volume: 82, Issue:11
Antitumor Activity of Vanicoside B Isolated from
AID333017Inhibition of PKC1994Journal of natural products, Feb, Volume: 57, Issue:2
Vanicosides A and B, protein kinase C inhibitors from Polygonum pensylvanicum.
AID1541003Induction of apoptosis in human MDA-MB-231 cells assessed as increase in PARP cleavage after 48 hrs by Western blot analysis2019Journal of natural products, 11-22, Volume: 82, Issue:11
Antitumor Activity of Vanicoside B Isolated from
AID1541006Induction of apoptosis in human HCC38 cells assessed as increase in PARP cleavage after 48 hrs by Western blot analysis2019Journal of natural products, 11-22, Volume: 82, Issue:11
Antitumor Activity of Vanicoside B Isolated from
AID1540992Antiproliferative activity against human HCC38 cells assessed as reduction in cell viability after 72 hrs by SRB assay2019Journal of natural products, 11-22, Volume: 82, Issue:11
Antitumor Activity of Vanicoside B Isolated from
AID1541004Inhibition of CDK8 in human HCC38 cells assessed as reduction in skp2 expression after 48 hrs by Western blot analysis2019Journal of natural products, 11-22, Volume: 82, Issue:11
Antitumor Activity of Vanicoside B Isolated from
AID1541032Antitumour activity against human MDA-MB-231 cells xenografted in Balb/c mouse assessed as reduction in tumour volume at 20 mg/kg, ip administered 3 times per week and measured 2 times per week for 29 days relative to control2019Journal of natural products, 11-22, Volume: 82, Issue:11
Antitumor Activity of Vanicoside B Isolated from
AID358237Cytotoxicity against human Raji cells assessed as cell viability at 10 molar ratio by Trypan blue method2001Journal of natural products, Oct, Volume: 64, Issue:10
New phenylpropanoid esters of sucrose from Polygonum lapathifolium.
AID358234Cytotoxicity against human Raji cells assessed as cell viability at 1000 molar ratio by Trypan blue method2001Journal of natural products, Oct, Volume: 64, Issue:10
New phenylpropanoid esters of sucrose from Polygonum lapathifolium.
AID1541016Inhibition of CDK8 in human HCC38 cells assessed as reduction in AXL expression after 24 hrs by Western blot analysis2019Journal of natural products, 11-22, Volume: 82, Issue:11
Antitumor Activity of Vanicoside B Isolated from
AID1541008Inhibition of CDK8 in human MDA-MB-231 cells assessed as increase in P27 expression at 10 uM after 24 hrs by RT-PCR analysis2019Journal of natural products, 11-22, Volume: 82, Issue:11
Antitumor Activity of Vanicoside B Isolated from
AID1541011Inhibition of CDK8 in human MDA-MB-231 cells assessed as reduction in STAT1 phosphorylation at Ser727 residue after 24 hrs by Western blot analysis2019Journal of natural products, 11-22, Volume: 82, Issue:11
Antitumor Activity of Vanicoside B Isolated from
AID1541013Inhibition of CDK8 in human MDA-MB-231 cells assessed as reduction in STAT3 phosphorylation after 24 hrs by Western blot analysis2019Journal of natural products, 11-22, Volume: 82, Issue:11
Antitumor Activity of Vanicoside B Isolated from
AID358232Inhibition of 12-O-tetradecanoylphorbol-13-acetate-induced EBV-early antigen activation in human Raji cells at 100 molar ratio relative to TPA2001Journal of natural products, Oct, Volume: 64, Issue:10
New phenylpropanoid esters of sucrose from Polygonum lapathifolium.
AID1541001Inhibition of CDK8 in human MDA-MB-231 cells assessed as reduction in skp2 expression after 48 hrs by Western blot analysis2019Journal of natural products, 11-22, Volume: 82, Issue:11
Antitumor Activity of Vanicoside B Isolated from
AID1541028Inhibition of epithelial-mesenchymal transition in human MDA-MB-231 cells reduction in N-cadherin expression at 5 uM after 24 hrs by RT-PCR analysis2019Journal of natural products, 11-22, Volume: 82, Issue:11
Antitumor Activity of Vanicoside B Isolated from
AID1541002Inhibition of CDK8 in human MDA-MB-231 cells assessed as increase in P27 expression after 48 hrs by Western blot analysis2019Journal of natural products, 11-22, Volume: 82, Issue:11
Antitumor Activity of Vanicoside B Isolated from
AID1541029Inhibition of epithelial-mesenchymal transition in human HCC38 cells increase in E-cadherin expression at 5 uM after 24 hrs by RT-PCR analysis2019Journal of natural products, 11-22, Volume: 82, Issue:11
Antitumor Activity of Vanicoside B Isolated from
AID1540997Cell cycle arrest in human MDA-MB-231 cells assessed as increase in accumulation of cells at sub-G1 phase at 2.5 to 10 uM by PI/RNase staining based flow cytometric analysis2019Journal of natural products, 11-22, Volume: 82, Issue:11
Antitumor Activity of Vanicoside B Isolated from
AID1541025Inhibition of epithelial-mesenchymal transition in human HCC38 cells reduction in BMP4 protein expression after 24 hrs by Western blot analysis2019Journal of natural products, 11-22, Volume: 82, Issue:11
Antitumor Activity of Vanicoside B Isolated from
AID1541030Inhibition of epithelial-mesenchymal transition in human HCC38 cells reduction in N-cadherin expression at 5 uM after 24 hrs by RT-PCR analysis2019Journal of natural products, 11-22, Volume: 82, Issue:11
Antitumor Activity of Vanicoside B Isolated from
AID1541023Inhibition of epithelial-mesenchymal transition in human MDA-MB-231 cells reduction in vimentin protein expression after 24 hrs by Western blot analysis2019Journal of natural products, 11-22, Volume: 82, Issue:11
Antitumor Activity of Vanicoside B Isolated from
AID1541022Inhibition of epithelial-mesenchymal transition in human MDA-MB-231 cells reduction in BMP4 protein expression after 24 hrs by Western blot analysis2019Journal of natural products, 11-22, Volume: 82, Issue:11
Antitumor Activity of Vanicoside B Isolated from
AID1541005Inhibition of CDK8 in human HCC38 cells assessed as increase in P27 expression after 48 hrs by Western blot analysis2019Journal of natural products, 11-22, Volume: 82, Issue:11
Antitumor Activity of Vanicoside B Isolated from
AID1541037Downregulation of Ki67 expression in Balb/c mouse xenografted with human MDA-MB-231 cells at 5 to 20 mg/kg, ip administered 3 times per week for 29 days by DAB staining based immunohistochemical analysis2019Journal of natural products, 11-22, Volume: 82, Issue:11
Antitumor Activity of Vanicoside B Isolated from
AID358231Inhibition of 12-O-tetradecanoylphorbol-13-acetate-induced EBV-early antigen activation in human Raji cells at 500 molar ratio relative to TPA2001Journal of natural products, Oct, Volume: 64, Issue:10
New phenylpropanoid esters of sucrose from Polygonum lapathifolium.
AID1541009Inhibition of CDK8 in human HCC38 cells assessed as reduction in HK1 expression at 10 uM after 24 hrs by RT-PCR analysis2019Journal of natural products, 11-22, Volume: 82, Issue:11
Antitumor Activity of Vanicoside B Isolated from
AID358230Inhibition of 12-O-tetradecanoylphorbol-13-acetate-induced EBV-early antigen activation in human Raji cells at 1000 molar ratio relative to TPA2001Journal of natural products, Oct, Volume: 64, Issue:10
New phenylpropanoid esters of sucrose from Polygonum lapathifolium.
AID358235Cytotoxicity against human Raji cells assessed as cell viability at 500 molar ratio by Trypan blue method2001Journal of natural products, Oct, Volume: 64, Issue:10
New phenylpropanoid esters of sucrose from Polygonum lapathifolium.
AID1541017Inhibition of CDK8 in human HCC38 cells assessed as reduction in STAT3 phosphorylation after 24 hrs by Western blot analysis2019Journal of natural products, 11-22, Volume: 82, Issue:11
Antitumor Activity of Vanicoside B Isolated from
AID333018Cytotoxicity against human MCF cells1994Journal of natural products, Feb, Volume: 57, Issue:2
Vanicosides A and B, protein kinase C inhibitors from Polygonum pensylvanicum.
AID1540995Inhibition of colony formation in human MDA-MB-231 cells assessed as reduction in colony size at 2.5 to 20 uM after 14 days by crystal violet staining based light microscopic analysis2019Journal of natural products, 11-22, Volume: 82, Issue:11
Antitumor Activity of Vanicoside B Isolated from
AID1541019Antimigratory activity against human MDA-MB-231 cells at 1.25 to 5 uM after 24 hrs by scratch wound healing based microscopic analysis2019Journal of natural products, 11-22, Volume: 82, Issue:11
Antitumor Activity of Vanicoside B Isolated from
AID1541036Downregulation of AXL expression in Balb/c mouse xenografted with human MDA-MB-231 cells at 5 to 20 mg/kg, ip administered 3 times per week for 29 days by DAB staining based immunohistochemical analysis2019Journal of natural products, 11-22, Volume: 82, Issue:11
Antitumor Activity of Vanicoside B Isolated from
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (8)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's1 (12.50)18.2507
2000's4 (50.00)29.6817
2010's1 (12.50)24.3611
2020's2 (25.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other9 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
sucrose
Saccharum: A plant genus of the family POACEAE widely cultivated in the tropics for the sweet cane that is processed into sugar.		7.730glycosyl glycosidealgal metabolite;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
osmolyte;
Saccharomyces cerevisiae metabolite;
sweetening agent
tetradecanoylphorbol acetate
Tetradecanoylphorbol Acetate: A phorbol ester found in CROTON OIL with very effective tumor promoting activity. It stimulates the synthesis of both DNA and RNA.. phorbol ester : Esters of phorbol, originally found in croton oil (from Croton tiglium, of the family Euphorbiaceae). A number of phorbol esters possess activity as tumour promoters and activate the mechanisms associated with cell growth. Some of these are used in experiments as activators of protein kinase C.. phorbol 13-acetate 12-myristate : A phorbol ester that is phorbol in which the hydroxy groups at the cyclopropane ring juction (position 13) and the adjacent carbon (position 12) have been converted into the corresponding acetate and myristate esters. It is a major active constituent of the seed oil of Croton tiglium. It has been used as a tumour promoting agent for skin carcinogenesis in rodents and is associated with increased cell proliferation of malignant cells. However its function is controversial since a decrease in cell proliferation has also been observed in several cancer cell types.		210acetate ester;
diester;
phorbol ester;
tertiary alpha-hydroxy ketone;
tetradecanoate ester		antineoplastic agent;
apoptosis inducer;
carcinogenic agent;
mitogen;
plant metabolite;
protein kinase C agonist;
reactive oxygen species generator
paclitaxel
Taxus: Genus of coniferous yew trees or shrubs, several species of which have medicinal uses. Notable is the Pacific yew, Taxus brevifolia, which is used to make the anti-neoplastic drug taxol (PACLITAXEL).		2.2110taxane diterpenoid;
tetracyclic diterpenoid		antineoplastic agent;
human metabolite;
metabolite;
microtubule-stabilising agent
(-)-catechin
(-)-catechin : The (-)-enantiomer of catechin.		210catechinmetabolite
3-hydroxystigmast-5-en-7-one
[no description available]		210steroid
glycosides
[no description available]		2.4220
methyl-p-coumarate
methyl-p-coumarate: structure in first source. 4-coumaric acid methyl ester : A cinnamate ester that is the methyl ester of 4-coumaric acid.		2104-coumaric acid methyl ester
lyoniside
daucosterol : A steroid saponin that is sitosterol attached to a beta-D-glucopyranosyl residue at position 3 via a glycosidic linkage. It has bee isolated from Panax japonicus var. major and Breynia fruticosa.		210beta-D-glucoside;
monosaccharide derivative;
steroid saponin		plant metabolite
vanicoside a
vanicoside A: isolated from Polygonum pensylvanicum; structure in first source		2.9440
ConditionIndicatedRelationship StrengthStudiesTrials
B-Cell Lymphoma
[description not available]		0210
Lymphoma, B-Cell
A group of heterogeneous lymphoid tumors generally expressing one or more B-cell antigens or representing malignant transformations of B-lymphocytes.		0210
ER-Negative PR-Negative HER2-Negative Breast Cancer
[description not available]		02.2110
Triple Negative Breast Neoplasms
Breast neoplasms that do not express ESTROGEN RECEPTORS; PROGESTERONE RECEPTORS; and do not overexpress the NEU RECEPTOR/HER-2 PROTO-ONCOGENE PROTEIN.		02.2110
Melanoma, Amelanotic
An unpigmented malignant melanoma. It is an anaplastic melanoma consisting of cells derived from melanoblasts but not forming melanin. (Dorland, 27th ed; Stedman, 25th ed)		02.2510
Malignant Melanoma
[description not available]		02.2510
Melanoma
A malignant neoplasm derived from cells that are capable of forming melanin, which may occur in the skin of any part of the body, in the eye, or, rarely, in the mucous membranes of the genitalia, anus, oral cavity, or other sites. It occurs mostly in adults and may originate de novo or from a pigmented nevus or malignant lentigo. Melanomas frequently metastasize widely, and the regional lymph nodes, liver, lungs, and brain are likely to be involved. The incidence of malignant skin melanomas is rising rapidly in all parts of the world. (Stedman, 25th ed; from Rook et al., Textbook of Dermatology, 4th ed, p2445)		02.2510
Benign Neoplasms
[description not available]		0210
Neoplasms
New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.		0210