plicatin B acrylate: isolated from the medicinal plants Psoralea juncaea and P. plicata; structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
| Flora | Rank | Flora Definition | Family | Family Definition |
|---|---|---|---|---|
| Psoralea | genus | A plant genus of the family FABACEAE that is a source of psoralen (FICUSIN).[MeSH] | Fabaceae | The large family of plants characterized by pods. Some are edible and some cause LATHYRISM or FAVISM and other forms of poisoning. Other species yield useful materials like gums from ACACIA and various LECTINS like PHYTOHEMAGGLUTININS from PHASEOLUS. Many of them harbor NITROGEN FIXATION bacteria on their roots. Many but not all species of beans belong to this family.[MeSH] |
| ID Source | ID |
|---|---|
| PubMed CID | 6438704 |
| CHEMBL ID | 451699 |
| SCHEMBL ID | 1227605 |
| MeSH ID | M0258738 |
| Synonym |
|---|
| plicatin b |
| CHEMBL451699 |
| methyl (e)-3-[4-hydroxy-3-(3-methylbut-2-enyl)phenyl]prop-2-enoate |
| methyl (e)-3-(4-hydroxy-3-(3-methyl-2-butenyl)phenyl)-2-propenoate |
| 72704-01-9 |
| plicatin b acrylate |
| 2-propenoic acid, 3-(4-hydroxy-3-(3-methyl-2-butenyl)phenyl)-, methyl ester, (e)- |
| methyl 3-(4-hydroxy-3-(3-methyl-2-butenyl)phenyl)-2-propenoate |
| SCHEMBL1227605 |
| LZEOAWXRNGQEHO-RMKNXTFCSA-N |
| Q7204957 |
| DTXSID801029774 |
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID614378 | Modulation of HIF1 expressed in HEK293 cells assessed as luciferase activity under hypoxic condition at 50 uM after 24 hrs by luminometer analysis relative to hypoxic control | 2011 | Bioorganic & medicinal chemistry, Sep-15, Volume: 19, Issue:18 | Isolation, identification, and biological evaluation of HIF-1-modulating compounds from Brazilian green propolis. |
| AID614387 | Cytotoxicity against human HCT116 cells assessed as cell viability under normoxic condition after 24 hrs by MTT assay | 2011 | Bioorganic & medicinal chemistry, Sep-15, Volume: 19, Issue:18 | Isolation, identification, and biological evaluation of HIF-1-modulating compounds from Brazilian green propolis. |
| AID377976 | Antimutagenic activity in Salmonella Typhimurium TA100 assessed as inhibition of ethyl methanesulfonate-induced mutation at 7.8 uM treated for 30 mins and measured after 2 days by modified Ames test | 1999 | Journal of natural products, Jan, Volume: 62, Issue:1 | Structure-antimutagenic activity relationship study of plicatin B. |
| AID377975 | Antimutagenic activity in Salmonella Typhimurium TA100 assessed as inhibition of ethyl methanesulfonate-induced mutation at 3.9 uM treated for 30 mins and measured after 2 days by modified Ames test | 1999 | Journal of natural products, Jan, Volume: 62, Issue:1 | Structure-antimutagenic activity relationship study of plicatin B. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (25.00) | 18.2507 |
| 2000's | 5 (62.50) | 29.6817 |
| 2010's | 1 (12.50) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.
| This Compound (12.36) All Compounds (24.57) |
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 1 (12.50%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 7 (87.50%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||