| Assay ID | Title | Year | Journal | Article |
|---|
| AID1752495 | Antiproliferative activity against human MDA-MB-231 cells assessed as cell viability for 72 hrs by MTT assay | 2021 | Bioorganic & medicinal chemistry, 10-01, Volume: 47 | Synthesis, antitumor activity and in silico analyses of amino acid derivatives of artepillin C, drupanin and baccharin from green propolis. |
| AID1630032 | Inhibition of recombinant AKR1C2 (unknown origin) assessed as reduction in S-tetralol catalyzed oxidation in presence of NADPH by fluorescence assay | 2016 | ACS medicinal chemistry letters, Aug-11, Volume: 7, Issue:8
| Selective AKR1C3 Inhibitors Potentiate Chemotherapeutic Activity in Multiple Acute Myeloid Leukemia (AML) Cell Lines. |
| AID614376 | Cytotoxicity against human HCT116 cells assessed as cell viability under hypoxic condition at 200 uM after 24 hrs by MTT assay | 2011 | Bioorganic & medicinal chemistry, Sep-15, Volume: 19, Issue:18
| Isolation, identification, and biological evaluation of HIF-1-modulating compounds from Brazilian green propolis. |
| AID1752499 | Antiproliferative activity against human PC-3 cells assessed as cell viability for 72 hrs by MTT assay | 2021 | Bioorganic & medicinal chemistry, 10-01, Volume: 47 | Synthesis, antitumor activity and in silico analyses of amino acid derivatives of artepillin C, drupanin and baccharin from green propolis. |
| AID641086 | Inhibition of human recombinant N-terminus His6-tagged AKR1B10 expressed in Escherichia coli BL21 DE3 assessed as pyridine-3-aldehyde reduction by spectrometric analysis | 2012 | European journal of medicinal chemistry, Feb, Volume: 48 | Design, synthesis and evaluation of caffeic acid phenethyl ester-based inhibitors targeting a selectivity pocket in the active site of human aldo-keto reductase 1B10. |
| AID614392 | Inhibition of HIF1-dependent HK2 mRNA expression in human HCT116 cells under hypoxic condition at 50 uM after 24 hrs by RT-PCR analysis | 2011 | Bioorganic & medicinal chemistry, Sep-15, Volume: 19, Issue:18
| Isolation, identification, and biological evaluation of HIF-1-modulating compounds from Brazilian green propolis. |
| AID664541 | Inhibition of human recombinant AKR1C2 expressed in Escherichia coli using S-tetralol as substrate by fluorometry | 2012 | Journal of natural products, Apr-27, Volume: 75, Issue:4
| Selective inhibition of human type-5 17β-hydroxysteroid dehydrogenase (AKR1C3) by baccharin, a component of Brazilian propolis. |
| AID377981 | Antimutagenic activity in Salmonella Typhimurium TA100 assessed as inhibition of ethyl methanesulfonate-induced mutation at 15.6 ug/mL treated for 30 mins and measured after 2 days by modified Ames test | 1999 | Journal of natural products, Jan, Volume: 62, Issue:1
| Structure-antimutagenic activity relationship study of plicatin B. |
| AID664561 | Cytotoxicity against human MCF7 cells at <100 uM after 6 hrs by MTT assay | 2012 | Journal of natural products, Apr-27, Volume: 75, Issue:4
| Selective inhibition of human type-5 17β-hydroxysteroid dehydrogenase (AKR1C3) by baccharin, a component of Brazilian propolis. |
| AID1645793 | Inhibition of recombinant human AKR1C2 expressed in Escherichia coli BL21 (D3) using S-tetralol as substrate in presence of NADP+ by UV-spectrophotometric method | 2019 | Journal of medicinal chemistry, 04-11, Volume: 62, Issue:7
| Potent and Highly Selective Aldo-Keto Reductase 1C3 (AKR1C3) Inhibitors Act as Chemotherapeutic Potentiators in Acute Myeloid Leukemia and T-Cell Acute Lymphoblastic Leukemia. |
| AID614378 | Modulation of HIF1 expressed in HEK293 cells assessed as luciferase activity under hypoxic condition at 50 uM after 24 hrs by luminometer analysis relative to hypoxic control | 2011 | Bioorganic & medicinal chemistry, Sep-15, Volume: 19, Issue:18
| Isolation, identification, and biological evaluation of HIF-1-modulating compounds from Brazilian green propolis. |
| AID377975 | Antimutagenic activity in Salmonella Typhimurium TA100 assessed as inhibition of ethyl methanesulfonate-induced mutation at 3.9 uM treated for 30 mins and measured after 2 days by modified Ames test | 1999 | Journal of natural products, Jan, Volume: 62, Issue:1
| Structure-antimutagenic activity relationship study of plicatin B. |
| AID402401 | Growth inhibition of last instar larvae of Tenebrio molitor assessed as duration of pupal stage at 120 ug/larvae, applied topically measured every 24 hrs for 30 days | 1998 | Journal of natural products, Oct, Volume: 61, Issue:10
| Growth-inhibitory activities of benzofuran and chromene derivatives toward Tenebrio molitor. |
| AID614393 | Inhibition of HIF1-dependent VEGFA mRNA expression in human HCT116 cells under hypoxic condition at 50 uM after 24 hrs by RT-PCR analysis | 2011 | Bioorganic & medicinal chemistry, Sep-15, Volume: 19, Issue:18
| Isolation, identification, and biological evaluation of HIF-1-modulating compounds from Brazilian green propolis. |
| AID614381 | Cytotoxicity against human HCT116 cells assessed as cell viability under normoxic condition at 200 uM after 7 days by clonogenic assay | 2011 | Bioorganic & medicinal chemistry, Sep-15, Volume: 19, Issue:18
| Isolation, identification, and biological evaluation of HIF-1-modulating compounds from Brazilian green propolis. |
| AID614390 | Inhibition of HIF1alpha expression in human HCT116 cells under hypoxic condition after 4 hrs by immunoblotting | 2011 | Bioorganic & medicinal chemistry, Sep-15, Volume: 19, Issue:18
| Isolation, identification, and biological evaluation of HIF-1-modulating compounds from Brazilian green propolis. |
| AID1630033 | Selectivity ratio of IC50 for recombinant AKR1C2 (unknown origin) to IC50 for recombinant AKR1C3 (unknown origin) | 2016 | ACS medicinal chemistry letters, Aug-11, Volume: 7, Issue:8
| Selective AKR1C3 Inhibitors Potentiate Chemotherapeutic Activity in Multiple Acute Myeloid Leukemia (AML) Cell Lines. |
| AID1645792 | Selectivity ratio of IC50 for recombinant human AKR1C2 expressed in Escherichia coli BL21 (D3) to IC50 for recombinant human AKR1C3 expressed in Escherichia coli BL21 (D3) | 2019 | Journal of medicinal chemistry, 04-11, Volume: 62, Issue:7
| Potent and Highly Selective Aldo-Keto Reductase 1C3 (AKR1C3) Inhibitors Act as Chemotherapeutic Potentiators in Acute Myeloid Leukemia and T-Cell Acute Lymphoblastic Leukemia. |
| AID1630098 | Inhibition of AKR1C3 in human HL60 cells assessed as potentiation of etoposide-induced cytotoxicity by measuring reduction in cell viability at 0.1 to 10 uM coincubated with 1 uM etoposide after 72 hrs by MTS assay | 2016 | ACS medicinal chemistry letters, Aug-11, Volume: 7, Issue:8
| Selective AKR1C3 Inhibitors Potentiate Chemotherapeutic Activity in Multiple Acute Myeloid Leukemia (AML) Cell Lines. |
| AID664542 | Inhibition of human recombinant AKR1C3 expressed in Escherichia coli JM109 cells using S-tetralol as substrate by fluorometry | 2012 | Journal of natural products, Apr-27, Volume: 75, Issue:4
| Selective inhibition of human type-5 17β-hydroxysteroid dehydrogenase (AKR1C3) by baccharin, a component of Brazilian propolis. |
| AID1752503 | Cytotoxicity against human PNT2 cells assessed as cell viability for 72 hrs by MTT assay | 2021 | Bioorganic & medicinal chemistry, 10-01, Volume: 47 | Synthesis, antitumor activity and in silico analyses of amino acid derivatives of artepillin C, drupanin and baccharin from green propolis. |
| AID1752500 | Antiproliferative activity against human DU-145 cells assessed as cell viability for 72 hrs by MTT assay | 2021 | Bioorganic & medicinal chemistry, 10-01, Volume: 47 | Synthesis, antitumor activity and in silico analyses of amino acid derivatives of artepillin C, drupanin and baccharin from green propolis. |
| AID614388 | Modulation of HIF1 expressed in HEK293 cells assessed as luciferase activity under hypoxic condition after 24 hrs by luminometer analysis | 2011 | Bioorganic & medicinal chemistry, Sep-15, Volume: 19, Issue:18
| Isolation, identification, and biological evaluation of HIF-1-modulating compounds from Brazilian green propolis. |
| AID664547 | Inhibition of human recombinant GST-tagged AKR1C4 expressed in Escherichia coli using S-tetralol as substrate at 100 uM by fluorometry | 2012 | Journal of natural products, Apr-27, Volume: 75, Issue:4
| Selective inhibition of human type-5 17β-hydroxysteroid dehydrogenase (AKR1C3) by baccharin, a component of Brazilian propolis. |
| AID402400 | Growth inhibition of last instar larvae of Tenebrio molitor assessed as successful pupation at 120 ug/larvae, applied topically measured every 24 hrs for 30 days | 1998 | Journal of natural products, Oct, Volume: 61, Issue:10
| Growth-inhibitory activities of benzofuran and chromene derivatives toward Tenebrio molitor. |
| AID614438 | Antiangiogenic activity in 3-day-old embryonated chicken eggs at 300 ng/CAM measured on 7th embryonic day by CAM assay | 2011 | Bioorganic & medicinal chemistry, Sep-15, Volume: 19, Issue:18
| Isolation, identification, and biological evaluation of HIF-1-modulating compounds from Brazilian green propolis. |
| AID614391 | Inhibition of HIF1-dependent GLUT1 mRNA expression in human HCT116 cells under hypoxic condition at 50 uM after 24 hrs by RT-PCR analysis | 2011 | Bioorganic & medicinal chemistry, Sep-15, Volume: 19, Issue:18
| Isolation, identification, and biological evaluation of HIF-1-modulating compounds from Brazilian green propolis. |
| AID614380 | Cytotoxicity against human HCT116 cells assessed as cell viability under hypoxic condition at 200 uM after 7 days by clonogenic assay | 2011 | Bioorganic & medicinal chemistry, Sep-15, Volume: 19, Issue:18
| Isolation, identification, and biological evaluation of HIF-1-modulating compounds from Brazilian green propolis. |
| AID1752498 | Cytotoxicity against human MCF-10A cells assessed as cell viability for 72 hrs by MTT assay | 2021 | Bioorganic & medicinal chemistry, 10-01, Volume: 47 | Synthesis, antitumor activity and in silico analyses of amino acid derivatives of artepillin C, drupanin and baccharin from green propolis. |
| AID377976 | Antimutagenic activity in Salmonella Typhimurium TA100 assessed as inhibition of ethyl methanesulfonate-induced mutation at 7.8 uM treated for 30 mins and measured after 2 days by modified Ames test | 1999 | Journal of natural products, Jan, Volume: 62, Issue:1
| Structure-antimutagenic activity relationship study of plicatin B. |
| AID664544 | Inhibition of human recombinant GST-tagged AKR1C1 expressed in Escherichia coli using S-tetralol as substrate at 100 uM by fluorometry | 2012 | Journal of natural products, Apr-27, Volume: 75, Issue:4
| Selective inhibition of human type-5 17β-hydroxysteroid dehydrogenase (AKR1C3) by baccharin, a component of Brazilian propolis. |
| AID614379 | Cytotoxicity against human HCT116 cells assessed as cell viability under normoxic condition at 200 uM after 24 hrs by MTT assay | 2011 | Bioorganic & medicinal chemistry, Sep-15, Volume: 19, Issue:18
| Isolation, identification, and biological evaluation of HIF-1-modulating compounds from Brazilian green propolis. |
| AID664563 | Inhibition of AKR1C3-mediated [14C]farnesal metabolism in human MCF7 cells at 100 uM incubated for 2 hrs prior to substrate addition measured after 6 hrs | 2012 | Journal of natural products, Apr-27, Volume: 75, Issue:4
| Selective inhibition of human type-5 17β-hydroxysteroid dehydrogenase (AKR1C3) by baccharin, a component of Brazilian propolis. |
| AID641085 | Inhibition of human recombinant N-terminus His6-tagged AKR1B1 expressed in Escherichia coli BL21 DE3 assessed as pyridine-3-aldehyde reduction by spectrometric analysis | 2012 | European journal of medicinal chemistry, Feb, Volume: 48 | Design, synthesis and evaluation of caffeic acid phenethyl ester-based inhibitors targeting a selectivity pocket in the active site of human aldo-keto reductase 1B10. |
| AID1630031 | Inhibition of recombinant AKR1C3 (unknown origin) assessed as reduction in S-tetralol catalyzed oxidation in presence of NADPH by fluorescence assay | 2016 | ACS medicinal chemistry letters, Aug-11, Volume: 7, Issue:8
| Selective AKR1C3 Inhibitors Potentiate Chemotherapeutic Activity in Multiple Acute Myeloid Leukemia (AML) Cell Lines. |
| AID456268 | Antiallergic activity in Ca(2+)-stimulated differentiated human HeLa cells assessed as inhibition of cys-leukotriene release after 6 days by ELISA | 2010 | Bioorganic & medicinal chemistry, Jan-01, Volume: 18, Issue:1
| Inhibitory activity of Brazilian green propolis components and their derivatives on the release of cys-leukotrienes. |
| AID1752494 | Antiproliferative activity against human MCF7 cells assessed as cell viability for 72 hrs by MTT assay | 2021 | Bioorganic & medicinal chemistry, 10-01, Volume: 47 | Synthesis, antitumor activity and in silico analyses of amino acid derivatives of artepillin C, drupanin and baccharin from green propolis. |
| AID1645794 | Inhibition of recombinant human AKR1C3 expressed in Escherichia coli BL21 (D3) using S-tetralol as substrate in presence of NADP+ by UV-spectrophotometric method | 2019 | Journal of medicinal chemistry, 04-11, Volume: 62, Issue:7
| Potent and Highly Selective Aldo-Keto Reductase 1C3 (AKR1C3) Inhibitors Act as Chemotherapeutic Potentiators in Acute Myeloid Leukemia and T-Cell Acute Lymphoblastic Leukemia. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |