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Neuraminidase
A neuraminidase subtype N2 (Influenza A virus) that is encoded in the genome of the H3N2 strain A/Memphis/1/1971. [PMID:12753908, PMID:15567494, PMID:15744059, PMID:16192481, PMID:6896994, PMID:6927853, PRO:CNA, PRO:DNx, UniProtKB:P03471]
Synonyms
EC 3.2.1.18
Research
Bioassay Publications (6)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 5 (83.33) | 24.3611 |
| 2020's | 1 (16.67) | 2.80 |
Compounds (3)
Drugs with Inhibition Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| zanamivir | Influenza A virus (A/Memphis/1/1971(H3N2)) | IC50 | 0.0147 | 4 | 4 |
| bcx 1812 | Influenza A virus (A/Memphis/1/1971(H3N2)) | IC50 | 0.0020 | 1 | 1 |
| gs 4071 | Influenza A virus (A/Memphis/1/1971(H3N2)) | IC50 | 0.0039 | 3 | 3 |
Discovery of novel 1,2,3-triazole oseltamivir derivatives as potent influenza neuraminidase inhibitors targeting the 430-cavity.European journal of medicinal chemistry, , Feb-01, Volume: 187, 2020
Synthesis and anti-influenza virus evaluation of triterpene-sialic acid conjugates.Bioorganic & medicinal chemistry, , 01-01, Volume: 26, Issue:1, 2018
Structural and Functional Analysis of Anti-Influenza Activity of 4-, 7-, 8- and 9-Deoxygenated 2,3-Difluoro- N-acetylneuraminic Acid Derivatives.Journal of medicinal chemistry, , 03-08, Volume: 61, Issue:5, 2018
Discovery of novel 1,2,3-triazole oseltamivir derivatives as potent influenza neuraminidase inhibitors targeting the 430-cavity.European journal of medicinal chemistry, , Feb-01, Volume: 187, 2020
Novel N-Substituted oseltamivir derivatives as potent influenza neuraminidase inhibitors: Design, synthesis, biological evaluation, ADME prediction and molecular docking studies.European journal of medicinal chemistry, , Nov-15, Volume: 182, 2019
[no title available]European journal of medicinal chemistry, , Sep-15, Volume: 178, 2019