D-serine biosynthetic process

Definition

Target type: biologicalprocess

The chemical reactions and pathways resulting in the formation of D-serine, the D-enantiomer of serine, i.e. (2R)-2-amino-3-hydroxypropanoic acid. D-serine is often formed by racemization of L-serine. [CHEBI:16523, GOC:jsg, GOC:mah]

D-serine biosynthesis is a metabolic pathway that produces D-serine, a non-proteinogenic amino acid that plays an important role in various biological processes, particularly in the nervous system. The pathway involves a series of enzymatic reactions, with the key enzyme being serine racemase. Serine racemase is a pyridoxal phosphate-dependent enzyme that catalyzes the interconversion of L-serine and D-serine. The reaction proceeds through a series of steps, including the formation of a Schiff base between pyridoxal phosphate and L-serine. This is followed by a series of protonation and deprotonation events that ultimately lead to the formation of D-serine. D-serine is a potent activator of the N-methyl-D-aspartate (NMDA) receptor, a glutamate receptor that plays a crucial role in synaptic plasticity and learning. D-serine is also involved in other processes, such as neuroprotection and the regulation of cell growth and differentiation. The biosynthesis of D-serine is tightly regulated, and its levels are influenced by factors such as age, diet, and stress.'
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Proteins (1)

Compounds (9)