Page last updated: 2024-12-05

7-methylcoumarin

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

7-Methylcoumarin is a derivative of coumarin, a naturally occurring compound found in various plants. It exhibits a bright blue fluorescence under ultraviolet light, making it a valuable compound in applications like fluorescent dyes, optical brighteners, and laser dyes. 7-Methylcoumarin is synthesized through various methods, including the Pechmann condensation, which involves reacting resorcinol with ethyl acetoacetate in the presence of an acid catalyst. Research into 7-Methylcoumarin is motivated by its diverse biological activities, including its potential as an antimicrobial, antifungal, and antioxidant agent. Studies have also explored its potential as a fluorescent probe in bioimaging and its use in developing novel organic light-emitting diodes (OLEDs). Its fluorescence properties and potential applications in various fields continue to drive research and development.'

7-methylcoumarin: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID17131
CHEMBL ID346541
CHEBI ID166605
SCHEMBL ID76393
MeSH IDM0584528

Synonyms (43)

Synonym
CHEBI:166605
AKOS015842507
NCI60_001631
einecs 219-499-3
brn 0122625
nsc 19511
7-methyl coumarin
7-methyl-2h-1-benzopyran-2-one
nsc-19511
coumarin, 7-methyl-
2h-1-benzopyran-2-one, 7-methyl-
nsc19511
2445-83-2
7-methylcoumarin
7-methylchromen-2-one
7-methyl-2h-chromen-2-one
7-methylcoumarin, >=98%
7-methyl-coumarin
CHEMBL346541
M1236
7-methylcumarin
5-17-10-00169 (beilstein handbook reference)
unii-ycn83t03qu
ycn83t03qu ,
FT-0634288
2h-1-benzopyran-2-one,7-methyl-
SCHEMBL76393
7-methyl-chromen-2-one
DTXSID0062424
7-methyl-2h-chromen-2-one #
TS-02124
mfcd00006880
7-methylcoumarin, analytical standard
CS-0032411
AML0010
Q27294453
P50004
7-methylcoumarin 100 microg/ml in acetonitrile
4-[(3-methyl-2-furoyl)amino]benzoicacid
EN300-98011
SY051344
HY-N5092
PD158960

Research Excerpts

Toxicity

ExcerptReferenceRelevance
"The available conventional remedies for the treatment of drug-induced liver diseases are highly inadequate and possess serious adverse effects; therefore, the development of new, effective drugs is considered necessary."( Ameliorative effects of 7-methylcoumarin and 7-methoxycoumarin against CCl4-induced hepatotoxicity in rats.
Sancheti, S; Seo, SY, 2013
)
0.7
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
coumarins
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Bioassays (33)

Assay IDTitleYearJournalArticle
AID625354Antioxidant activity assessed as hydroxyl radical scavenging activity at 100 uM after 30 mins2011European journal of medicinal chemistry, Dec, Volume: 46, Issue:12
Synthesis and biological evaluation of (2,5-dihydro-1H-pyrrol-1-yl)-2H-chromen-2-ones as free radical scavengers.
AID392745Antioxidant activity assessed as DPPH radical scavenging activity at 0.01 mM after 60 mins2009Bioorganic & medicinal chemistry letters, Feb-15, Volume: 19, Issue:4
Synthesis of hydroxycoumarins and hydroxybenzo[f]- or [h]coumarins as lipid peroxidation inhibitors.
AID215739Compound was evaluated for in vitro inhibition of trypsin acting as esterase at 1 mM concentration2004Bioorganic & medicinal chemistry letters, Feb-09, Volume: 14, Issue:3
Synthesis and biological evaluation of novel coumarin derivatives with a 7-azomethine linkage.
AID226952Interaction percent with DPPH after 20 minutes was determined at 0.5 mM concentration2004Bioorganic & medicinal chemistry letters, Feb-09, Volume: 14, Issue:3
Synthesis and biological evaluation of novel coumarin derivatives with a 7-azomethine linkage.
AID52641Compound was evaluated for in vitro inhibition of chymotrypsinogen induced proteolysis at 0.1 mM concentration2004Bioorganic & medicinal chemistry letters, Feb-09, Volume: 14, Issue:3
Synthesis and biological evaluation of novel coumarin derivatives with a 7-azomethine linkage.
AID228472Competition percent of compound with DMSO for hydroxyl radical was determined at 0.1 mM concentration2004Bioorganic & medicinal chemistry letters, Feb-09, Volume: 14, Issue:3
Synthesis and biological evaluation of novel coumarin derivatives with a 7-azomethine linkage.
AID49194Compound was evaluated for percent inhibition of carrageenan induced rat paw edema at 0.005 mmol/kg2004Bioorganic & medicinal chemistry letters, Feb-09, Volume: 14, Issue:3
Synthesis and biological evaluation of novel coumarin derivatives with a 7-azomethine linkage.
AID226950Interaction percent with DPPH after 20 minutes was determined at 0.2 mM concentration2004Bioorganic & medicinal chemistry letters, Feb-09, Volume: 14, Issue:3
Synthesis and biological evaluation of novel coumarin derivatives with a 7-azomethine linkage.
AID392748Antiinflammatory activity in rat assessed as inhibition of carrageenan-induced paw edema at 0.01 mmol/kg, ip after 3.5 hrs2009Bioorganic & medicinal chemistry letters, Feb-15, Volume: 19, Issue:4
Synthesis of hydroxycoumarins and hydroxybenzo[f]- or [h]coumarins as lipid peroxidation inhibitors.
AID104173Compound was evaluated for in vitro inhibition of soybean lipoxygenase at 0.1 mM concentration2004Bioorganic & medicinal chemistry letters, Feb-09, Volume: 14, Issue:3
Synthesis and biological evaluation of novel coumarin derivatives with a 7-azomethine linkage.
AID625352Antioxidant activity assessed as DPPH free radical scavenging activity at 100 uM after 20 mins2011European journal of medicinal chemistry, Dec, Volume: 46, Issue:12
Synthesis and biological evaluation of (2,5-dihydro-1H-pyrrol-1-yl)-2H-chromen-2-ones as free radical scavengers.
AID392742Antioxidant activity assessed as DPPH radical scavenging activity at 0.05 mM after 20 mins2009Bioorganic & medicinal chemistry letters, Feb-15, Volume: 19, Issue:4
Synthesis of hydroxycoumarins and hydroxybenzo[f]- or [h]coumarins as lipid peroxidation inhibitors.
AID226949Interaction percent with DPPH after 20 minutes was determined at 0.1 mM concentration2004Bioorganic & medicinal chemistry letters, Feb-09, Volume: 14, Issue:3
Synthesis and biological evaluation of novel coumarin derivatives with a 7-azomethine linkage.
AID40454Compound was evaluated for in vitro inhibition of beta-glucuronidase at 1 mM concentration2004Bioorganic & medicinal chemistry letters, Feb-09, Volume: 14, Issue:3
Synthesis and biological evaluation of novel coumarin derivatives with a 7-azomethine linkage.
AID40452Compound was evaluated for in vitro inhibition of beta-glucuronidase at 0.1 mM concentration; no action2004Bioorganic & medicinal chemistry letters, Feb-09, Volume: 14, Issue:3
Synthesis and biological evaluation of novel coumarin derivatives with a 7-azomethine linkage.
AID392744Antioxidant activity assessed as DPPH radical scavenging activity at 0.01 mM after 20 mins2009Bioorganic & medicinal chemistry letters, Feb-15, Volume: 19, Issue:4
Synthesis of hydroxycoumarins and hydroxybenzo[f]- or [h]coumarins as lipid peroxidation inhibitors.
AID230347Interaction percent with DPPH after 60 minutes was determined at 0.2 mM concentration2004Bioorganic & medicinal chemistry letters, Feb-09, Volume: 14, Issue:3
Synthesis and biological evaluation of novel coumarin derivatives with a 7-azomethine linkage.
AID215742Compound was evaluated for in vitro inhibition of trypsin induced proteolysis at 1 mM concentration2004Bioorganic & medicinal chemistry letters, Feb-09, Volume: 14, Issue:3
Synthesis and biological evaluation of novel coumarin derivatives with a 7-azomethine linkage.
AID215740Compound was evaluated for in vitro inhibition of trypsin induced proteolysis at 0.1 mM concentration2004Bioorganic & medicinal chemistry letters, Feb-09, Volume: 14, Issue:3
Synthesis and biological evaluation of novel coumarin derivatives with a 7-azomethine linkage.
AID226953Interaction percent with DPPH after 60 minutes was determined at 0.1 mM concentration2004Bioorganic & medicinal chemistry letters, Feb-09, Volume: 14, Issue:3
Synthesis and biological evaluation of novel coumarin derivatives with a 7-azomethine linkage.
AID52643Compound was evaluated for in vitro inhibition of chymotrypsinogen induced proteolysis at 1 mM concentration2004Bioorganic & medicinal chemistry letters, Feb-09, Volume: 14, Issue:3
Synthesis and biological evaluation of novel coumarin derivatives with a 7-azomethine linkage.
AID625356Inhibition of soybean lipoxygenase assessed as conversion of sodium linoleate to 13-hydroperoxylinoleic acid at 100 uM2011European journal of medicinal chemistry, Dec, Volume: 46, Issue:12
Synthesis and biological evaluation of (2,5-dihydro-1H-pyrrol-1-yl)-2H-chromen-2-ones as free radical scavengers.
AID593513Binding affinity to corpus collosum myelin in central nervous system of mouse at 100 uM after 20 mins by fluorescent microscopy2011Journal of medicinal chemistry, Apr-14, Volume: 54, Issue:7
Design, synthesis, and evaluation of coumarin-based molecular probes for imaging of myelination.
AID215738Compound was evaluated for in vitro inhibition of trypsin acting as esterase at 0.1 mM concentration2004Bioorganic & medicinal chemistry letters, Feb-09, Volume: 14, Issue:3
Synthesis and biological evaluation of novel coumarin derivatives with a 7-azomethine linkage.
AID392743Antioxidant activity assessed as DPPH radical scavenging activity at 0.05 mM after 60 mins2009Bioorganic & medicinal chemistry letters, Feb-15, Volume: 19, Issue:4
Synthesis of hydroxycoumarins and hydroxybenzo[f]- or [h]coumarins as lipid peroxidation inhibitors.
AID52639Compound was evaluated for in vitro inhibition of chymotrypsinogen acting as esterase at 0.1 mM concentration2004Bioorganic & medicinal chemistry letters, Feb-09, Volume: 14, Issue:3
Synthesis and biological evaluation of novel coumarin derivatives with a 7-azomethine linkage.
AID104176Compound was evaluated for in vitro inhibition of soybean lipoxygenase at 1 mM concentration2004Bioorganic & medicinal chemistry letters, Feb-09, Volume: 14, Issue:3
Synthesis and biological evaluation of novel coumarin derivatives with a 7-azomethine linkage.
AID228470Competition percent of compound with DMSO for hydroxyl radical was determined at 0.01 mM concentration2004Bioorganic & medicinal chemistry letters, Feb-09, Volume: 14, Issue:3
Synthesis and biological evaluation of novel coumarin derivatives with a 7-azomethine linkage.
AID230349Interaction percent with DPPH after 60 minutes was determined at 0.5 mM concentration2004Bioorganic & medicinal chemistry letters, Feb-09, Volume: 14, Issue:3
Synthesis and biological evaluation of novel coumarin derivatives with a 7-azomethine linkage.
AID52640Compound was evaluated for in vitro inhibition of chymotrypsinogen acting as esterase at 1 mM concentration2004Bioorganic & medicinal chemistry letters, Feb-09, Volume: 14, Issue:3
Synthesis and biological evaluation of novel coumarin derivatives with a 7-azomethine linkage.
AID625358Antioxidant activity assessed as DPPH free radical scavenging activity at 100 uM2011European journal of medicinal chemistry, Dec, Volume: 46, Issue:12
Synthesis and biological evaluation of (2,5-dihydro-1H-pyrrol-1-yl)-2H-chromen-2-ones as free radical scavengers.
AID392747Inhibition of soybean lipoxygenase at 100 uM by UV absorbance based assay2009Bioorganic & medicinal chemistry letters, Feb-15, Volume: 19, Issue:4
Synthesis of hydroxycoumarins and hydroxybenzo[f]- or [h]coumarins as lipid peroxidation inhibitors.
AID625353Antioxidant activity assessed as DPPH free radical scavenging activity at 100 uM after 60 mins2011European journal of medicinal chemistry, Dec, Volume: 46, Issue:12
Synthesis and biological evaluation of (2,5-dihydro-1H-pyrrol-1-yl)-2H-chromen-2-ones as free radical scavengers.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (10)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's2 (20.00)29.6817
2010's8 (80.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 50.88

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be very strong demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index50.88 (24.57)
Research Supply Index2.40 (2.92)
Research Growth Index5.08 (4.65)
Search Engine Demand Index75.08 (26.88)
Search Engine Supply Index2.01 (0.95)

This Compound (50.88)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other10 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]