7-methylcoumarin

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

7-Methylcoumarin is a derivative of coumarin, a naturally occurring compound found in various plants. It exhibits a bright blue fluorescence under ultraviolet light, making it a valuable compound in applications like fluorescent dyes, optical brighteners, and laser dyes. 7-Methylcoumarin is synthesized through various methods, including the Pechmann condensation, which involves reacting resorcinol with ethyl acetoacetate in the presence of an acid catalyst. Research into 7-Methylcoumarin is motivated by its diverse biological activities, including its potential as an antimicrobial, antifungal, and antioxidant agent. Studies have also explored its potential as a fluorescent probe in bioimaging and its use in developing novel organic light-emitting diodes (OLEDs). Its fluorescence properties and potential applications in various fields continue to drive research and development.'

7-methylcoumarin: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID Source	ID
PubMed CID	17131
CHEMBL ID	346541
CHEBI ID	166605
SCHEMBL ID	76393
MeSH ID	M0584528

Synonyms (43)

Synonym
CHEBI:166605
AKOS015842507
NCI60_001631
einecs 219-499-3
brn 0122625
nsc 19511
7-methyl coumarin
7-methyl-2h-1-benzopyran-2-one
nsc-19511
coumarin, 7-methyl-
2h-1-benzopyran-2-one, 7-methyl-
nsc19511
2445-83-2
7-methylcoumarin
7-methylchromen-2-one
7-methyl-2h-chromen-2-one
7-methylcoumarin, >=98%
7-methyl-coumarin
CHEMBL346541
M1236
7-methylcumarin
5-17-10-00169 (beilstein handbook reference)
unii-ycn83t03qu
ycn83t03qu ,
FT-0634288
2h-1-benzopyran-2-one,7-methyl-
SCHEMBL76393
7-methyl-chromen-2-one
DTXSID0062424
7-methyl-2h-chromen-2-one #
TS-02124
mfcd00006880
7-methylcoumarin, analytical standard
CS-0032411
AML0010
Q27294453
P50004
7-methylcoumarin 100 microg/ml in acetonitrile
4-[(3-methyl-2-furoyl)amino]benzoicacid
EN300-98011
SY051344
HY-N5092
PD158960

Research Excerpts

Toxicity

Excerpt	Reference	Relevance
"The available conventional remedies for the treatment of drug-induced liver diseases are highly inadequate and possess serious adverse effects; therefore, the development of new, effective drugs is considered necessary."	( Ameliorative effects of 7-methylcoumarin and 7-methoxycoumarin against CCl4-induced hepatotoxicity in rats. Sancheti, S; Seo, SY, 2013)	0.7

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

Class	Description
coumarins
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Bioassays (33)

Assay ID	Title	Year	Journal	Article
AID625354	Antioxidant activity assessed as hydroxyl radical scavenging activity at 100 uM after 30 mins	2011	European journal of medicinal chemistry, Dec, Volume: 46, Issue:12	Synthesis and biological evaluation of (2,5-dihydro-1H-pyrrol-1-yl)-2H-chromen-2-ones as free radical scavengers.
AID392745	Antioxidant activity assessed as DPPH radical scavenging activity at 0.01 mM after 60 mins	2009	Bioorganic & medicinal chemistry letters, Feb-15, Volume: 19, Issue:4	Synthesis of hydroxycoumarins and hydroxybenzo[f]- or [h]coumarins as lipid peroxidation inhibitors.
AID215739	Compound was evaluated for in vitro inhibition of trypsin acting as esterase at 1 mM concentration	2004	Bioorganic & medicinal chemistry letters, Feb-09, Volume: 14, Issue:3	Synthesis and biological evaluation of novel coumarin derivatives with a 7-azomethine linkage.
AID226952	Interaction percent with DPPH after 20 minutes was determined at 0.5 mM concentration	2004	Bioorganic & medicinal chemistry letters, Feb-09, Volume: 14, Issue:3	Synthesis and biological evaluation of novel coumarin derivatives with a 7-azomethine linkage.
AID52641	Compound was evaluated for in vitro inhibition of chymotrypsinogen induced proteolysis at 0.1 mM concentration	2004	Bioorganic & medicinal chemistry letters, Feb-09, Volume: 14, Issue:3	Synthesis and biological evaluation of novel coumarin derivatives with a 7-azomethine linkage.
AID228472	Competition percent of compound with DMSO for hydroxyl radical was determined at 0.1 mM concentration	2004	Bioorganic & medicinal chemistry letters, Feb-09, Volume: 14, Issue:3	Synthesis and biological evaluation of novel coumarin derivatives with a 7-azomethine linkage.
AID49194	Compound was evaluated for percent inhibition of carrageenan induced rat paw edema at 0.005 mmol/kg	2004	Bioorganic & medicinal chemistry letters, Feb-09, Volume: 14, Issue:3	Synthesis and biological evaluation of novel coumarin derivatives with a 7-azomethine linkage.
AID226950	Interaction percent with DPPH after 20 minutes was determined at 0.2 mM concentration	2004	Bioorganic & medicinal chemistry letters, Feb-09, Volume: 14, Issue:3	Synthesis and biological evaluation of novel coumarin derivatives with a 7-azomethine linkage.
AID392748	Antiinflammatory activity in rat assessed as inhibition of carrageenan-induced paw edema at 0.01 mmol/kg, ip after 3.5 hrs	2009	Bioorganic & medicinal chemistry letters, Feb-15, Volume: 19, Issue:4	Synthesis of hydroxycoumarins and hydroxybenzo[f]- or [h]coumarins as lipid peroxidation inhibitors.
AID104173	Compound was evaluated for in vitro inhibition of soybean lipoxygenase at 0.1 mM concentration	2004	Bioorganic & medicinal chemistry letters, Feb-09, Volume: 14, Issue:3	Synthesis and biological evaluation of novel coumarin derivatives with a 7-azomethine linkage.
AID625352	Antioxidant activity assessed as DPPH free radical scavenging activity at 100 uM after 20 mins	2011	European journal of medicinal chemistry, Dec, Volume: 46, Issue:12	Synthesis and biological evaluation of (2,5-dihydro-1H-pyrrol-1-yl)-2H-chromen-2-ones as free radical scavengers.
AID392742	Antioxidant activity assessed as DPPH radical scavenging activity at 0.05 mM after 20 mins	2009	Bioorganic & medicinal chemistry letters, Feb-15, Volume: 19, Issue:4	Synthesis of hydroxycoumarins and hydroxybenzo[f]- or [h]coumarins as lipid peroxidation inhibitors.
AID226949	Interaction percent with DPPH after 20 minutes was determined at 0.1 mM concentration	2004	Bioorganic & medicinal chemistry letters, Feb-09, Volume: 14, Issue:3	Synthesis and biological evaluation of novel coumarin derivatives with a 7-azomethine linkage.
AID40454	Compound was evaluated for in vitro inhibition of beta-glucuronidase at 1 mM concentration	2004	Bioorganic & medicinal chemistry letters, Feb-09, Volume: 14, Issue:3	Synthesis and biological evaluation of novel coumarin derivatives with a 7-azomethine linkage.
AID40452	Compound was evaluated for in vitro inhibition of beta-glucuronidase at 0.1 mM concentration; no action	2004	Bioorganic & medicinal chemistry letters, Feb-09, Volume: 14, Issue:3	Synthesis and biological evaluation of novel coumarin derivatives with a 7-azomethine linkage.
AID392744	Antioxidant activity assessed as DPPH radical scavenging activity at 0.01 mM after 20 mins	2009	Bioorganic & medicinal chemistry letters, Feb-15, Volume: 19, Issue:4	Synthesis of hydroxycoumarins and hydroxybenzo[f]- or [h]coumarins as lipid peroxidation inhibitors.
AID230347	Interaction percent with DPPH after 60 minutes was determined at 0.2 mM concentration	2004	Bioorganic & medicinal chemistry letters, Feb-09, Volume: 14, Issue:3	Synthesis and biological evaluation of novel coumarin derivatives with a 7-azomethine linkage.
AID215742	Compound was evaluated for in vitro inhibition of trypsin induced proteolysis at 1 mM concentration	2004	Bioorganic & medicinal chemistry letters, Feb-09, Volume: 14, Issue:3	Synthesis and biological evaluation of novel coumarin derivatives with a 7-azomethine linkage.
AID215740	Compound was evaluated for in vitro inhibition of trypsin induced proteolysis at 0.1 mM concentration	2004	Bioorganic & medicinal chemistry letters, Feb-09, Volume: 14, Issue:3	Synthesis and biological evaluation of novel coumarin derivatives with a 7-azomethine linkage.
AID226953	Interaction percent with DPPH after 60 minutes was determined at 0.1 mM concentration	2004	Bioorganic & medicinal chemistry letters, Feb-09, Volume: 14, Issue:3	Synthesis and biological evaluation of novel coumarin derivatives with a 7-azomethine linkage.
AID52643	Compound was evaluated for in vitro inhibition of chymotrypsinogen induced proteolysis at 1 mM concentration	2004	Bioorganic & medicinal chemistry letters, Feb-09, Volume: 14, Issue:3	Synthesis and biological evaluation of novel coumarin derivatives with a 7-azomethine linkage.
AID625356	Inhibition of soybean lipoxygenase assessed as conversion of sodium linoleate to 13-hydroperoxylinoleic acid at 100 uM	2011	European journal of medicinal chemistry, Dec, Volume: 46, Issue:12	Synthesis and biological evaluation of (2,5-dihydro-1H-pyrrol-1-yl)-2H-chromen-2-ones as free radical scavengers.
AID593513	Binding affinity to corpus collosum myelin in central nervous system of mouse at 100 uM after 20 mins by fluorescent microscopy	2011	Journal of medicinal chemistry, Apr-14, Volume: 54, Issue:7	Design, synthesis, and evaluation of coumarin-based molecular probes for imaging of myelination.
AID215738	Compound was evaluated for in vitro inhibition of trypsin acting as esterase at 0.1 mM concentration	2004	Bioorganic & medicinal chemistry letters, Feb-09, Volume: 14, Issue:3	Synthesis and biological evaluation of novel coumarin derivatives with a 7-azomethine linkage.
AID392743	Antioxidant activity assessed as DPPH radical scavenging activity at 0.05 mM after 60 mins	2009	Bioorganic & medicinal chemistry letters, Feb-15, Volume: 19, Issue:4	Synthesis of hydroxycoumarins and hydroxybenzo[f]- or [h]coumarins as lipid peroxidation inhibitors.
AID52639	Compound was evaluated for in vitro inhibition of chymotrypsinogen acting as esterase at 0.1 mM concentration	2004	Bioorganic & medicinal chemistry letters, Feb-09, Volume: 14, Issue:3	Synthesis and biological evaluation of novel coumarin derivatives with a 7-azomethine linkage.
AID104176	Compound was evaluated for in vitro inhibition of soybean lipoxygenase at 1 mM concentration	2004	Bioorganic & medicinal chemistry letters, Feb-09, Volume: 14, Issue:3	Synthesis and biological evaluation of novel coumarin derivatives with a 7-azomethine linkage.
AID228470	Competition percent of compound with DMSO for hydroxyl radical was determined at 0.01 mM concentration	2004	Bioorganic & medicinal chemistry letters, Feb-09, Volume: 14, Issue:3	Synthesis and biological evaluation of novel coumarin derivatives with a 7-azomethine linkage.
AID230349	Interaction percent with DPPH after 60 minutes was determined at 0.5 mM concentration	2004	Bioorganic & medicinal chemistry letters, Feb-09, Volume: 14, Issue:3	Synthesis and biological evaluation of novel coumarin derivatives with a 7-azomethine linkage.
AID52640	Compound was evaluated for in vitro inhibition of chymotrypsinogen acting as esterase at 1 mM concentration	2004	Bioorganic & medicinal chemistry letters, Feb-09, Volume: 14, Issue:3	Synthesis and biological evaluation of novel coumarin derivatives with a 7-azomethine linkage.
AID625358	Antioxidant activity assessed as DPPH free radical scavenging activity at 100 uM	2011	European journal of medicinal chemistry, Dec, Volume: 46, Issue:12	Synthesis and biological evaluation of (2,5-dihydro-1H-pyrrol-1-yl)-2H-chromen-2-ones as free radical scavengers.
AID392747	Inhibition of soybean lipoxygenase at 100 uM by UV absorbance based assay	2009	Bioorganic & medicinal chemistry letters, Feb-15, Volume: 19, Issue:4	Synthesis of hydroxycoumarins and hydroxybenzo[f]- or [h]coumarins as lipid peroxidation inhibitors.
AID625353	Antioxidant activity assessed as DPPH free radical scavenging activity at 100 uM after 60 mins	2011	European journal of medicinal chemistry, Dec, Volume: 46, Issue:12	Synthesis and biological evaluation of (2,5-dihydro-1H-pyrrol-1-yl)-2H-chromen-2-ones as free radical scavengers.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (10)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	2 (20.00)	29.6817
2010's	8 (80.00)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 50.88

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be very strong demand-to-supply ratio for research on this compound.

Metric	This Compound (vs All)
Research Demand Index	50.88 (24.57)
Research Supply Index	2.40 (2.92)
Research Growth Index	5.08 (4.65)
Search Engine Demand Index	75.08 (26.88)
Search Engine Supply Index	2.01 (0.95)

This Compound (50.88)

All Compounds (24.57)

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	10 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
coumarin 2H-chromen-2-one: coumarin derivative	2.96	4	coumarins	fluorescent dye; human metabolite; plant metabolite
indomethacin Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.. indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.	2.44	2	aromatic ether; indole-3-acetic acids; monochlorobenzenes; N-acylindole	analgesic; drug metabolite; EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor; environmental contaminant; gout suppressant; non-steroidal anti-inflammatory drug; xenobiotic metabolite; xenobiotic
masoprocol nordihydroguaretic acid: antioxidant compound found in the creosote bush (Larrea tridentata)	2.46	2	catechols; lignan; tetrol	antioxidant; ferroptosis inhibitor; geroprotector; plant metabolite
carbon tetrachloride Carbon Tetrachloride: A solvent for oils, fats, lacquers, varnishes, rubber waxes, and resins, and a starting material in the manufacturing of organic compounds. Poisoning by inhalation, ingestion or skin absorption is possible and may be fatal. (Merck Index, 11th ed). tetrachloromethane : A chlorocarbon that is methane in which all the hydrogens have been replaced by chloro groups.	2.08	1	chlorocarbon; chloromethanes	hepatotoxic agent; refrigerant
6-methylcoumarin 6-methylcoumarin: synthetic fragrance causing contact photoallergy. 6-methylcoumarin : A member of the class of coumarins that is coumarin in which the hydrogen at position 6 is replaced by a methyl group.	7.13	1	coumarins	allergen; fragrance
scoparone scoparone: structure. scoparone : A member of the class of coumarins that is esculetin in which the two hydroxy groups at positions 6 and 7 are replaced by methoxy groups. It is a major constituent of the Chinese herbal medicine Yin Chen Hao, and exhibits a variety of pharmacological activities such as anti-inflammatory, anti-allergic, and anti-tumor activities.	2.17	1	aromatic ether; coumarins	anti-allergic agent; anti-inflammatory agent; antihypertensive agent; antilipemic drug; immunosuppressive agent; plant metabolite
herniarin herniarin: methoxy analog of umbelliferone; structure. herniarin : A member of the class of coumarins that is coumarin substituted by a methoxy group at position 7.	2.06	1	coumarins	fluorochrome
docusate Dioctyl Sulfosuccinic Acid: All-purpose surfactant, wetting agent, and solubilizer used in the drug, cosmetics, and food industries. It has also been used in laxatives and as cerumenolytics. It is usually administered as either the calcium, potassium, or sodium salt.	2.17	1	diester; organosulfonic acid
3-hydroxy-1-benzopyran-2-one 3-hydroxycoumarin: Photoprotective from sea urchin gametes and embryonic cells; structure in first source. hydroxycoumarin : Any coumarin carrying at least one hydroxy substituent.	2.06	1	hydroxycoumarin
titanium Titanium: A dark-gray, metallic element of widespread distribution but occurring in small amounts with atomic number, 22, atomic weight, 47.867 and symbol, Ti; specific gravity, 4.5; used for fixation of fractures.	2.08	1	titanium group element atom
titanium dioxide titanium dioxide: used medically as protectant against externally caused irritation & sunlight; high concentrations of dust may cause irritation to respiratory tract; RN given refers to titanium oxide (TiO2); structure. titanium dioxide : A titanium oxide with the formula TiO2. A naturally occurring oxide sourced from ilmenite, rutile and anatase, it has a wide range of applications.	2.08	1	titanium oxides	food colouring
iodine [no description available]	2.17	1	halide anion; monoatomic iodine	human metabolite
7-ethoxycoumarin 7-ethoxycoumarin : A member of the class of coumarins that is umbelliferone in which the hydroxy group at position 7 is replaced by an ethoxy group.	2.1	1	aromatic ether; coumarins
6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid [no description available]	2.46	2	chromanol; monocarboxylic acid; phenols	antioxidant; ferroptosis inhibitor; neuroprotective agent; radical scavenger; Wnt signalling inhibitor
4-methyl-7-ethoxycoumarin [no description available]	2.1	1	coumarins
7-amino-4-methylcoumarin 7-amino-4-methylcoumarin: RN given refers to parent cpd	2.06	1	7-aminocoumarins	fluorochrome
7-amino-4-trifluoromethylcoumarin coumarin 151: structure in first source	2.06	1	7-aminocoumarins	fluorochrome
8-hydroxycoumarin 8-hydroxycoumarin: structure given in first source	2.05	1
3-(4-aminophenyl)-2h-chromen-2-one 3-(4-aminophenyl)-2H-chromen-2-one: fluorescent dye for imaging myelin; structure in first source	2.06	1
caffeic acid trans-caffeic acid : The trans-isomer of caffeic acid.	2.05	1	caffeic acid	geroprotector; mouse metabolite
7-hydroxycoumarin 7-oxycoumarin: derivatives have anti-oxidant properties. umbelliferone : A hydroxycoumarin that is coumarin substituted by a hydroxy group ay position 7.	2.47	2	hydroxycoumarin	fluorescent probe; food component; plant metabolite
7-hydroxy-4-trifluoromethylcoumarin 7-hydroxy-4-trifluoromethylcoumarin: structure given in first source	2.06	1
dicumarol Dicumarol: An oral anticoagulant that interferes with the metabolism of vitamin K. It is also used in biochemical experiments as an inhibitor of reductases.	2.06	1	hydroxycoumarin	anticoagulant; EC 1.6.5.2 [NAD(P)H dehydrogenase (quinone)] inhibitor; Hsp90 inhibitor; vitamin K antagonist
warfarin Warfarin: An anticoagulant that acts by inhibiting the synthesis of vitamin K-dependent coagulation factors. Warfarin is indicated for the prophylaxis and/or treatment of venous thrombosis and its extension, pulmonary embolism, and atrial fibrillation with embolization. It is also used as an adjunct in the prophylaxis of systemic embolism after myocardial infarction. Warfarin is also used as a rodenticide.. warfarin : A racemate comprising equal amounts of (R)- and (S)-warfarin. Extensively used as both an anticoagulant drug and as a pesticide against rats and mice.. 4-hydroxy-3-(3-oxo-1-phenylbutyl)-1-benzopyran-2-one : A member of the class of coumarins that is 4-hydroxycoumarin which is substituted at position 3 by a 1-phenyl-3-oxo-1-butyl group.	3.47	7	benzenes; hydroxycoumarin; methyl ketone
4-hydroxycoumarin 2-hydroxychromone: structure	2.06	1	hydroxycoumarin

Condition	Relationship Strength	Studies
Anasarca [description not available]	2.44	2
Innate Inflammatory Response [description not available]	2.02	1
Edema Abnormal fluid accumulation in TISSUES or body cavities. Most cases of edema are present under the SKIN in SUBCUTANEOUS TISSUE.	2.44	2
Inflammation A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.	2.02	1

chemdatabank.com