Compounds > bensulide
Page last updated: 2024-12-05

bensulide

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Occurs in Manufacturing Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Cross-References

ID SourceID
PubMed CID12932
CHEMBL ID1895252
CHEBI ID81899
SCHEMBL ID55205
MeSH IDM0042227

Synonyms (86)

Synonym
phosphorodithioic acid, o,o-bis(1-methylethyl) s-[2-[(phenylsulfonyl)amino]ethyl] ester
bensulide
s-beta-(benzenesulfonamido)ethyl o,o-diisopropyl dithiophosphate
prefer
hsdb 393
epa pesticide chemical code 009801
r 4461
benzulfide
o,o-diisopropyl phosphorothioate s-ester with n-(2-mercaptoethyl)benzenesulfonamide
n-(2-(o,o-diisopropyldithiophosphoryl)ethyl)benzenesulfonamide
o,o-diisopropyl dithiophosphate s-ester with n-(2-mercaptoethyl)benzenesulphonamide
n-(2-mercaptoethylbenzene)sulfonamide s-(o,o-diisopropylphosphorodithioate)
s-2-benzenesulfonamidoethyl o,o-di-isopropyl phosphorodithioate
brn 2164989
exporsan
sap (herbicide)
einecs 212-010-4
betasan [obsolete]
s-(o,o-diisopropyl phosphorodithioate) ester of n-(2-mercaptoethyl)benzenesulfonamide
o,o-bis(1-methylethyl) s-(2-((phenylsulfonyl)amino)ethyl)phosphorodithioate
phosphorodithioic acid, o,o-bis(1-methylethyl) s-(2-((phenylsulfonyl)amino)ethyl) ester
caswell no. 357
phosphorodithioic acid, o,o-diisopropyl ester, s-ester with n-(2-mercaptoethyl)benzenesulfonamide
n-(2-mercaptoethyl)benzenesulfonamide s-(o,o-diisopropyl phosphorodithioate)
disan (pesticide)
r-4461
o,o-di-isopropyl s-2-phenylsulphonylaminoethyl phosphorodithioate
kayaphenone
bensulide [bsi:iso]
(n-(2-mercaptoethyl)benzenesulfonamide)
n-(2-ethylthio)benzene sulphonamide-s,o,o-diisopropylphosphorodithioate
betasan e
benzenesulfonamide, n-(2-mercaptoethyl)-, s-ester with o,o-diisopropylphosphorodithioate
o,o-bis(1-methylethyl)-s-(2-((phenylsulfonyl)amino)ethyl) phosphorodithioate
pre-san
s-(o,o-diisopropylphosphorodithioate) of n-(2-mercaptoethyl)benzenesulfonamide
prefar
prefar e
betasan g
o,o-bis(1-methylethyl) s-(2-((phenylsulfonyl)amino)ethyl)pheosphorodithioate
betamec
o,o-diisopropyl s-(2-benzenesulfonylaminoethyl) phosphorodithioate
o,o-diisopropyl 2-(benzenesulfonamido)ethyl dithiophosphate
betasan
o,o-diisopropyl phosphorodithioate s-ester with n-(2-mercaptoethyl)benzenesulfonamide
disan
s-2-benzenesulphonamidoethyl o,o-diisopropyl phosphorodithioate
n-(beta-o,o-diisopropyldithiophosphorylethyl)benzenesulfonamide
SAP ,
741-58-2
o,o-diisopropyl s-{2-[(phenylsulfonyl)amino]ethyl} dithiophosphate
NCGC00168292-01
NCGC00168292-02
NCGC00168292-03
n-[2-di(propan-2-yloxy)phosphinothioylsulfanylethyl]benzenesulfonamide
NCGC00168292-04
C18703
tox21_300733
dtxsid9032329 ,
cas-741-58-2
NCGC00254639-01
dtxcid7012329
ccris 9246
9882bw2q2s ,
unii-9882bw2q2s
AKOS015902619
CHEMBL1895252
chebi:81899 ,
bensumec
(n-(2-ethylthio)benzene sulfonamido-s,o,o- diisopropylphosphorodithioate
bensulide [iso]
bensulide [hsdb]
phosphorodithioic acid-o,o-bis(1-methylethyl)-s-(2-((phenylsulfonyl)amino)ethyl)ester
SCHEMBL55205
n-[2-(o,o-diisopropyldithiophosphoryl)ethyl]benzenesulfonamide
s-.beta.-(benzenesulfonamido)ethyl o,o-diisopropyl dithiophosphate
o,o-diisopropyl s-(2-[(phenylsulfonyl)amino]ethyl) dithiophosphate #
bensulide, pestanal(r), analytical standard
bensulide 100 microg/ml in methanol
bensulide 10 microg/ml in acetonitrile
o,o'-diisopropyl s-[2-(benzenesulfonamido)ethyl]dithiophosphate
o,o'-diisopropyl s-[2-(benzenesulfonamido)ethyl]phosphorodithioate
s-{2-[(benzenesulfonyl)amino]ethyl} o,o-dipropan-2-yl phosphorodithioate
Q414584
o,o-diisopropyl s-(2-benzenesulfonylaminoethyl)phosphorodithioate
phosphorodithioic acid o,o-bis(1-methylethyl) s-[2-[(phenylsulfonyl)amino]ethyl] ester

Research Excerpts

Overview

Bensulide is an organophosphate herbicide commonly used in agricultural crops. No studies have reported on its toxic effects in the embryonic development of vertebrates.

ExcerptReferenceRelevance
"Bensulide is an organophosphate herbicide commonly used in agricultural crops; however, no studies have reported on its toxic effects in the embryonic development of vertebrates, particularly gene expression level and cellular response. "( Bensulide-induced oxidative stress causes developmental defects of cardiovascular system and liver in zebrafish (Danio rerio).
An, G; Kim, M; Lim, W; Park, J; Song, G, 2023)		3.8

Compound-Compound Interactions

ExcerptReferenceRelevance
"Continuous flow microextraction (CFME) combined with high-performance liquid chromatography-ultraviolet (HPLC-UV) detection has been applied to the analysis of five widely used pesticides, simazine, fensulfothion, etridiazole, mepronil and bensulide, present at trace levels in water samples."( Continuous flow microextraction combined with high-performance liquid chromatography for the analysis of pesticides in natural waters.
He, Y; Lee, HK, 2006)		0.52
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Occurs in Manufacturing (5 Product(s))

Product Categories

Product CategoryProducts
Beauty & Personal Care4
Vitamins & Supplements1

Products

ProductBrandCategoryCompounds Matched from IngredientsDate Retrieved
Oi Organic Initiative Incontinence Liners - Very Light -- 26 LinersOi Organic InitiativeBeauty & Personal CareSAP2024-11-29 10:47:42
Oi Organic Initiative Incontinence Pads - Maximum -- 8 PadsOi Organic InitiativeBeauty & Personal CareSAP2024-11-29 10:47:42
Oi Organic Initiative Incontinence Pads - Regular -- 12 PadsOi Organic InitiativeBeauty & Personal CareSAP2024-11-29 10:47:42
Oi Organic Initiative Incontinence Pads - Ultimate -- 8 PadsOi Organic InitiativeBeauty & Personal CareSAP2024-11-29 10:47:42
Source Naturals Daily Essential Enzymes -- 500 mg - 120 CapsulesSource NaturalsVitamins & SupplementsLipase, SAP, calcium sulfate, Cellulase, FIP, AG, stearic acid2024-11-29 10:47:42

Drug Classes (1)

ClassDescription
benzenesAny benzenoid aromatic compound consisting of the benzene skeleton and its substituted derivatives.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein Targets (24)

Potency Measurements

ProteinTaxonomyMeasurementAverage (µ)Min (ref.)Avg (ref.)Max (ref.)Bioassay(s)
pregnane X receptorRattus norvegicus (Norway rat)Potency2.57880.025127.9203501.1870AID651751
RAR-related orphan receptor gammaMus musculus (house mouse)Potency46.86730.006038.004119,952.5996AID1159521; AID1159523
GLI family zinc finger 3Homo sapiens (human)Potency42.90560.000714.592883.7951AID1259369; AID1259392
AR proteinHomo sapiens (human)Potency53.98920.000221.22318,912.5098AID1259243; AID1259247; AID743035; AID743042; AID743054; AID743063
estrogen receptor 2 (ER beta)Homo sapiens (human)Potency30.63790.000657.913322,387.1992AID1259378
nuclear receptor subfamily 1, group I, member 3Homo sapiens (human)Potency37.81950.001022.650876.6163AID1224838; AID1224839; AID1224893
progesterone receptorHomo sapiens (human)Potency54.48270.000417.946075.1148AID1346795
retinoic acid nuclear receptor alpha variant 1Homo sapiens (human)Potency62.84970.003041.611522,387.1992AID1159552; AID1159553; AID1159555
retinoid X nuclear receptor alphaHomo sapiens (human)Potency42.91830.000817.505159.3239AID1159527; AID1159531
estrogen-related nuclear receptor alphaHomo sapiens (human)Potency48.69820.001530.607315,848.9004AID1224841; AID1224842; AID1224848; AID1224849; AID1259401; AID1259403
farnesoid X nuclear receptorHomo sapiens (human)Potency28.93420.375827.485161.6524AID588526
pregnane X nuclear receptorHomo sapiens (human)Potency1.41410.005428.02631,258.9301AID1346982; AID720659
estrogen nuclear receptor alphaHomo sapiens (human)Potency43.76180.000229.305416,493.5996AID1259244; AID1259248; AID743069; AID743075; AID743078; AID743079; AID743080; AID743091
peroxisome proliferator-activated receptor deltaHomo sapiens (human)Potency37.17540.001024.504861.6448AID588535; AID743212; AID743215
peroxisome proliferator activated receptor gammaHomo sapiens (human)Potency42.70680.001019.414170.9645AID588537; AID743191
vitamin D (1,25- dihydroxyvitamin D3) receptorHomo sapiens (human)Potency39.81070.023723.228263.5986AID588541
aryl hydrocarbon receptorHomo sapiens (human)Potency5.60970.000723.06741,258.9301AID743085; AID743122
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_aHomo sapiens (human)Potency68.58960.001723.839378.1014AID743083
v-jun sarcoma virus 17 oncogene homolog (avian)Homo sapiens (human)Potency21.87240.057821.109761.2679AID1159526; AID1159528
thyroid hormone receptor beta isoform aHomo sapiens (human)Potency50.11870.010039.53711,122.0200AID588547
thyroid hormone receptor beta isoform 2Rattus norvegicus (Norway rat)Potency64.86010.000323.4451159.6830AID743065; AID743067
nuclear factor erythroid 2-related factor 2 isoform 1Homo sapiens (human)Potency48.75680.000627.21521,122.0200AID743202; AID743219
Voltage-dependent calcium channel gamma-2 subunitMus musculus (house mouse)Potency61.13060.001557.789015,848.9004AID1259244
Glutamate receptor 2Rattus norvegicus (Norway rat)Potency61.13060.001551.739315,848.9004AID1259244
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Ceullar Components (1)

Processvia Protein(s)Taxonomy
plasma membraneGlutamate receptor 2Rattus norvegicus (Norway rat)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (9)

Assay IDTitleYearJournalArticle
AID1090128Inhibition of Arbidopsis thaliana C-terminal His-tagged KCS1 expressed in Saccharomyces cerevisiae INVSc1 at 100 uM after 18 to 20 hr by GC/MS analysis2004Proceedings of the National Academy of Sciences of the United States of America, Aug-10, Volume: 101, Issue:32
Specific and differential inhibition of very-long-chain fatty acid elongases from Arabidopsis thaliana by different herbicides.
AID1090119Inhibition of Saccharomyces cerevisiae INVSc1 ELO at 100 uM after 18 to 20 hr by GC/MS analysis2004Proceedings of the National Academy of Sciences of the United States of America, Aug-10, Volume: 101, Issue:32
Specific and differential inhibition of very-long-chain fatty acid elongases from Arabidopsis thaliana by different herbicides.
AID1090120Growth inhibition of Saccharomyces cerevisiae INVSc1 at 100 uM after 18 to 20 hr2004Proceedings of the National Academy of Sciences of the United States of America, Aug-10, Volume: 101, Issue:32
Specific and differential inhibition of very-long-chain fatty acid elongases from Arabidopsis thaliana by different herbicides.
AID1090124Inhibition of Arbidopsis thaliana C-terminal His-tagged At5g43760 expressed in Saccharomyces cerevisiae INVSc1 at 100 uM after 18 to 20 hr by GC/MS analysis2004Proceedings of the National Academy of Sciences of the United States of America, Aug-10, Volume: 101, Issue:32
Specific and differential inhibition of very-long-chain fatty acid elongases from Arabidopsis thaliana by different herbicides.
AID1090123Herbicidal activity against Arabidopsis thaliana assessed as apperance of fiddle head phenotype2004Proceedings of the National Academy of Sciences of the United States of America, Aug-10, Volume: 101, Issue:32
Specific and differential inhibition of very-long-chain fatty acid elongases from Arabidopsis thaliana by different herbicides.
AID1090127Inhibition of Arbidopsis thaliana C-terminal His-tagged KCS2 expressed in Saccharomyces cerevisiae INVSc1 at 100 uM after 18 to 20 hr by GC/MS analysis2004Proceedings of the National Academy of Sciences of the United States of America, Aug-10, Volume: 101, Issue:32
Specific and differential inhibition of very-long-chain fatty acid elongases from Arabidopsis thaliana by different herbicides.
AID1090126Inhibition of Arbidopsis thaliana C-terminal His-tagged CER60 expressed in Saccharomyces cerevisiae INVSc1 at 100 uM after 18 to 20 hr by GC/MS analysis2004Proceedings of the National Academy of Sciences of the United States of America, Aug-10, Volume: 101, Issue:32
Specific and differential inhibition of very-long-chain fatty acid elongases from Arabidopsis thaliana by different herbicides.
AID1090125Inhibition of Arbidopsis thaliana C-terminal His-tagged At1g04220 expressed in Saccharomyces cerevisiae INVSc1 at 100 uM after 18 to 20 hr by GC/MS analysis2004Proceedings of the National Academy of Sciences of the United States of America, Aug-10, Volume: 101, Issue:32
Specific and differential inhibition of very-long-chain fatty acid elongases from Arabidopsis thaliana by different herbicides.
AID1090129Inhibition of Arbidopsis thaliana C-terminal His-tagged FAE1 expressed in Saccharomyces cerevisiae INVSc1 at 100 uM after 18 to 20 hr by GC/MS analysis2004Proceedings of the National Academy of Sciences of the United States of America, Aug-10, Volume: 101, Issue:32
Specific and differential inhibition of very-long-chain fatty acid elongases from Arabidopsis thaliana by different herbicides.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (6)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's2 (33.33)29.6817
2010's3 (50.00)24.3611
2020's1 (16.67)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 31.70

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index31.70 (24.57)
Research Supply Index1.95 (2.92)
Research Growth Index4.59 (4.65)
Search Engine Demand Index43.64 (26.88)
Search Engine Supply Index2.52 (0.95)

This Compound (31.70)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other6 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
alachlor
alachlor : An aromatic amide that is N-(2,6-diethylphenyl)acetamide substituted by a methoxymethyl group at at the nitrogen atom while one of the hydrogens of the methyl group has been replaced by a chlorine atom.		2.0210aromatic amide;
monocarboxylic acid amide;
organochlorine compound		environmental contaminant;
herbicide;
xenobiotic
coumaphos
Coumaphos: A organothiophosphorus cholinesterase inhibitor that is used as an anthelmintic, insecticide, and as a nematocide.		2.0710organic thiophosphate;
organochlorine compound;
organothiophosphate insecticide		acaricide;
agrochemical;
antinematodal drug;
avicide;
EC 3.1.1.8 (cholinesterase) inhibitor
disulfoton
Disulfoton: An organothiophosphate insecticide.. disulfoton : An organic thiophosphate that is the diethyl ester of S-[2-(ethylsulfanyl)ethyl] dihydrogen phosphorodithioate.		2.0610organic thiophosphate;
organothiophosphate insecticide		acaricide;
agrochemical;
EC 3.1.1.7 (acetylcholinesterase) inhibitor
ethoprophos
ethoprop: structure		2.0610organic thiophosphate;
organothiophosphate insecticide		agrochemical;
antinematodal drug;
EC 3.1.1.7 (acetylcholinesterase) inhibitor
methamidophos
methamidophos: structure. methamidophos : An organic thiophosphate resulting from the N-deacylation of the proinsecticide acephate.		2.0610organic thiophosphate;
organothiophosphate insecticide;
phosphoramide		acaricide;
agrochemical;
avicide
methyl parathion
Methyl Parathion: The methyl homolog of parathion. An effective, but highly toxic, organothiophosphate insecticide and cholinesterase inhibitor.. parathion-methyl : A C-nitro compound that is 4-nitrophenol substituted by a (dimethoxyphosphorothioyl)oxy group at position 4.		2.0610C-nitro compound;
organic thiophosphate;
organothiophosphate insecticide		acaricide;
agrochemical;
antifungal agent;
EC 3.1.1.7 (acetylcholinesterase) inhibitor;
EC 3.1.1.8 (cholinesterase) inhibitor;
environmental contaminant;
genotoxin
phorate
Phorate: A cholinesterase inhibitor that is used as an insecticide.. phosphatidylcholine O-34:2 : A glycerophosphocholine that is an alkyl,acyl-sn-glycero-3-phosphocholine in which the alkyl or acyl groups at positions 1 and 2 contain a total of 34 carbons and 2 double bonds.		2.0610organic thiophosphate;
organothiophosphate insecticide		acaricide;
agrochemical;
EC 3.1.1.7 (acetylcholinesterase) inhibitor;
EC 3.1.1.8 (cholinesterase) inhibitor
simazine
Simazine: A triazine herbicide.. simazine : A diamino-1,3,5-triazine that is N,N'-diethyl-1,3,5-triazine-2,4-diamine substituted by a chloro group at position 6.		2.0310chloro-1,3,5-triazine;
diamino-1,3,5-triazine		environmental contaminant;
herbicide;
xenobiotic
triallate
Triallate: A pre-emergence, selective herbicide for the control of wild oats in various crops.		2.0210tertiary amine
fensulfothion
fensulfothion: was MH 1972-92 (see under INSECTICIDES, ORGANOTHIOPHOSPHATE 1972-90); use ORGANOTHIOPHOSPHORUS COMPOUNDS to search FENSULFOTHION 1972-92		2.0310organic thiophosphate;
organothiophosphate insecticide;
sulfoxide		agrochemical;
avicide;
EC 3.1.1.7 (acetylcholinesterase) inhibitor;
nematicide
paraoxon
[no description available]		2.0710aryl dialkyl phosphate;
organophosphate insecticide		EC 3.1.1.7 (acetylcholinesterase) inhibitor;
mouse metabolite
methidathion
methidathion: widely used on citrus, tobacco, alfalfa, cotton, sorghum & several other crops		2.0610organic thiophosphate;
organothiophosphate insecticide		acaricide;
agrochemical;
EC 3.1.1.7 (acetylcholinesterase) inhibitor
diphenamid
diphenamid: do not confuse with anti-inflammatory agent difenpiramide; structure		2.0210diarylmethane
etridiazol
etridiazol: structure. etridiazole : A member of the class of thiadiazoles that is 1,2,4-thiadiazole which is substituted at positions 3 and 5 by trichloromethyl and ethoxy groups, respectively. A fungicide, it has been used particularly for the control of Phytophthora and Pythium species in soils.		2.0310aromatic ether;
organochlorine compound;
thiadiazole antifungal agent;
thiadiazoles		antifungal agrochemical;
nitrification inhibitor
devrinol
devrinol: structure. napropamide : A racemate composed of equimolar amounts of (S)- and (R)-napropamide.. N,N-diethyl-2-(naphthalen-1-yloxy)propanamide : A monocarboxylic acid amide that is propanamide substituted by two ethyl groups at the nitrogen atom and a naphthalen-1-yloxy group at position 2.		2.0210aromatic ether;
monocarboxylic acid amide;
naphthalenes
fenamiphos
[no description available]		2.0610organophosphate insecticide;
organophosphate nematicide;
phosphoramidate ester		acaricide;
agrochemical;
EC 3.1.1.7 (acetylcholinesterase) inhibitor
ethofumesate
ethofumesate: structure in first source. ethofumesate : A racemate comprising of equimolar amounts of (S)- and (R)-ethofumesate.. 2-ethoxy-3,3-dimethyl-2,3-dihydro-1-benzofuran-5-yl methanesulfonate : A methanesulfonate ester that is methanesulfonic acid in which the hydrogen of the hydroxy group has been replaced by a 2-ethoxy-3,3-dimethyl-2,3-dihydro-1-benzofuran-5-yl group.		2.02101-benzofurans;
ether;
methanesulfonate ester
foe 5043
FOE 5043: an oxyacetamide with herbicidal activity; structure given in first source. flufenacet : An aromatic amide that is acetamide in which the amino hydrogens have been replaced by a propan-2-yl and 4-fluorophenyl groups while the methyl hydrogen is replaced by a [5-(trifluoromethyl)-1,3,4-thiadiazol-2-yl]oxy group.		2.0210aromatic amide;
monofluorobenzenes;
thiadiazoles		environmental contaminant;
herbicide;
xenobiotic
cafenstrole
cafenstrole: structure in first source		2.0210benzenes;
sulfone;
triazoles		agrochemical;
antimitotic;
herbicide
ConditionIndicatedRelationship StrengthStudiesTrials