Compounds > demeton-s-methyl
Page last updated: 2024-11-05

demeton-s-methyl

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Demeton-S-methyl is an organophosphate insecticide that was widely used in agriculture and horticulture. It is a highly effective insecticide that acts by inhibiting the enzyme acetylcholinesterase, which is essential for nerve function. This inhibition leads to a buildup of acetylcholine in the synapses, causing paralysis and death in insects. Demeton-S-methyl is highly toxic to humans and animals, and its use has been restricted in many countries due to its environmental and health risks. It is still used in some areas of the world, but its use is declining due to concerns about its safety. Research on demeton-S-methyl is primarily focused on understanding its toxicity, environmental fate, and potential health effects. Studies have also been conducted to develop safer alternatives to this insecticide. Demeton-S-methyl has been the subject of extensive research due to its significant impact on human health and the environment. Understanding its properties and effects is crucial for developing safe and effective pest management strategies.'

Cross-References

ID SourceID
PubMed CID13526
CHEMBL ID1898805
CHEBI ID38624
SCHEMBL ID73358
MeSH IDM0095411

Synonyms (91)

Synonym
o,o-dimethyl-s-(2-aethylthio-aethyl)-monothiophosphat
demeton-s-methyl [iso:bsi]
hu8bo5s9wk ,
unii-hu8bo5s9wk
thiophosphate de o,o-dimethyle et de s-2-ethylthio-ethyle
o,o-dimetil-s-(2-etiltio-etil)-monotiofosfato
o,o-dimethyl-s-(3-thia-pentyl)-monothiophosphat
o,o-dimethyl-s-(2-ethylthio-ethyl)-monothiofosfaat
demeton-s-metile
demeton-s-methyl
phosphorothioic acid, s-[2-(ethylthio)ethyl] o,o-dimethyl ester
o,o-dimethyl s-(2-(ethylthio)ethyl)phosphorothioate
o,o-dimethyl s-ethylmercaptoethyl thiophosphate
s-[2-(ethylsulfanyl)ethyl] o,o-dimethyl thiophosphate
919-86-8
CHEBI:38624 ,
s-[2-(ethylsulfanyl)ethyl] o,o-dimethyl phosphorothioate
2-ethylthioethyl dimethyl phosphorothioate
dimethyl s-(2-eththioethyl)thiophosphate
methyl demeton thioester
methylmercaptofostiol (ussr)
ethanethiol, 2-(ethylthio)-, s-ester with o,o-dimethyl phosphorothioate
dep 836 349
metaisoseptox
metasystox 55
metasystox (i)
thiophosphate de o,o-dimethyle et de s-2-ethylthio-ethyle [french]
bayer 25/154
brn 1707311
methyl thionodemeton
einecs 213-052-6
phosphorothioic acid, o,o-dimethyl s-(2-(ethylthio)ethyl) ester
s-(2-(ethylthio)ethyl) dimethyl phosphorothiolate
metasystox j
demeton-s-metile [italian]
demetox
o,o-dimetil-s-(2-etiltio-etil)-monotiofosfato [italian]
hsdb 6410
s-(2-(ethylthio)ethyl) o,o-dimethyl thiophosphate
metaisosystox
methyl-mercaptofos teolovy (ussr)
mifatox
s-(2-(ethylthio)ethyl) o,o-dimethyl phosphorothioate
phosphorothioic acid, s-(2-(ethylthio)ethyl) o,o-dimethyl ester
thiometon oxon
o,o-dimethyl-s-(2-ethylthio-ethyl)-monothiofosfaat [dutch]
ccris 5215
methyl isosystox
bay 18436
bayer 18 436
usp 2 571 989
o,o-dimethyl 2-ethylmercaptoethyl thiophosphate, thiolo isomer
o,o-dimethyl s-(2-eththioethyl)phosphorothioate
demeton-s-methyl [bsi:iso]
ai3-24963
duratox
o,o-dimethyl-s-(2-aethylthio-aethyl)-monothiophosphat [german]
o,o-dimethyl-s-(3-thia-pentyl)-monothiophosphat [german]
NCGC00163787-01
1-dimethoxyphosphorylsulfanyl-2-ethylsulfanylethane
C18655
methylthionodemeton
metasystox i
s-[2-(ethylthio)ethyl] o,o-dimethyl phosphorothioate
AKOS015902495
CHEMBL1898805
demeton-s-methyl [iso]
demeton-s-methyl [mi]
bay-18436
demeton-s-methyl [hsdb]
SCHEMBL73358
s-[2-(ethylsulfanyl)ethyl] o,o-dimethyl thiophosphate #
o,o-dimethyl s-2-(ethylthio)ethyl phosphorothioate
demeton-s-methyl sulfide
meta-isosystox
persyst
power dsm
s-[2-(ethylthio)ethyl] o,o-dimethyl thiophosphate
WEBQKRLKWNIYKK-UHFFFAOYSA-N
methylmercaptofostiol
methyl-mercaptofos teolery
demetone-s-methyl
s-[2-(ethylthio)ethyl] o,o-dimethyl phophorothioate
DTXSID5037521
bdbm50487990
demeton-s-methyl, analytical standard
demeton-s-methyl 100 microg/ml in acetonitrile
dimethyl {[2-(ethylsulfanyl)ethyl]sulfanyl}phosphonate
Q1865134
demeton-s-methyl 1000 microg/ml in acetone
o,o-dimethyl s-[2-(ethylthio)ethyl]thiophosphate
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Roles (3)

RoleDescription
acaricideA substance used to destroy pests of the subclass Acari (mites and ticks).
agrochemicalAn agrochemical is a substance that is used in agriculture or horticulture.
EC 3.1.1.7 (acetylcholinesterase) inhibitorAn EC 3.1.1.* (carboxylic ester hydrolase) inhibitor that interferes with the action of enzyme acetylcholinesterase (EC 3.1.1.7), which helps breaking down of acetylcholine into choline and acetic acid.
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Drug Classes (2)

ClassDescription
organic thiophosphate
organothiophosphate insecticide
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein Targets (3)

Potency Measurements

ProteinTaxonomyMeasurementAverage (µ)Min (ref.)Avg (ref.)Max (ref.)Bioassay(s)
farnesoid X nuclear receptorHomo sapiens (human)Potency0.00130.375827.485161.6524AID588527
vitamin D (1,25- dihydroxyvitamin D3) receptorHomo sapiens (human)Potency25.11890.023723.228263.5986AID588541
nuclear factor erythroid 2-related factor 2 isoform 1Homo sapiens (human)Potency54.48270.000627.21521,122.0200AID651741
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (10)

Assay IDTitleYearJournalArticle
AID1101171Insecticidal activity against organophosphate-resistant clone of Schizaphis graminum OR1 adult or last-instar nymphs assessed as insect mortality after 8 hr2000Journal of agricultural and food chemistry, Oct, Volume: 48, Issue:10
Comparative toxicity of selected organophosphate insecticides against resistant and susceptible clones of the greenbug, Schizaphis graminum (Homoptera: aphididae).
AID1101169Resistance index, ratio of LC50 for organophosphate-resistant clone of Schizaphis graminum OR1 adult or last-instar nymphs to LC50 for organophosphate-susceptible clone of Schizaphis graminum OSS adult or last-instar nymphs2000Journal of agricultural and food chemistry, Oct, Volume: 48, Issue:10
Comparative toxicity of selected organophosphate insecticides against resistant and susceptible clones of the greenbug, Schizaphis graminum (Homoptera: aphididae).
AID1101164Resistance index, ratio of bimolecular rate constant Ki for AChE in rganophosphate-resistant clone of Schizaphis graminum OR1 to bimolecular rate constant Ki for AChE in organophosphate-susceptible clone of Schizaphis graminum OSS2000Journal of agricultural and food chemistry, Oct, Volume: 48, Issue:10
Comparative toxicity of selected organophosphate insecticides against resistant and susceptible clones of the greenbug, Schizaphis graminum (Homoptera: aphididae).
AID1101163Resistance index, ratio of bimolecular rate constant Ki for AChE in rganophosphate-resistant clone of Schizaphis graminum OR2 to bimolecular rate constant Ki for AChE in organophosphate-susceptible clone of Schizaphis graminum OSS2000Journal of agricultural and food chemistry, Oct, Volume: 48, Issue:10
Comparative toxicity of selected organophosphate insecticides against resistant and susceptible clones of the greenbug, Schizaphis graminum (Homoptera: aphididae).
AID1101166Inhibition of AChE in organophosphate-resistant clone of Schizaphis graminum OR1 adult or last-instar nymphs homogenates assessed as bimolecular rate constant pre-incubated with compound for 2 min at 25 degC before addition of ATC and DTNB solution2000Journal of agricultural and food chemistry, Oct, Volume: 48, Issue:10
Comparative toxicity of selected organophosphate insecticides against resistant and susceptible clones of the greenbug, Schizaphis graminum (Homoptera: aphididae).
AID1101172Insecticidal activity against organophosphate-susceptible clone of Schizaphis graminum OSS adult or last-instar nymphs assessed as insect mortality after 8 hr2000Journal of agricultural and food chemistry, Oct, Volume: 48, Issue:10
Comparative toxicity of selected organophosphate insecticides against resistant and susceptible clones of the greenbug, Schizaphis graminum (Homoptera: aphididae).
AID1101167Inhibition of AChE in organophosphate-susceptible clone of Schizaphis graminum OSS adult or last-instar nymphs homogenates assessed as bimolecular rate constant pre-incubated with compound for 2 min at 25 degC before addition of ATC and DTNB solution2000Journal of agricultural and food chemistry, Oct, Volume: 48, Issue:10
Comparative toxicity of selected organophosphate insecticides against resistant and susceptible clones of the greenbug, Schizaphis graminum (Homoptera: aphididae).
AID1101170Insecticidal activity against organophosphate-resistant clone of Schizaphis graminum OR2 adult or last-instar nymphs assessed as insect mortality after 8 hr2000Journal of agricultural and food chemistry, Oct, Volume: 48, Issue:10
Comparative toxicity of selected organophosphate insecticides against resistant and susceptible clones of the greenbug, Schizaphis graminum (Homoptera: aphididae).
AID1101165Inhibition of AChE in organophosphate-resistant clone of Schizaphis graminum OR2 adult or last-instar nymphs homogenates assessed as bimolecular rate constant pre-incubated with compound for 2 min at 25 degC before addition of ATC and DTNB solution2000Journal of agricultural and food chemistry, Oct, Volume: 48, Issue:10
Comparative toxicity of selected organophosphate insecticides against resistant and susceptible clones of the greenbug, Schizaphis graminum (Homoptera: aphididae).
AID1101168Resistance index, ratio of LC50 for organophosphate-resistant clone of Schizaphis graminum OR2 adult or last-instar nymphs to LC50 for organophosphate-susceptible clone of Schizaphis graminum OSS adult or last-instar nymphs2000Journal of agricultural and food chemistry, Oct, Volume: 48, Issue:10
Comparative toxicity of selected organophosphate insecticides against resistant and susceptible clones of the greenbug, Schizaphis graminum (Homoptera: aphididae).
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (25)

TimeframeStudies, This Drug (%)All Drugs %
pre-19909 (36.00)18.7374
1990's5 (20.00)18.2507
2000's8 (32.00)29.6817
2010's3 (12.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 36.64

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be strong demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index36.64 (24.57)
Research Supply Index3.26 (2.92)
Research Growth Index4.21 (4.65)
Search Engine Demand Index49.28 (26.88)
Search Engine Supply Index2.02 (0.95)

This Compound (36.64)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies5 (20.00%)4.05%
Observational0 (0.00%)0.25%
Other20 (80.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
carbon monoxide
Carbon Monoxide: Carbon monoxide (CO). A poisonous colorless, odorless, tasteless gas. It combines with hemoglobin to form carboxyhemoglobin, which has no oxygen carrying capacity. The resultant oxygen deprivation causes headache, dizziness, decreased pulse and respiratory rates, unconsciousness, and death. (From Merck Index, 11th ed). carbon monoxide : A one-carbon compound in which the carbon is joined only to a single oxygen. It is a colourless, odourless, tasteless, toxic gas.		1.9910carbon oxide;
gas molecular entity;
one-carbon compound		biomarker;
EC 1.9.3.1 (cytochrome c oxidase) inhibitor;
human metabolite;
ligand;
metabolite;
mitochondrial respiratory-chain inhibitor;
mouse metabolite;
neurotoxin;
neurotransmitter;
P450 inhibitor;
probe;
signalling molecule;
vasodilator agent
dibenzofuran
Dibenzofurans: Compounds that include the structure of dibenzofuran.. dibenzofurans : Any organic heterotricyclic compound based on a dibenzofuran skeleton and its substituted derivatives thereof.. dibenzofuran : A mancude organic heterotricyclic parent that consists of a furan ring flanked by two benzene rings ortho-fused across the 2,3- and 4,5-positions.		1.9910dibenzofurans;
mancude organic heterotricyclic parent;
polycyclic heteroarene		xenobiotic
methanol
Methanol: A colorless, flammable liquid used in the manufacture of FORMALDEHYDE and ACETIC ACID, in chemical synthesis, antifreeze, and as a solvent. Ingestion of methanol is toxic and may cause blindness.. primary alcohol : A primary alcohol is a compound in which a hydroxy group, -OH, is attached to a saturated carbon atom which has either three hydrogen atoms attached to it or only one other carbon atom and two hydrogen atoms attached to it.. methanol : The primary alcohol that is the simplest aliphatic alcohol, comprising a methyl and an alcohol group.		1.9910alkyl alcohol;
one-carbon compound;
primary alcohol;
volatile organic compound		amphiprotic solvent;
Escherichia coli metabolite;
fuel;
human metabolite;
mouse metabolite;
Mycoplasma genitalium metabolite
parathion
[no description available]		2.940C-nitro compound;
organic thiophosphate;
organothiophosphate insecticide		acaricide;
agrochemical;
avicide;
EC 3.1.1.7 (acetylcholinesterase) inhibitor;
EC 3.1.1.8 (cholinesterase) inhibitor;
mouse metabolite
chlorpyrifos
Chlorpyrifos: An organothiophosphate cholinesterase inhibitor that is used as an insecticide and as an acaricide.. chlorpyrifos : An organic thiophosphate that is O,O-diethyl hydrogen phosphorothioate in which the hydrogen of the hydroxy group has been replaced by a 3,5,6-trichloropyridin-2-yl group.		2.3920chloropyridine;
organic thiophosphate		acaricide;
agrochemical;
EC 3.1.1.7 (acetylcholinesterase) inhibitor;
EC 3.1.1.8 (cholinesterase) inhibitor;
environmental contaminant;
insecticide;
xenobiotic
cypermethrin
cypermethrin : A carboxylic ester resulting from the formal condensation between 3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylic acid and the alcoholic hydroxy group of hydroxy(3-phenoxyphenyl)acetonitrile.. zeta-cypermethrin : A diastereoisomeric mixture comprising the isomeric pair (1R)-cis-(alphaS)- and (1S)-trans-(alphaR)-cypermethrin together with the isomeric pair (1S)-cis-(alphaS)- and (1S)-trans-(alphaS)-cypermethrin where the ratio between the isomeric pairs lies in the range 45:55 to 55:45.		6.9610aromatic ether;
cyclopropanecarboxylate ester;
nitrile;
organochlorine compound		agrochemical;
molluscicide;
pyrethroid ester acaricide;
pyrethroid ester insecticide
dichlorvos
Dichlorvos: An organophosphorus insecticide that inhibits ACETYLCHOLINESTERASE.. dichlorvos : An alkenyl phosphate that is the 2,2-dichloroethenyl ester of dimethyl phosphate.		1.9610alkenyl phosphate;
dialkyl phosphate;
organochlorine acaricide;
organophosphate insecticide		anthelminthic drug;
antibacterial agent;
antifungal agent;
EC 3.1.1.7 (acetylcholinesterase) inhibitor;
EC 3.1.1.8 (cholinesterase) inhibitor
dimethoate
Dimethoate: An organothiophosphorus cholinesterase inhibitor that is used as a systemic and contact insecticide.. dimethoate : A monocarboxylic acid amide that is N-methylacetamide in which one of the hydrogens of the methyl group attached to the carbonyl moiety is replaced by a (dimethoxyphosphorothioyl)sulfanediyl group.		2.8940monocarboxylic acid amide;
organic thiophosphate		acaricide;
agrochemical;
EC 3.1.1.7 (acetylcholinesterase) inhibitor;
EC 3.1.1.8 (cholinesterase) inhibitor;
environmental contaminant;
insecticide;
xenobiotic
disulfoton
Disulfoton: An organothiophosphate insecticide.. disulfoton : An organic thiophosphate that is the diethyl ester of S-[2-(ethylsulfanyl)ethyl] dihydrogen phosphorodithioate.		210organic thiophosphate;
organothiophosphate insecticide		acaricide;
agrochemical;
EC 3.1.1.7 (acetylcholinesterase) inhibitor
malathion
Malathion: A wide spectrum aliphatic organophosphate insecticide widely used for both domestic and commercial agricultural purposes.. malathion : A racemate comprising equimolar amounts of (R) and (S)-malathion. It is a broad spectrum organophosphate proinsecticide used to control a wide range of pests including Coleoptera, Diptera, fruit flies, mosquitos and spider mites.. diethyl 2-[(dimethoxyphosphorothioyl)thio]succinate : A diester that is diethyl succinate in which position 2 is substituted by a (dimethoxyphosphorothioyl)thio group.		2.420diester;
ethyl ester;
organic thiophosphate
methyl parathion
Methyl Parathion: The methyl homolog of parathion. An effective, but highly toxic, organothiophosphate insecticide and cholinesterase inhibitor.. parathion-methyl : A C-nitro compound that is 4-nitrophenol substituted by a (dimethoxyphosphorothioyl)oxy group at position 4.		210C-nitro compound;
organic thiophosphate;
organothiophosphate insecticide		acaricide;
agrochemical;
antifungal agent;
EC 3.1.1.7 (acetylcholinesterase) inhibitor;
EC 3.1.1.8 (cholinesterase) inhibitor;
environmental contaminant;
genotoxin
trichlorfon
Trichlorfon: An organochlorophosphate cholinesterase inhibitor that is used as an insecticide for the control of flies and roaches. It is also used in anthelmintic compositions for animals. (From Merck, 11th ed). trichlorfon : A phosphonic ester that is dimethyl phosphonate in which the hydrogen atom attched to the phosphorous is substituted by a 2,2,2-trichloro-1-hydroxyethyl group.		1.9610organic phosphonate;
organochlorine compound;
phosphonic ester		agrochemical;
anthelminthic drug;
EC 3.1.1.7 (acetylcholinesterase) inhibitor;
EC 3.1.1.8 (cholinesterase) inhibitor;
insecticide
isoflurophate
Isoflurophate: A di-isopropyl-fluorophosphate which is an irreversible cholinesterase inhibitor used to investigate the NERVOUS SYSTEM.		2.4220dialkyl phosphate
obidoxime chloride
Obidoxime Chloride: Cholinesterase reactivator occurring in two interchangeable isomeric forms, syn and anti.		2.420
paraoxon
[no description available]		2.9440aryl dialkyl phosphate;
organophosphate insecticide		EC 3.1.1.7 (acetylcholinesterase) inhibitor;
mouse metabolite
methylparaoxon
[no description available]		210C-nitro compound
dimethoxon
dimethoxon: pesticide		210organic thiophosphate;
organothiophosphate insecticide		acaricide;
agrochemical;
EC 3.1.1.7 (acetylcholinesterase) inhibitor
phenylphosphonothioic acid, 2-ethyl 2-(4-nitrophenyl) ester
Phenylphosphonothioic Acid, 2-Ethyl 2-(4-Nitrophenyl) Ester: An organothiophosphorus cholinesterase inhibitor that is used as an insecticide and as a acaricide.		210organic phosphonate;
organothiophosphate insecticide;
phosphonic ester		acaricide;
agrochemical;
EC 3.1.1.7 (acetylcholinesterase) inhibitor
mercury
Mercury: A silver metallic element that exists as a liquid at room temperature. It has the atomic symbol Hg (from hydrargyrum, liquid silver), atomic number 80, and atomic weight 200.59. Mercury is used in many industrial applications and its salts have been employed therapeutically as purgatives, antisyphilitics, disinfectants, and astringents. It can be absorbed through the skin and mucous membranes which leads to MERCURY POISONING. Because of its toxicity, the clinical use of mercury and mercurials is diminishing.. mercury(0) : Elemental mercury of oxidation state zero.		2.0210elemental mercury;
zinc group element atom		neurotoxin
methyl demeton
methyl mercaptophos: was MH 1972-91 (see under INSECTICIDES, ORGANOTHIOPHOSPHATE (1975-90, Prov 1972-74))		2.0510
vx
VX nerve agent : A organic thiophosphate that is the ethyl ester of S-{2-[di(propan-2-yl)amino]ethyl} O hydrogen methylphosphonothioate. A toxic nerve agent used in chemical warfare.		7.9540organic thiophosphate;
tertiary amino compound		EC 3.1.1.7 (acetylcholinesterase) inhibitor;
neurotoxin
heptenophos
heptenophos: structure		2.3720organochlorine compound;
organophosphate insecticide;
trialkyl phosphate		acaricide;
agrochemical;
EC 3.1.1.7 (acetylcholinesterase) inhibitor
teflubenzuron
teflubenzuron: effective against development of house fly larvae (Musca domestica). teflubenzuron : A N-acylurea that is N-carbamoyl-2,6-difluorobenzamide substituted by a 3,5-dichloro-2,4-difluorophenyl group at the terminal nitrogen atom.		1.9910dichlorobenzene;
difluorobenzene;
N-acylurea		environmental contaminant;
insecticide;
xenobiotic
tris(2-carboxyethyl)phosphine
tris(2-carboxyethyl)phosphine: water-soluble reagent which irreversibly reduces disulfides to thiols at room temperature & is active below neutral pH; used for quantitation of iodine and iodate. TCEP : A tertiary phosphine in which phosphane is substituted with three 2-carboxyethyl groups. It is a commonly used reducing agent.		1.9910phosphine derivative;
tricarboxylic acid		reducing agent
atropine
tropan-3alpha-yl 3-hydroxy-2-phenylpropanoate : A tropane alkaloid that is (1R,5)-8-methyl-8-azabicyclo[3.2.1]octane substituted by a (3-hydroxy-2-phenylpropanoyl)oxy group at position 3.		2.6730
benzofurans
Benzofurans: Compounds that contain a BENZENE ring fused to a furan ring.		1.9910
quinidine
Quinidine: An optical isomer of quinine, extracted from the bark of the CHINCHONA tree and similar plant species. This alkaloid dampens the excitability of cardiac and skeletal muscles by blocking sodium and potassium currents across cellular membranes. It prolongs cellular ACTION POTENTIALS, and decreases automaticity. Quinidine also blocks muscarinic and alpha-adrenergic neurotransmission.. quinidine : A cinchona alkaloid consisting of cinchonine with the hydrogen at the 6-position of the quinoline ring substituted by methoxy.		1.9610cinchona alkaloidalpha-adrenergic antagonist;
anti-arrhythmia drug;
antimalarial;
drug allergen;
EC 1.14.13.181 (13-deoxydaunorubicin hydroxylase) inhibitor;
EC 3.6.3.44 (xenobiotic-transporting ATPase) inhibitor;
muscarinic antagonist;
P450 inhibitor;
potassium channel blocker;
sodium channel blocker
D-fructopyranose
[no description available]		210cyclic hemiketal;
D-fructose;
fructopyranose		sweetening agent
boron
Boron: A trace element with the atomic symbol B, atomic number 5, and atomic weight [10.806; 10.821]. Boron-10, an isotope of boron, is used as a neutron absorber in BORON NEUTRON CAPTURE THERAPY.		1.9910boron group element atom;
metalloid atom;
nonmetal atom		micronutrient
pyrethrins
[no description available]		1.9610
pralidoxime
pralidoxime: RN given refers to parent cpd; chloride was minor descriptor (75-80); on-line & Index Medicus search PRALIDOXIME COMPOUNDS (66-80). pralidoxime : A pyridinium ion that is 1-methylpyridinium substituted by a (hydroxyimino)methyl group at position 2.		1.9610pyridinium ionantidote to organophosphate poisoning;
antidote to sarin poisoning;
cholinergic drug;
cholinesterase reactivator
ConditionIndicatedRelationship StrengthStudiesTrials
Organophosphorus Poisoning
[description not available]		03.4780
Diseases, Occupational
[description not available]		01.9610
Organophosphate Poisoning
Poisoning due to exposure to ORGANOPHOSPHORUS COMPOUNDS, such as ORGANOPHOSPHATES; ORGANOTHIOPHOSPHATES; and ORGANOTHIOPHOSPHONATES.		03.4780
Poisoning
Used with drugs, chemicals, and industrial materials for human or animal poisoning, acute or chronic, whether the poisoning is accidental, occupational, suicidal, by medication error, or by environmental exposure.		07.420
Amyotonia Congenita
[description not available]		01.9710
Neuromuscular Diseases
A general term encompassing lower MOTOR NEURON DISEASE; PERIPHERAL NERVOUS SYSTEM DISEASES; and certain MUSCULAR DISEASES. Manifestations include MUSCLE WEAKNESS; FASCICULATION; muscle ATROPHY; SPASM; MYOKYMIA; MUSCLE HYPERTONIA, myalgias, and MUSCLE HYPOTONIA.		01.9710
Abnormalities, Autosome
[description not available]		01.9610
Acute Disease
Disease having a short and relatively severe course.		01.9610