Compounds > isazophos
Page last updated: 2024-11-06

isazophos

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Cross-References

ID SourceID
PubMed CID39223
CHEMBL ID1879142
CHEBI ID82135
SCHEMBL ID121685
MeSH IDM0105280

Synonyms (49)

Synonym
isazophos
o-(5-chloro-1-(1-methylethyl)-1h-1,2,4-triazol-3-yl) o,o-diethyl phosphorothioate
triumph
a-12223
einecs 255-863-8
o-(5-chloro-1-isopropyl-1h-1,2,4-triazol-3-yl) o,o-diethylphosphorothioate
cga-12223
ciba 12223
isazofos [bsi:iso]
o-5-chloro-1-isopropyl-1h-1,2,4-triazol-3-yl o,o-diethyl phosphorothioate
brace
hsdb 6684
miral 10 g
phosphorothioic acid, o-(5-chloro-1-(1-methylethyl)-1h-1,2,4-triazol-3-yl) o,o-diethyl ester
o-(5-chloro-1-isopropyl-1,2,4-triazol-3-yl) o,o-diethyl phosphorothioate
ai3-29128
miral
isazofos
o-(5-chloro-1-isopropyl-1h-1,2,4-triazol-3-yl) o,o-diethyl thiophosphate
42509-80-8
NCGC00168321-01
NCGC00168321-02
C19001
cas-42509-80-8
NCGC00254737-01
dtxsid7034676 ,
dtxcid5014676
tox21_300833
cf67cg9stq ,
ccris 8221
unii-cf67cg9stq
FT-0630627
isazofos [iso]
o-(5-chloro-1-isopropyl-1h-1,2,4-triazol-3-yl) o,o-diethyl phosphorothioate
isazofos [mi]
phosphorothioic acid o-(5-chloro-1-(1-methylethyl)-1h-1,2,4-triazol-3-yl) o,o-diethyl ester
isazofos [hsdb]
SCHEMBL121685
CHEBI:82135 ,
XRHGWAGWAHHFLF-UHFFFAOYSA-N
phosphorothioic acid, o-[5-chloro-1-(1-methylethyl)-1h-1,2,4-triazol-3-yl] o,o-diethyl ester
o-(5-chloro-1-isopropyl-1h-1,2,4-triazol-3-yl) o,o-diethyl thiophosphate #
CHEMBL1879142
isazophos, pestanal(r), analytical standard
isazofos 10 microg/ml in isooctane
Q27155763
(5-chloro-1-propan-2-yl-1,2,4-triazol-3-yl)oxy-diethoxy-sulfanylidene-lambda5-phosphane
STARBLD0009607
CS-0452387

Research Excerpts

Dosage Studied

ExcerptRelevanceReference
" The tips of the villi were necrotic in the high dosage groups of isazofos- and pyraclofos-treated quail."( Risk assessment of the organophosphate pesticides isazofos and pyraclofos using a 21-day dietary toxicity study in Japanese quail.
Bae, BK; Cho, SA; Kim, DJ; Park, JH; Seok, SH, 2008)		0.35
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
organic thiophosphate
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein Targets (9)

Potency Measurements

ProteinTaxonomyMeasurementAverage (µ)Min (ref.)Avg (ref.)Max (ref.)Bioassay(s)
LuciferasePhotinus pyralis (common eastern firefly)Potency89.35840.007215.758889.3584AID1224835
acetylcholinesteraseHomo sapiens (human)Potency4.54000.002541.796015,848.9004AID1347395; AID1347397; AID1347398; AID1347399
pregnane X receptorRattus norvegicus (Norway rat)Potency12.58930.025127.9203501.1870AID651751
nuclear receptor subfamily 1, group I, member 3Homo sapiens (human)Potency12.94840.001022.650876.6163AID1224838; AID1224839; AID1224893
progesterone receptorHomo sapiens (human)Potency61.13060.000417.946075.1148AID1346784
pregnane X nuclear receptorHomo sapiens (human)Potency5.66290.005428.02631,258.9301AID1346982; AID720659
estrogen nuclear receptor alphaHomo sapiens (human)Potency22.57900.000229.305416,493.5996AID588514; AID743075
aryl hydrocarbon receptorHomo sapiens (human)Potency22.21250.000723.06741,258.9301AID651777; AID743085; AID743122
thyroid stimulating hormone receptorHomo sapiens (human)Potency2.43370.001628.015177.1139AID1259385
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (8)

TimeframeStudies, This Drug (%)All Drugs %
pre-19902 (25.00)18.7374
1990's2 (25.00)18.2507
2000's3 (37.50)29.6817
2010's1 (12.50)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 19.64

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index19.64 (24.57)
Research Supply Index2.40 (2.92)
Research Growth Index4.40 (4.65)
Search Engine Demand Index15.26 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (19.64)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials1 (11.11%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other8 (88.89%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
disulfoton
Disulfoton: An organothiophosphate insecticide.. disulfoton : An organic thiophosphate that is the diethyl ester of S-[2-(ethylsulfanyl)ethyl] dihydrogen phosphorodithioate.		2.0210organic thiophosphate;
organothiophosphate insecticide		acaricide;
agrochemical;
EC 3.1.1.7 (acetylcholinesterase) inhibitor
famophos
famophos: structure		210organic thiophosphate;
organothiophosphate insecticide		agrochemical;
anthelminthic drug;
EC 3.1.1.7 (acetylcholinesterase) inhibitor
isofenphos
[no description available]		7.3820isopropyl ester;
organic phosphonate;
organothiophosphate insecticide;
phosphonic ester;
salicylates		agrochemical;
EC 3.1.1.7 (acetylcholinesterase) inhibitor
profenofos
[no description available]		2.0210monochlorobenzenes;
organic thiophosphate;
organochlorine insecticide;
organophosphate insecticide		acaricide;
agrochemical;
EC 3.1.1.7 (acetylcholinesterase) inhibitor
pyraclofos
[no description available]		3.4311monochlorobenzenes;
organic thiophosphate;
organochlorine insecticide;
organosulfur compound;
organothiophosphate insecticide;
pyrazoles		agrochemical;
EC 3.1.1.7 (acetylcholinesterase) inhibitor
ConditionIndicatedRelationship StrengthStudiesTrials
Chronic Illness
[description not available]		02.0610
Chronic Disease
Diseases which have one or more of the following characteristics: they are permanent, leave residual disability, are caused by nonreversible pathological alteration, require special training of the patient for rehabilitation, or may be expected to require a long period of supervision, observation, or care (Dictionary of Health Services Management, 2d ed). For epidemiological studies chronic disease often includes HEART DISEASES; STROKE; CANCER; and diabetes (DIABETES MELLITUS, TYPE 2).		02.0610
Brain Emboli
[description not available]		01.9310
Constriction, Pathological
[description not available]		01.9310
Mitral Stenosis
[description not available]		01.9310
Blood Clot
[description not available]		01.9310
Brain Embolism and Thrombosis
[description not available]		01.9310
Constriction, Pathologic
The condition of an anatomical structure's being constricted beyond normal dimensions.		01.9310
Mitral Valve Stenosis
Narrowing of the passage through the MITRAL VALVE due to FIBROSIS, and CALCINOSIS in the leaflets and chordal areas. This elevates the left atrial pressure which, in turn, raises pulmonary venous and capillary pressure leading to bouts of DYSPNEA and TACHYCARDIA during physical exertion. RHEUMATIC FEVER is its primary cause.		01.9310
Thrombosis
Formation and development of a thrombus or blood clot in the blood vessel.		01.9310
Bovine Diseases
[description not available]		0210