Target type: biologicalprocess
The process of removing one or more phosphate groups from a phosphorylated anandamide. [GOC:BHF, PMID:16938887]
Phosphoanandamide (2-arachidonoylglycerol phosphate, 2-AGP) dephosphorylation is a crucial step in the regulation of endocannabinoid signaling. 2-AGP, a phosphorylated form of the endocannabinoid 2-arachidonoylglycerol (2-AG), is produced by the phosphorylation of 2-AG by diacylglycerol kinases (DGKs). This phosphorylation event reduces the signaling activity of 2-AG, effectively sequestering it from binding to cannabinoid receptors.
The dephosphorylation of 2-AGP is catalyzed by a specific class of lipid phosphatases known as phospholipase C (PLC) enzymes. These enzymes hydrolyze the phosphate group from 2-AGP, generating 2-AG, which can then bind to cannabinoid receptors and exert its signaling effects.
Dephosphorylation is a dynamic process, ensuring that 2-AG levels are tightly controlled and signaling is precisely regulated. The interplay between DGKs and PLCs dictates the intracellular levels of 2-AG and ultimately governs the strength and duration of endocannabinoid signaling.
Several factors can influence the activity of PLCs, including intracellular calcium levels, phosphorylation status, and the presence of specific regulatory proteins. These intricate mechanisms ensure that the dephosphorylation of 2-AGP is tightly regulated in response to diverse physiological stimuli.
The dephosphorylation of 2-AGP is an essential step in the endocannabinoid system, contributing to the fine-tuning of cannabinoid signaling and the regulation of diverse physiological processes, including pain perception, appetite, memory, and mood.'
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| Protein | Definition | Taxonomy |
|---|---|---|
| Tyrosine-protein phosphatase non-receptor type 22 | A tyrosine-protein phosphatase non-receptor type 22 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9Y2R2] | Homo sapiens (human) |
| Compound | Definition | Classes | Roles |
|---|---|---|---|
| lawsone | lawsone : 1,4-Naphthoquinone carrying a hydroxy function at C-2. It is obtained from the leaves of Lawsonia inermis. lawsone: a molluscacide from leaves of Lawsonia inermis L. topical sunscreening agent; structure; powdered leaves of Lawsonia inermis(Lythraceae) used as brown hair dye | ||
| 1,2-naphthoquinone | 1,2-naphthoquinone : The parent structure of the family of 1,2-naphthoquinones, in which the oxo groups of the quinone moiety are at positions 1 and 2 of the naphthalene ring. It is a metabolite of naphthalene and is found in diesel exhaust particles. naphthalene-1,2-dione: structure given in first source | 1,2-naphthoquinones | aryl hydrocarbon receptor agonist; carcinogenic agent |
| 1,2-dihydroxynaphthalene | 1,2-dihydroxynaphthalene: RN given refers to parent cpd | naphthalenediol | mouse metabolite |
| cefsulodin | cefsulodin : A pyridinium-substituted semi-synthetic, broad-spectrum, cephalosporin antibiotic. Cefsulodin: A pyridinium-substituted semisynthetic, broad-spectrum antibacterial used especially for Pseudomonas infections in debilitated patients. | cephalosporin; organosulfonic acid; primary carboxamide | antibacterial drug |
| morusin | morusin : An extended flavonoid that is flavone substituted by hydroxy groups at positions 5, 2' and 4', a prenyl group at position 3 and a 2,2-dimethyl pyran group across positions 7 and 8. morusin: from Morus root bark; structure given in first source | extended flavonoid; trihydroxyflavone | antineoplastic agent; plant metabolite |
| trans-2,3',4,5'-tetrahydroxystilbene | trans-2,3',4,5'-tetrahydroxystilbene: hydroxystilbene oxyresveratrol | stilbenoid | |
| Norartocarpetin | flavones | ||
| cudraflavanone a | cudraflavanone A: antineoplastic from Cudrania tricuspidata; structure in first source | ||
| 3-(1-(3-(biphenyl-4-ylamino)-3-oxopropyl)-1h-1,2,3-triazol-4-yl)-6-hydroxy-1-methyl-2-phenyl-1h-indole-5-carboxylic acid | 3-(1-(3-(biphenyl-4-ylamino)-3-oxopropyl)-1H-1,2,3-triazol-4-yl)-6-hydroxy-1-methyl-2-phenyl-1H-indole-5-carboxylic acid: an SHP2 inhibitor; structure in first source |