Page last updated: 2024-09-27

Implant Capsular Contracture

The shrinkage of the foreign body encapsulation scar tissue that forms around artificial implants imbedded in body tissues.

Synonyms(1)

Synonym
Implant Capsular Contracture

Research

Studies (53)

TimeframeStudies, This Condition (%)All Conditions %
pre-19900 (0.00)23.3326
1990's0 (0.00)12.5806
2000's0 (0.00)18.1394
2010's41 (77.36)28.8240
2020's12 (22.64)9.53
DrugIndicatedRelationship StrengthStudiesTrials
iodine0low10
pentoxifylline0low10
propranolol0low10
ici 204,2190low40
mitomycin0medium31
methylene blue0low10
triamcinolone acetonide0low10
d-alpha tocopherol0low10
titanium0low10
chromium0medium11
hypochlorous acid0low10
cromolyn sodium0low20
phenyl acetate0low30
pirfenidone0medium11
nicotine0low10
cobalt0medium21
povidone-iodine0low70
fibrin0low20
elastin0low10
bromochloroacetic acid0low10
cobaltous chloride0low10
montelukast0low50
tranilast0low10
ramipril0low10
silicon0low10
chlorhexidine0low10
rifamycins0low10
chitosan0low20
interleukin-80low20
transforming growth factor beta0low10
rome0low10
orabase0low20
lipoteichoic acid0low20

Protein Targets (442)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
RAR-related orphan receptor gamma5005
AR protein110011
aldehyde dehydrogenase 1 family, member A14004
nuclear receptor subfamily 1, group I, member 35005
retinoic acid nuclear receptor alpha variant 17007
thyroid stimulating hormone receptor3003
nuclear factor erythroid 2-related factor 2 isoform 16006
Cellular tumor antigen p537007
Nuclear receptor ROR-gamma3003
Chain A, JmjC domain-containing histone demethylation protein 3A2002
Chain A, BCL-2-RELATED PROTEIN A10011
Chain A, Cruzipain1001
Luciferase6006
acid sphingomyelinase1001
interleukin 82002
acetylcholinesterase3003
PAX80001
glp-1 receptor, partial2002
15-lipoxygenase, partial1001
pregnane X receptor1001
phosphopantetheinyl transferase2002
hypoxia-inducible factor 1 alpha subunit7007
SMAD family member 23003
USP1 protein, partial4004
SMAD family member 33003
TDP1 protein7007
GLI family zinc finger 38008
caspase 7, apoptosis-related cysteine protease3003
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)3003
PINK11001
thyroid stimulating hormone receptor2002
estrogen receptor 2 (ER beta)4004
progesterone receptor5005
cytochrome P450 family 3 subfamily A polypeptide 47007
glucocorticoid receptor [Homo sapiens]7007
retinoid X nuclear receptor alpha7007
estrogen-related nuclear receptor alpha7007
farnesoid X nuclear receptor5005
pregnane X nuclear receptor6006
estrogen nuclear receptor alpha110011
G3003
cytochrome P450 2D65005
67.9K protein2002
glucocerebrosidase1001
Parkin2002
peroxisome proliferator-activated receptor delta5005
peroxisome proliferator activated receptor gamma5005
vitamin D (1,25- dihydroxyvitamin D3) receptor4004
heat shock protein 900011
caspase-33003
IDH14004
euchromatic histone-lysine N-methyltransferase 29009
calcineurin A1, putative0011
aryl hydrocarbon receptor8008
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a6006
activating transcription factor 65005
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a5005
v-jun sarcoma virus 17 oncogene homolog (avian)3003
Histone H2A.x3003
cytochrome P450 2D6 isoform 11001
hepatocyte nuclear factor 4-alpha isoform 20101
cellular tumor antigen p53 isoform a2002
cytochrome P450 2C19 precursor1001
cytochrome P450 2C9 precursor1001
perilipin-50101
thyroid hormone receptor beta isoform a2002
perilipin-10101
nuclear factor erythroid 2-related factor 2 isoform 24004
potassium voltage-gated channel subfamily H member 2 isoform d2002
transcriptional regulator ERG isoform 31001
thyroid hormone receptor beta isoform 26006
heat shock protein beta-14004
huntingtin isoform 22002
importin subunit beta-1 isoform 12002
mitogen-activated protein kinase 14004
ubiquitin-conjugating enzyme E2 N0101
nuclear factor NF-kappa-B p105 subunit isoform 11001
flap endonuclease 13003
protein AF-9 isoform a0002
snurportin-12002
melanocortin receptor 40101
CAAX prenyl protease0001
urokinase-type plasminogen activator precursor4004
plasminogen precursor4004
bcl-2-related protein A10101
urokinase plasminogen activator surface receptor precursor4004
nuclear receptor ROR-gamma isoform 14004
geminin8008
1-acylglycerol-3-phosphate O-acyltransferase ABHD5 isoform a0101
DNA polymerase kappa isoform 12002
peripheral myelin protein 221001
cytochrome P450 3A4 isoform 12002
glycogen synthase kinase-3 alpha0001
hexokinase HKDC10101
DNA repair protein RAD52 homolog isoform a0002
bcl-2-like protein 11 isoform 10011
lethal factor (plasmid)1001
lamin isoform A-delta104004
Gamma-aminobutyric acid receptor subunit pi2114
Synaptojanin-20101
Solute carrier family 22 member 20202
Solute carrier family 22 member 1 0203
Polyunsaturated fatty acid lipoxygenase ALOX15B1001
Synaptojanin-10101
Solute carrier family 22 member 30101
Voltage-dependent calcium channel gamma-2 subunit4004
Glutathione reductase, mitochondrial0204
Interferon beta3003
HLA class I histocompatibility antigen, B alpha chain 3003
Integrin beta-32002
72 kDa type IV collagenase0101
Integrin alpha-IIb2002
Matrix metalloproteinase-90101
Gamma-aminobutyric acid receptor subunit beta-12114
Gamma-aminobutyric acid receptor subunit delta2114
Gamma-aminobutyric acid receptor subunit gamma-22114
Glutamate receptor 24004
Gamma-aminobutyric acid receptor subunit alpha-52114
Gamma-aminobutyric acid receptor subunit alpha-32114
Gamma-aminobutyric acid receptor subunit gamma-12114
Gamma-aminobutyric acid receptor subunit alpha-22114
Gamma-aminobutyric acid receptor subunit alpha-42114
Gamma-aminobutyric acid receptor subunit gamma-32114
Trypanothione reductase0101
Gamma-aminobutyric acid receptor subunit alpha-62114
Alpha-synuclein2002
Histamine H2 receptor1001
Spike glycoprotein6006
Gamma-aminobutyric acid receptor subunit alpha-12114
Gamma-aminobutyric acid receptor subunit beta-32114
Gamma-aminobutyric acid receptor subunit beta-22114
TAR DNA-binding protein 434004
Peroxisomal N(1)-acetyl-spermine/spermidine oxidase0101
Multidrug and toxin extrusion protein 20202
Rap guanine nucleotide exchange factor 41001
GABA theta subunit2114
Inositol hexakisphosphate kinase 13003
Multidrug and toxin extrusion protein 10202
ATPase family AAA domain-containing protein 54004
Ataxin-25005
Gamma-aminobutyric acid receptor subunit epsilon2114
Spermine oxidase0101
cytochrome P450 2C9, partial3003
Alkaline phosphatase, germ cell type0101
G protein-coupled receptor GPR350011
G-protein coupled receptor 350011
G-protein coupled receptor 350011
Microtubule-associated protein tau4004
GTP-binding nuclear protein Ran isoform 11001
Rap guanine nucleotide exchange factor 31001
Glutathione S-transferase P0101
Alpha-tocopherol transfer protein0011
Chain A, TYROSYL-DNA PHOSPHODIESTERASE2002
Chain A, Beta-lactamase2002
Chain A, ATP-DEPENDENT DNA HELICASE Q12002
EWS/FLI fusion protein2002
bromodomain adjacent to zinc finger domain 2B3003
vitamin D3 receptor isoform VDRA1001
DNA polymerase beta2002
histone acetyltransferase KAT2A isoform 12002
streptokinase A precursor0011
neuropeptide S receptor isoform A3003
ATP-binding cassette sub-family C member 30707
Multidrug resistance-associated protein 40707
Nuclear receptor subfamily 1 group I member 20011
Bile salt export pump0707
Epidermal growth factor receptor0202
Estrogen receptor0011
Adenosine receptor A30516
Cytochrome P450 2C9 0303
Alpha-1B adrenergic receptor0617
Thromboxane-A synthase 0202
Mitogen-activated protein kinase 3 0101
Mitogen-activated protein kinase 10101
Bifunctional epoxide hydrolase 20101
Peroxisome proliferator-activated receptor gamma0011
Alpha-1A adrenergic receptor0617
Cytosolic phospholipase A20101
Sodium/bile acid cotransporter0202
Mitogen-activated protein kinase 140303
Cysteinyl leukotriene receptor 10303
Estrogen receptor beta0011
Canalicular multispecific organic anion transporter 10707
Cysteinyl leukotriene receptor 20303
Nuclear receptor subfamily 1 group I member 20011
Cysteinyl leukotriene receptor 10426
histone deacetylase 9 isoform 32002
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE4004
Chain E, Fibrin beta chain0101
Chain A, Putative fructose-1,6-bisphosphate aldolase1001
Chain A, 2-oxoglutarate Oxygenase3003
Chain A, Ferritin light chain1001
T cell receptor, partial1001
luteinizing hormone receptor1001
integrase, partial0101
chaperonin-containing TCP-1 beta subunit homolog1001
lens epithelium-derived growth factor p750101
Caspase 6, apoptosis-related cysteine peptidase0001
ATAD5 protein, partial4004
Fumarate hydratase2002
PPM1D protein1001
TSHR protein1001
Apoptotic peptidase activating factor 10101
thioredoxin glutathione reductase1001
Smad32002
hypothetical protein, conserved1001
isocitrate dehydrogenase 1, partial1001
polyprotein2002
luciferase1001
serine-protein kinase ATM isoform a1001
Bloom syndrome protein isoform 12002
neutrophil cytosol factor 10101
parathyroid hormone/parathyroid hormone-related peptide receptor precursor2002
caspase-9 isoform alpha precursor0101
pyruvate kinase PKM isoform a1001
caspase-3 isoform a preproprotein0101
histone-lysine N-methyltransferase 2A isoform 2 precursor2002
peptidyl-prolyl cis-trans isomerase NIMA-interacting 11001
DNA polymerase eta isoform 11001
DNA polymerase iota isoform a (long)3003
Vpr1001
survival motor neuron protein isoform d3003
muscleblind-like protein 1 isoform 12002
replicative DNA helicase0001
recombinase A0011
POsterior Segregation0011
Glutathione reductase0101
Glycoprotein hormones alpha chain1001
Albumin0001
Amyloid-beta precursor protein0101
Dihydrolipoyl dehydrogenase, mitochondrial0102
Microtubule-associated protein tau0112
Amine oxidase [flavin-containing] A0101
Alpha-1D adrenergic receptor0213
Sodium-dependent noradrenaline transporter 0213
Cruzipain0101
Guanine nucleotide-binding protein G1001
Inositol monophosphatase 13003
Thioredoxin reductase 1, cytoplasmic0102
Dihydrolipoyl dehydrogenase 0102
Zinc finger protein mex-50011
phosphoglycerate kinase1001
ATP-dependent phosphofructokinase2002
nuclear receptor subfamily 1, group I, member 22002
Indoleamine 2,3-dioxygenase 10101
Tyrosine-protein kinase Fyn0101
Beta-2 adrenergic receptor0415
Aldo-keto reductase family 1 member B10202
Alpha-2A adrenergic receptor0326
Cytochrome P450 2C80202
Muscarinic acetylcholine receptor M10314
Beta-3 adrenergic receptor0415
Alpha-2C adrenergic receptor0326
Muscarinic acetylcholine receptor M30314
Substance-K receptor0202
D(3) dopamine receptor0202
Delta-type opioid receptor0314
5-hydroxytryptamine receptor 2B0415
Sodium-dependent dopamine transporter 0202
Uracil nucleotide/cysteinyl leukotriene receptor0101
Leukotriene C4 synthase0101
5-hydroxytryptamine receptor 3E0101
thioredoxin reductase4004
regulator of G-protein signaling 43003
arylsulfatase A5005
D(1A) dopamine receptor2002
chromobox protein homolog 13003
Neuronal acetylcholine receptor subunit alpha-40213
Transient receptor potential cation channel subfamily A member 10112
5-hydroxytryptamine receptor 3B0101
Acetylcholine receptor subunit alpha0213
Acetylcholine receptor subunit alpha0213
Acetylcholine receptor subunit beta0213
Acetylcholine receptor subunit gamma0213
Acetylcholine receptor subunit delta0213
Neuronal acetylcholine receptor subunit alpha-30225
Cytochrome P450 1A20202
Acetylcholine receptor subunit gamma0213
Muscarinic acetylcholine receptor M10101
Muscarinic acetylcholine receptor M30101
Muscarinic acetylcholine receptor M40202
Cytochrome P450 3A40202
Muscarinic acetylcholine receptor M50101
Neuronal acetylcholine receptor subunit alpha-40101
Neuronal acetylcholine receptor subunit alpha-40225
Muscarinic acetylcholine receptor M20101
Acetylcholine receptor subunit beta0213
Cytochrome P450 2A60213
Neuronal acetylcholine receptor subunit alpha-20225
Neuronal acetylcholine receptor subunit beta-20225
Neuronal acetylcholine receptor subunit beta-30225
Neuronal acetylcholine receptor subunit beta-40225
Translocator protein0101
Neuronal acetylcholine receptor subunit beta-20213
Neuronal acetylcholine receptor subunit alpha-50225
Cytochrome P450 2A50101
Acetylcholine receptor subunit beta-like 20202
Neuronal acetylcholine receptor subunit alpha-50011
Neuronal acetylcholine receptor subunit beta-40213
Muscarinic acetylcholine receptor M40101
Neuronal acetylcholine receptor subunit alpha-30213
Delta-type opioid receptor0101
Delta-type opioid receptor0101
Mu-type opioid receptor0101
Neuronal acetylcholine receptor subunit alpha-70224
Neuronal acetylcholine receptor subunit alpha-60225
Neuronal acetylcholine receptor subunit alpha-90225
Neuronal acetylcholine receptor subunit alpha-40213
5-hydroxytryptamine receptor 3A0101
Neuronal acetylcholine receptor subunit alpha-70202
Acetylcholine-binding protein0112
Mu-type opioid receptor0101
Acetylcholine receptor subunit epsilon0011
Neuronal acetylcholine receptor subunit beta-30112
Neuronal acetylcholine receptor subunit alpha-70225
Acetylcholine receptor subunit delta0213
Potassium voltage-gated channel subfamily H member 20202
Neuronal acetylcholine receptor subunit alpha-20101
Neuronal acetylcholine receptor subunit alpha-60112
Cytochrome P450 2A130112
Neuronal acetylcholine receptor subunit alpha-50202
Liver carboxylesterase B-10101
Solute carrier family 22 member 10101
5-hydroxytryptamine receptor 3D0101
Transient receptor potential cation channel subfamily A member 10011
Neuronal acetylcholine receptor subunit beta-30202
Neuronal acetylcholine receptor subunit beta-40202
Neuronal acetylcholine receptor subunit alpha-30202
Soluble acetylcholine receptor0101
5-hydroxytryptamine receptor 3C0101
Neuronal acetylcholine receptor subunit alpha-20202
Neuronal acetylcholine receptor subunit beta-20213
Neuronal acetylcholine receptor subunit alpha-100225
Solute carrier family 22 member 20101
Neuronal acetylcholine receptor subunit alpha-60202
Integrin beta0011
Glycoprotein IIb0011
Transporter0113
endonuclease IV1001
dopamine D1 receptor2002
NFKB1 protein, partial2002
peripheral myelin protein 22 isoform 12002
vasopressin V1b receptor1001
ubiquitin carboxyl-terminal hydrolase 2 isoform a1001
relaxin receptor 1 isoform 11001
muscarinic acetylcholine receptor M12002
cGMP-dependent 3',5'-cyclic phosphodiesterase0101
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A0101
cGMP-specific 3',5'-cyclic phosphodiesterase0101
Tumor necrosis factor0101
Cholinesterase0101
Acetylcholinesterase0101
cAMP-specific 3',5'-cyclic phosphodiesterase 4A0101
Adenosine receptor A2b0101
Disintegrin and metalloproteinase domain-containing protein 171001
cAMP-specific 3',5'-cyclic phosphodiesterase 4B0101
cAMP-specific 3',5'-cyclic phosphodiesterase 4D0101
Chitotriosidase-10213
cGMP-inhibited 3',5'-cyclic phosphodiesterase A0101
Endochitinase B10213
Chain A, HADH2 protein1001
Chain B, HADH2 protein1001
ClpP1001
GALC protein1001
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 12002
Transforming growth factor beta-1 proprotein0101
Mothers against decapentaplegic homolog 3 0101
Beta-1 adrenergic receptor 0113
Voltage-dependent L-type calcium channel subunit alpha-1C0101
Bile salt export pump0101
5-hydroxytryptamine receptor 40202
Albumin0011
Muscarinic acetylcholine receptor M20112
ATP-dependent translocase ABCB10202
Beta-1 adrenergic receptor0213
5-hydroxytryptamine receptor 1A0101
Beta-2 adrenergic receptor0203
Cytochrome P450 2D60101
D(2) dopamine receptor0112
Alpha-2B adrenergic receptor0012
Beta-1 adrenergic receptor0214
D(3) dopamine receptor0101
5-hydroxytryptamine receptor 1A0214
Alpha-2B adrenergic receptor0011
D(1A) dopamine receptor0112
Voltage-dependent L-type calcium channel subunit alpha-1C0101
Alpha-2C adrenergic receptor0011
Alpha-2A adrenergic receptor0011
Alpha-1D adrenergic receptor0012
Endothelin-1 receptor0112
Beta-3 adrenergic receptor0202
5-hydroxytryptamine receptor 1B0213
5-hydroxytryptamine receptor 2A0213
5-hydroxytryptamine receptor 2C0213
5-hydroxytryptamine receptor 1B0202
Adenosine receptor A2a0112
Neuromedin-K receptor0011
Type-1 angiotensin II receptor0112
Sodium-dependent serotonin transporter0202
Cholecystokinin receptor type A0112
Cytochrome P450 2C190101
5-hydroxytryptamine receptor 70112
Beta-1 adrenergic receptor0101
Alpha-1A adrenergic receptor0124
Alpha-1B adrenergic receptor0012
Mu-type opioid receptor0112
Vasopressin V1a receptor0112
Kappa-type opioid receptor0112
5-hydroxytryptamine receptor 60213
5-hydroxytryptamine receptor 70101
Cytochrome P450 2J20101
Beta-2 adrenergic receptor0101
Voltage-dependent L-type calcium channel subunit alpha-1C0101
Sodium channel protein type 5 subunit alpha0101
Beta-2 adrenergic receptor0113
Sigma non-opioid intracellular receptor 10202
Nuclear receptor subfamily 2 group E member 10022
Angiotensin-converting enzyme 0101
Angiotensin-converting enzyme0101
Sphingosine kinase 20202
Sphingosine kinase 10101
MSH0001
Thrombopoietin1001
nonstructural protein 11001
pyruvate kinase1001
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)1001
NPC intracellular cholesterol transporter 1 precursor1001
polyunsaturated fatty acid lipoxygenase ALOX121001
atrial natriuretic peptide receptor 1 precursor1001
atrial natriuretic peptide receptor 2 precursor1001
ras-related protein Rab-9A1001
M-phase phosphoprotein 81001
pyruvate kinase PKM isoform b1001
Hematopoietic prostaglandin D synthase0101
Ornithine decarboxylase1001
NACHT, LRR and PYD domains-containing protein 3 0101
Transient receptor potential cation channel subfamily V member 20101
Glucocorticoid receptor0202
Glycine receptor subunit alpha-10202
Glycine receptor subunit beta0202
Glycine receptor subunit alpha-20202
Glycine receptor subunit alpha-30202
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]