Compounds > 1-aminoanthracene
Page last updated: 2024-12-05

1-aminoanthracene

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

1-Aminoanthracene is an organic compound with the molecular formula C₁₄H₁₁N. It is a derivative of anthracene, with an amino group (-NH₂) attached to the first carbon atom of the anthracene ring.

Here's why it's important for research:

**1. Fluorescent Properties:** 1-Aminoanthracene is a fluorescent molecule, meaning it absorbs light at a specific wavelength and emits light at a longer wavelength. This property makes it useful for:

* **Fluorescence Spectroscopy:** Studying the properties of biological molecules, including proteins, nucleic acids, and enzymes, by attaching 1-Aminoanthracene as a fluorescent probe. This helps in understanding their structure, function, and interactions.
* **Fluorescent Labeling:** Tagging other molecules for visualization and tracking, particularly in biological and chemical systems. This is useful in areas like cell imaging, flow cytometry, and drug delivery research.

**2. Photophysical Properties:** 1-Aminoanthracene exhibits unique photophysical properties, including:

* **High Fluorescence Quantum Yield:** This means it efficiently converts absorbed light into fluorescence, making it a bright emitter.
* **Sensitivity to Environmental Changes:** Its fluorescence intensity and lifetime are influenced by the surrounding environment (e.g., pH, polarity, viscosity). This sensitivity makes it useful for sensing applications.

**3. Chemical Reactivity:** 1-Aminoanthracene's amine group allows for further chemical modifications. It can be reacted with various reagents to create new derivatives with specific functionalities, opening up possibilities for:

* **Synthesis of New Fluorescent Probes:** Creating probes with tailored properties for specific applications.
* **Development of New Materials:** Incorporating 1-Aminoanthracene into polymers, nanoparticles, and other materials to impart fluorescence and other desired properties.

**4. Applications:** Due to its diverse properties, 1-Aminoanthracene has applications in:

* **Bioimaging:** Visualizing cellular structures and processes in live cells and tissues.
* **Environmental Monitoring:** Detecting pollutants and environmental changes.
* **Material Science:** Creating fluorescent materials with diverse properties.
* **Drug Development:** Developing fluorescent probes for drug delivery and tracking.

**Overall, 1-Aminoanthracene's unique properties make it a valuable tool for research in diverse fields. Its fluorescent properties, photophysical characteristics, chemical reactivity, and potential applications continue to attract significant research interest.**

Cross-References

ID SourceID
PubMed CID11885
CHEMBL ID82321
CHEBI ID40678
SCHEMBL ID168479
MeSH IDM0140783

Synonyms (49)

Synonym
BIDD:GT0165
CHEMBL82321
ccris 749
nsc 60017
anthracene, 1-amino-
ai3-52497
einecs 210-225-8
brn 2209406
anthracene, amino-
.alpha.-aminoanthracene
wln: l c666j dz
610-49-1
1-anthracylamine
1-anthramine
nsc60017
nsc-60017
1-aminoanthracene
1-anthracenamine
ANC ,
anthracen-1-ylamine
1-aminoanthracene, technical grade, 90%
alpha-aminoanthracene
1HN2
1-anthrylamine
DB01976
1GT1
CHEBI:40678 ,
anthracen-1-amine
aminoanthracene
inchi=1/c14h11n/c15-14-7-3-6-12-8-10-4-1-2-5-11(10)9-13(12)14/h1-9h,15h2
yuenfnplgjcnrb-uhfffaoysa-
A833023
AKOS004114680
62813-37-0
anthracenamine
unii-8h6056dwn2
8h6056dwn2 ,
FT-0632544
aminoanthracene, 1-
1-anthracenylamine
SCHEMBL168479
mfcd00003579
DTXSID00209859
1-aminoanthracene, technical, >=90% (gc/nt)
F21276
Q4117196
(s)-1-pyrrolidin-2-(4-hydroxybenzyl)-2-(n-cbz-n-methyl)amino-ethane
AS-56925
CS-W015766

Research Excerpts

Dosage Studied

ExcerptRelevanceReference
" Stage 40-47 tadpoles were also incubated 1 h with microtubule stabilizing agents, epothilone D or discodermolide, followed by dosing with 1-aminoanthracene."( Direct modulation of microtubule stability contributes to anthracene general anesthesia.
Dmochowski, IJ; Eckenhoff, RG; Emerson, DJ; Fiamengo, A; Liao, Z; Psonis, J; Smith, AB; Sugasawa, K; Taratula, O; Wang, X; Weiser, BP, 2013)		0.59
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
anthracenamine
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein Targets (2)

Activation Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Chain A, Odorant-binding ProteinBos taurus (cattle)Kd1.00001.00001.00001.0000AID977611
Chain A, Odorant-binding ProteinBos taurus (cattle)Kd1.00001.00001.00001.0000AID977611
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (11)

Assay IDTitleYearJournalArticle
AID307625Partition coefficient, log P of the compound
AID307626Solubility in water
AID160321Competition for [3H]benzo[a]pyrene-binding site of polycyclic aromatic hydrocarbon binding protein (PBP) from mouse liver1990Journal of medicinal chemistry, Feb, Volume: 33, Issue:2
Voronoi binding site model of a polycyclic aromatic hydrocarbon binding protein.
AID168093Compound was tested for carcinogenic activity on liver after topical administration of the compound; - denotes non carcinogenic activity.1981Journal of medicinal chemistry, Mar, Volume: 24, Issue:3
Computer-assisted structure-activity studies of chemical carcinogens. Aromatic amines.
AID167945Compound was tested for carcinogenic activity on breast after topical administration of the compound; - denotes non carcinogenic activity.1981Journal of medicinal chemistry, Mar, Volume: 24, Issue:3
Computer-assisted structure-activity studies of chemical carcinogens. Aromatic amines.
AID168118Compound was tested for carcinogenic activity on other sites after topical administration of the compound; - denotes non carcinogenic activity.1981Journal of medicinal chemistry, Mar, Volume: 24, Issue:3
Computer-assisted structure-activity studies of chemical carcinogens. Aromatic amines.
AID167934Compound was tested for carcinogenic activity on all sites after topical administration of the compound; - denotes non carcinogenic activity.1981Journal of medicinal chemistry, Mar, Volume: 24, Issue:3
Computer-assisted structure-activity studies of chemical carcinogens. Aromatic amines.
AID168104Compound was tested for carcinogenic activity on mixed data after topical administration of the compound; - denotes non carcinogenic activity.1981Journal of medicinal chemistry, Mar, Volume: 24, Issue:3
Computer-assisted structure-activity studies of chemical carcinogens. Aromatic amines.
AID168080Compound was tested for carcinogenic activity on ear duct after topical administration of the compound; - denotes non carcinogenic activity.1981Journal of medicinal chemistry, Mar, Volume: 24, Issue:3
Computer-assisted structure-activity studies of chemical carcinogens. Aromatic amines.
AID977611Experimentally measured binding affinity data (Kd) for protein-ligand complexes derived from PDB2001The Journal of biological chemistry, Mar-09, Volume: 276, Issue:10
The insect attractant 1-octen-3-ol is the natural ligand of bovine odorant-binding protein.
AID1811Experimentally measured binding affinity data derived from PDB2001The Journal of biological chemistry, Mar-09, Volume: 276, Issue:10
The insect attractant 1-octen-3-ol is the natural ligand of bovine odorant-binding protein.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (35)

TimeframeStudies, This Drug (%)All Drugs %
pre-19902 (5.71)18.7374
1990's5 (14.29)18.2507
2000's13 (37.14)29.6817
2010's13 (37.14)24.3611
2020's2 (5.71)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 22.99

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index22.99 (24.57)
Research Supply Index3.61 (2.92)
Research Growth Index4.95 (4.65)
Search Engine Demand Index23.28 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (22.99)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other36 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
acetylcarnitine
Acetylcarnitine: An acetic acid ester of CARNITINE that facilitates movement of ACETYL COA into the matrices of mammalian MITOCHONDRIA during the oxidation of FATTY ACIDS.		1.9910O-acylcarnitinehuman metabolite
gamma-aminobutyric acid
gamma-Aminobutyric Acid: The most common inhibitory neurotransmitter in the central nervous system.. gamma-aminobutyric acid : A gamma-amino acid that is butanoic acid with the amino substituent located at C-4.		2.0510amino acid zwitterion;
gamma-amino acid;
monocarboxylic acid		human metabolite;
neurotransmitter;
Saccharomyces cerevisiae metabolite;
signalling molecule
carnitine
[no description available]		6.9910amino-acid betainehuman metabolite;
mouse metabolite
dimethyl sulfoxide
Dimethyl Sulfoxide: A highly polar organic liquid, that is used widely as a chemical solvent. Because of its ability to penetrate biological membranes, it is used as a vehicle for topical application of pharmaceuticals. It is also used to protect tissue during CRYOPRESERVATION. Dimethyl sulfoxide shows a range of pharmacological activity including analgesia and anti-inflammation.. dimethyl sulfoxide : A 2-carbon sulfoxide in which the sulfur atom has two methyl substituents.		210sulfoxide;
volatile organic compound		alkylating agent;
antidote;
Escherichia coli metabolite;
geroprotector;
MRI contrast agent;
non-narcotic analgesic;
polar aprotic solvent;
radical scavenger
glycine
[no description available]		2.0110alpha-amino acid;
amino acid zwitterion;
proteinogenic amino acid;
serine family amino acid		EC 2.1.2.1 (glycine hydroxymethyltransferase) inhibitor;
fundamental metabolite;
hepatoprotective agent;
micronutrient;
neurotransmitter;
NMDA receptor agonist;
nutraceutical
nitrites
Nitrites: Salts of nitrous acid or compounds containing the group NO2-. The inorganic nitrites of the type MNO2 (where M=metal) are all insoluble, except the alkali nitrites. The organic nitrites may be isomeric, but not identical with the corresponding nitro compounds. (Grant & Hackh's Chemical Dictionary, 5th ed)		1.9710monovalent inorganic anion;
nitrogen oxoanion;
reactive nitrogen species		human metabolite
1-anilino-8-naphthalenesulfonate
1-anilino-8-naphthalenesulfonate: RN given refers to parent cpd. 8-anilinonaphthalene-1-sulfonic acid : A naphthalenesulfonic acid that is naphthalene-1-sulfonic acid substituted by a phenylamino group at position 8.		2.0110aminonaphthalene;
naphthalenesulfonic acid		fluorescent probe
2-aminofluorene
[no description available]		2.6630
amitrole
Amitrole: A non-selective post-emergence, translocated herbicide. According to the Seventh Annual Report on Carcinogens (PB95-109781, 1994) this substance may reasonably be anticipated to be a carcinogen. (From Merck Index, 12th ed) It is an irreversible inhibitor of CATALASE, and thus impairs activity of peroxisomes.. amitrole : A member of the class of triazoles that is 1H-1,2,4-triazole substituted by an amino group at position 3. Used to control annual grasses and aquatic weeds (but not on food crops because it causes cancer in laboratory animals). Its use within the EU was banned from September 2017 on the grounds of potential groundwater contamination and risks to aquatic life; there have also been concerns about its endocrine-disrupting properties.		1.9610aromatic amine;
triazoles		carotenoid biosynthesis inhibitor;
EC 1.11.1.6 (catalase) inhibitor;
herbicide
3-methylcholanthrene
Methylcholanthrene: A carcinogen that is often used in experimental cancer studies.. 3-methylcholanthrene : A pentacyclic ortho- and peri-fused polycyclic arene consisting of a dihydrocyclopenta[ij]tetraphene ring system with a methyl substituent at the 3-position.		2.3820ortho- and peri-fused polycyclic arenearyl hydrocarbon receptor agonist;
carcinogenic agent
azathioprine
Azathioprine: An immunosuppressive agent used in combination with cyclophosphamide and hydroxychloroquine in the treatment of rheumatoid arthritis. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), this substance has been listed as a known carcinogen. (Merck Index, 11th ed). azathioprine : A thiopurine that is 6-mercaptopurine in which the mercapto hydrogen is replaced by a 1-methyl-4-nitroimidazol-5-yl group. It is a prodrug for mercaptopurine and is used as an immunosuppressant, prescribed for the treatment of inflammatory conditions and after organ transplantation and also for treatment of Crohn's didease and MS.		1.9610aryl sulfide;
C-nitro compound;
imidazoles;
thiopurine		antimetabolite;
antineoplastic agent;
carcinogenic agent;
DNA synthesis inhibitor;
hepatotoxic agent;
immunosuppressive agent;
prodrug
benzo(a)pyrene
Benzo(a)pyrene: A potent mutagen and carcinogen. It is a public health concern because of its possible effects on industrial workers, as an environmental pollutant, an as a component of tobacco smoke.. benzo[a]pyrene : An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.		2.3820ortho- and peri-fused polycyclic arenecarcinogenic agent;
mouse metabolite
benzophenone
benzophenone : The simplest member of the class of benzophenones, being formaldehyde in which both hydrogens are replaced by phenyl groups.		2.0210benzophenonesphotosensitizing agent;
plant metabolite
guanidine
Guanidine: A strong organic base existing primarily as guanidium ions at physiological pH. It is found in the urine as a normal product of protein metabolism. It is also used in laboratory research as a protein denaturant. (From Martindale, the Extra Pharmacopoeia, 30th ed and Merck Index, 12th ed) It is also used in the treatment of myasthenia and as a fluorescent probe in HPLC.. guanidine : An aminocarboxamidine, the parent compound of the guanidines.		2.0110carboxamidine;
guanidines;
one-carbon compound
isoflurane
Isoflurane: A stable, non-explosive inhalation anesthetic, relatively free from significant side effects.		2.4720organofluorine compoundinhalation anaesthetic
propofol
Propofol: An intravenous anesthetic agent which has the advantage of a very rapid onset after infusion or bolus injection plus a very short recovery period of a couple of minutes. (From Smith and Reynard, Textbook of Pharmacology, 1992, 1st ed, p206). Propofol has been used as ANTICONVULSANTS and ANTIEMETICS.. propofol : A phenol resulting from the formal substitution of the hydrogen at the 2 position of 1,3-diisopropylbenzene by a hydroxy group.		2.0510phenolsanticonvulsant;
antiemetic;
intravenous anaesthetic;
radical scavenger;
sedative
suramin
Suramin: A polyanionic compound with an unknown mechanism of action. It is used parenterally in the treatment of African trypanosomiasis and it has been used clinically with diethylcarbamazine to kill the adult Onchocerca. (From AMA Drug Evaluations Annual, 1992, p1643) It has also been shown to have potent antineoplastic properties.. suramin : A member of the class of phenylureas that is urea in which each of the amino groups has been substituted by a 3-({2-methyl-5-[(4,6,8-trisulfo-1-naphthyl)carbamoyl]phenyl}carbamoyl)phenyl group. An activator of both the rabbit skeletal muscle RyR1 and sheep cardiac RyR2 isoform ryanodine receptor channels, it has been used for the treatment of human African trypanosomiasis for over 100 years.		1.9610naphthalenesulfonic acid;
phenylureas;
secondary carboxamide		angiogenesis inhibitor;
antinematodal drug;
antineoplastic agent;
apoptosis inhibitor;
EC 2.7.11.13 (protein kinase C) inhibitor;
GABA antagonist;
GABA-gated chloride channel antagonist;
purinergic receptor P2 antagonist;
ryanodine receptor agonist;
trypanocidal drug
n-hydroxy-2-aminofluorene
N-hydroxy-2-aminofluorene: structure		1.9610
hydroxyacetylaminofluorene
Hydroxyacetylaminofluorene: A N-hydroxylated derivative of 2-ACETYLAMINOFLUORENE that has demonstrated carcinogenic action.		1.96102-acetamidofluorenes
2-acetylaminofluorene
2-Acetylaminofluorene: A hepatic carcinogen whose mechanism of activation involves N-hydroxylation to the aryl hydroxamic acid followed by enzymatic sulfonation to sulfoxyfluorenylacetamide. It is used to study the carcinogenicity and mutagenicity of aromatic amines.		2.66302-acetamidofluorenesantimitotic;
carcinogenic agent;
epitope;
mutagen
serine
Serine: A non-essential amino acid occurring in natural form as the L-isomer. It is synthesized from GLYCINE or THREONINE. It is involved in the biosynthesis of PURINES; PYRIMIDINES; and other amino acids.. serine : An alpha-amino acid that is alanine substituted at position 3 by a hydroxy group.		2.0110L-alpha-amino acid;
proteinogenic amino acid;
serine family amino acid;
serine zwitterion;
serine		algal metabolite;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite
benz(a)anthracene
benz(a)anthracene: 4 fused rings of which one is angular in contrast to the linear NAPHTHACENES. tetraphene : An angular ortho-fused polycyclic arene consisting of four fused benzene rings.		1.9810ortho-fused polycyclic arene;
tetraphenes
9,10-dimethyl-1,2-benzanthracene
9,10-Dimethyl-1,2-benzanthracene: Polycyclic aromatic hydrocarbon found in tobacco smoke that is a potent carcinogen.. 7,12-dimethyltetraphene : A tetraphene having methyl substituents at the 7- and 12-positions. It is a potent carcinogen and is present in tobacco smoke.		1.9810ortho-fused polycyclic arene;
tetraphenes		carcinogenic agent
p-aminoazobenzene
p-Aminoazobenzene: Used in the form of its salts as a dye and as an intermediate in manufacture of Acid Yellow, diazo dyes, and indulines.. 4-(phenylazo)aniline : Azobenzene substituted at one of the 4-positions by an amino group. It has a role as a dye and an allergen.		1.9610
tyrosine
Tyrosine: A non-essential amino acid. In animals it is synthesized from PHENYLALANINE. It is also the precursor of EPINEPHRINE; THYROID HORMONES; and melanin.. tyrosine : An alpha-amino acid that is phenylalanine bearing a hydroxy substituent at position 4 on the phenyl ring.		2.0510amino acid zwitterion;
erythrose 4-phosphate/phosphoenolpyruvate family amino acid;
L-alpha-amino acid;
proteinogenic amino acid;
tyrosine		EC 1.3.1.43 (arogenate dehydrogenase) inhibitor;
fundamental metabolite;
micronutrient;
nutraceutical
aniline
[no description available]		1.9710anilines;
primary arylamine
phenylalanine
Phenylalanine: An essential aromatic amino acid that is a precursor of MELANIN; DOPAMINE; noradrenalin (NOREPINEPHRINE), and THYROXINE.. L-phenylalanine : The L-enantiomer of phenylalanine.. phenylalanine : An aromatic amino acid that is alanine in which one of the methyl hydrogens is substituted by a phenyl group.		2.0510amino acid zwitterion;
erythrose 4-phosphate/phosphoenolpyruvate family amino acid;
L-alpha-amino acid;
phenylalanine;
proteinogenic amino acid		algal metabolite;
EC 3.1.3.1 (alkaline phosphatase) inhibitor;
Escherichia coli metabolite;
human xenobiotic metabolite;
micronutrient;
mouse metabolite;
nutraceutical;
plant metabolite;
Saccharomyces cerevisiae metabolite
tryptophan
Tryptophan: An essential amino acid that is necessary for normal growth in infants and for NITROGEN balance in adults. It is a precursor of INDOLE ALKALOIDS in plants. It is a precursor of SEROTONIN (hence its use as an antidepressant and sleep aid). It can be a precursor to NIACIN, albeit inefficiently, in mammals.. tryptophan : An alpha-amino acid that is alanine bearing an indol-3-yl substituent at position 3.		2.7530erythrose 4-phosphate/phosphoenolpyruvate family amino acid;
L-alpha-amino acid zwitterion;
L-alpha-amino acid;
proteinogenic amino acid;
tryptophan zwitterion;
tryptophan		antidepressant;
Escherichia coli metabolite;
human metabolite;
micronutrient;
mouse metabolite;
nutraceutical;
plant metabolite;
Saccharomyces cerevisiae metabolite
acetonitrile
acetonitrile: RN given refers to unlabeled cpd. acetonitrile : A nitrile that is hydrogen cyanide in which the hydrogen has been replaced by a methyl group.		2.3110aliphatic nitrile;
volatile organic compound		EC 3.5.1.4 (amidase) inhibitor;
NMR chemical shift reference compound;
polar aprotic solvent
1-aminoanthraquinone
[no description available]		6.9610
1-phenylazo-2-naphthylamine
[no description available]		1.9610
fluorene
[no description available]		1.9810ortho-fused polycyclic arene;
ortho-fused tricyclic hydrocarbon
2-naphthylamine
2-Naphthylamine: A naphthalene derivative with carcinogenic action.. 2-naphthylamine : A naphthylamine carrying the amino group at position 2.		2.3720naphthylaminecarcinogenic agent
3,3'-dichlorobenzidine
3,3'-Dichlorobenzidine: A material used in the manufacture of azo dyes that is toxic to skin and carcinogenic in several species.		1.9610biphenyls;
monochlorobenzenes;
organochlorine compound
4-biphenylamine
4-biphenylamine: used in detection of sulfates, & as a carcinogen in cancer research; RN given refers to parent cpd; structure. biphenyl-4-amine : An aminobiphenyl that is biphenyl substituted by an amino group at position 4.		1.9610aminobiphenylcarcinogenic agent
benzidine
benzidine: RN given refers to parent cpd. benzidine : A member of the class of biphenyls that is 1,1'-biphenyl in which the hydrogen at the para-position of each phenyl group has been replaced by an amino group.		1.9610biphenyls;
substituted aniline		carcinogenic agent
o-aminoazotoluene
o-Aminoazotoluene: An azo dye with carcinogenic properties.		1.9610
methylenebis(chloroaniline)
Methylenebis(chloroaniline): Aromatic diamine used in the plastics industry as curing agent for epoxy resins and urethane rubbers. It causes bladder, liver, lung, and other neoplasms.. 4,4'-methylene-bis-(2-chloroaniline) : A chloroaniline that consists of two 2-chloroaniline units joined by a methylene bridge.		1.9610chloroanilinemetabolite
4,4'-diaminodiphenylmethane
4,4'-diaminodiphenylmethane: RN given refers to parent cpd; structure. 4,4'-diaminodiphenylmethane : An aromatic amine that is diphenylmethane substituted at the 4-position of each benzene ring by an amino group.		1.9610aromatic amineallergen;
carcinogenic agent
3,7-dimethyloctan-1-ol
3,7-dimethyloctan-1-ol: penetration enhancer for transdermal delivery of 5-fluorouracil; ligand for odorant-binding protein; RN given refers to parent cpd		2.0210aliphatic alcohol
undecanal
undecanal : A saturated fatty aldehyde formally arising from reduction of the carboxylic acid group of undecanoic acid. It is a component of essential oils from citrus plants like Citrus reticulata.		2.0210medium-chain fatty aldehyde;
n-alkanal;
saturated fatty aldehyde		antimycobacterial drug;
plant metabolite;
volatile oil component
2-aminoanthraquinone
[no description available]		1.9610anthraquinone
2-tolidine
2-tolidine: RN given refers to parent cpd; structure		1.9610biphenyls
anthracene
acene : A polycyclic aromatic hydrocarbon consisting of fused benzene rings in a rectilinear arrangement.. acenes : Polycyclic aromatic hydrocarbons consisting of fused benzene rings in a rectilinear arrangement and their substitution derivatives.		2.4420acene;
anthracenes;
ortho-fused tricyclic hydrocarbon
yellow ob
[no description available]		1.9610
1-naphthylamine
1-Naphthylamine: A suspected industrial carcinogen (and listed as such by OSHA). Its N-hydroxy metabolite is strongly carcinogenic and mutagenic.. naphthylamine : A primary arylamine that is naphthalene substituted by an amino group at unspecified position.. 1-naphthylamine : A naphthylamine that is naphthalene substituted by an amino group at position 1.		2.3820naphthylaminehuman xenobiotic metabolite
fluoranthene
fluoranthene: structure. fluoranthene : An ortho- and peri-fused polycyclic arene consisting of a naphthalene and benzene unit connected by a five-membered ring.		1.9710ortho- and peri-fused polycyclic arene
benzotriphenylene
[no description available]		1.9710carbopolycyclic compound
chrysene
chrysene: structure in Merck Index, 9th ed, #2252. chrysene : An ortho-fused polycyclic arene found commonly in the coal tar.		1.9710ortho-fused polycyclic areneplant metabolite
pyrazines
Pyrazines: A heterocyclic aromatic organic compound with the chemical formula C4H4N2.. pyrazine : A diazine that is benzene in which the carbon atoms at positions 1 and 4 have been replaced by nitrogen atoms.		210diazine;
pyrazines		Daphnia magna metabolite
2,7-diacetylaminofluorene
2,7-diacetylaminofluorene: has been found to induce leukemia in animals; minor descriptor (75-84); on-line search 2-ACETYLAMINOFLUORENE/AA (75-84); Index Medicus search 2-ACETYLAMINOFLUORENE/AA (80-82), FLUORENES (75-79)		1.9610
2,7-fluorenediamine
2,7-fluorenediamine: peroxidase reagent for blood smears; RN given refers to parent cpd		2.3720
n-hydroxy-1-naphthylamine
N-hydroxy-1-naphthylamine: carcinogen		1.9610N-substituted amine
2-anthramine
2-anthramine: structure		2.6630anthracenamine
9,10-dimethylanthracene
9,10-dimethylanthracene: RN given refers to parent ion		1.9810
4,4'-methylene bis(2-methylaniline)
4,4'-methylene bis(2-methylaniline): structure		1.9610diarylmethane
9-aminophenanthrene
[no description available]		2.3720phenanthrenamine
1-aminopyrene
[no description available]		2.3820
3-methoxy-4-aminoazobenzene
[no description available]		1.9610
n-hydroxy-n-(2-fluorenyl)benzamide
N-hydroxy-N-(2-fluorenyl)benzamide: structure given in first source		1.9610
4-acetylaminobiphenyl
[no description available]		1.9610biphenyls
2-acetamidophenanthrene
[no description available]		1.9610
n-hydroxy-4-acetylaminobiphenyl
N-hydroxy-4-acetylaminobiphenyl: structure. N-hydroxy-4-acetylaminobiphenyl : A hydroxamic acid that is biphenyl-4-amine bearing N-hydroxy and N-acetyl substituents.		1.9610hydroxamic acid
acetoxyacetylaminofluorene
Acetoxyacetylaminofluorene: An alkylating agent that forms DNA ADDUCTS at the C-8 position in GUANINE, resulting in single strand breaks. It has demonstrated carcinogenic action.. N-acetoxy-2-acetamidofluorene : A 2-acetamidofluorene compound in which the parent 2-acetamidofluorene is substituted on nitrogen by an acetoxy group.		1.96102-acetamidofluorenescarcinogenic agent;
mutagen
3-acetylaminofluorene
3-acetylaminofluorene: non-carcinogenic structural isomer of carcinogen N-2-fluorenylacetamide		1.9610
potassium sulfate
potassium sulfate: RN given refers to cpd with MF of K2-H2SO4		2.3110inorganic potassium salt;
potassium salt
2',3-dimethyl-4-aminobiphenyl
2',3-dimethyl-4-aminobiphenyl: RN given refers to parent cpd; structure		1.9610
9-hydroxybenzo(a)pyrene
9-hydroxybenzo(a)pyrene: RN given refers to unlabeled parent cpd		1.9710ortho- and peri-fused polycyclic arene
pyrene
pyrene: structure in Merck Index, 9th ed, #7746. pyrene : An ortho- and peri-fused polycyclic arene consisting of four fused benzene rings, resulting in a flat aromatic system.		2.3820ortho- and peri-fused polycyclic arenefluorescent probe;
persistent organic pollutant
fanft
FANFT: A potent nitrofuran derivative tumor initiator. It causes bladder tumors in all animals studied and is mutagenic to many bacteria.		1.9610
2-isobutyl-3-methoxypyrazine
[no description available]		210
azides
Azides: Organic or inorganic compounds that contain the -N3 group.. azide : Any nitrogen molecular entity containing the group -N3.		2.5220pseudohalide anionmitochondrial respiratory-chain inhibitor
cyclopenta(c,d)pyrene
cyclopenta(c,d)pyrene: structure		1.9710pyrenes
N-fluorenylacetamide
[no description available]		1.9610fluorenes
4-acetylaminofluorene
4-acetylaminofluorene : A member of the class of acetamides that is acetamide in which one of the hydrogens attached to the nitrogen is replaced by a 9H-fluoren-4-yl group.		1.9810acetamides;
fluorenes		mitogen
acridine orange
Acridine Orange: A cationic cytochemical stain specific for cell nuclei, especially DNA. It is used as a supravital stain and in fluorescence cytochemistry. It may cause mutations in microorganisms.. acridine orange : Fluorescent dye useful for cell cycle determination. It is cell-permeable, and interacts with DNA and RNA by intercalation or electrostatic attractions respectively.. acridine orange free base : A member of the class of aminoacridines that is acridine carrying two dimethylamino substituents at positions 3 and 6. The hydrochloride salt is the fluorescent dye 'acridine orange', used for cell cycle determination.		1.9610aminoacridines;
aromatic amine;
tertiary amino compound		fluorochrome;
histological dye
n-hydroxy-2-naphthylamine
[no description available]		1.9610
n-acetoxy-4-acetylaminobiphenyl
[no description available]		1.9610
7-iodo-n-2-acetylaminofluorene
[no description available]		1.9610
daq
[no description available]		2.0510
n-hydroxy-4-aminoazobenzene
N-hydroxy-4-aminoazobenzene: RN given refers to parent cpd		1.9610
propionylcarnitine
propionylcarnitine: RN given refers to cpd without isomeric designation		1.9910O-acylcarnitineanalgesic;
antirheumatic drug;
cardiotonic drug;
human metabolite;
peripheral nervous system drug
5,5'-bis(8-(phenylamino)-1-naphthalenesulfonate)
[no description available]		210
geraniol
[no description available]		2.02103,7-dimethylocta-2,6-dien-1-ol;
monoterpenoid;
primary alcohol		allergen;
fragrance;
plant metabolite;
volatile oil component
4-dimethylaminostilbene
4-dimethylaminostilbene: RN given refers to cpd without isomeric designation; structure		1.9610
4-acetylaminostilbene
4-acetylaminostilbene: RN given refers to non-specified isomer		1.9610
4-aminostilbene
4-aminostilbene: RN given refers to cpd without isomeric designation		1.9610
3,4-diaminocyclobut-3-ene-1,2-dione
3,4-diaminocyclobut-3-ene-1,2-dione: structure in first source		2.3110
quinine
[no description available]		2.3110cinchona alkaloidantimalarial;
muscle relaxant;
non-narcotic analgesic
nefurthiazole
nefurthiazole: structure		1.9610C-nitro compound;
furans
4,4'-diaminostilbene
[no description available]		1.9610
ConditionIndicatedRelationship StrengthStudiesTrials
Anesthesia
A state characterized by loss of feeling or sensation. This depression of nerve function is usually the result of pharmacologic action and is induced to allow performance of surgery or other painful procedures.		02.0810
Sensitivity and Specificity
Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)		01.9910