paroxetine maleate profile

paroxetine maleate : A maleate salt obtained by reaction of paroxetine with one equivalent of maleic acid. Highly potent and selective 5-HT uptake inhibitor that binds with high affinity to the serotonin transporter (Ki = 0.05 nM). Ki values are 1.1, 350 and 1100 nM for inhibition of [3H]-5-HT, [3H]-l-NA and [3H]-DA uptake respectively. Displays minimal affinity for alpha1-, alpha2- or beta-adrenoceptors, 5-HT2A, 5-HT1A, D2 or H1 receptors at concentrations below 1000 nM, however displays weak affinity for muscarinic ACh receptors (Ki = 42 nM). Antidepressant and anxiolytic in vivo. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

ID Source	ID
PubMed CID	6435921
CHEMBL ID	1449490
CHEBI ID	64194
SCHEMBL ID	140608
MeSH ID	M0329208

Synonym
HMS3268L15
piperidine, 3-((1,3-benzodioxol-5-yloxy)methyl)-4-(4-fluorophenyl)-, trans-(-)-, (z)-2-butenedioate
gf 74
fg 7051 maleate
(-)-alpha-4-(4-fluorophenyl)-3-(1,3-benzdioxolyl-(3))-oxymethyl piperidine maleate
trans-(-)-3-((1,3-benzodioxol-5-yloxy)methyl)-4-(4-fluorophenyl)piperidine maleate
MLS001401441
smr000466269
MLS000758308
paroxetine maleate
64006-44-6
smr000499580
MLS001076681
paroxetine maleate
HMS2051I21
HMS2230L21
HMS2231N17
CCG-100827
f726g2563q ,
unii-f726g2563q
(3s-trans)-3-[(1,3-benzodioxol-5-yloxy)methyl]-4-(4-fluorophenyl)piperidine maleate salt
paroxetine maleate salt
(3s,4r)-3-[(1,3-benzodioxol-5-yloxy)methyl]-4-(4-fluorophenyl)piperidinium (2z)-3-carboxyacrylate
(3s,4r)-3-[(1,3-benzodioxol-5-yloxy)methyl]-4-(4-fluorophenyl)piperidine maleate
CHEBI:64194 ,
REGID_FOR_CID_6435921
paroxetine maleate [mi]
fg-7051 maleate
(3s,4r)-3-((1,3-benzodioxol-5-yloxy)methyl)-4-(4-fluorophenyl)-piperidine maleate
SCHEMBL140608
NC00077
DTXSID9042590
CHEMBL1449490
(3s,4r)-3-[(1,3-benzodioxol-5-yloxy)methyl]-4-(4-fluorophenyl)-piperidine maleate
AKOS024456951
SR-01000597775-1
sr-01000597775
AEIUZSKXSWGSRU-QXGDPHCHSA-N
paroxetine maleate salt, >=98% (hplc), solid
HMS3677G13
Q27133113
HMS3413G13
(3s,4r)-3-(1,3-benzodioxol-5-yloxymethyl)-4-(4-fluorophenyl)piperidine;(z)-but-2-enedioic acid
ps21 - paroxetine
paroxetine maleate; piperidine, 3-[(1,3-benzodioxol-5-yloxy)methyl]-4-(4-fluorophenyl)-, (3s,4r)-, (2z)-2-butenedioate (1:1); piperidine, 3-[(1,3-benzodioxol-5-yloxy)methyl]-4-(4-fluorophenyl)-, (3s-trans)-, (z)-2-butenedioate; fg 7051 maleate; paroxetine

Role	Description
antidepressant	Antidepressants are mood-stimulating drugs used primarily in the treatment of affective disorders and related conditions.
anxiolytic drug	Anxiolytic drugs are agents that alleviate anxiety, tension, and anxiety disorders, promote sedation, and have a calming effect without affecting clarity of consciousness or neurologic conditions.
serotonin uptake inhibitor	A compound that specifically inhibits the reuptake of serotonin in the brain. This increases the serotonin concentration in the synaptic cleft which then activates serotonin receptors to a greater extent.
hepatotoxic agent	A role played by a chemical compound exihibiting itself through the ability to induce damage to the liver in animals.
P450 inhibitor	An enzyme inhibitor that interferes with the activity of cytochrome P450 involved in catalysis of organic substances.
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Class	Description
maleate salt	Salts from maleic acid.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein	Taxonomy	Measurement	Average (µ)	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
Chain A, JmjC domain-containing histone demethylation protein 3A	Homo sapiens (human)	Potency	31.0989	0.6310	35.7641	100.0000	AID504339
glp-1 receptor, partial	Homo sapiens (human)	Potency	10.6101	0.0184	6.8060	14.1254	AID624417
TDP1 protein	Homo sapiens (human)	Potency	10.2713	0.0008	11.3822	44.6684	AID686978; AID686979
Smad3	Homo sapiens (human)	Potency	35.4813	0.0052	7.8098	29.0929	AID588855
apical membrane antigen 1, AMA1	Plasmodium falciparum 3D7	Potency	33.9972	0.7079	12.1943	39.8107	AID720542
67.9K protein	Vaccinia virus	Potency	15.9541	0.0001	8.4406	100.0000	AID720579; AID720580
bromodomain adjacent to zinc finger domain 2B	Homo sapiens (human)	Potency	50.1187	0.7079	36.9043	89.1251	AID504333
IDH1	Homo sapiens (human)	Potency	18.4782	0.0052	10.8652	35.4813	AID686970
euchromatic histone-lysine N-methyltransferase 2	Homo sapiens (human)	Potency	35.4813	0.0355	20.9770	89.1251	AID504332
chromobox protein homolog 1	Homo sapiens (human)	Potency	18.8677	0.0060	26.1688	89.1251	AID540317
urokinase-type plasminogen activator precursor	Mus musculus (house mouse)	Potency	8.2852	0.1585	5.2879	12.5893	AID540303
plasminogen precursor	Mus musculus (house mouse)	Potency	8.2852	0.1585	5.2879	12.5893	AID540303
urokinase plasminogen activator surface receptor precursor	Mus musculus (house mouse)	Potency	8.2852	0.1585	5.2879	12.5893	AID540303
nuclear receptor ROR-gamma isoform 1	Mus musculus (house mouse)	Potency	7.1912	0.0079	8.2332	1,122.0200	AID2546; AID2551
geminin	Homo sapiens (human)	Potency	22.4945	0.0046	11.3741	33.4983	AID624296; AID624297
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Protein	Taxonomy	Measurement	Average	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
short transient receptor potential channel 6 isoform 1	Mus musculus (house mouse)	EC50 (µMol)	44.6700	0.0200	20.5189	70.7900	AID2696
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Protein	Taxonomy	Measurement	Average	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
protein AF-9 isoform a	Homo sapiens (human)	AC50	15.7100	0.0800	8.3802	17.9800	AID720495
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (39)

Assay ID	Title	Year	Journal	Article
AID588497	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set	2010	Current protocols in cytometry, Oct, Volume: Chapter 13	Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588497	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set	2006	Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5	Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588497	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set	2010	Assay and drug development technologies, Feb, Volume: 8, Issue:1	High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID588499	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set	2010	Current protocols in cytometry, Oct, Volume: Chapter 13	Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588499	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set	2006	Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5	Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588499	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set	2010	Assay and drug development technologies, Feb, Volume: 8, Issue:1	High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID588501	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set	2010	Current protocols in cytometry, Oct, Volume: Chapter 13	Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588501	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set	2006	Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5	Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588501	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set	2010	Assay and drug development technologies, Feb, Volume: 8, Issue:1	High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID1745845	Primary qHTS for Inhibitors of ATXN expression
AID651635	Viability Counterscreen for Primary qHTS for Inhibitors of ATXN expression
AID1223668	Drug metabolism in Sprague-Dawley rat hepatocytes assessed as (2S,3R,4S,5S,6R)-2-(4-(((4R)-4-(4-fluorophenyl)piperidin-3-yl)methoxy)-2-methoxyphenoxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol level at 1 uM by radio-chromatogram analysis	2013	Drug metabolism and disposition: the biological fate of chemicals, Apr, Volume: 41, Issue:4	Evaluation of hepatic disposition of paroxetine using sandwich-cultured rat and human hepatocytes.
AID1223723	Drug metabolism in 4 days of sandwich-cultured human hepatocytes assessed as parent compound level at 1 uM after 24 hrs by radio-chromatogram analysis	2013	Drug metabolism and disposition: the biological fate of chemicals, Apr, Volume: 41, Issue:4	Evaluation of hepatic disposition of paroxetine using sandwich-cultured rat and human hepatocytes.
AID1223669	Drug metabolism in Sprague-Dawley rat hepatocytes assessed as 4-(((4R)-4-(4-fluorophenyl)piperidin-3-yl)methoxy)-2-methoxyphenyl hydrogen sulfate level at 1 uM by radio-chromatogram analysis	2013	Drug metabolism and disposition: the biological fate of chemicals, Apr, Volume: 41, Issue:4	Evaluation of hepatic disposition of paroxetine using sandwich-cultured rat and human hepatocytes.
AID1223675	Drug metabolism in Sprague-Dawley rat hepatocytes assessed as parent compound level at 1 uM after 3 hrs by radio-chromatogram analysis	2013	Drug metabolism and disposition: the biological fate of chemicals, Apr, Volume: 41, Issue:4	Evaluation of hepatic disposition of paroxetine using sandwich-cultured rat and human hepatocytes.
AID1223717	Drug metabolism in 4 days of sandwich-cultured Sprague-Dawley rat hepatocytes assessed as total recovered parent compound level at 1 uM after 24 hrs by radio-chromatogram analysis	2013	Drug metabolism and disposition: the biological fate of chemicals, Apr, Volume: 41, Issue:4	Evaluation of hepatic disposition of paroxetine using sandwich-cultured rat and human hepatocytes.
AID1223736	Drug metabolism in 4 days of sandwich-cultured Sprague-Dawley rat hepatocytes assessed as biliary excretion index of parent compound at 1 uM after 1 hr by radio-chromatogram analysis	2013	Drug metabolism and disposition: the biological fate of chemicals, Apr, Volume: 41, Issue:4	Evaluation of hepatic disposition of paroxetine using sandwich-cultured rat and human hepatocytes.
AID1223726	Drug metabolism in human hepatocytes assessed as total recovered parent compound level at 1 uM after 3 hrs by radio-chromatogram analysis	2013	Drug metabolism and disposition: the biological fate of chemicals, Apr, Volume: 41, Issue:4	Evaluation of hepatic disposition of paroxetine using sandwich-cultured rat and human hepatocytes.
AID1223681	Drug metabolism in Sprague-Dawley rat hepatocytes assessed as total recovered parent compound level at 1 uM after 3 hrs by radio-chromatogram analysis	2013	Drug metabolism and disposition: the biological fate of chemicals, Apr, Volume: 41, Issue:4	Evaluation of hepatic disposition of paroxetine using sandwich-cultured rat and human hepatocytes.
AID1223672	Drug metabolism in 4 days of sandwich-cultured Sprague-Dawley rat hepatocytes assessed as (2S,3R,4S,5S,6R)-2-(4-(((4R)-4-(4-fluorophenyl)piperidin-3-yl)methoxy)-2-methoxyphenoxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol level at 1 uM by radio-chro	2013	Drug metabolism and disposition: the biological fate of chemicals, Apr, Volume: 41, Issue:4	Evaluation of hepatic disposition of paroxetine using sandwich-cultured rat and human hepatocytes.
AID1223691	Drug metabolism in 4 days of sandwich-cultured human hepatocytes assessed as biliary excretion index of parent compound at 1 uM after 1 hr by radio-chromatogram analysis	2013	Drug metabolism and disposition: the biological fate of chemicals, Apr, Volume: 41, Issue:4	Evaluation of hepatic disposition of paroxetine using sandwich-cultured rat and human hepatocytes.
AID1223689	Drug metabolism in 4 days of sandwich-cultured human hepatocytes assessed as biliary excretion index of parent compound at 1 uM after 0.25 hrs by radio-chromatogram analysis	2013	Drug metabolism and disposition: the biological fate of chemicals, Apr, Volume: 41, Issue:4	Evaluation of hepatic disposition of paroxetine using sandwich-cultured rat and human hepatocytes.
AID1223690	Drug metabolism in 4 days of sandwich-cultured human hepatocytes assessed as biliary excretion index of parent compound at 1 uM after 0.5 hrs by radio-chromatogram analysis	2013	Drug metabolism and disposition: the biological fate of chemicals, Apr, Volume: 41, Issue:4	Evaluation of hepatic disposition of paroxetine using sandwich-cultured rat and human hepatocytes.
AID1223683	Drug metabolism in 4 days of sandwich-cultured Sprague-Dawley rat hepatocytes assessed as biliary excretion index of parent compound at 1 uM after 24 hrs by radio-chromatogram analysis	2013	Drug metabolism and disposition: the biological fate of chemicals, Apr, Volume: 41, Issue:4	Evaluation of hepatic disposition of paroxetine using sandwich-cultured rat and human hepatocytes.
AID1223682	Drug metabolism in 4 days of sandwich-cultured Sprague-Dawley rat hepatocytes assessed as biliary excretion index of parent compound at 1 uM after 4 hrs by radio-chromatogram analysis	2013	Drug metabolism and disposition: the biological fate of chemicals, Apr, Volume: 41, Issue:4	Evaluation of hepatic disposition of paroxetine using sandwich-cultured rat and human hepatocytes.
AID1223735	Drug metabolism in 4 days of sandwich-cultured Sprague-Dawley rat hepatocytes assessed as biliary excretion index of parent compound at 1 uM after 0.5 hrs by radio-chromatogram analysis	2013	Drug metabolism and disposition: the biological fate of chemicals, Apr, Volume: 41, Issue:4	Evaluation of hepatic disposition of paroxetine using sandwich-cultured rat and human hepatocytes.
AID1223692	Drug metabolism in 4 days of sandwich-cultured human hepatocytes assessed as biliary excretion index of parent compound at 1 uM after 4 hrs by radio-chromatogram analysis	2013	Drug metabolism and disposition: the biological fate of chemicals, Apr, Volume: 41, Issue:4	Evaluation of hepatic disposition of paroxetine using sandwich-cultured rat and human hepatocytes.
AID1223676	Drug metabolism in 4 days of sandwich-cultured Sprague-Dawley rat hepatocytes assessed as parent compound level at 1 uM after 24 hrs by radio-chromatogram analysis	2013	Drug metabolism and disposition: the biological fate of chemicals, Apr, Volume: 41, Issue:4	Evaluation of hepatic disposition of paroxetine using sandwich-cultured rat and human hepatocytes.
AID1223671	Drug metabolism in 4 days of sandwich-cultured Sprague-Dawley rat hepatocytes assessed as parent compound level at 1 uM by radio-chromatogram analysis	2013	Drug metabolism and disposition: the biological fate of chemicals, Apr, Volume: 41, Issue:4	Evaluation of hepatic disposition of paroxetine using sandwich-cultured rat and human hepatocytes.
AID1223734	Drug metabolism in 4 days of sandwich-cultured Sprague-Dawley rat hepatocytes assessed as biliary excretion index of parent compound at 1 uM after 0.25 hrs by radio-chromatogram analysis	2013	Drug metabolism and disposition: the biological fate of chemicals, Apr, Volume: 41, Issue:4	Evaluation of hepatic disposition of paroxetine using sandwich-cultured rat and human hepatocytes.
AID1223729	Drug metabolism in 4 days of sandwich-cultured human hepatocytes assessed as total recovered parent compound level at 1 uM after 24 hrs by radio-chromatogram analysis	2013	Drug metabolism and disposition: the biological fate of chemicals, Apr, Volume: 41, Issue:4	Evaluation of hepatic disposition of paroxetine using sandwich-cultured rat and human hepatocytes.
AID1223713	Drug metabolism in rat assessed as biliary excretion of (2S,3R,4S,5S,6R)-2-(4-(((4R)-4-(4-fluorophenyl)piperidin-3-yl)methoxy)-2-methoxyphenoxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol	2013	Drug metabolism and disposition: the biological fate of chemicals, Apr, Volume: 41, Issue:4	Evaluation of hepatic disposition of paroxetine using sandwich-cultured rat and human hepatocytes.
AID1223720	Drug metabolism in human hepatocytes assessed as parent compound level at 1 uM after 3 hrs by radio-chromatogram analysis	2013	Drug metabolism and disposition: the biological fate of chemicals, Apr, Volume: 41, Issue:4	Evaluation of hepatic disposition of paroxetine using sandwich-cultured rat and human hepatocytes.
AID1223667	Drug metabolism in Sprague-Dawley rat hepatocytes assessed as parent compound level at 1 uM by radio-chromatogram analysis	2013	Drug metabolism and disposition: the biological fate of chemicals, Apr, Volume: 41, Issue:4	Evaluation of hepatic disposition of paroxetine using sandwich-cultured rat and human hepatocytes.
AID1223673	Drug metabolism in 4 days of sandwich-cultured Sprague-Dawley rat hepatocytes assessed as 4-(((4R)-4-(4-fluorophenyl)piperidin-3-yl)methoxy)-2-methoxyphenyl hydrogen sulfate level at 1 uM by radio-chromatogram analysis	2013	Drug metabolism and disposition: the biological fate of chemicals, Apr, Volume: 41, Issue:4	Evaluation of hepatic disposition of paroxetine using sandwich-cultured rat and human hepatocytes.
AID1223714	Drug metabolism in human assessed as biliary excretion of (2S,3R,4S,5S,6R)-2-(4-(((4R)-4-(4-fluorophenyl)piperidin-3-yl)methoxy)-2-methoxyphenoxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol	2013	Drug metabolism and disposition: the biological fate of chemicals, Apr, Volume: 41, Issue:4	Evaluation of hepatic disposition of paroxetine using sandwich-cultured rat and human hepatocytes.
AID1223693	Drug metabolism in 4 days of sandwich-cultured human hepatocytes assessed as biliary excretion index of parent compound at 1 uM after 24 hrs by radio-chromatogram analysis	2013	Drug metabolism and disposition: the biological fate of chemicals, Apr, Volume: 41, Issue:4	Evaluation of hepatic disposition of paroxetine using sandwich-cultured rat and human hepatocytes.
AID504810	Antagonists of the Thyroid Stimulating Hormone Receptor: HTS campaign	2010	Endocrinology, Jul, Volume: 151, Issue:7	A small molecule inverse agonist for the human thyroid-stimulating hormone receptor.
AID504812	Inverse Agonists of the Thyroid Stimulating Hormone Receptor: HTS campaign	2010	Endocrinology, Jul, Volume: 151, Issue:7	A small molecule inverse agonist for the human thyroid-stimulating hormone receptor.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	1 (16.67)	29.6817
2010's	4 (66.67)	24.3611
2020's	1 (16.67)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	6 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Condition	Indicated	Relationship Strength	Studies	Trials
Innate Inflammatory Response [description not available]	0	2.05	1	0
Inflammation A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.	0	2.05	1	0

paroxetine maleate

Description

Cross-References

Synonyms (45)

Roles (5)

Drug Classes (1)

Protein Targets (17)

Potency Measurements

Activation Measurements

Other Measurements

Bioassays (39)

Research

Studies (6)

Market Indicators

Research Demand Index: 12.35

Study Types

paroxetine maleate

Description

Cross-References

Synonyms (45)

Roles (5)

Drug Classes (1)

Protein Targets (17)

Potency Measurements

Activation Measurements

Other Measurements

Bioassays (39)

Research

Studies (6)

Market Indicators

Research Demand Index: 12.35

Study Types

Related Conditions (2)