Abscess, Tubercular, Intracranial

A well-circumscribed mass composed of tuberculous granulation tissue that may occur in the cerebral hemispheres, cerebellum, brain stem, or perimeningeal spaces. Multiple lesions are quite common. Management of intracranial manifestations vary with lesion site. Intracranial tuberculomas may be associated with SEIZURES, focal neurologic deficits, and INTRACRANIAL HYPERTENSION. Spinal cord tuberculomas may be associated with localized or radicular pain, weakness, sensory loss, and incontinence. Tuberculomas may arise as OPPORTUNISTIC INFECTIONS, but also occur in immunocompetent individuals.

Synonym
Abscess, Tubercular, Intracranial
Tuberculoma, Intracranial
Intracranial Tuberculoma

Excerpt	Reference
"A case of extensive intracranial tuberculoma is presented."	( al-Hokail, AA; Coates, RK; el-Yazigi, A; Ellis, ME; Halim, MA; Hussain Qadri, SM, 1991)
"Intracranial tuberculomas are a rare manifestation of neurotuberculosis and are due to hematogenous dissemination of distant focuses of Mycobacterium tuberculosis infection."	( Alves, SM; Belo Neto, E; Brandão, RZ; Novis, SA; Pimentel, ML, 2000)
"Intracranial tuberculomas are known to develop during treatment of tuberculous meningitis (TBM)."	( Ira, S, 2005)
"Intracranial tuberculoma is a possible complication of meningeal, miliary or pulmonary tuberculosis."	( Alosi, MM; Ruggeri, C; Scibilia, G; Valenzise, M; Wasniewska, M, 2005)
"Intracranial tuberculomas are uncommon complications of tuberculosis, especially in immuno-competent individuals with no evidence of extra-cranial foci."	( Adeyekun, AA; Ogunrin, AO, 2007)
"Intracranial tuberculomas are commonly observed neuroimaging abnormalities in tuberculous meningitis (TBM)."	( Agarwal, A; Anuradha, HK; Garg, RK; Shukla, R; Singh, MK; Sinha, MK; Verma, R, 2011)
"Intracranial tuberculomas are rare yet lethal forms of tuberculosis."	( Alva-Diaz, C; Esteban-Arias, D; López-Saavedra, A; Metcalf, T; Orellana-Tovar, I; Pacheco-Barrios, K; Rodriguez-López, E; Velásquez-Rimachi, V, 2020)
"Solitary intracranial tuberculomas are rare and frequently misdiagnosed as brain tumors."	( Arakawa, Y; Fushimi, Y; Nakamoto, Y; Sakata, A; Shimizu, Y, 2023)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	1 (1.11)	23.3326
1990's	23 (25.56)	12.5806
2000's	32 (35.56)	18.1394
2010's	30 (33.33)	28.8240
2020's	4 (4.44)	9.53

Drug	Relationship Strength	Studies	Trials
phosphoserine	low	1	0
choline	low	2	0
salicylic acid	low	2	0
creatine	low	1	0
lactic acid	low	1	0
formaldehyde	low	1	0
pyrazinamide	medium	14	1
pyridoxine	low	1	0
albendazole	low	1	0
azathioprine	low	1	0
carbamazepine	low	1	0
ciprofloxacin	low	1	0
pentetic acid	low	2	0
isoniazid	medium	21	1
ofloxacin	low	2	0
thalidomide	low	3	0
prednisolone	low	5	0
prednisone	low	5	0
alanine	low	1	0
aspartic acid	low	2	0
methionine	low	1	0
methylprednisolone	low	2	0
meglumine	low	1	0
betamethasone	low	1	0
ethambutol	low	10	0
streptomycin	low	8	0
cladribine	low	1	0
gadolinium	low	2	0
thallium chloride	low	1	0
misonidazole	low	1	0
propiconazole	low	1	0
n-acetylaspartic acid	low	2	0
fluorodeoxyglucose f18	low	1	0
fluoromisonidazole	low	1	0
levofloxacin	low	1	0
moxifloxacin	low	2	0
trimethoprim, sulfamethoxazole drug combination	low	1	0
ethionamide	low	1	0
amphotericin b	low	1	0
thallium	low	1	0
gadolinium dtpa	low	7	0
amoxicillin-potassium clavulanate combination	low	1	0
technetium tc 99m exametazime	low	1	0
clove	low	1	0
cosyntropin	low	1	0
glycolipids	low	1	0
acenocoumarol	low	1	0
transforming growth factor beta	medium	1	1
rifampin	medium	20	1
eye	low	1	0

Protein Targets (428)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	10	0	0	10
Luciferase	3	0	0	3
RAR-related orphan receptor gamma	11	0	0	11
retinoid X nuclear receptor alpha	9	0	0	9
G	4	0	0	4
peroxisome proliferator activated receptor gamma	5	0	0	5
euchromatic histone-lysine N-methyltransferase 2	14	0	0	14
thyroid stimulating hormone receptor	3	0	0	3
chromobox protein homolog 1	4	0	0	4
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	3	0	0	3
geminin	12	0	0	12
muscleblind-like protein 1 isoform 1	5	0	0	5
Interferon beta	6	0	0	6
HLA class I histocompatibility antigen, B alpha chain	4	0	0	4
Guanine nucleotide-binding protein G	2	0	0	2
Inositol hexakisphosphate kinase 1	4	0	0	4
cytochrome P450 2C9, partial	4	0	0	4
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	5	0	0	5
Carbonic anhydrase 1	0	2	0	4
Carbonic anhydrase 2	0	2	0	4
Alanine racemase, biosynthetic	0	0	0	1
5-hydroxytryptamine receptor 1D	0	0	0	2
Glutamate receptor ionotropic, NMDA 1	0	2	0	2
Proton-coupled amino acid transporter 1	0	2	0	2
Adenosine deaminase	0	0	0	1
Carbonic anhydrase 4	0	0	0	2
Chain A, Beta-lactamase	3	0	0	3
glp-1 receptor, partial	3	0	0	3
hypoxia-inducible factor 1 alpha subunit	3	0	0	3
ATAD5 protein, partial	3	0	0	3
Fumarate hydratase	3	0	0	3
TDP1 protein	13	0	0	13
GLI family zinc finger 3	13	0	0	13
AR protein	15	0	0	15
caspase 7, apoptosis-related cysteine protease	1	0	0	1
nuclear receptor subfamily 1, group I, member 3	6	0	0	6
progesterone receptor	6	0	0	6
glucocorticoid receptor [Homo sapiens]	13	0	0	13
retinoic acid nuclear receptor alpha variant 1	9	0	0	9
estrogen-related nuclear receptor alpha	11	0	0	11
farnesoid X nuclear receptor	7	0	0	7
pregnane X nuclear receptor	10	0	0	10
estrogen nuclear receptor alpha	18	0	0	18
polyprotein	3	0	0	3
67.9K protein	4	0	0	4
vitamin D (1,25- dihydroxyvitamin D3) receptor	8	0	0	8
caspase-3	1	0	0	1
IDH1	6	0	0	6
aryl hydrocarbon receptor	6	0	0	6
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	8	0	0	8
v-jun sarcoma virus 17 oncogene homolog (avian)	5	0	0	5
nuclear receptor subfamily 1, group I, member 2	4	0	0	4
Histone H2A.x	3	0	0	3
cellular tumor antigen p53 isoform a	4	0	0	4
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	5	0	0	5
nuclear factor erythroid 2-related factor 2 isoform 2	10	0	0	10
transcriptional regulator ERG isoform 3	2	0	0	2
thyroid hormone receptor beta isoform 2	7	0	0	7
histone deacetylase 9 isoform 3	1	0	0	1
heat shock protein beta-1	2	0	0	2
mitogen-activated protein kinase 1	2	0	0	2
urokinase-type plasminogen activator precursor	2	0	0	2
plasminogen precursor	2	0	0	2
urokinase plasminogen activator surface receptor precursor	2	0	0	2
Vif	0	0	0	1
peripheral myelin protein 22	4	0	0	4
survival motor neuron protein isoform d	4	0	0	4
DNA dC->dU-editing enzyme APOBEC-3G isoform 1	1	0	0	1
lamin isoform A-delta10	8	0	0	8
neuropeptide S receptor isoform A	1	0	0	1
ATP-binding cassette sub-family C member 3	0	13	0	13
Multidrug resistance-associated protein 4	0	13	0	13
Voltage-dependent calcium channel gamma-2 subunit	5	0	0	5
Bile salt export pump	0	19	0	19
Cellular tumor antigen p53	8	0	0	8
Integrin beta-3	3	0	0	3
Integrin alpha-IIb	3	0	0	3
Methionine aminopeptidase	0	1	0	1
Glutamate receptor 2	5	0	0	5
Fatty-acid amide hydrolase 1	0	2	0	2
Inositol monophosphatase 1	1	0	0	1
Canalicular multispecific organic anion transporter 1	0	13	0	13
ATPase family AAA domain-containing protein 5	7	0	0	7
Ataxin-2	7	0	0	7
Chain A, HADH2 protein	5	0	0	5
Chain B, HADH2 protein	5	0	0	5
Chain A, Cruzipain	3	0	0	3
interleukin 8	3	0	0	3
phosphopantetheinyl transferase	5	0	0	5
GLS protein	2	0	0	2
peroxisome proliferator-activated receptor delta	8	0	0	8
tumor necrosis factor	1	0	0	1
vitamin D3 receptor isoform VDRA	4	0	0	4
nuclear factor erythroid 2-related factor 2 isoform 1	10	0	0	10
Cytochrome P450 1A2	0	3	0	3
Cytochrome P450 3A4	0	5	0	5
Cytochrome P450 2D6	0	2	0	2
Cytochrome P450 2C9	0	4	0	4
Cytochrome P450 2C19	0	3	0	3
Nuclear receptor ROR-gamma	4	0	0	4
Potassium voltage-gated channel subfamily H member 2	0	8	0	10
Aurora kinase B	0	1	0	1
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	2	0	2
Chain A, Ferritin light chain	4	0	0	4
aldehyde dehydrogenase 1 family, member A1	9	0	0	9
arylsulfatase A	6	0	0	6
Bloom syndrome protein isoform 1	4	0	0	4
cytochrome P450 2C19 precursor	2	0	0	2
lethal factor (plasmid)	1	0	0	1
Metabotropic glutamate receptor 6	0	0	1	1
Excitatory amino acid transporter 4	0	1	0	1
Glutamate transporter homolog	0	0	1	1
N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase	0	1	0	1
Excitatory amino acid transporter 1	0	1	0	1
Excitatory amino acid transporter 2	0	1	0	1
Excitatory amino acid transporter 3	0	1	0	1
Glutamate receptor ionotropic, NMDA 2A	0	1	0	1
Glutamate receptor ionotropic, NMDA 2B	0	1	0	1
Glutamate receptor ionotropic, NMDA 2C	0	1	0	1
Metabotropic glutamate receptor 1	0	0	1	1
Metabotropic glutamate receptor 2	0	0	1	1
Carbonic anhydrase-like protein, putative	0	0	0	1
Glutamate receptor ionotropic, NMDA 2D	0	1	0	1
Glutamate receptor ionotropic, NMDA 3B	0	1	0	1
Glutamate receptor ionotropic, NMDA 3A	0	1	0	1
acetylcholinesterase	4	0	0	4
thioredoxin reductase	5	0	0	5
SMAD family member 2	2	0	0	2
SMAD family member 3	2	0	0	2
Microtubule-associated protein tau	2	0	0	2
thioredoxin glutathione reductase	3	0	0	3
EWS/FLI fusion protein	8	0	0	8
P53	1	0	0	1
activating transcription factor 6	3	0	0	3
peripheral myelin protein 22 isoform 1	2	0	0	2
hemoglobin subunit beta	1	0	0	1
DNA polymerase iota isoform a (long)	2	0	0	2
cytochrome P450 3A4 isoform 1	2	0	0	2
M-phase phosphoprotein 8	2	0	0	2
muscarinic acetylcholine receptor M1	2	0	0	2
Gamma-aminobutyric acid receptor subunit pi	2	2	0	4
Bile salt export pump	0	9	0	9
Gamma-aminobutyric acid receptor subunit beta-1	2	2	0	4
Gamma-aminobutyric acid receptor subunit delta	2	2	0	4
Gamma-aminobutyric acid receptor subunit gamma-2	2	2	0	4
Gamma-aminobutyric acid receptor subunit alpha-5	2	2	0	4
Gamma-aminobutyric acid receptor subunit alpha-3	2	2	0	4
Gamma-aminobutyric acid receptor subunit gamma-1	2	2	0	4
Gamma-aminobutyric acid receptor subunit alpha-2	2	2	0	4
Gamma-aminobutyric acid receptor subunit alpha-4	2	2	0	4
Gamma-aminobutyric acid receptor subunit gamma-3	2	2	0	4
Gamma-aminobutyric acid receptor subunit alpha-6	2	2	0	4
Gamma-aminobutyric acid receptor subunit alpha-1	2	2	0	4
Gamma-aminobutyric acid receptor subunit beta-3	2	2	0	4
Gamma-aminobutyric acid receptor subunit beta-2	2	2	0	4
GABA theta subunit	2	2	0	4
Gamma-aminobutyric acid receptor subunit epsilon	2	2	0	4
Protein-arginine deiminase type-4	0	3	0	3
pregnane X receptor	3	0	0	3
cytochrome P450 family 3 subfamily A polypeptide 4	7	0	0	7
thyroid hormone receptor beta isoform a	5	0	0	5
galanin receptor type 3	0	1	0	1
Glucocorticoid receptor	0	8	2	15
Glycine receptor subunit alpha-1	0	8	0	8
Glycine receptor subunit beta	0	8	0	8
Glycine receptor subunit alpha-2	0	8	0	8
Glycine receptor subunit alpha-3	0	8	0	8
ORF73	0	0	1	1
USP1 protein, partial	3	0	0	3
thyroid stimulating hormone receptor	4	0	0	4
Vpr	1	0	0	1
Albumin	0	0	1	1
Major prion protein	0	0	1	1
Sodium channel protein type 1 subunit alpha	0	1	0	1
Sodium channel protein type 2 subunit alpha	0	1	0	1
Sodium channel protein type 3 subunit alpha	0	1	0	1
UDP-glucuronosyltransferase 2B7	0	0	0	1
Cytochrome P450 2B6	0	0	2	2
Sodium channel protein type 4 subunit alpha	0	1	0	2
Cytochrome P450 2J2	0	2	0	2
Sodium channel protein type 9 subunit alpha	0	2	0	2
Frizzled-8	0	0	1	1
P2X purinoceptor 4	0	1	0	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Putative Glycine Betaine-binding Abc Transporter Protein	0	0	1	1
Chain A, PUTATIVE GLYCINE BETAINE-BINDING ABC TRANSPORTER PROTEIN	0	0	1	1
Chain A, Glycine betaine/carnitine/choline-binding protein	0	0	1	1
Chain A, Glycine betaine/carnitine/choline-binding protein	0	0	1	1
Chain A, Glycine betaine/carnitine/choline-binding protein	0	0	1	1
Chain A, Glycine betaine/carnitine/choline-binding protein	0	0	1	1
Chain A, Choline-binding protein	0	0	1	1
Solute carrier family 22 member 1	0	1	0	2
Solute carrier family 22 member 2	0	0	0	1
Solute carrier family 22 member 1	0	0	0	1
Solute carrier family 22 member 2	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-3	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-4	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-2	0	1	0	1
Neuronal acetylcholine receptor subunit beta-2	0	1	0	1
Neuronal acetylcholine receptor subunit beta-3	0	1	0	1
Neuronal acetylcholine receptor subunit beta-4	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-5	0	1	0	1
Acetylcholinesterase	0	2	0	2
Sodium- and chloride-dependent creatine transporter 1	0	1	0	1
Choline O-acetyltransferase	0	0	0	1
Neuronal acetylcholine receptor subunit alpha-6	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-9	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-7	0	1	0	1
Solute carrier family 22 member 1	0	1	0	2
High affinity choline transporter 1	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-10	0	1	0	1
Solute carrier family 22 member 2	0	1	0	2
ATP-dependent phosphofructokinase	3	0	0	3
Chain A, 2-oxoglutarate Oxygenase	7	0	0	7
cytochrome P450 2C9 precursor	1	0	0	1
DNA gyrase subunit B	0	1	0	1
DNA gyrase subunit A	0	1	0	1
DNA gyrase subunit B	0	2	0	3
DNA gyrase subunit A	0	4	0	8
DNA gyrase subunit B	0	4	0	8
DNA topoisomerase 4 subunit A	0	1	0	1
DNA topoisomerase 4 subunit B	0	1	0	2
DNA topoisomerase 4 subunit A	0	2	0	3
DNA topoisomerase 2-alpha	0	1	0	5
DNA gyrase subunit A	0	2	0	3
Multidrug resistance protein MdtK	0	0	1	1
Histamine H2 receptor	4	0	0	4
DNA gyrase subunit B	0	5	0	7
DNA gyrase subunit A	0	6	0	8
Enoyl-[acyl-carrier-protein] reductase [NADH]	0	2	0	7
DNA topoisomerase 4 subunit A	0	1	0	1
DNA topoisomerase 4 subunit B	0	1	0	1
Integrase	0	1	0	1
Chain A, BCL-2-RELATED PROTEIN A1	0	0	1	1
Smad3	2	0	0	2
huntingtin isoform 2	1	0	0	1
tyrosine-protein kinase Yes	1	0	0	1
nuclear receptor ROR-gamma isoform 1	4	0	0	4
relaxin receptor 1 isoform 1	1	0	0	1
bcl-2-like protein 11 isoform 1	0	0	1	1
cGMP-dependent 3',5'-cyclic phosphodiesterase	0	1	0	1
Deoxycytidine kinase	0	0	0	1
Adenosine receptor A3	0	1	0	1
Rap guanine nucleotide exchange factor 4	2	0	0	2
Sodium- and chloride-dependent creatine transporter 1	0	1	0	1
Pantothenate synthetase	0	2	0	2
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	1	0	0	1
DNA polymerase beta	2	0	0	2
Polyphenol oxidase 2	0	3	0	5
bromodomain adjacent to zinc finger domain 2B	2	0	0	2
3-oxoacyl-[acyl-carrier-protein] synthase 3	0	1	0	1
cytochrome P450 2D6 isoform 1	1	0	0	1
potassium voltage-gated channel subfamily H member 2 isoform d	2	0	0	2
histone acetyltransferase KAT2A isoform 1	4	0	0	4
N-glycosylase/DNA lyase	0	1	0	1
Myeloperoxidase	0	1	0	1
Formamidopyrimidine-DNA glycosylase	0	1	0	1
Cytochrome P450 2C8	0	1	0	1
Cytochrome P450 2A6	0	1	0	1
Macrophage migration inhibitory factor	0	1	0	1
Endonuclease III-like protein 1	0	1	0	1
Isocitrate lyase	0	1	0	1
Putative FAD-containing monooxygenase MymA	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Endonuclease 8-like 1	0	1	0	1
estrogen receptor 2 (ER beta)	5	0	0	5
cytochrome P450 2D6	2	0	0	2
Chain A, JmjC domain-containing histone demethylation protein 3A	1	0	0	1
Replicase polyprotein 1ab	0	1	0	1
CAAX prenyl protease 2 isoform 2	0	0	0	1
streptokinase A precursor	0	0	2	2
Tubulin beta-4A chain	0	1	0	1
Tubulin beta chain	0	1	0	1
ATP-dependent translocase ABCB1	0	0	0	1
Tubulin alpha-3C chain	0	1	0	1
Spike glycoprotein	3	0	0	3
Tubulin alpha-1B chain	0	1	0	1
Tubulin alpha-4A chain	0	1	0	1
Tubulin beta-4B chain	0	1	0	1
DNA primase	0	1	0	1
Tubulin beta-3 chain	0	1	0	1
Tubulin beta-2A chain	0	1	0	1
Tubulin beta-8 chain	0	1	0	1
Tubulin alpha-3E chain	0	1	0	1
Tubulin alpha-1A chain	0	1	0	1
Multidrug and toxin extrusion protein 1	0	1	0	1
Tubulin alpha-1C chain	0	1	0	1
Tubulin beta-6 chain	0	1	0	1
Tubulin beta-2B chain	0	1	0	1
Tubulin beta-1 chain	0	1	0	1
Chain A, Methionyl-tRNA synthetase	0	0	1	1
Chain A, Methionyl-tRNA synthetase	0	0	1	1
Chain A, Aminopeptidase	0	1	0	1
Chain A, Methionine aminopeptidase	0	1	0	1
S-ribosylhomocysteine lyase	0	1	0	1
Adenylate cyclase type 5	0	0	0	1
S-adenosylmethionine synthase isoform type-1	0	0	0	1
S-adenosylmethionine synthase isoform type-2	0	0	0	1
Fatty acid synthase	0	1	0	1
Large neutral amino acids transporter small subunit 1	0	1	0	1
PPM1D protein	1	0	0	1
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	2	0	0	2
nonstructural protein 1	3	0	0	3
Nuclear receptor subfamily 1 group I member 2	0	0	2	2
Androgen receptor	0	3	0	3
Nuclear receptor subfamily 1 group I member 2	0	0	1	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1F	0	1	0	1
DNA gyrase subunit B	0	1	0	1
Replicase polyprotein 1ab	0	1	0	1
Replicase polyprotein 1ab	0	1	0	1
Potassium voltage-gated channel subfamily E member 1	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
Potassium voltage-gated channel subfamily KQT member 1	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1D	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1S	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
Sodium channel protein type 5 subunit alpha	0	1	0	1
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	1	0	0	1
DNA polymerase kappa isoform 1	1	0	0	1
Solute carrier family 22 member 20	0	2	0	2
Solute carrier family 22 member 6	0	2	0	2
STE24	0	0	0	1
flap endonuclease 1	2	0	0	2
CAAX prenyl protease	0	0	0	1
Trypsin	0	0	0	1
Albumin	0	1	2	3
Chain A, Putative fructose-1,6-bisphosphate aldolase	1	0	0	1
endonuclease IV	1	0	0	1
15-lipoxygenase, partial	2	0	0	2
GALC protein	1	0	0	1
Polyunsaturated fatty acid lipoxygenase ALOX15B	3	0	0	3
luciferase	0	0	0	1
Fatty acid-binding protein, liver	0	1	0	1
Estrogen receptor	0	2	0	2
Progesterone receptor	0	2	0	3
Glucocorticoid receptor	0	1	1	2
Glucocorticoid receptor	0	0	1	1
Corticosteroid-binding globulin	0	1	0	1
Mineralocorticoid receptor	0	2	1	3
Androgen receptor	0	2	0	2
Glutamine synthetase	0	0	1	1
Histamine H1 receptor	0	0	1	1
Prostaglandin G/H synthase 2	0	2	0	2
Nociceptin receptor	0	0	1	1
Estrogen receptor beta	0	2	0	2
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	1	0	0	1
heat shock protein HSP 90-alpha isoform 2	0	0	0	1
TAR DNA-binding protein 43	1	0	0	1
heat shock protein 90, putative	0	0	0	1
dopamine D1 receptor	1	0	0	1
NAD-dependent protein deacetylase sirtuin-6	0	1	0	1
Pyridoxal kinase	0	0	0	1
DNA-directed RNA polymerase subunit beta	0	1	0	1
Solute carrier organic anion transporter family member 1A4	0	1	0	1
Solute carrier organic anion transporter family member 2B1	0	2	0	2
NH(3)-dependent NAD(+) synthetase	0	1	0	1
60 kDa heat shock protein, mitochondrial	0	1	0	1
Polyunsaturated fatty acid lipoxygenase ALOX15	0	1	0	1
Arylacetamide deacetylase	0	1	0	2
Caspase-1	0	1	0	1
Alpha-synuclein	0	1	0	1
Solute carrier organic anion transporter family member 1A1	0	1	0	1
Solute carrier organic anion transporter family member 1A2	0	1	0	1
10 kDa heat shock protein, mitochondrial	0	1	0	1
Glutathione S-transferase omega-1	0	1	0	1
DNA-directed RNA polymerase subunit beta	0	1	0	1
Thiosulfate sulfurtransferase	0	1	0	1
Lanosterol 14-alpha demethylase	0	1	0	1
60 kDa chaperonin	0	1	0	1
10 kDa chaperonin	0	1	0	1
Solute carrier organic anion transporter family member 1B3	0	2	0	3
Solute carrier organic anion transporter family member 1B1	0	2	0	3
chaperonin-containing TCP-1 beta subunit homolog	1	0	0	1
Estrogen receptor beta	0	0	0	1
Inhibitor of nuclear factor kappa-B kinase subunit beta	0	0	0	1
Solute carrier family 22 member 6	0	1	0	1
Carbonic anhydrase 12	0	1	0	1
5'-AMP-activated protein kinase subunit beta-2	0	0	0	1
Polymerase acidic protein	0	0	1	1
Carbonic anhydrase 3	0	1	0	1
Stromelysin-1	0	0	1	1
Tyrosine-protein phosphatase YopH	0	1	0	1
High mobility group protein B1	0	0	1	1
Aldo-keto reductase family 1 member B1	0	1	0	1
Prolyl 4-hydroxylase subunit alpha-1	0	1	0	1
Tyrosine-protein phosphatase non-receptor type 1	0	1	0	3
Estrogen receptor	0	0	0	1
Carbonic anhydrase 4	0	1	0	1
Prostaglandin G/H synthase 1	0	1	0	1
Carbonic anhydrase 6	0	1	0	1
Cystathionine gamma-lyase	0	1	0	1
Carbonic anhydrase 5A, mitochondrial	0	1	0	1
Carbonic anhydrase 7	0	1	0	1
5'-AMP-activated protein kinase subunit gamma-1	0	0	0	1
5'-AMP-activated protein kinase catalytic subunit alpha-2	0	0	0	1
Xanthine dehydrogenase/oxidase	0	1	0	1
5'-AMP-activated protein kinase catalytic subunit alpha-1	0	0	0	1
Carbonic anhydrase 9	0	1	0	1
Carbonic anhydrase	0	1	0	1
Solute carrier family 22 member 6	0	1	0	1
Solute carrier family 22 member 7	0	0	0	1
Nicotinate phosphoribosyltransferase	0	1	0	1
Solute carrier family 22 member 8	0	1	0	1
Ubiquitin-like domain-containing CTD phosphatase 1	0	1	0	1
Carbonic anhydrase 15	0	1	0	1
Carbonic anhydrase 13	0	1	0	1
5'-AMP-activated protein kinase subunit gamma-3	0	0	0	1
5'-AMP-activated protein kinase subunit gamma-2	0	0	0	1
Carbonic anhydrase 14	0	1	0	1
Carbonic anhydrase 5B, mitochondrial	0	1	0	1
5'-AMP-activated protein kinase subunit beta-1	0	0	0	1
Cereblon isoform 4	0	2	0	2
Prostaglandin G/H synthase 1	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4A	0	1	0	1
Prostaglandin G/H synthase 2	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4C	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	1	0	1
DNA-binding protein Ikaros	0	0	0	1
DNA damage-binding protein 1	0	1	1	2
Protein cereblon	0	2	1	4
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Abscess, Tubercular, Intracranial

Synonyms(3)

Research Excerpts

Overview

Research

Studies (90)

Protein Targets (428)

Abscess, Tubercular, Intracranial

Synonyms(3)

Research Excerpts

Overview

Research

Studies (90)

Drugs Studied (54)

Protein Targets (428)