Page last updated: 2024-11-13
dorrigocin b
Description
Research Excerpts
Clinical Trials
Roles
Classes
Pathways
Study Profile
Bioassays
Related Drugs
Related Conditions
Protein Interactions
Research Growth
Market Indicators
Description
dorrigocin B: isolated from the fermentation broth & mycelium of Streptomyces platensis; structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
Cross-References
ID Source | ID |
---|---|
PubMed CID | 44543727 |
CHEMBL ID | 1221965 |
SCHEMBL ID | 9009372 |
MeSH ID | M0236913 |
Synonyms (4)
Synonym |
---|
CHEMBL1221965 |
dorrigocin b |
YQDJUXPUIRGKNV-NRWIMSPQSA-N |
SCHEMBL9009372 |
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
Bioassays (54)
Assay ID | Title | Year | Journal | Article |
---|---|---|---|---|
AID1347378 | qHTS for H2AX Agonists against the NCATS CANVASS Library | 2018 | ACS central science, Dec-26, Volume: 4, Issue:12 | Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space. |
AID1347393 | qHTS for inhibitors of ER calcium dysfunction: SERCaMP assay screened against the NCATS CANVASS Library | 2018 | ACS central science, Dec-26, Volume: 4, Issue:12 | Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space. |
AID1347377 | DH5-alpha competent E. coli microbial cell viability qHTS against the NCATS CANVASS Library | 2018 | ACS central science, Dec-26, Volume: 4, Issue:12 | Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space. |
AID1347388 | qHTS for Activators of p53 Stress Response Pathway screened against the NCATS CANVASS Library | 2018 | ACS central science, Dec-26, Volume: 4, Issue:12 | Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space. |
AID1347372 | qHTS for Constitutive Androstane Receptor (CAR) Antagonist screened against the NCATS CANVASS Library | 2018 | ACS central science, Dec-26, Volume: 4, Issue:12 | Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space. |
AID1347387 | Cytotoxicity qHTS for assessment of Hepg2 cells membrane integrity screened against the NCATS CANVASS Library | 2018 | ACS central science, Dec-26, Volume: 4, Issue:12 | Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space. |
AID1347373 | qHTS for Constitutive Androstane Receptor (CAR) Agonist screened against the NCATS CANVASS Library | 2018 | ACS central science, Dec-26, Volume: 4, Issue:12 | Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space. |
AID1347358 | HPAF-II 12hr Apoptosis Induction qHTS against the NCATS CANVASS Library | 2018 | ACS central science, Dec-26, Volume: 4, Issue:12 | Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space. |
AID1347349 | Panc-1005 Cancer Cell Toxicity qHTS against the NCATS CANVASS Library | 2018 | ACS central science, Dec-26, Volume: 4, Issue:12 | Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space. |
AID1347346 | HPAF-II Cancer Cell Toxicity qHTS against the NCATS CANVASS Library | 2018 | ACS central science, Dec-26, Volume: 4, Issue:12 | Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space. |
AID1347381 | Inflammasome Signaling qHTS Counterscreen: IL-1-beta AlphaLISA counterscreen against the NCATS CANVASS Library | 2018 | ACS central science, Dec-26, Volume: 4, Issue:12 | Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space. |
AID1347359 | HEK293 24hr Apoptosis Induction qHTS against the NCATS CANVASS Library | 2018 | ACS central science, Dec-26, Volume: 4, Issue:12 | Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space. |
AID1347392 | qHTS for activators of dead-cell proteases activity screened against the NCATS CANVASS Library | 2018 | ACS central science, Dec-26, Volume: 4, Issue:12 | Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space. |
AID1347369 | MCF7 Cancer Cell Toxicity qHTS against the NCATS CANVASS Library | 2018 | ACS central science, Dec-26, Volume: 4, Issue:12 | Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space. |
AID1347366 | KB-3-1 Cancer Cell Toxicity qHTS against the NCATS CANVASS Library | 2018 | ACS central science, Dec-26, Volume: 4, Issue:12 | Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space. |
AID1347390 | Secretion counterscreen for inhibitors of the SERCaMP assay screened against the NCATS CANVASS Library | 2018 | ACS central science, Dec-26, Volume: 4, Issue:12 | Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space. |
AID1347345 | OV-KATE Cancer Cell Toxicity qHTS against the NCATS CANVASS Library | 2018 | ACS central science, Dec-26, Volume: 4, Issue:12 | Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space. |
AID1347360 | HPAF-II 18hr Apoptosis Induction qHTS against the NCATS CANVASS Library | 2018 | ACS central science, Dec-26, Volume: 4, Issue:12 | Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space. |
AID1347389 | qHTS assay for small molecule disruptors of mitochondrial membrane potential screened against the NCATS CANVASS Library | 2018 | ACS central science, Dec-26, Volume: 4, Issue:12 | Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space. |
AID1347352 | COV-362 Cancer Cell Toxicity qHTS against the NCATS CANVASS Library | 2018 | ACS central science, Dec-26, Volume: 4, Issue:12 | Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space. |
AID1347375 | qHTS for Hypoxia signaling pathway (HIF-1) agonists against the NCATS CANVASS Library | 2018 | ACS central science, Dec-26, Volume: 4, Issue:12 | Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space. |
AID1347347 | UWB1.289 Cancer Cell Toxicity qHTS against the NCATS CANVASS Library | 2018 | ACS central science, Dec-26, Volume: 4, Issue:12 | Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space. |
AID1347380 | qHTS for Antimalaria activity screened against the NCATS CANVASS Library | 2018 | ACS central science, Dec-26, Volume: 4, Issue:12 | Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space. |
AID1347160 | Primary screen NINDS Rhodamine qHTS for Zika virus inhibitors | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49 | Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
AID1347361 | HEK293 12hr Apoptosis Induction qHTS against the NCATS CANVASS Library | 2018 | ACS central science, Dec-26, Volume: 4, Issue:12 | Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space. |
AID1347348 | OV-SAHO Cancer Cell Toxicity qHTS against the NCATS CANVASS Library | 2018 | ACS central science, Dec-26, Volume: 4, Issue:12 | Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space. |
AID1347379 | qHTS for Inflammasome Signaling Inhibitors: IL-1-beta AlphaLISA screen against the NCATS CANVASS Library | 2018 | ACS central science, Dec-26, Volume: 4, Issue:12 | Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space. |
AID1347367 | qHTS for ATAD5 Agonist screened against the NCATS CANVASS Library | 2018 | ACS central science, Dec-26, Volume: 4, Issue:12 | Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space. |
AID1347400 | Viability qHTS for inhibitors of the SERCaMP assay screened against the NCATS CANVASS Library | 2018 | ACS central science, Dec-26, Volume: 4, Issue:12 | Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space. |
AID1347365 | SDT Cancer Cell Toxicity qHTS against the NCATS CANVASS Library | 2018 | ACS central science, Dec-26, Volume: 4, Issue:12 | Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space. |
AID1347355 | HEK-293 Cancer Cell Toxicity qHTS against the NCATS CANVASS Library | 2018 | ACS central science, Dec-26, Volume: 4, Issue:12 | Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space. |
AID1347354 | UWB1.289-WTBRCA1 Cancer Cell Toxicity qHTS against the NCATS CANVASS Library | 2018 | ACS central science, Dec-26, Volume: 4, Issue:12 | Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space. |
AID1347391 | qHTS for activators of Nrf2/ARE signaling pathway screened against the NCATS CANVASS Library | 2018 | ACS central science, Dec-26, Volume: 4, Issue:12 | Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space. |
AID1347357 | HEK293 18hr Apoptosis Induction qHTS against the NCATS CANVASS Library | 2018 | ACS central science, Dec-26, Volume: 4, Issue:12 | Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space. |
AID1347368 | G06 Cancer Cell Toxicity qHTS against the NCATS CANVASS Library | 2018 | ACS central science, Dec-26, Volume: 4, Issue:12 | Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space. |
AID1347363 | Firefly luciferase counterscreen qHTS: Assay Interference Panel against the NCATS CANVASS Library | 2018 | ACS central science, Dec-26, Volume: 4, Issue:12 | Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space. |
AID1347374 | qHTS for Hypoxia signaling pathway (HIF-1) antagonists against the NCATS CANVASS Library | 2018 | ACS central science, Dec-26, Volume: 4, Issue:12 | Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space. |
AID1347362 | Diaphorse counterscreen qHTS: Assay Interference Panel against the NCATS CANVASS Library | 2018 | ACS central science, Dec-26, Volume: 4, Issue:12 | Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space. |
AID1347353 | A2780 Cisplatin Sensitive Ovarian Cancer Cell Toxicity qHTS against the NCATS CANVASS Library | 2018 | ACS central science, Dec-26, Volume: 4, Issue:12 | Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space. |
AID1347364 | KB-8-5-11 Cancer Cell Toxicity qHTS against the NCATS CANVASS Library | 2018 | ACS central science, Dec-26, Volume: 4, Issue:12 | Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space. |
AID1347401 | Redox Reaction Profiling qHTS: Assay Interference Panel against the NCATS CANVASS Library | 2018 | ACS central science, Dec-26, Volume: 4, Issue:12 | Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space. |
AID1347371 | J3T Cancer Cell Toxicity qHTS against the NCATS CANVASS Library | 2018 | ACS central science, Dec-26, Volume: 4, Issue:12 | Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space. |
AID1347396 | qHTS for inhibitors of Wild type Zika virus screened against the NCATS CANVASS Library | 2018 | ACS central science, Dec-26, Volume: 4, Issue:12 | Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space. |
AID1347356 | HPAF-II 24hr Apoptosis Induction qHTS against the NCATS CANVASS Library | 2018 | ACS central science, Dec-26, Volume: 4, Issue:12 | Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space. |
AID1347402 | qHTS for inhibitors of Rabies Virus screened against the NCATS CANVASS Library | 2018 | ACS central science, Dec-26, Volume: 4, Issue:12 | Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space. |
AID1347350 | SW1088 Cancer Cell Toxicity qHTS against the NCATS CANVASS Library | 2018 | ACS central science, Dec-26, Volume: 4, Issue:12 | Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space. |
AID1347376 | 10-beta competent E. coli microbial cell viability qHTS against the NCATS CANVASS Library | 2018 | ACS central science, Dec-26, Volume: 4, Issue:12 | Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space. |
AID1347351 | U-118MG Cancer Cell Toxicity qHTS against the NCATS CANVASS Library | 2018 | ACS central science, Dec-26, Volume: 4, Issue:12 | Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space. |
AID1347370 | qHTS for ATAD5 Antagonist screened against the NCATS CANVASS Library | 2018 | ACS central science, Dec-26, Volume: 4, Issue:12 | Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space. |
AID1347394 | Vero-766 cells viability qHTS against the NCATS CANVASS Library: Counterscreen for Zika virus inhibition assay | 2018 | ACS central science, Dec-26, Volume: 4, Issue:12 | Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space. |
AID501211 | Antiproliferative activity against human HeLa cells assessed as incorporation of [3H]thymidine in nuclear DNA at 2.5 uM after 24 hrs by scintillation counting | 2010 | Nature chemical biology, Mar, Volume: 6, Issue:3 | Inhibition of eukaryotic translation elongation by cycloheximide and lactimidomycin. |
AID501214 | Inhibition of protein synthesis in human HeLa cells assessed as [35S]cysteine/methionine utilization after 2 hrs by scintillation spectroscopy | 2010 | Nature chemical biology, Mar, Volume: 6, Issue:3 | Inhibition of eukaryotic translation elongation by cycloheximide and lactimidomycin. |
AID501213 | Antiproliferative activity against human Jurkat cells assessed as incorporation of [3H]thymidine in nuclear DNA at 2.5 uM after 24 hrs by scintillation counting | 2010 | Nature chemical biology, Mar, Volume: 6, Issue:3 | Inhibition of eukaryotic translation elongation by cycloheximide and lactimidomycin. |
AID501212 | Antiproliferative activity against human MDA-MB-231 cells assessed as incorporation of [3H]thymidine in nuclear DNA at 2.5 uM after 24 hrs by scintillation counting | 2010 | Nature chemical biology, Mar, Volume: 6, Issue:3 | Inhibition of eukaryotic translation elongation by cycloheximide and lactimidomycin. |
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |
Research
Studies (7)
Timeframe | Studies, This Drug (%) | All Drugs % |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 3 (42.86) | 18.2507 |
2000's | 1 (14.29) | 29.6817 |
2010's | 2 (28.57) | 24.3611 |
2020's | 1 (14.29) | 2.80 |
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |
Market Indicators
Research Demand Index: 12.37
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.
| This Compound (12.37) All Compounds (24.57) |
Study Types
Publication Type | This drug (%) | All Drugs (%) |
---|---|---|
Trials | 0 (0.00%) | 5.53% |
Reviews | 0 (0.00%) | 6.00% |
Case Studies | 0 (0.00%) | 4.05% |
Observational | 0 (0.00%) | 0.25% |
Other | 7 (100.00%) | 84.16% |
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |