Page last updated: 2024-12-04

4',7-dihydroxyflavanone

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Cross-References

ID SourceID
PubMed CID1889
CHEMBL ID271939
CHEBI ID136678
SCHEMBL ID1071066

Synonyms (41)

Synonym
7-hydroxy-2-(4-hydroxyphenyl)chroman-4-one
MLS000697612
smr000470946
41680-09-5
OPREA1_134668
7-hydroxy-2-(4-hydroxyphenyl)-2,3-dihydro-4h-1-benzopyran-4-one
CHEBI:136678
4'',7-dihydroxyflavanone
7-hydroxy-2-(4''-hydroxyphenyl)chroman-4-one
bdbm50228333
cid_1889
7,4''-dihydroxyflavanone
CHEMBL271939 ,
7-hydroxy-2-(4-hydroxyphenyl)-2,3-dihydrochromen-4-one
NCGC00247525-01
4h-1-benzopyran-4-one, 2,3-dihydro-7-hydroxy-2-(4-hydroxyphenyl)-
HMS2268K07
CCG-103352
FT-0627876
69097-97-8
dl-liquiritigenin
SCHEMBL1071066
7-hydroxy-2-(4-hydroxyphenyl)-2,3-dihydro-4h-chromen-4-one #
FURUXTVZLHCCNA-UHFFFAOYSA-N
AKOS024462907
HMS3604C10
DTXSID90274339
(r/s)-liquiritigenin
mfcd00017478
(+/-)-liquiritigenin
FT-0777980
DTXSID90961898
B0005-464393
SY076300
mfcd00287289
( inverted exclamation marka)-liquiritigenin
()-dihydrodaidzein
HY-N0377A
CS-0145110
liquiritin rhamnoside
7-hydroxy-2-(4-hydroxyphenyl)-3,4-dihydro-2h-1-benzopyran-4-one
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Roles (2)

RoleDescription
Brassica napus metaboliteAny plant metabolite that is produced by rapeseed (Brassica napus).
fungal xenobiotic metaboliteAny fungal metabolite produced by metabolism of a xenobiotic compound in fungi.
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Drug Classes (3)

ClassDescription
dihydroxyflavanoneAny hydroxyflavanone carrying two hydroxy substituents.
polyphenolMembers of the class of phenols that contain 2 or more benzene rings each of which is substituted by at least one hydroxy group.
4'-hydroxyflavanonesAny hydroxyflavanone having a hydroxy substituent located at position 4'.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Pathways (1)

PathwayProteinsCompounds
Flavonoid Biosynthesis1150

Protein Targets (2)

Potency Measurements

ProteinTaxonomyMeasurementAverage (µ)Min (ref.)Avg (ref.)Max (ref.)Bioassay(s)
67.9K proteinVaccinia virusPotency0.50120.00018.4406100.0000AID720579
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Activation Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
glycogen synthase kinase-3 beta isoform 1Homo sapiens (human)EC50 (µMol)300.00000.212522.156283.9400AID434954
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (89)

Assay IDTitleYearJournalArticle
AID588497High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set2010Current protocols in cytometry, Oct, Volume: Chapter 13Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588497High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set2006Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588497High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set2010Assay and drug development technologies, Feb, Volume: 8, Issue:1
High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID651635Viability Counterscreen for Primary qHTS for Inhibitors of ATXN expression
AID588501High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set2010Current protocols in cytometry, Oct, Volume: Chapter 13Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588501High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set2006Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588501High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set2010Assay and drug development technologies, Feb, Volume: 8, Issue:1
High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID588499High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set2010Current protocols in cytometry, Oct, Volume: Chapter 13Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588499High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set2006Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588499High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set2010Assay and drug development technologies, Feb, Volume: 8, Issue:1
High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID1745845Primary qHTS for Inhibitors of ATXN expression
AID1347363Firefly luciferase counterscreen qHTS: Assay Interference Panel against the NCATS CANVASS Library2018ACS central science, Dec-26, Volume: 4, Issue:12
Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space.
AID1347360HPAF-II 18hr Apoptosis Induction qHTS against the NCATS CANVASS Library2018ACS central science, Dec-26, Volume: 4, Issue:12
Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space.
AID1347350SW1088 Cancer Cell Toxicity qHTS against the NCATS CANVASS Library2018ACS central science, Dec-26, Volume: 4, Issue:12
Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space.
AID1347365SDT Cancer Cell Toxicity qHTS against the NCATS CANVASS Library2018ACS central science, Dec-26, Volume: 4, Issue:12
Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space.
AID1347381Inflammasome Signaling qHTS Counterscreen: IL-1-beta AlphaLISA counterscreen against the NCATS CANVASS Library2018ACS central science, Dec-26, Volume: 4, Issue:12
Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space.
AID1347351U-118MG Cancer Cell Toxicity qHTS against the NCATS CANVASS Library2018ACS central science, Dec-26, Volume: 4, Issue:12
Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space.
AID1347402qHTS for inhibitors of Rabies Virus screened against the NCATS CANVASS Library2018ACS central science, Dec-26, Volume: 4, Issue:12
Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space.
AID1347160Primary screen NINDS Rhodamine qHTS for Zika virus inhibitors2020Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
AID1347375qHTS for Hypoxia signaling pathway (HIF-1) agonists against the NCATS CANVASS Library2018ACS central science, Dec-26, Volume: 4, Issue:12
Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space.
AID1347352COV-362 Cancer Cell Toxicity qHTS against the NCATS CANVASS Library2018ACS central science, Dec-26, Volume: 4, Issue:12
Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space.
AID1347361HEK293 12hr Apoptosis Induction qHTS against the NCATS CANVASS Library2018ACS central science, Dec-26, Volume: 4, Issue:12
Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space.
AID1347394Vero-766 cells viability qHTS against the NCATS CANVASS Library: Counterscreen for Zika virus inhibition assay2018ACS central science, Dec-26, Volume: 4, Issue:12
Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space.
AID1347357HEK293 18hr Apoptosis Induction qHTS against the NCATS CANVASS Library2018ACS central science, Dec-26, Volume: 4, Issue:12
Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space.
AID1347378qHTS for H2AX Agonists against the NCATS CANVASS Library2018ACS central science, Dec-26, Volume: 4, Issue:12
Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space.
AID1347373qHTS for Constitutive Androstane Receptor (CAR) Agonist screened against the NCATS CANVASS Library2018ACS central science, Dec-26, Volume: 4, Issue:12
Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space.
AID1347372qHTS for Constitutive Androstane Receptor (CAR) Antagonist screened against the NCATS CANVASS Library2018ACS central science, Dec-26, Volume: 4, Issue:12
Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space.
AID1347359HEK293 24hr Apoptosis Induction qHTS against the NCATS CANVASS Library2018ACS central science, Dec-26, Volume: 4, Issue:12
Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space.
AID1347349Panc-1005 Cancer Cell Toxicity qHTS against the NCATS CANVASS Library2018ACS central science, Dec-26, Volume: 4, Issue:12
Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space.
AID1347379qHTS for Inflammasome Signaling Inhibitors: IL-1-beta AlphaLISA screen against the NCATS CANVASS Library2018ACS central science, Dec-26, Volume: 4, Issue:12
Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space.
AID1347345OV-KATE Cancer Cell Toxicity qHTS against the NCATS CANVASS Library2018ACS central science, Dec-26, Volume: 4, Issue:12
Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space.
AID1347388qHTS for Activators of p53 Stress Response Pathway screened against the NCATS CANVASS Library2018ACS central science, Dec-26, Volume: 4, Issue:12
Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space.
AID1347347UWB1.289 Cancer Cell Toxicity qHTS against the NCATS CANVASS Library2018ACS central science, Dec-26, Volume: 4, Issue:12
Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space.
AID1347391qHTS for activators of Nrf2/ARE signaling pathway screened against the NCATS CANVASS Library2018ACS central science, Dec-26, Volume: 4, Issue:12
Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space.
AID134737610-beta competent E. coli microbial cell viability qHTS against the NCATS CANVASS Library2018ACS central science, Dec-26, Volume: 4, Issue:12
Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space.
AID1347396qHTS for inhibitors of Wild type Zika virus screened against the NCATS CANVASS Library2018ACS central science, Dec-26, Volume: 4, Issue:12
Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space.
AID1347392qHTS for activators of dead-cell proteases activity screened against the NCATS CANVASS Library2018ACS central science, Dec-26, Volume: 4, Issue:12
Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space.
AID1347389qHTS assay for small molecule disruptors of mitochondrial membrane potential screened against the NCATS CANVASS Library2018ACS central science, Dec-26, Volume: 4, Issue:12
Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space.
AID1347390Secretion counterscreen for inhibitors of the SERCaMP assay screened against the NCATS CANVASS Library2018ACS central science, Dec-26, Volume: 4, Issue:12
Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space.
AID1347400Viability qHTS for inhibitors of the SERCaMP assay screened against the NCATS CANVASS Library2018ACS central science, Dec-26, Volume: 4, Issue:12
Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space.
AID1347380qHTS for Antimalaria activity screened against the NCATS CANVASS Library2018ACS central science, Dec-26, Volume: 4, Issue:12
Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space.
AID1347364KB-8-5-11 Cancer Cell Toxicity qHTS against the NCATS CANVASS Library2018ACS central science, Dec-26, Volume: 4, Issue:12
Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space.
AID1347369MCF7 Cancer Cell Toxicity qHTS against the NCATS CANVASS Library2018ACS central science, Dec-26, Volume: 4, Issue:12
Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space.
AID1347353A2780 Cisplatin Sensitive Ovarian Cancer Cell Toxicity qHTS against the NCATS CANVASS Library2018ACS central science, Dec-26, Volume: 4, Issue:12
Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space.
AID1347368G06 Cancer Cell Toxicity qHTS against the NCATS CANVASS Library2018ACS central science, Dec-26, Volume: 4, Issue:12
Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space.
AID1347366KB-3-1 Cancer Cell Toxicity qHTS against the NCATS CANVASS Library2018ACS central science, Dec-26, Volume: 4, Issue:12
Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space.
AID1347348OV-SAHO Cancer Cell Toxicity qHTS against the NCATS CANVASS Library2018ACS central science, Dec-26, Volume: 4, Issue:12
Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space.
AID1347377DH5-alpha competent E. coli microbial cell viability qHTS against the NCATS CANVASS Library2018ACS central science, Dec-26, Volume: 4, Issue:12
Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space.
AID1347346HPAF-II Cancer Cell Toxicity qHTS against the NCATS CANVASS Library2018ACS central science, Dec-26, Volume: 4, Issue:12
Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space.
AID1347393qHTS for inhibitors of ER calcium dysfunction: SERCaMP assay screened against the NCATS CANVASS Library2018ACS central science, Dec-26, Volume: 4, Issue:12
Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space.
AID1347356HPAF-II 24hr Apoptosis Induction qHTS against the NCATS CANVASS Library2018ACS central science, Dec-26, Volume: 4, Issue:12
Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space.
AID1347387Cytotoxicity qHTS for assessment of Hepg2 cells membrane integrity screened against the NCATS CANVASS Library2018ACS central science, Dec-26, Volume: 4, Issue:12
Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space.
AID1347355HEK-293 Cancer Cell Toxicity qHTS against the NCATS CANVASS Library2018ACS central science, Dec-26, Volume: 4, Issue:12
Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space.
AID1347367qHTS for ATAD5 Agonist screened against the NCATS CANVASS Library2018ACS central science, Dec-26, Volume: 4, Issue:12
Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space.
AID1347362Diaphorse counterscreen qHTS: Assay Interference Panel against the NCATS CANVASS Library2018ACS central science, Dec-26, Volume: 4, Issue:12
Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space.
AID1347374qHTS for Hypoxia signaling pathway (HIF-1) antagonists against the NCATS CANVASS Library2018ACS central science, Dec-26, Volume: 4, Issue:12
Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space.
AID1347358HPAF-II 12hr Apoptosis Induction qHTS against the NCATS CANVASS Library2018ACS central science, Dec-26, Volume: 4, Issue:12
Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space.
AID1347401Redox Reaction Profiling qHTS: Assay Interference Panel against the NCATS CANVASS Library2018ACS central science, Dec-26, Volume: 4, Issue:12
Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space.
AID1347354UWB1.289-WTBRCA1 Cancer Cell Toxicity qHTS against the NCATS CANVASS Library2018ACS central science, Dec-26, Volume: 4, Issue:12
Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space.
AID1347371J3T Cancer Cell Toxicity qHTS against the NCATS CANVASS Library2018ACS central science, Dec-26, Volume: 4, Issue:12
Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space.
AID1347370qHTS for ATAD5 Antagonist screened against the NCATS CANVASS Library2018ACS central science, Dec-26, Volume: 4, Issue:12
Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space.
AID1467653Cytoprotective activity against GOX-induced cytotoxicity in mouse NIH/3T3 cells assessed as decrease in LDH release treated for 5 hrs with 15 mU/ml GOX challenge by spectrophotometric method2017Bioorganic & medicinal chemistry letters, 07-15, Volume: 27, Issue:14
Minor phenolics from Angelica keiskei and their proliferative effects on Hep3B cells.
AID1467633Proliferative activity against human Hep3B cells assessed as cell viability after 4 days by cell counting method2017Bioorganic & medicinal chemistry letters, 07-15, Volume: 27, Issue:14
Minor phenolics from Angelica keiskei and their proliferative effects on Hep3B cells.
AID1467647Cytoprotective activity against GOX-induced cytotoxicity in human Hep3B cells assessed as LDH release at 100 uM treated for 5 hrs with 15 mU/ml GOX challenge by spectrophotometric method (Rvb = 60.94 +/- 1.18%)2017Bioorganic & medicinal chemistry letters, 07-15, Volume: 27, Issue:14
Minor phenolics from Angelica keiskei and their proliferative effects on Hep3B cells.
AID1467637Cytoprotective activity against GOX-induced oxidative stress in human Hep3B cells assessed as cell survival at 10 uM treated for 5 hrs with 15 mU/ml GOX challenge by MTT assay (Rvb = 41.51 +/- 1.39%)2017Bioorganic & medicinal chemistry letters, 07-15, Volume: 27, Issue:14
Minor phenolics from Angelica keiskei and their proliferative effects on Hep3B cells.
AID1467652Cytoprotective activity against GOX-induced cytotoxicity in mouse NIH/3T3 cells assessed as LDH release at 100 uM treated for 5 hrs with 15 mU/ml GOX challenge by spectrophotometric method (Rvb = 63.34 +/- 1.85%)2017Bioorganic & medicinal chemistry letters, 07-15, Volume: 27, Issue:14
Minor phenolics from Angelica keiskei and their proliferative effects on Hep3B cells.
AID1467636Cytoprotective activity against GOX-induced oxidative stress in human Hep3B cells assessed as cell survival at 1 uM treated for 5 hrs with 15 mU/ml GOX challenge by MTT assay (Rvb = 41.51 +/- 1.39%)2017Bioorganic & medicinal chemistry letters, 07-15, Volume: 27, Issue:14
Minor phenolics from Angelica keiskei and their proliferative effects on Hep3B cells.
AID1467655Cytotoxicity against human Hep3B cells assessed as effect on cell morphology at 0.1 to 100 uM measured every day during 4 days incubation period by microscopic method2017Bioorganic & medicinal chemistry letters, 07-15, Volume: 27, Issue:14
Minor phenolics from Angelica keiskei and their proliferative effects on Hep3B cells.
AID1467642Cytoprotective activity against GOX-induced oxidative stress in mouse NIH/3T3 cells assessed as cell survival at 100 uM treated for 5 hrs with 15 mU/ml GOX challenge by MTT assay (Rvb = 42.71 +/- 2.10%)2017Bioorganic & medicinal chemistry letters, 07-15, Volume: 27, Issue:14
Minor phenolics from Angelica keiskei and their proliferative effects on Hep3B cells.
AID1467635Cytoprotective activity against GOX-induced oxidative stress in human Hep3B cells assessed as cell survival at 100 uM treated for 5 hrs with 15 mU/ml GOX challenge by MTT assay (Rvb = 41.51 +/- 1.39%)2017Bioorganic & medicinal chemistry letters, 07-15, Volume: 27, Issue:14
Minor phenolics from Angelica keiskei and their proliferative effects on Hep3B cells.
AID1467648Cytoprotective activity against GOX-induced cytotoxicity in human Hep3B cells assessed as decrease in LDH release treated for 5 hrs with 15 mU/ml GOX challenge by spectrophotometric method2017Bioorganic & medicinal chemistry letters, 07-15, Volume: 27, Issue:14
Minor phenolics from Angelica keiskei and their proliferative effects on Hep3B cells.
AID1467646Cytoprotective activity against GOX-induced cytotoxicity in human Hep3B cells assessed as LDH release at 10 uM treated for 5 hrs with 15 mU/ml GOX challenge by spectrophotometric method (Rvb = 60.94 +/- 1.18%)2017Bioorganic & medicinal chemistry letters, 07-15, Volume: 27, Issue:14
Minor phenolics from Angelica keiskei and their proliferative effects on Hep3B cells.
AID1467644Cytoprotective activity against GOX-induced cytotoxicity in human Hep3B cells assessed as LDH release at 0.1 uM treated for 5 hrs with 15 mU/ml GOX challenge by spectrophotometric method (Rvb = 60.94 +/- 1.18%)2017Bioorganic & medicinal chemistry letters, 07-15, Volume: 27, Issue:14
Minor phenolics from Angelica keiskei and their proliferative effects on Hep3B cells.
AID1467651Cytoprotective activity against GOX-induced cytotoxicity in mouse NIH/3T3 cells assessed as LDH release at 10 uM treated for 5 hrs with 15 mU/ml GOX challenge by spectrophotometric method (Rvb = 63.34 +/- 1.85%)2017Bioorganic & medicinal chemistry letters, 07-15, Volume: 27, Issue:14
Minor phenolics from Angelica keiskei and their proliferative effects on Hep3B cells.
AID1467649Cytoprotective activity against GOX-induced cytotoxicity in mouse NIH/3T3 cells assessed as LDH release at 0.1 uM treated for 5 hrs with 15 mU/ml GOX challenge by spectrophotometric method (Rvb = 63.34 +/- 1.85%)2017Bioorganic & medicinal chemistry letters, 07-15, Volume: 27, Issue:14
Minor phenolics from Angelica keiskei and their proliferative effects on Hep3B cells.
AID1467654Cytotoxicity against human Hep3B cells assessed as effect on cell attachment at 0.1 to 100 uM measured every day during 4 days incubation period by microscopic method2017Bioorganic & medicinal chemistry letters, 07-15, Volume: 27, Issue:14
Minor phenolics from Angelica keiskei and their proliferative effects on Hep3B cells.
AID598368Antifungal activity against Aspergillus niger ATCC 16404 after 48 hrs by broth microdilution technique2011Bioorganic & medicinal chemistry, May-15, Volume: 19, Issue:10
Synthesis and antifungal activities of natural and synthetic biflavonoids.
AID1467650Cytoprotective activity against GOX-induced cytotoxicity in mouse NIH/3T3 cells assessed as LDH release at 1 uM treated for 5 hrs with 15 mU/ml GOX challenge by spectrophotometric method (Rvb = 63.34 +/- 1.85%)2017Bioorganic & medicinal chemistry letters, 07-15, Volume: 27, Issue:14
Minor phenolics from Angelica keiskei and their proliferative effects on Hep3B cells.
AID1467643Cytoprotective activity against GOX-induced oxidative stress in mouse NIH/3T3 cells assessed as increase in cell survival treated for 5 hrs with 15 mU/ml GOX challenge by MTT assay2017Bioorganic & medicinal chemistry letters, 07-15, Volume: 27, Issue:14
Minor phenolics from Angelica keiskei and their proliferative effects on Hep3B cells.
AID1467640Cytoprotective activity against GOX-induced oxidative stress in mouse NIH/3T3 cells assessed as cell survival at 1 uM treated for 5 hrs with 15 mU/ml GOX challenge by MTT assay (Rvb = 42.71 +/- 2.10%)2017Bioorganic & medicinal chemistry letters, 07-15, Volume: 27, Issue:14
Minor phenolics from Angelica keiskei and their proliferative effects on Hep3B cells.
AID1467631Proliferative activity against human Hep3B cells assessed as cell viability at 10 uM after 4 days by cell counting method relative to control2017Bioorganic & medicinal chemistry letters, 07-15, Volume: 27, Issue:14
Minor phenolics from Angelica keiskei and their proliferative effects on Hep3B cells.
AID1467634Cytoprotective activity against GOX-induced oxidative stress in human Hep3B cells assessed as cell survival at 0.1 uM treated for 5 hrs with 15 mU/ml GOX challenge by MTT assay (Rvb = 41.51 +/- 1.39%)2017Bioorganic & medicinal chemistry letters, 07-15, Volume: 27, Issue:14
Minor phenolics from Angelica keiskei and their proliferative effects on Hep3B cells.
AID1467639Cytoprotective activity against GOX-induced oxidative stress in human Hep3B cells assessed as increase in cell survival treated for 5 hrs with 15 mU/ml GOX challenge by MTT assay2017Bioorganic & medicinal chemistry letters, 07-15, Volume: 27, Issue:14
Minor phenolics from Angelica keiskei and their proliferative effects on Hep3B cells.
AID1467632Proliferative activity against human Hep3B cells assessed as cell viability at 100 uM after 4 days by cell counting method relative to control2017Bioorganic & medicinal chemistry letters, 07-15, Volume: 27, Issue:14
Minor phenolics from Angelica keiskei and their proliferative effects on Hep3B cells.
AID1467630Proliferative activity against human Hep3B cells assessed as cell viability at 1 uM after 4 days by cell counting method relative to control2017Bioorganic & medicinal chemistry letters, 07-15, Volume: 27, Issue:14
Minor phenolics from Angelica keiskei and their proliferative effects on Hep3B cells.
AID1467645Cytoprotective activity against GOX-induced cytotoxicity in human Hep3B cells assessed as LDH release at 1 uM treated for 5 hrs with 15 mU/ml GOX challenge by spectrophotometric method (Rvb = 60.94 +/- 1.18%)2017Bioorganic & medicinal chemistry letters, 07-15, Volume: 27, Issue:14
Minor phenolics from Angelica keiskei and their proliferative effects on Hep3B cells.
AID1467641Cytoprotective activity against GOX-induced oxidative stress in mouse NIH/3T3 cells assessed as cell survival at 10 uM treated for 5 hrs with 15 mU/ml GOX challenge by MTT assay (Rvb = 42.71 +/- 2.10%)2017Bioorganic & medicinal chemistry letters, 07-15, Volume: 27, Issue:14
Minor phenolics from Angelica keiskei and their proliferative effects on Hep3B cells.
AID1467638Cytoprotective activity against GOX-induced oxidative stress in mouse NIH/3T3 cells assessed as cell survival at 0.1 uM treated for 5 hrs with 15 mU/ml GOX challenge by MTT assay (Rvb = 42.71 +/- 2.10%)2017Bioorganic & medicinal chemistry letters, 07-15, Volume: 27, Issue:14
Minor phenolics from Angelica keiskei and their proliferative effects on Hep3B cells.
AID1467629Proliferative activity against human Hep3B cells assessed as cell viability at 0.1 uM after 4 days by cell counting method relative to control2017Bioorganic & medicinal chemistry letters, 07-15, Volume: 27, Issue:14
Minor phenolics from Angelica keiskei and their proliferative effects on Hep3B cells.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (8)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (12.50)29.6817
2010's5 (62.50)24.3611
2020's2 (25.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.39

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.39 (24.57)
Research Supply Index2.20 (2.92)
Research Growth Index4.59 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.39)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other8 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]