Lymphangioleiomyoma

A tumorlike condition characterized by SMOOTH MUSCLE and ENDOTHELIUM proliferation of LYMPHATIC VESSELS and LYMPH NODES in the MEDIASTINUM and retroperitoneum, also in the lung. It may be manifested by chylous PLEURAL EFFUSION and ASCITES.

Synonym
Lymphangiomyoma
Lymphangioleiomyoma

Excerpt	Reference
"Lymphangioleiomyomas are lymphatic masses that can be associated with lymphangioleiomyomatosis."	( Atallah, D; Chahine, G; Checrallah, A; Ghossain, MA; Rouzier, R, 2006)
"Lymphangiomyomas are relatively rare, benign neoplasms."	( Hemrom, A; Kumar, A; Kumar, R; Mohan, N; Tupalli, A, 2021)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	28 (43.75)	23.3326
1990's	21 (32.81)	12.5806
2000's	6 (9.38)	18.1394
2010's	6 (9.38)	28.8240
2020's	3 (4.69)	9.53

Drug	Relationship Strength	Studies
nitrous oxide	low	1
azathioprine	low	1
bupivacaine	low	2
enflurane	low	1
hydralazine	low	1
iodixanol	low	1
terbutaline	low	1
thalidomide	low	1
prednisone	low	1
medroxyprogesterone acetate	low	5
medroxyprogesterone	low	14
megestrol acetate	low	1
megestrol	low	1
danazol	low	1
buserelin	low	3
elastin	low	1
flutropium bromide	low	1
tamoxifen	low	21
sirolimus	low	9
goserelin	low	2
mart-1 antigen	low	1
tetracycline	low	1
technetium tc 99m sulfur colloid	low	1

Protein Targets (677)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	3	0	0	3
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	2	0	0	2
Chain A, Ferritin light chain	2	0	0	2
interleukin 8	2	0	0	2
acetylcholinesterase	3	0	0	3
thioredoxin reductase	3	0	0	3
phosphopantetheinyl transferase	3	0	0	3
RAR-related orphan receptor gamma	10	0	0	10
SMAD family member 2	6	0	0	6
ATAD5 protein, partial	3	0	0	3
Fumarate hydratase	2	0	0	2
SMAD family member 3	6	0	0	6
TDP1 protein	9	0	0	9
GLI family zinc finger 3	8	0	0	8
Microtubule-associated protein tau	3	0	0	3
AR protein	9	0	0	9
thioredoxin glutathione reductase	2	0	0	2
nuclear receptor subfamily 1, group I, member 3	9	0	0	9
EWS/FLI fusion protein	3	0	0	3
glucocorticoid receptor [Homo sapiens]	8	0	0	8
retinoic acid nuclear receptor alpha variant 1	7	0	0	7
retinoid X nuclear receptor alpha	6	0	0	6
estrogen-related nuclear receptor alpha	7	0	0	7
farnesoid X nuclear receptor	6	0	0	6
pregnane X nuclear receptor	7	0	0	7
estrogen nuclear receptor alpha	9	0	0	9
G	5	0	0	5
polyprotein	2	0	0	2
P53	1	0	0	1
peroxisome proliferator-activated receptor delta	5	0	0	5
peroxisome proliferator activated receptor gamma	7	0	0	7
arylsulfatase A	5	0	0	5
IDH1	3	0	0	3
euchromatic histone-lysine N-methyltransferase 2	6	0	0	6
aryl hydrocarbon receptor	1	0	0	1
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	7	0	0	7
thyroid stimulating hormone receptor	5	0	0	5
activating transcription factor 6	2	0	0	2
v-jun sarcoma virus 17 oncogene homolog (avian)	5	0	0	5
Histone H2A.x	4	0	0	4
Bloom syndrome protein isoform 1	2	0	0	2
peripheral myelin protein 22 isoform 1	1	0	0	1
hemoglobin subunit beta	1	0	0	1
cellular tumor antigen p53 isoform a	3	0	0	3
thyroid hormone receptor beta isoform 2	8	0	0	8
heat shock protein beta-1	3	0	0	3
nuclear factor erythroid 2-related factor 2 isoform 1	8	0	0	8
DNA polymerase iota isoform a (long)	2	0	0	2
geminin	7	0	0	7
peripheral myelin protein 22	4	0	0	4
survival motor neuron protein isoform d	3	0	0	3
cytochrome P450 3A4 isoform 1	4	0	0	4
M-phase phosphoprotein 8	2	0	0	2
muscleblind-like protein 1 isoform 1	2	0	0	2
muscarinic acetylcholine receptor M1	2	0	0	2
lamin isoform A-delta10	5	0	0	5
Gamma-aminobutyric acid receptor subunit pi	4	0	0	4
ATP-binding cassette sub-family C member 3	0	7	0	7
Multidrug resistance-associated protein 4	0	7	0	7
Bile salt export pump	0	1	0	1
Voltage-dependent calcium channel gamma-2 subunit	4	0	0	4
Bile salt export pump	0	10	0	10
Interferon beta	6	0	0	6
HLA class I histocompatibility antigen, B alpha chain	5	0	0	5
Cellular tumor antigen p53	8	0	0	8
Gamma-aminobutyric acid receptor subunit beta-1	4	0	0	4
Gamma-aminobutyric acid receptor subunit delta	4	0	0	4
Gamma-aminobutyric acid receptor subunit gamma-2	4	0	0	4
Glutamate receptor 2	4	0	0	4
Gamma-aminobutyric acid receptor subunit alpha-5	4	0	0	4
Gamma-aminobutyric acid receptor subunit alpha-3	4	0	0	4
Gamma-aminobutyric acid receptor subunit gamma-1	4	0	0	4
Gamma-aminobutyric acid receptor subunit alpha-2	4	0	0	4
Gamma-aminobutyric acid receptor subunit alpha-4	4	0	0	4
Gamma-aminobutyric acid receptor subunit gamma-3	4	0	0	4
Gamma-aminobutyric acid receptor subunit alpha-6	4	0	0	4
Nuclear receptor ROR-gamma	4	0	0	4
Gamma-aminobutyric acid receptor subunit alpha-1	4	0	0	4
Gamma-aminobutyric acid receptor subunit beta-3	4	0	0	4
Gamma-aminobutyric acid receptor subunit beta-2	4	0	0	4
GABA theta subunit	4	0	0	4
Inositol hexakisphosphate kinase 1	5	0	0	5
Canalicular multispecific organic anion transporter 1	0	7	0	7
ATPase family AAA domain-containing protein 5	4	0	0	4
Ataxin-2	5	0	0	5
Gamma-aminobutyric acid receptor subunit epsilon	4	0	0	4
Protein-arginine deiminase type-4	0	2	0	2
cytochrome P450 2C9, partial	5	0	0	5
aldehyde dehydrogenase 1 family, member A1	5	0	0	5
Potassium channel subfamily K member 3	0	1	0	1
Potassium channel subfamily K member 3	0	1	0	1
Potassium channel subfamily K member 2	0	0	1	1
Potassium channel subfamily K member 9	0	1	0	1
glp-1 receptor, partial	2	0	0	2
pregnane X receptor	3	0	0	3
hypoxia-inducible factor 1 alpha subunit	2	0	0	2
estrogen receptor 2 (ER beta)	3	0	0	3
progesterone receptor	6	0	0	6
cytochrome P450 family 3 subfamily A polypeptide 4	5	0	0	5
cytochrome P450 2D6	3	0	0	3
vitamin D (1,25- dihydroxyvitamin D3) receptor	6	0	0	6
nuclear receptor subfamily 1, group I, member 2	3	0	0	3
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	2	0	0	2
Rap guanine nucleotide exchange factor 3	1	0	0	1
Estrogen receptor	0	5	2	8
Glucocorticoid receptor	0	10	2	12
Sex hormone-binding globulin	0	0	2	2
Cytochrome P450 1A2	0	1	0	1
Glycine receptor subunit alpha-1	0	10	0	10
Aldo-keto reductase family 1 member B1	0	4	0	4
Alpha-2A adrenergic receptor	0	4	0	4
Adenosine receptor A3	0	4	0	4
Cytochrome P450 2C9	0	3	0	3
Beta-3 adrenergic receptor	0	4	1	5
Androgen receptor	0	10	0	10
Alpha-1B adrenergic receptor	0	5	0	5
Alpha-2B adrenergic receptor	0	4	0	4
Alpha-2C adrenergic receptor	0	2	0	2
Muscarinic acetylcholine receptor M3	0	4	0	4
Glycine receptor subunit beta	0	10	0	10
Substance-K receptor	0	4	0	4
D(1A) dopamine receptor	0	4	0	4
Glycine receptor subunit alpha-2	0	10	0	10
Sodium-dependent noradrenaline transporter	0	4	0	4
Glycine receptor subunit alpha-3	0	10	0	10
5-hydroxytryptamine receptor 2A	0	4	0	4
Sodium-dependent serotonin transporter	0	4	0	4
Mu-type opioid receptor	0	4	0	4
D(3) dopamine receptor	0	4	0	4
Kappa-type opioid receptor	0	4	0	4
Alpha-1A adrenergic receptor	0	5	0	5
Cytochrome P450 2J2	0	2	0	2
Spike glycoprotein	5	0	1	6
Sodium-dependent dopamine transporter	0	4	0	4
Chain A, Putative fructose-1,6-bisphosphate aldolase	1	0	0	1
Chain A, 2-oxoglutarate Oxygenase	1	0	0	1
Luciferase	1	0	0	1
GLS protein	2	0	0	2
Thrombopoietin	1	0	0	1
Parkin	3	0	0	3
pyruvate kinase	1	0	0	1
cytochrome P450 2D6 isoform 1	2	0	0	2
NPC intracellular cholesterol transporter 1 precursor	2	0	0	2
ras-related protein Rab-9A	2	0	0	2
nuclear receptor ROR-gamma isoform 1	4	0	0	4
pyruvate kinase PKM isoform b	1	0	0	1
N-glycosylase/DNA lyase	0	1	0	1
Integrin beta-3	2	0	0	2
Myeloperoxidase	0	1	0	1
Integrin alpha-IIb	2	0	0	2
Ornithine decarboxylase	1	0	0	1
Polyunsaturated fatty acid lipoxygenase ALOX15	0	1	0	1
Aspartate aminotransferase, cytoplasmic	0	1	0	1
Lactoperoxidase	0	1	0	1
Single-stranded DNA cytosine deaminase	1	0	0	1
HLA class I histocompatibility antigen, A alpha chain	0	1	0	1
5-hydroxytryptamine receptor 2C	0	1	0	1
5-hydroxytryptamine receptor 2A	0	1	0	1
5-hydroxytryptamine receptor 2B	0	1	0	1
Gastrin/cholecystokinin type B receptor	0	1	0	1
Chain A, Beta-lactamase	4	0	0	4
GALC protein	1	0	0	1
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	3	0	0	3
PINK1	2	0	0	2
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	4	0	0	4
chromobox protein homolog 1	2	0	0	2
Cytochrome P450 2C19	0	2	0	2
Chain A, Cruzipain	2	0	0	2
nonstructural protein 1	1	0	0	1
nuclear factor erythroid 2-related factor 2 isoform 2	3	0	0	3
transcriptional regulator ERG isoform 3	2	0	0	2
neuropeptide S receptor isoform A	2	0	0	2
Progesterone receptor	0	3	1	4
Mineralocorticoid receptor	0	1	0	1
Androgen receptor	0	2	2	4
Androgen receptor	0	0	1	1
Histamine H2 receptor	0	4	0	4
5-hydroxytryptamine receptor 1B	0	3	0	3
Alpha-synuclein	3	1	0	4
Aldo-keto reductase family 1 member C3	0	1	0	1
Aldo-keto reductase family 1 member C2	0	1	0	1
Guanine nucleotide-binding protein G	1	0	0	1
Aldo-keto reductase family 1 member C1	0	1	0	1
Estrogen receptor beta	0	3	2	5
bioA	0	0	0	1
DNA polymerase beta	1	0	0	1
Chain A, HADH2 protein	1	0	0	1
Chain B, HADH2 protein	1	0	0	1
vitamin D3 receptor isoform VDRA	2	0	0	2
USP1 protein, partial	2	0	0	2
Smad3	1	0	0	1
67.9K protein	2	0	0	2
Bone morphogenetic protein receptor type-1B	0	0	1	1
Cell division cycle 7-related protein kinase	0	0	1	1
Serine/threonine-protein kinase PLK4	0	0	1	1
ATP-dependent RNA helicase DDX3X	0	0	1	1
Pyridoxal kinase	0	0	1	1
Citron Rho-interacting kinase	0	0	1	1
Serine/threonine-protein kinase Chk1	0	0	1	1
Aurora kinase A	0	0	1	1
Cyclin-G-associated kinase	0	0	1	1
Ephrin type-B receptor 6	0	0	1	1
Peroxisomal acyl-coenzyme A oxidase 3	0	0	1	1
Receptor-interacting serine/threonine-protein kinase 2	0	0	1	1
Mitotic checkpoint serine/threonine-protein kinase BUB1	0	0	1	1
Dynamin-like 120 kDa protein, mitochondrial	0	0	1	1
Tyrosine-protein kinase JAK2	0	0	1	1
Eukaryotic translation initiation factor 5B	0	0	1	1
Rho-associated protein kinase 2	0	0	1	1
Serine/threonine-protein kinase ULK1	0	0	1	1
Serine/threonine-protein kinase/endoribonuclease IRE1	0	0	1	1
Nuclear receptor subfamily 1 group I member 2	0	0	1	1
Ribosomal protein S6 kinase alpha-5	0	0	1	1
U5 small nuclear ribonucleoprotein 200 kDa helicase	0	0	1	1
Ribosomal protein S6 kinase alpha-4	0	0	1	1
Serine/threonine-protein kinase 16	0	0	1	1
Cyclin-dependent kinase-like 5	0	0	1	1
Serine/threonine-protein kinase 10	0	0	1	1
Serine/threonine-protein kinase D3	0	1	1	2
Structural maintenance of chromosomes protein 2	0	0	1	1
Mitogen-activated protein kinase kinase kinase 6	0	0	1	1
Mitogen-activated protein kinase kinase kinase kinase 4	0	0	1	1
Serine/threonine-protein kinase LATS1	0	0	1	1
Serine/threonine-protein kinase PAK 4	0	0	1	1
Tyrosine-protein kinase ABL1	0	0	1	1
Epidermal growth factor receptor	0	1	1	2
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	0	1	0	1
High affinity nerve growth factor receptor	0	0	1	1
ADP/ATP translocase 2	0	0	1	1
Protein kinase C beta type	0	1	1	2
Insulin receptor	0	0	1	1
Tyrosine-protein kinase Lck	0	1	1	2
Tyrosine-protein kinase Fyn	0	1	1	2
Cyclin-dependent kinase 1	0	0	1	1
Eukaryotic translation initiation factor 4E	0	0	1	1
Glycogen phosphorylase, liver form	0	0	1	1
Tyrosine-protein kinase Fes/Fps	0	0	1	1
Adenine phosphoribosyltransferase	0	0	1	1
Tyrosine-protein kinase Yes	0	0	1	1
Tyrosine-protein kinase Lyn	0	0	1	1
Proto-oncogene tyrosine-protein kinase receptor Ret	0	0	1	1
Insulin-like growth factor 1 receptor	0	0	1	1
ATP-dependent translocase ABCB1	0	3	1	4
Signal recognition particle receptor subunit alpha	0	0	1	1
Cytochrome c1, heme protein, mitochondrial	0	0	1	1
Hepatocyte growth factor receptor	0	0	1	1
Tyrosine-protein kinase HCK	0	0	1	1
Cytochrome P450 3A4	0	2	0	2
Platelet-derived growth factor receptor beta	0	0	1	1
Tyrosine-protein kinase Fgr	0	0	1	1
Serine/threonine-protein kinase A-Raf	0	0	1	1
Glycogen phosphorylase, brain form	0	0	1	1
Breakpoint cluster region protein	0	0	1	1
Serine/threonine-protein kinase pim-1	0	0	1	1
Fibroblast growth factor receptor 1	0	0	1	1
DNA topoisomerase 2-alpha	0	0	1	1
Cyclin-dependent kinase 4	0	0	1	1
ADP/ATP translocase 3	0	0	1	1
Inosine-5'-monophosphate dehydrogenase 2	0	0	1	1
Proto-oncogene tyrosine-protein kinase Src	0	0	1	1
cAMP-dependent protein kinase type II-alpha regulatory subunit	0	0	1	1
Serine/threonine-protein kinase B-raf	0	0	1	1
Phosphorylase b kinase gamma catalytic chain, liver/testis isoform	0	0	1	1
Ribosyldihydronicotinamide dehydrogenase [quinone]	0	0	1	1
Tyrosine-protein kinase Fer	0	0	1	1
Protein kinase C alpha type	0	1	1	2
cAMP-dependent protein kinase catalytic subunit alpha	0	0	1	1
General transcription and DNA repair factor IIH helicase subunit XPD	0	0	1	1
Casein kinase II subunit alpha'	0	0	1	1
Ras-related protein Rab-6A	0	0	1	1
Ephrin type-A receptor 1	0	0	1	1
Multifunctional protein ADE2	0	0	1	1
cAMP-dependent protein kinase catalytic subunit beta	0	0	1	1
Ferrochelatase, mitochondrial	0	0	1	1
Ribosomal protein S6 kinase beta-1	0	0	1	1
Tyrosine-protein kinase JAK1	0	0	1	1
Cyclin-dependent kinase 2	0	0	1	1
Beta-adrenergic receptor kinase 1	0	0	2	2
Probable ATP-dependent RNA helicase DDX6	0	0	1	1
Peptidyl-prolyl cis-trans isomerase FKBP1A	0	1	0	1
Mitogen-activated protein kinase 3	0	0	1	1
MAP/microtubule affinity-regulating kinase 3	0	0	1	1
Deoxycytidine kinase	0	0	1	1
Mitogen-activated protein kinase 1	0	0	1	1
Ephrin type-A receptor 2	0	0	1	1
Ephrin type-B receptor 2	0	0	1	1
Non-receptor tyrosine-protein kinase TYK2	0	0	1	1
UMP-CMP kinase	0	0	1	1
Phosphatidylethanolamine-binding protein 1	0	0	1	1
Wee1-like protein kinase	0	0	1	1
Heme oxygenase 2	0	0	1	1
S-adenosylmethionine synthase isoform type-2	0	0	1	1
DnaJ homolog subfamily A member 1	0	0	1	1
RAC-alpha serine/threonine-protein kinase	0	0	1	1
RAC-beta serine/threonine-protein kinase	0	0	1	1
Dual specificity protein kinase TTK	0	0	1	1
DNA replication licensing factor MCM4	0	0	1	1
Myosin-10	0	0	1	1
Dual specificity mitogen-activated protein kinase kinase 2	0	0	1	1
Receptor-type tyrosine-protein kinase FLT3	0	0	1	1
Bone morphogenetic protein receptor type-1A	0	0	1	1
Activin receptor type-1B	0	0	1	1
TGF-beta receptor type-1	0	0	1	1
Serine/threonine-protein kinase receptor R3	0	0	1	1
TGF-beta receptor type-2	0	0	1	1
Electron transfer flavoprotein subunit beta	0	0	1	1
Tyrosine-protein kinase CSK	0	0	1	1
Glycine--tRNA ligase	0	0	1	1
Protein kinase C iota type	0	1	1	2
Exosome RNA helicase MTR4	0	0	1	1
Serine/threonine-protein kinase mTOR	0	1	1	2
Tyrosine-protein kinase Tec	0	0	1	1
Tyrosine-protein kinase ABL2	0	0	1	1
Tyrosine-protein kinase FRK	0	0	1	1
G protein-coupled receptor kinase 6	0	0	1	1
Tyrosine-protein kinase SYK	0	0	1	1
26S proteasome regulatory subunit 6B	0	0	1	1
Mitogen-activated protein kinase 8	0	0	1	1
Mitogen-activated protein kinase 9	0	0	1	1
Dual specificity mitogen-activated protein kinase kinase 3	0	0	1	1
Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha	0	0	1	1
Casein kinase I isoform alpha	0	0	1	1
Casein kinase I isoform delta	0	0	1	1
MAP kinase-activated protein kinase 2	0	0	1	1
Elongation factor Tu, mitochondrial	0	0	1	1
Choline-phosphate cytidylyltransferase A	0	0	1	1
Cysteine--tRNA ligase, cytoplasmic	0	0	1	1
Casein kinase I isoform epsilon	0	0	1	1
Very long-chain specific acyl-CoA dehydrogenase, mitochondrial	0	0	1	1
Dual specificity protein kinase CLK1	0	0	1	1
Dual specificity protein kinase CLK2	0	0	1	1
Dual specificity protein kinase CLK3	0	0	1	1
Glycogen synthase kinase-3 alpha	0	0	1	1
Glycogen synthase kinase-3 beta	0	0	1	1
Cyclin-dependent kinase 7	0	0	1	1
Cyclin-dependent kinase 9	0	0	1	1
Ras-related protein Rab-27A	0	0	1	1
Interleukin-1 receptor-associated kinase 1	0	0	1	1
Ribosomal protein S6 kinase alpha-3	0	0	1	1
Serine/threonine-protein kinase Nek2	0	0	1	1
Serine/threonine-protein kinase Nek3	0	0	1	1
Dual specificity mitogen-activated protein kinase kinase 6	0	0	1	1
Serine/threonine-protein kinase PLK1	0	0	1	1
LIM domain kinase 1	0	0	1	1
LIM domain kinase 2	0	0	1	1
Mitogen-activated protein kinase 10	0	0	1	1
Tyrosine--tRNA ligase, cytoplasmic	0	0	1	1
5'-AMP-activated protein kinase subunit gamma-1	0	0	1	1
Ephrin type-B receptor 3	0	0	1	1
Ephrin type-A receptor 5	0	0	1	1
Ephrin type-B receptor 4	0	0	1	1
Ephrin type-A receptor 4	0	0	1	1
Adenylate kinase 2, mitochondrial	0	0	1	1
Adenosine kinase	0	0	1	1
Ras-related protein Rab-10	0	0	1	1
Actin-related protein 3	0	0	1	1
Actin-related protein 2	0	0	1	1
GTP-binding nuclear protein Ran	0	0	1	1
Peptidyl-prolyl cis-trans isomerase FKBP1A	0	2	1	3
Peptidyl-prolyl cis-trans isomerase FKBP1B	0	0	1	1
Casein kinase I isoform gamma-2	0	0	1	1
Cyclin-dependent kinase 6	0	0	1	1
Cyclin-dependent-like kinase 5	0	0	1	1
Cyclin-dependent kinase 16	0	0	1	1
Cyclin-dependent kinase 17	0	0	1	1
ATP-dependent 6-phosphofructokinase, platelet type	0	0	1	1
Dual specificity mitogen-activated protein kinase kinase 1	0	0	1	1
DNA topoisomerase 2-beta	0	0	1	1
Protein kinase C theta type	0	1	1	2
Activin receptor type-1	0	0	1	1
Macrophage-stimulating protein receptor	0	0	1	1
Focal adhesion kinase 1	0	0	1	1
Protein kinase C zeta type	0	1	1	2
Protein kinase C delta type	0	1	1	2
Tyrosine-protein kinase BTK	0	0	1	1
Cyclin-dependent kinase 18	0	0	1	1
Activated CDC42 kinase 1	0	0	1	1
Epithelial discoidin domain-containing receptor 1	0	0	1	1
Mitogen-activated protein kinase kinase kinase kinase 2	0	0	1	1
Tyrosine-protein kinase Mer	0	0	1	1
Serine/threonine-protein kinase 4	0	0	1	1
5'-AMP-activated protein kinase catalytic subunit alpha-1	0	0	1	1
Dual specificity mitogen-activated protein kinase kinase 5	0	0	1	1
Mitogen-activated protein kinase 7	0	0	1	1
Serine/threonine-protein kinase PAK 2	0	0	1	1
Serine/threonine-protein kinase 3	0	0	1	1
Mitogen-activated protein kinase kinase kinase 1	0	0	1	1
Integrin-linked protein kinase	0	0	1	1
Peptidyl-prolyl cis-trans isomerase FKBP5	0	1	0	1
Rho-associated protein kinase 1	0	0	1	1
Non-receptor tyrosine-protein kinase TNK1	0	0	1	1
Calcium/calmodulin-dependent protein kinase type II subunit gamma	0	0	1	1
Calcium/calmodulin-dependent protein kinase type II subunit delta	0	0	1	1
Dual specificity tyrosine-phosphorylation-regulated kinase 1A	0	0	1	1
Activin receptor type-2B	0	0	1	1
Bone morphogenetic protein receptor type-2	0	0	1	1
Protein-tyrosine kinase 6	0	0	1	1
cGMP-dependent protein kinase 1	0	0	1	1
Cyclin-dependent kinase 13	0	0	1	1
Inhibitor of nuclear factor kappa-B kinase subunit epsilon	0	0	1	1
Protein-tyrosine kinase 2-beta	0	0	1	1
Maternal embryonic leucine zipper kinase	0	0	1	1
Structural maintenance of chromosomes protein 1A	0	0	1	1
Chromodomain-helicase-DNA-binding protein 4	0	0	1	1
Peroxisomal acyl-coenzyme A oxidase 1	0	0	1	1
Delta(24)-sterol reductase	0	0	1	1
Ribosomal protein S6 kinase alpha-1	0	0	1	1
Dual specificity testis-specific protein kinase 1	0	0	1	1
Myosin light chain kinase, smooth muscle	0	0	1	1
Mitogen-activated protein kinase 11	0	0	1	1
Serine/threonine-protein kinase STK11	0	0	1	1
Serine/threonine-protein kinase N1	0	0	1	1
Serine/threonine-protein kinase N2	0	0	1	1
Mitogen-activated protein kinase 14	0	0	1	1
Calcium/calmodulin-dependent protein kinase type IV	0	0	1	1
Mitogen-activated protein kinase kinase kinase 11	0	0	1	1
Discoidin domain-containing receptor 2	0	0	1	1
AP2-associated protein kinase 1	0	0	1	1
Myosin light chain kinase 3	0	0	1	1
Uncharacterized aarF domain-containing protein kinase 5	0	0	1	1
Programmed cell death protein 4	0	0	1	1
Putative heat shock protein HSP 90-beta 2	0	0	1	1
Serine/threonine-protein kinase MRCK alpha	0	0	1	1
Serine/threonine-protein kinase MRCK gamma	0	0	1	1
Acyl-CoA dehydrogenase family member 10	0	0	1	1
Serine/threonine-protein kinase N3	0	0	1	1
Serine/threonine-protein kinase ULK3	0	0	1	1
Uncharacterized protein FLJ45252	0	0	1	1
Acyl-CoA dehydrogenase family member 11	0	0	1	1
Serine/threonine-protein kinase/endoribonuclease IRE2	0	0	1	1
Serine/threonine-protein kinase MARK2	0	0	1	1
ATP-dependent RNA helicase DHX30	0	0	1	1
Serine/threonine-protein kinase TAO1	0	0	1	1
STE20-related kinase adapter protein alpha	0	0	1	1
Myosin-14	0	0	1	1
AarF domain-containing protein kinase 1	0	0	1	1
Mitogen-activated protein kinase kinase kinase kinase 3	0	0	1	1
MAP kinase-activated protein kinase 5	0	0	1	1
Regulatory-associated protein of mTOR	0	1	0	1
Misshapen-like kinase 1	0	0	1	1
Atypical kinase COQ8A, mitochondrial	0	0	1	1
Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma	0	0	1	1
Mitogen-activated protein kinase 15	0	0	1	1
Serine/threonine-protein kinase Nek9	0	0	1	1
ATP-dependent RNA helicase DDX1	0	0	1	1
Mitogen-activated protein kinase kinase kinase kinase 1	0	0	1	1
Aurora kinase B	0	0	1	1
MAP/microtubule affinity-regulating kinase 4	0	0	1	1
Calcium/calmodulin-dependent protein kinase type 1G	0	0	1	1
Serine/threonine-protein kinase Nek1	0	0	1	1
PAS domain-containing serine/threonine-protein kinase	0	0	1	1
Calcium/calmodulin-dependent protein kinase kinase 2	0	0	1	1
EKC/KEOPS complex subunit TP53RK	0	0	1	1
Dual specificity testis-specific protein kinase 2	0	0	1	1
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	0	0	1	1
Mitogen-activated protein kinase kinase kinase 5	0	0	1	1
Mitogen-activated protein kinase kinase kinase 3	0	0	1	1
Eukaryotic translation initiation factor 2-alpha kinase 1	0	0	1	1
Target of rapamycin complex subunit LST8	0	1	0	1
Nucleolar GTP-binding protein 1	0	0	1	1
Serine/threonine-protein kinase D2	0	0	1	1
RNA cytidine acetyltransferase	0	0	1	1
Serine/threonine-protein kinase SIK2	0	0	1	1
STE20-like serine/threonine-protein kinase	0	0	1	1
Serine/threonine-protein kinase TAO3	0	0	1	1
dCTP pyrophosphatase 1	0	0	1	1
Dual specificity protein kinase CLK4	0	0	1	1
Casein kinase I isoform gamma-1	0	0	1	1
Serine/threonine-protein kinase mTOR	0	1	0	1
Phenylalanine--tRNA ligase beta subunit	0	0	1	1
Isoleucine--tRNA ligase, mitochondrial	0	0	1	1
BMP-2-inducible protein kinase	0	0	1	1
Obg-like ATPase 1	0	0	1	1
Midasin	0	0	1	1
Interleukin-1 receptor-associated kinase 4	0	0	1	1
Mitogen-activated protein kinase kinase kinase 20	0	0	1	1
Cyclin-dependent kinase 12	0	0	1	1
Serine/threonine-protein kinase 26	0	0	1	1
Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial	0	0	1	1
Serine/threonine-protein kinase NLK	0	0	1	1
5'-AMP-activated protein kinase subunit gamma-2	0	0	1	1
Serine/threonine-protein kinase TBK1	0	0	1	1
Septin-9	0	0	1	1
Ribosomal protein S6 kinase alpha-6	0	0	1	1
TRAF2 and NCK-interacting protein kinase	0	0	1	1
Serine/threonine-protein kinase TAO2	0	0	1	1
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	1	0	1
Serine/threonine-protein kinase ICK	0	0	1	1
RAC-gamma serine/threonine-protein kinase	0	0	1	1
Serine/threonine-protein kinase SIK3	0	0	1	1
Mitogen-activated protein kinase kinase kinase 2	0	0	1	1
Thyroid hormone receptor-associated protein 3	0	0	1	1
Dual specificity tyrosine-phosphorylation-regulated kinase 1B	0	0	1	1
Mitogen-activated protein kinase kinase kinase kinase 5	0	0	1	1
Receptor-interacting serine/threonine-protein kinase 3	0	0	1	1
Serine/threonine-protein kinase MRCK beta	0	0	1	1
Interleukin-1 receptor-associated kinase 3	0	0	1	1
Serine/threonine-protein kinase 24	0	0	1	1
Solute carrier organic anion transporter family member 1B1	0	1	0	1
Casein kinase I isoform gamma-3	0	0	1	1
Mitogen-activated protein kinase kinase kinase 4	0	0	1	1
Chain A, CES1 protein	0	1	0	1
Chain A, JmjC domain-containing histone demethylation protein 3A	1	0	0	1
PPM1D protein	1	0	0	1
apical membrane antigen 1, AMA1	1	0	0	1
DNA polymerase III, partial	1	0	0	1
caspase 7, apoptosis-related cysteine protease	1	0	0	1
regulator of G-protein signaling 4	1	0	0	1
glucocerebrosidase	1	0	0	1
bromodomain adjacent to zinc finger domain 2B	1	0	0	1
caspase-3	1	0	0	1
thyrotropin-releasing hormone receptor	1	0	0	1
Caspase-7	1	0	0	1
Spike glycoprotein	0	0	1	1
Replicase polyprotein 1ab	0	0	1	1
interferon gamma precursor	0	0	0	1
D(1A) dopamine receptor	1	0	0	1
caspase-3	1	0	0	1
ubiquitin-conjugating enzyme E2 N	0	1	0	1
serine/threonine-protein kinase mTOR isoform 1	1	0	0	1
streptokinase A precursor	0	0	1	1
lethal factor (plasmid)	1	0	0	1
Polyunsaturated fatty acid lipoxygenase ALOX15B	1	0	0	1
Transmembrane protease serine 2	0	0	1	1
5-hydroxytryptamine receptor 4	0	2	0	2
Lysosomal acid glucosylceramidase	0	0	1	1
Receptor tyrosine-protein kinase erbB-2	0	1	0	1
Protein kinase C gamma type	0	1	0	1
Protein kinase C alpha type	0	1	0	1
Estrogen receptor	0	0	1	2
Procathepsin L	0	0	1	1
Muscarinic acetylcholine receptor M2	0	3	0	3
Muscarinic acetylcholine receptor M4	0	2	0	2
Beta-1 adrenergic receptor	0	2	1	3
Muscarinic acetylcholine receptor M5	0	2	0	2
Protein kinase C delta type	0	1	0	1
Protein kinase C epsilon type	0	1	0	1
Protein kinase C zeta type	0	1	0	1
Polyunsaturated fatty acid 5-lipoxygenase	0	1	0	1
Replicase polyprotein 1a	0	0	1	1
Replicase polyprotein 1ab	0	0	1	1
Replicase polyprotein 1ab	0	0	1	1
Replicase polyprotein 1ab	0	0	1	1
Muscarinic acetylcholine receptor M1	0	2	0	2
Steroid hormone receptor ERR1	0	1	0	1
Transcriptional activator protein LuxR	0	1	0	1
Angiotensin-converting enzyme	0	2	0	2
D(2) dopamine receptor	0	2	0	2
5-hydroxytryptamine receptor 1A	0	2	0	2
Cytochrome P450 2B6	0	1	0	1
D(4) dopamine receptor	0	2	0	2
UDP-glucuronosyltransferase 1A4	0	0	0	1
Prostaglandin G/H synthase 1	0	1	0	1
Thromboxane-A synthase	0	1	0	1
Protein kinase C eta type	0	1	0	1
Alpha-1D adrenergic receptor	0	2	0	2
Substance-P receptor	0	2	0	2
5-hydroxytryptamine receptor 2C	0	2	0	2
Adenosine receptor A2a	0	2	0	2
B2 bradykinin receptor	0	2	0	2
Adenosine receptor A1	0	2	0	2
Melanocortin receptor 4	0	2	0	2
C-8 sterol isomerase	0	1	0	1
Melanocortin receptor 5	0	2	0	2
Delta-type opioid receptor	0	2	0	2
5-hydroxytryptamine receptor 2B	0	2	0	2
Melanocortin receptor 3	0	2	0	2
Histamine H2 receptor	1	0	0	1
D(1A) dopamine receptor	1	0	0	1
5-hydroxytryptamine receptor 6	0	2	0	2
Estrogen-related receptor gamma	0	1	0	1
Protein kinase C gamma type	0	1	0	1
Protein kinase C beta type	0	1	0	1
Phospholipase D1	0	1	0	1
Protein kinase C epsilon type	0	1	0	1
Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform	0	1	0	1
Potassium voltage-gated channel subfamily H member 2	0	2	0	2
Platelet-activating factor acetylhydrolase	0	1	0	1
Phospholipase D1	0	1	0	1
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase	0	2	1	3
Serine/threonine-protein kinase D1	0	1	0	1
Estrogen receptor beta	0	0	1	2
Protein kinase C eta type	0	1	0	1
Nuclear receptor subfamily 3 group C member 3	0	2	0	2
Sigma non-opioid intracellular receptor 1	0	2	0	2
Emopamil-binding protein-like	0	1	0	1
Angiotensin-converting enzyme 2	0	0	1	1
7-dehydrocholesterol reductase	0	1	1	2
Protein kinase C theta type	0	1	0	1
beta-2 adrenergic receptor	1	0	0	1
Beta-2 adrenergic receptor	0	0	2	2
Beta-2 adrenergic receptor	0	0	1	3
ATP-dependent phosphofructokinase	1	0	0	1
90-kda heat shock protein beta HSP90 beta, partial	0	1	0	1
estrogen receptor beta isoform 1	0	1	0	1
heat shock protein HSP 90-alpha isoform 2	0	1	0	1
tyrosine-protein phosphatase non-receptor type 7 isoform 2	0	1	0	1
Dihydroxyacetone phosphate acyltransferase	0	0	0	1
30S ribosomal protein S6	0	1	0	1
30S ribosomal protein S7	0	1	0	1
50S ribosomal protein L15	0	1	0	1
Tetracycline resistance protein, class B	0	0	0	1
72 kDa type IV collagenase	0	1	0	1
Stromelysin-1	0	1	0	1
50S ribosomal protein L10	0	1	0	1
50S ribosomal protein L11	0	1	0	1
50S ribosomal protein L7/L12	0	1	0	1
50S ribosomal protein L19	0	1	0	1
50S ribosomal protein L1	0	1	0	1
50S ribosomal protein L20	0	1	0	1
50S ribosomal protein L27	0	1	0	1
50S ribosomal protein L28	0	1	0	1
50S ribosomal protein L29	0	1	0	1
50S ribosomal protein L31	0	1	0	1
50S ribosomal protein L31 type B	0	1	0	1
50S ribosomal protein L32	0	1	0	1
50S ribosomal protein L33	0	1	0	1
50S ribosomal protein L34	0	1	0	1
50S ribosomal protein L35	0	1	0	1
50S ribosomal protein L36	0	1	0	1
30S ribosomal protein S10	0	1	0	1
30S ribosomal protein S11	0	1	0	1
30S ribosomal protein S12	0	1	0	1
30S ribosomal protein S13	0	1	0	1
30S ribosomal protein S16	0	1	0	1
30S ribosomal protein S18	0	1	0	1
30S ribosomal protein S19	0	1	0	1
30S ribosomal protein S20	0	1	0	1
30S ribosomal protein S2	0	1	0	1
30S ribosomal protein S3	0	1	0	1
30S ribosomal protein S4	0	1	0	1
30S ribosomal protein S5	0	1	0	1
30S ribosomal protein S8	0	1	0	1
30S ribosomal protein S9	0	1	0	1
50S ribosomal protein L13	0	1	0	1
50S ribosomal protein L14	0	1	0	1
50S ribosomal protein L16	0	1	0	1
50S ribosomal protein L23	0	1	0	1
30S ribosomal protein S15	0	1	0	1
Multidrug transporter MdfA	0	1	0	1
50S ribosomal protein L17	0	1	0	1
50S ribosomal protein L21	0	1	0	1
50S ribosomal protein L30	0	1	0	1
50S ribosomal protein L6	0	1	0	1
30S ribosomal protein S14	0	1	0	1
30S ribosomal protein S17	0	1	0	1
30S ribosomal protein S1	0	1	0	1
50S ribosomal protein L18	0	1	0	1
Neutrophil collagenase	0	1	0	1
Alpha-1D adrenergic receptor	0	1	0	1
Collagenase 3	0	1	0	1
Cannabinoid receptor 1	0	1	0	1
50S ribosomal protein L2	0	1	0	1
50S ribosomal protein L3	0	1	0	1
50S ribosomal protein L24	0	1	0	1
50S ribosomal protein L4	0	1	0	1
50S ribosomal protein L22	0	1	0	1
50S ribosomal protein L5	0	1	0	1
30S ribosomal protein S21	0	1	0	1
50S ribosomal protein L25	0	1	0	1
50S ribosomal protein L36 2	0	1	0	1
Integrase	0	1	0	1
Solute carrier family 22 member 8	0	0	0	1
P2Y purinoceptor 12	0	1	0	1
Solute carrier family 22 member 11	0	0	0	1
Solute carrier family 22 member 7	0	0	0	1
Cereblon isoform 4	0	2	0	2
thyroid hormone receptor beta isoform a	1	0	0	1
Prostaglandin G/H synthase 1	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4A	0	1	0	1
Prostaglandin G/H synthase 2	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4C	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	1	0	1
DNA-binding protein Ikaros	0	0	0	1
DNA damage-binding protein 1	0	1	1	2
Protein cereblon	0	2	1	4
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Synonyms(2)

Research Excerpts

Overview

Research

Studies (64)

Protein Targets (677)

Lymphangioleiomyoma

Synonyms(2)

Research Excerpts

Overview

Research

Studies (64)

Drugs Studied (30)

Protein Targets (677)