Page last updated: 2024-09-28

Gastroesophageal Laceration-Hemorrhage

A condition characterized by mucosal tears at the ESOPHAGOGASTRIC JUNCTION, sometimes with HEMATEMESIS. Typically it is caused by forceful bouts of retching or VOMITING.

Synonyms(5)

Synonym
Mucosal Lacerations-Gastroesophageal Junction
Mallory-Weiss Laceration
Mallory-Weiss Syndrome
Gastroesophageal Laceration-Hemorrhage
Mallory-Weiss Tear

Research

Studies (71)

TimeframeStudies, This Condition (%)All Conditions %
pre-199041 (57.75)23.3326
1990's9 (12.68)12.5806
2000's15 (21.13)18.1394
2010's4 (5.63)28.8240
2020's2 (2.82)9.53
DrugIndicatedRelationship StrengthStudiesTrials
ammonium hydroxide0low10
diatrizoic acid0low10
aspirin0low30
cimetidine0low10
famotidine0low10
fluorouracil0low20
gentamicin0low10
mechlorethamine0low10
mescaline0low10
midazolam0low10
omeprazole0low10
phenylbutazone0low10
procarbazine0low10
propofol0low10
propranolol0low10
semustine0low10
reserpine0low10
prednisone0low20
dimenhydrinate0low10
lithium carbonate0low10
methylnitrosourea0low10
enbucrilate0low10
argon0low10
barium sulfate0low60
4-methoxyamphetamine0low10
feracryl0low10
polidocanol0medium51
metiamide0low10
indigo carmine0low10
ranitidine0low20
lithium0low10
burimamide0low10
barium0low20
naltrexone0low10
pituitrin0low120
salicylates0low20
folic acid0low10

Protein Targets (431)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
5-hydroxytryptamine receptor 2C0235
5-hydroxytryptamine receptor 2A0235
5-hydroxytryptamine receptor 1A0337
5-hydroxytryptamine receptor 1B0325
5-hydroxytryptamine receptor 1D0123
5-hydroxytryptamine receptor 1F0123
5-hydroxytryptamine receptor 2B0123
5-hydroxytryptamine receptor 60022
Sodium-dependent serotonin transporter0213
Sodium-dependent serotonin transporter0101
5-hydroxytryptamine receptor 7 0022
5-hydroxytryptamine receptor 5A0022
5-hydroxytryptamine receptor 5B0022
5-hydroxytryptamine receptor 3A0022
5-hydroxytryptamine receptor 4 0022
5-hydroxytryptamine receptor 3B0022
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE4004
Chain A, TYROSYL-DNA PHOSPHODIESTERASE5005
Chain A, Phospholipase A2 isoform 30011
Chain A, HADH2 protein8008
Chain B, HADH2 protein8008
Chain A, 2-oxoglutarate Oxygenase4004
GTP-binding protein (rab7)0011
ras protein, partial0011
interleukin 84004
thioredoxin reductase4004
GLS protein6006
AR protein120012
aldehyde dehydrogenase 1 family, member A1100010
thyroid stimulating hormone receptor7007
hypothetical protein, conserved1001
cytochrome P450 family 3 subfamily A polypeptide 47007
EWS/FLI fusion protein6006
glucocorticoid receptor [Homo sapiens]7007
retinoic acid nuclear receptor alpha variant 1120012
estrogen-related nuclear receptor alpha140014
estrogen nuclear receptor alpha160016
cytochrome P450 2D66006
glucocerebrosidase2002
peroxisome proliferator-activated receptor delta4004
Rac1 protein0011
IDH13003
cell division cycle 42 (GTP binding protein, 25kDa), partial0011
euchromatic histone-lysine N-methyltransferase 2100010
Bloom syndrome protein isoform 14004
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 15005
DNA polymerase iota isoform a (long)6006
DNA polymerase kappa isoform 13003
muscarinic acetylcholine receptor M15005
lethal factor (plasmid)2002
Prostaglandin-H2 D-isomerase0101
ATP-binding cassette sub-family C member 30808
Multidrug resistance-associated protein 40809
Solute carrier family 22 member 60303
Prostaglandin G/H synthase 1 0101
Prostaglandin G/H synthase 2 0101
Bile salt export pump012012
Epidermal growth factor receptor0202
Carbonic anhydrase 10404
Carbonic anhydrase 20404
Fatty acid-binding protein, liver0101
Integrin beta-30101
Myeloperoxidase0101
Prostaglandin G/H synthase 10202
Seed linoleate 13S-lipoxygenase-10101
Integrin alpha-IIb0101
Glutathione hydrolase 1 proenzyme0101
Prostaglandin G/H synthase 10303
Adenosine receptor A10101
Adenosine receptor A2a0101
Substance-P receptor0101
Prostaglandin G/H synthase 20303
Urotensin-2 receptor0101
4-aminobutyrate aminotransferase, mitochondrial0101
Nuclear receptor ROR-gamma4004
Ras-related protein Rab-2A0011
Gamma-aminobutyric acid receptor subunit alpha-154211
Prostaglandin G/H synthase 20101
Rho-associated protein kinase 20101
Nicotinate phosphoribosyltransferase0202
Solute carrier family 22 member 200101
Solute carrier family 22 member 60101
Canalicular multispecific organic anion transporter 10909
Sigma non-opioid intracellular receptor 10415
Sigma non-opioid intracellular receptor 10011
Chain A, Putative fructose-1,6-bisphosphate aldolase3003
phosphopantetheinyl transferase5005
Histamine H2 receptor0303
Histamine H1 receptor0112
Histamine H4 receptor0314
Histamine H3 receptor0101
progesterone receptor7007
G6006
vitamin D (1,25- dihydroxyvitamin D3) receptor6006
arylsulfatase A3003
alpha-galactosidase2002
cytochrome P450 2C19 precursor4004
geminin7007
peripheral myelin protein 227007
survival motor neuron protein isoform d5005
cytochrome P450 3A4 isoform 15005
M-phase phosphoprotein 83003
lamin isoform A-delta107007
Solute carrier family 22 member 10101
Gamma-aminobutyric acid receptor subunit pi53210
Solute carrier family 22 member 20203
Solute carrier family 22 member 1 0505
Solute carrier family 22 member 20101
cGMP-specific 3',5'-cyclic phosphodiesterase0202
Interferon beta7007
HLA class I histocompatibility antigen, B alpha chain 6006
Cellular tumor antigen p53110011
ATP-dependent translocase ABCB10303
ATP-dependent translocase ABCB10707
Cytochrome P450 3A40404
Cytochrome P450 2D60405
Cytochrome P450 2C9 0505
Gamma-aminobutyric acid receptor subunit beta-153210
Gamma-aminobutyric acid receptor subunit delta53210
Gamma-aminobutyric acid receptor subunit gamma-253210
Gamma-aminobutyric acid receptor subunit alpha-553210
Gamma-aminobutyric acid receptor subunit alpha-353210
Potassium-transporting ATPase alpha chain 10202
ATP-dependent translocase ABCB10303
Gamma-aminobutyric acid receptor subunit gamma-153210
Gamma-aminobutyric acid receptor subunit alpha-253210
Gamma-aminobutyric acid receptor subunit alpha-453210
Gamma-aminobutyric acid receptor subunit gamma-353210
Gamma-aminobutyric acid receptor subunit alpha-653210
Histamine H2 receptor2215
Potassium-transporting ATPase subunit beta0202
Cytochrome P450 2J20303
Gamma-aminobutyric acid receptor subunit beta-353210
Gamma-aminobutyric acid receptor subunit beta-253210
Aldehyde oxidase0101
Solute carrier family 22 member 60101
Solute carrier family 22 member 10303
Multidrug and toxin extrusion protein 20101
Solute carrier family 22 member 80304
GABA theta subunit53210
Inositol hexakisphosphate kinase 16006
Multidrug and toxin extrusion protein 10101
Gamma-aminobutyric acid receptor subunit epsilon53210
Solute carrier family 22 member 110101
Solute carrier family 22 member 20202
Solute carrier family 22 member 40101
Solute carrier family 22 member 80202
cytochrome P450 2C9, partial6006
ATP-dependent phosphofructokinase5005
hypoxia-inducible factor 1 alpha subunit4004
RAR-related orphan receptor gamma8008
GLI family zinc finger 3100010
nuclear receptor subfamily 1, group I, member 38008
pregnane X nuclear receptor110011
thyroid stimulating hormone receptor4004
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a5005
v-jun sarcoma virus 17 oncogene homolog (avian)6006
Histone H2A.x4004
potassium voltage-gated channel subfamily H member 2 isoform d3003
thyroid hormone receptor beta isoform 27007
heat shock protein beta-15005
nuclear factor erythroid 2-related factor 2 isoform 17007
5-hydroxytryptamine receptor 40606
Voltage-dependent calcium channel gamma-2 subunit5005
Aldo-keto reductase family 1 member B10404
Muscarinic acetylcholine receptor M20314
Muscarinic acetylcholine receptor M40202
Muscarinic acetylcholine receptor M50202
Alpha-2A adrenergic receptor0528
Muscarinic acetylcholine receptor M10314
Alpha-2B adrenergic receptor0214
Glutamate receptor 25005
Muscarinic acetylcholine receptor M30314
Sodium-dependent noradrenaline transporter 0404
Alpha-1D adrenergic receptor0214
5-hydroxytryptamine receptor 2A0617
5-hydroxytryptamine receptor 2C0718
Histamine H1 receptor0202
5-hydroxytryptamine receptor 2B0718
Inositol monophosphatase 11001
Sodium-dependent dopamine transporter 0202
Chain A, Uracil Phosphoribosyltransferase0101
Luciferase6006
endonuclease IV2002
acetylcholinesterase4004
glp-1 receptor, partial3003
Skn7p0001
pregnane X receptor3003
ATAD5 protein, partial2002
TDP1 protein9009
Microtubule-associated protein tau5005
Thrombopoietin2002
estrogen receptor 2 (ER beta)7007
nonstructural protein 13003
retinoid X nuclear receptor alpha6006
farnesoid X nuclear receptor5005
67.9K protein1001
peroxisome proliferator activated receptor gamma5005
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a6006
peripheral myelin protein 22 isoform 12002
hemoglobin subunit beta2002
chromobox protein homolog 15005
nuclear factor erythroid 2-related factor 2 isoform 24004
huntingtin isoform 23003
flap endonuclease 12002
serine/threonine-protein kinase mTOR isoform 11001
urokinase-type plasminogen activator precursor1001
plasminogen precursor1001
urokinase plasminogen activator surface receptor precursor1001
Vpr1001
muscleblind-like protein 1 isoform 13003
Solute carrier family 22 member 80001
Amyloid-beta precursor protein1001
Thymidylate synthase0202
Aromatase0101
ATPase family AAA domain-containing protein 54004
Ataxin-25005
HSP40, subfamily A [Plasmodium falciparum 3D7]0001
Chain A, Dihydrofolate reductase0011
Chain A, Ferritin light chain2002
acid sphingomyelinase1001
USP1 protein, partial8008
activating transcription factor 65005
lysosomal alpha-glucosidase preproprotein1001
DNA polymerase beta2002
Thymidylate synthase0202
Dihydrofolate reductase0011
Aldo-keto reductase family 1 member B10101
Alpha-synuclein1001
Folylpolyglutamate synthase, mitochondrial0001
Solute carrier organic anion transporter family member 1A30101
Folylpolyglutamate synthase, mitochondrial0001
Multidrug resistance associated protein0001
aryl hydrocarbon receptor5005
histone deacetylase 9 isoform 31001
Fumarate hydratase1001
PPM1D protein1001
polyprotein1001
nuclear receptor ROR-gamma isoform 14004
Translocator protein0101
UDP-glucuronosyltransferase 2B70202
UDP-glucuronosyltransferase 1-60202
UDP-glucuronosyltransferase 1A1 0203
UDP-glucuronosyltransferase 1A40202
UDP-glucuronosyltransferase 2B10 0202
5-hydroxytryptamine receptor 3E0101
5-hydroxytryptamine receptor 3B0101
Histidine decarboxylase0011
Delta-type opioid receptor0214
Delta-type opioid receptor0213
Kappa-type opioid receptor0213
Mu-type opioid receptor0213
Kappa-type opioid receptor0213
Mu-type opioid receptor05310
Delta-type opioid receptor0338
Kappa-type opioid receptor0203
Kappa-type opioid receptor0328
Nociceptin receptor0101
Mu-type opioid receptor0214
5-hydroxytryptamine receptor 3A0101
Mu-type opioid receptor0214
5-hydroxytryptamine receptor 3D0101
5-hydroxytryptamine receptor 3C0101
UDP-glucuronosyltransferase 1A80002
Chain A, JmjC domain-containing histone demethylation protein 3A2002
ClpP1001
Mcl-10101
SMAD family member 23003
SMAD family member 33003
apical membrane antigen 1, AMA11001
regulator of G-protein signaling 43003
bromodomain adjacent to zinc finger domain 2B2002
vitamin D3 receptor isoform VDRA4004
pyruvate kinase PKM isoform a1001
serine/threonine-protein kinase PLK11001
histone acetyltransferase KAT2A isoform 13003
Polyunsaturated fatty acid lipoxygenase ALOX15B1001
N(G),N(G)-dimethylarginine dimethylaminohydrolase 10101
Sodium/potassium-transporting ATPase subunit alpha-1 0101
Sodium/potassium-transporting ATPase subunit beta-10101
Sodium/potassium-transporting ATPase subunit alpha-30101
Sodium/potassium-transporting ATPase subunit beta-20101
Bifunctional cytochrome P450/NADPH--P450 reductase0011
Potassium-transporting ATPase subunit beta0101
Potassium-transporting ATPase alpha chain 10101
Bombesin receptor subtype-30011
Cytochrome P450 2C190203
Fatty acid synthase0202
Sodium/potassium-transporting ATPase subunit alpha-20101
Potassium-transporting ATPase alpha chain 20001
Sodium/potassium-transporting ATPase subunit beta-30101
Sodium/potassium-transporting ATPase subunit gamma0101
Spike glycoprotein2002
WD repeat-containing protein 50101
Glutathione S-transferase omega-10101
Histone-lysine N-methyltransferase 2A0101
Sodium/potassium-transporting ATPase subunit alpha-40101
Cytosolic endo-beta-N-acetylglucosaminidase0101
Muscarinic acetylcholine receptor0101
Broad substrate specificity ATP-binding cassette transporter ABCG20202
Estrogen receptor 10101
Parkin1001
cytochrome P450 2C9 precursor1001
D(1A) dopamine receptor3003
parathyroid hormone/parathyroid hormone-related peptide receptor precursor1001
fMet-Leu-Phe receptor0101
mitogen-activated protein kinase 12002
neuropeptide S receptor isoform A2002
Prostaglandin G/H synthase 2 0101
TAR DNA-binding protein 431001
Prostaglandin G/H synthase 1 0101
Cyclooxygenase-2 0101
caspase 7, apoptosis-related cysteine protease3003
caspase-33003
nuclear receptor subfamily 1, group I, member 22002
thyroid hormone receptor beta isoform a2002
thioredoxin glutathione reductase1001
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)3003
Glucocorticoid receptor0213
Glycine receptor subunit alpha-10202
Glycine receptor subunit beta0202
Glycine receptor subunit alpha-20202
Glycine receptor subunit alpha-30202
15-lipoxygenase, partial2002
Chain A, Ferritin light chain0011
Chain A, Ferritin light chain0011
Chain A, Ferritin light chain0011
Chain A, Ferritin light chain0011
Chain A, Ferritin light chain0011
Chain A, Ferritin light chain0011
Chain A, Ferritin light chain0011
Fatty-acid amide hydrolase 10101
UDP-glucuronosyltransferase 1A90001
Gamma-aminobutyric acid receptor subunit alpha-10001
Gamma-aminobutyric acid receptor subunit beta-10001
Gamma-aminobutyric acid receptor subunit alpha-20001
Gamma-aminobutyric acid receptor subunit alpha-30001
Polyunsaturated fatty acid lipoxygenase ALOX150101
Gamma-aminobutyric acid receptor subunit alpha-10112
Gamma-aminobutyric acid receptor subunit beta-10011
Gamma-aminobutyric acid receptor subunit gamma-20112
Gamma-aminobutyric acid receptor subunit alpha-40001
Gamma-aminobutyric acid receptor subunit gamma-20001
Sodium- and chloride-dependent GABA transporter 10101
Gamma-aminobutyric acid receptor subunit beta-30112
Gamma-aminobutyric acid receptor subunit alpha-50011
Sodium- and chloride-dependent GABA transporter 20101
Sodium- and chloride-dependent GABA transporter 30101
Gamma-aminobutyric acid receptor subunit alpha-30011
Gamma-aminobutyric acid receptor subunit alpha-20011
Gamma-aminobutyric acid receptor subunit beta-20011
Sodium- and chloride-dependent betaine transporter0101
Gamma-aminobutyric acid receptor subunit alpha-40011
Fatty-acid amide hydrolase 10101
Gamma-aminobutyric acid receptor subunit alpha-60011
Beta-1 adrenergic receptor 0113
Voltage-dependent L-type calcium channel subunit alpha-1C0101
Bile salt export pump0101
Albumin0011
Cytochrome P450 1A20101
Beta-2 adrenergic receptor0213
Beta-1 adrenergic receptor0213
5-hydroxytryptamine receptor 1A0101
Adenosine receptor A30112
Beta-2 adrenergic receptor0203
Cytochrome P450 2C80101
Beta-3 adrenergic receptor0213
D(2) dopamine receptor0112
Alpha-1B adrenergic receptor0112
Beta-1 adrenergic receptor0214
Alpha-2C adrenergic receptor0124
D(3) dopamine receptor0101
Alpha-2B adrenergic receptor0011
D(1A) dopamine receptor0112
Voltage-dependent L-type calcium channel subunit alpha-1C0101
Alpha-2C adrenergic receptor0011
Alpha-2A adrenergic receptor0011
Alpha-1D adrenergic receptor0112
Endothelin-1 receptor0112
Beta-3 adrenergic receptor0202
5-hydroxytryptamine receptor 1B0213
Adenosine receptor A2a0112
Neuromedin-K receptor0011
Type-1 angiotensin II receptor0112
Cholecystokinin receptor type A0112
5-hydroxytryptamine receptor 70112
Beta-1 adrenergic receptor0101
Alpha-1A adrenergic receptor0124
Alpha-1B adrenergic receptor0012
Vasopressin V1a receptor0112
Alpha-1A adrenergic receptor0112
5-hydroxytryptamine receptor 60213
5-hydroxytryptamine receptor 70101
Beta-2 adrenergic receptor0101
Potassium voltage-gated channel subfamily H member 20101
Voltage-dependent L-type calcium channel subunit alpha-1C0101
Sodium channel protein type 5 subunit alpha0101
Sodium/bile acid cotransporter0101
Beta-2 adrenergic receptor0113
Nuclear receptor subfamily 2 group E member 10022
NFKB1 protein, partial1001
Chain A, Beta-lactamase1001
importin subunit beta-1 isoform 11001
nuclear factor NF-kappa-B p105 subunit isoform 11001
snurportin-11001
histone-lysine N-methyltransferase 2A isoform 2 precursor1001
peptidyl-prolyl cis-trans isomerase NIMA-interacting 11001
GTP-binding nuclear protein Ran isoform 11001
DNA polymerase eta isoform 12002
lethal(3)malignant brain tumor-like protein 1 isoform I1001
caspase-1 isoform alpha precursor1001
DNA dC->dU-editing enzyme APOBEC-3F isoform a1001
Quinolone resistance protein NorA0102
DNA topoisomerase 10101
Chromaffin granule amine transporter0101
Caspase-71001
Synaptic vesicular amine transporter0101
Synaptic vesicular amine transporter0213
Synaptic vesicular amine transporter0101
Chain A, Lysr-type Regulatory Protein0011
Chain A, Lysr-type Regulatory Protein0011
Chain A, Lysr-type Regulatory Protein0011
Chain A, 146aa long hypothetical transcriptional regulator0011
Chain A, Anthranilate phosphoribosyltransferase0101
Chain A, Anthranilate phosphoribosyltransferase0101
Chain A, Anthranilate phosphoribosyltransferase0101
Chain B, Anthranilate phosphoribosyltransferase0101
Chain C, Anthranilate phosphoribosyltransferase0101
Chain A, Anthranilate phosphoribosyltransferase0101
Anthranilate phosphoribosyltransferase0101
BRCA11001
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]