Page last updated: 2024-09-27

Dunnigan Syndrome

This type can be caused by mutation in the gene encoding PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA.

Synonyms(15)

Synonym
Koberling-Dunnigan Syndrome
Familial Partial Lipodystrophy, Kobberling Type
Familial Partial Lipodystrophy
Lipodystrophy, Familial Partial, Dunnigan Type
Lipodystrophy, Familial Partial, Kobberling Type
Lipodystrophy, Familial Partial, Type 1
Lipodystrophy, Familial Partial, Type 2
Dunnigan Syndrome
Lipodystrophy, Familial Partial, Type 3
Lipodystrophy, Familial, of Limbs and Lower Trunk
Lipodystrophy, Reverse Partial
Lipodystrophy, Familial Partial, Associated With PPARg Mutations
Familial Partial Lipodystrophy, Type 3
Familial Partial Lipodystrophy, Type 2
Familial Partial Lipodystrophy, Type 1

Research Excerpts

Overview

ExcerptReference
"Familial partial lipodystrophy are Mendelian disorders involving abnormal body fat distribution and insulin resistance."( Araújo-Vilar, D; Casanueva, FF; Castro-Pais, A; Fernández-Marmiesse, A; González-Méndez, B; Guillín-Amarelle, C; Ordóñez-Mayán, L; Pazos, M; Rodriguez-Cañete, L; Rodríguez-García, S; Sánchez-Iglesias, S, 2016)

Research

Studies (55)

TimeframeStudies, This Condition (%)All Conditions %
pre-19900 (0.00)23.3326
1990's0 (0.00)12.5806
2000's19 (34.55)18.1394
2010's30 (54.55)28.8240
2020's6 (10.91)9.53
DrugIndicatedRelationship StrengthStudiesTrials
carnitine0low10
palmitic acid0low10
clofibric acid0low10
metformin0low50
pioglitazone0low90
troglitazone0low10
spironolactone0low10
glutamine0low10
leucine0low10
histidine0low10
tryptophan0low10
arginine0low30
cdaa0low10
s-adenosylmethionine0low10
nelfinavir0low10
rosiglitazone0low40
lopinavir0low10
angiotensin ii0low10
glycogen0low10
isomethyleugenol0low10
gw96620low10
indinavir sulfate0low10
cysteine0low10
emerin0low40
oligonucleotides0low20
liraglutide0low10
transforming growth factor beta0low20
leptin0medium152

Protein Targets (466)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
glucocerebrosidase2002
DNA polymerase kappa isoform 13003
histone acetyltransferase KAT2A isoform 15005
Atrial natriuretic peptide receptor 30101
Type-1A angiotensin II receptor 0213
Type-1 angiotensin II receptor0011
Type-1B angiotensin II receptor0202
Type-1 angiotensin II receptor0224
Type-2 angiotensin II receptor0202
Type-2 angiotensin II receptor0202
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE4004
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN0022
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN0022
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN0022
thioredoxin reductase4004
phosphopantetheinyl transferase3003
NFKB1 protein, partial2002
GLS protein4004
thyroid stimulating hormone receptor3003
alpha-galactosidase2002
euchromatic histone-lysine N-methyltransferase 26006
cytochrome P450 2C19 precursor3003
chromobox protein homolog 12002
flap endonuclease 15005
DNA polymerase iota isoform a (long)2002
muscarinic acetylcholine receptor M12002
lethal factor (plasmid)1001
Cytochrome P450 3A40619
Nitric oxide synthase, endothelial0002
Nitric oxide synthase, brain0001
Nitric oxide synthase, brain 0001
Nitric oxide synthase, inducible0001
Nitric oxide synthase, inducible0013
Cationic amino acid transporter 30101
ATP-dependent phosphofructokinase3003
Solute carrier family 22 member 50001
Solute carrier family 22 member 50001
Bile salt export pump0909
Solute carrier family 22 member 160001
Solute carrier family 22 member 210001
Solute carrier family 22 member 50001
Chain A, Beta-lactamase1001
USP1 protein, partial6006
TDP1 protein9009
Microtubule-associated protein tau4004
glucocorticoid receptor [Homo sapiens]9009
peroxisome proliferator-activated receptor delta6006
cytochrome P450 2D6 isoform 12002
thyroid hormone receptor beta isoform a3003
cytochrome P450 3A4 isoform 14004
Gamma-aminobutyric acid receptor subunit pi4004
Glutamate receptor ionotropic, NMDA 2D0022
Glutamate receptor ionotropic, NMDA 3B0022
Fatty acid-binding protein, intestinal0202
Gamma-aminobutyric acid receptor subunit beta-14004
Gamma-aminobutyric acid receptor subunit delta4004
Gamma-aminobutyric acid receptor subunit gamma-24004
Gamma-aminobutyric acid receptor subunit alpha-54004
Gamma-aminobutyric acid receptor subunit alpha-34004
Peroxisome proliferator-activated receptor alpha0224
Gamma-aminobutyric acid receptor subunit gamma-14004
Gamma-aminobutyric acid receptor subunit alpha-24004
Gamma-aminobutyric acid receptor subunit alpha-44004
Gamma-aminobutyric acid receptor subunit gamma-34004
Gamma-aminobutyric acid receptor subunit alpha-64004
Peroxisome proliferator-activated receptor gamma07717
Peroxisome proliferator-activated receptor gamma0145
Gamma-aminobutyric acid receptor subunit alpha-14004
Gamma-aminobutyric acid receptor subunit beta-34004
Gamma-aminobutyric acid receptor subunit beta-24004
Peroxisome proliferator-activated receptor delta0224
Glutamate receptor ionotropic, NMDA 10022
Neuronal acetylcholine receptor subunit alpha-70011
Peroxisome proliferator-activated receptor alpha1349
Glutamate receptor ionotropic, NMDA 2A0022
Glutamate receptor ionotropic, NMDA 2B0022
Glutamate receptor ionotropic, NMDA 2C0022
Glutamate receptor ionotropic, NMDA 3A0022
GABA theta subunit4004
Gamma-aminobutyric acid receptor subunit epsilon4004
Chain A, Glutamine Binding Protein0011
15-lipoxygenase, partial1001
arylsulfatase A3003
Bloom syndrome protein isoform 12002
peripheral myelin protein 22 isoform 13003
histone-lysine N-methyltransferase 2A isoform 2 precursor2002
Carbonic anhydrase 10004
Carbonic anhydrase 20307
Neutral amino acid transporter A0101
Asc-type amino acid transporter 10101
Neutral amino acid transporter B(0)0101
Carbonic anhydrase-like protein, putative0003
Amino acid transporter0101
Chain A, Ferritin light chain4004
Luciferase3003
Nrf21001
SMAD family member 24004
ATAD5 protein, partial2002
SMAD family member 34004
GLI family zinc finger 36006
Thrombopoietin1001
AR protein7007
estrogen receptor 2 (ER beta)4004
nuclear receptor subfamily 1, group I, member 34004
retinoic acid nuclear receptor alpha variant 16006
retinoid X nuclear receptor alpha4004
estrogen-related nuclear receptor alpha7007
pregnane X nuclear receptor4004
estrogen nuclear receptor alpha8008
bromodomain adjacent to zinc finger domain 2B3003
peroxisome proliferator activated receptor gamma7007
vitamin D (1,25- dihydroxyvitamin D3) receptor3003
pyruvate kinase1001
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)1001
aryl hydrocarbon receptor2002
neutrophil cytosol factor 10101
cellular tumor antigen p53 isoform a1001
cytochrome P450 2C9 precursor1001
thyroid hormone receptor beta isoform 27007
heat shock protein beta-12002
mitogen-activated protein kinase 11001
serine/threonine-protein kinase mTOR isoform 11001
eyes absent homolog 2 isoform a1001
nuclear factor erythroid 2-related factor 2 isoform 15005
geminin8008
survival motor neuron protein isoform d1001
M-phase phosphoprotein 82002
muscleblind-like protein 1 isoform 11001
lamin isoform A-delta104004
pyruvate kinase PKM isoform b1001
Voltage-dependent calcium channel gamma-2 subunit4004
Cellular tumor antigen p537007
Integrin beta-31001
Integrin alpha-IIb1001
Ornithine decarboxylase1001
Glutamate receptor 24004
Histamine H2 receptor2002
Nuclear receptor ROR-gamma0101
Chain A, HISTIDINE-BINDING PROTEIN0011
Carbonic anhydrase 120002
Plasma kallikrein0002
Carbonic anhydrase 30002
Histidine-binding periplasmic protein0011
Carbonic anhydrase 40002
Carbonic anhydrase 60002
Adenosine receptor A10001
5-hydroxytryptamine receptor 1D0001
Adenosine receptor A2a0001
Carbonic anhydrase 5A, mitochondrial0002
Glutamate receptor ionotropic, NMDA 1 0013
Carbonic anhydrase0002
Carbonic anhydrase 70002
Carbonic anhydrase0002
Glutamate receptor ionotropic, NMDA 2A 0002
Glutamate receptor ionotropic, NMDA 2B0002
Glutamate receptor ionotropic, NMDA 2C0002
Large neutral amino acids transporter small subunit 10303
Glutaminyl-peptide cyclotransferase0101
Carbonic anhydrase 90002
Carbonic anhydrase 0002
Carbonic anhydrase0002
Carbonic anhydrase0002
Glutamate receptor ionotropic, NMDA 2D0002
Carbonic anhydrase 0002
Carbonic anhydrase 130001
Glutamate receptor ionotropic, NMDA 3B0002
Carbonic anhydrase 40001
Carbonic anhydrase 150002
Carbonic anhydrase 130002
Glutamate receptor ionotropic, NMDA 3A0002
Carbonic anhydrase 140002
Carbonic anhydrase 5B, mitochondrial0002
Chain A, PROTEIN (PROTEASE)0101
Chain B, PROTEIN (PROTEASE)0101
Chain A, PROTEIN (PROTEASE)0101
Chain B, PROTEIN (PROTEASE)0101
Chain A, HIV-1 PROTEASE0101
Chain B, HIV-1 PROTEASE0101
Chain A, HIV-II PROTEASE0101
Chain B, HIV-II PROTEASE0101
Chain A, POL polyprotein0011
Chain B, POL polyprotein0011
Chain A, POL polyprotein0011
Chain B, POL polyprotein0011
Chain A, POL polyprotein0011
Chain B, POL polyprotein0011
Chain A, POL polyprotein0011
Chain B, POL polyprotein0011
Chain A, protease RETROPEPSIN0101
Chain B, protease RETROPEPSIN0101
Chain A, protease RETROPEPSIN0101
Chain B, protease RETROPEPSIN0101
Chain A, protease RETROPEPSIN0101
Chain B, protease RETROPEPSIN0101
Chain A, POL polyprotein0101
Chain B, POL polyprotein0101
Chain A, POL polyprotein0101
Chain B, POL polyprotein0101
Chain A, HIV-1 protease0101
Chain B, HIV-1 protease0101
Chain A, Pol polyprotein0101
Chain B, Pol polyprotein0101
Chain A, Pol polyprotein0101
Chain B, Pol polyprotein0101
Chain A, Pol polyprotein0101
Chain B, Pol polyprotein0101
Chain A, Pol polyprotein0101
Chain B, Pol polyprotein0101
Chain A, Hiv-1 Protease0101
Chain B, Hiv-1 Protease0101
Chain A, Hiv-1 Protease0101
Chain B, Hiv-1 Protease0101
Chain A, Hiv-1 Protease0101
Chain B, Hiv-1 Protease0101
cytochrome P450 family 3 subfamily A polypeptide 45005
G3003
cytochrome P450 2D63003
Solute carrier family 22 member 20202
Solute carrier family 22 member 1 0202
ATP-binding cassette sub-family C member 30808
Multidrug resistance-associated protein 40808
Solute carrier family 22 member 30101
Interferon beta3003
HLA class I histocompatibility antigen, B alpha chain 3003
Albumin0006
Gag-Pol polyprotein0404
Gag-Pol polyprotein0101
Gag-Pol polyprotein0202
Gag polyprotein0101
Gag-Pol polyprotein0303
ATP-dependent translocase ABCB10404
Replicase polyprotein 1ab0314
Replicase polyprotein 1ab0415
Cytochrome P450 2D60101
Gag-Pol polyprotein0303
Alpha-1B adrenergic receptor0606
Substance-K receptor0404
Alpha-1D adrenergic receptor0303
Thromboxane-A synthase 0404
Gag-Pol polyprotein0303
Alpha-1A adrenergic receptor0606
Thromboxane-A synthase0001
Genome polyprotein 0101
Solute carrier family 22 member 10203
Protease 06313
Multidrug and toxin extrusion protein 20101
Inositol hexakisphosphate kinase 13003
Canalicular multispecific organic anion transporter 10505
Multidrug and toxin extrusion protein 10303
Protease 06411
Protease 0101
cytochrome P450 2C9, partial3003
Chain A, AMINOPEPTIDASE0101
Chain A, AMINOPEPTIDASE0101
Chain A, Leucine Aminopeptidase0101
Alkaline phosphatase, tissue-nonspecific isozyme0202
Intestinal-type alkaline phosphatase0202
Proton-coupled amino acid transporter 10102
Phospholipase A-2-activating protein0202
Glucagon-like peptide 1 receptor0224
Chain A, protease0101
Chain B, protease0101
Chain A, protease0011
Chain B, protease0011
Chain A, protease0011
Chain B, protease0011
Chain A, protease0011
Chain B, protease0011
Chain A, protease0011
Chain B, protease0011
Chain A, protease0011
Chain B, protease0011
Chain A, Protease0101
Chain B, Protease0101
Chain A, Protease0101
Chain B, Protease0101
Chain A, Protease0101
Chain B, Protease0101
Chain A, PROTEASE RETROPEPSIN0101
Chain B, PROTEASE RETROPEPSIN0101
Chain A, Protease Retropepsin0101
Chain B, Protease Retropepsin0101
Chain A, Protease Retropepsin0101
Chain B, Protease Retropepsin0101
RAR-related orphan receptor gamma4004
Fumarate hydratase1001
Smad33003
progesterone receptor3003
EWS/FLI fusion protein4004
farnesoid X nuclear receptor4004
polyprotein1001
67.9K protein3003
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a5005
nuclear receptor subfamily 1, group I, member 22002
Spike glycoprotein0011
Replicase polyprotein 1ab0112
potassium voltage-gated channel subfamily H member 2 isoform d1001
nuclear receptor ROR-gamma isoform 14004
peripheral myelin protein 225005
Transmembrane protease serine 20011
Gag-Pol polyprotein0101
Procathepsin L0011
Replicase polyprotein 1a0011
Replicase polyprotein 1ab0011
Spike glycoprotein3014
Potassium voltage-gated channel subfamily H member 20303
CAAX prenyl protease 1 homolog0101
Plasmepsin V 0101
ATPase family AAA domain-containing protein 53003
Ataxin-23003
Angiotensin-converting enzyme 2 0011
Broad substrate specificity ATP-binding cassette transporter ABCG20303
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a3003
Dihydrofolate reductase0303
Dipeptidyl peptidase 40101
Chain A, ASPARTYLPROTEASE0101
Chain B, ASPARTYLPROTEASE0101
glp-1 receptor, partial2002
nonstructural protein 11001
IDH12002
nuclear factor erythroid 2-related factor 2 isoform 21001
DNA polymerase beta1001
urokinase-type plasminogen activator precursor1001
plasminogen precursor1001
urokinase plasminogen activator surface receptor precursor1001
Epidermal growth factor receptor0101
Tyrosine-protein kinase Lck0101
Tyrosine-protein kinase Fyn0101
Aldo-keto reductase family 1 member B10202
Muscarinic acetylcholine receptor M50202
Adenosine receptor A30404
Polyunsaturated fatty acid lipoxygenase ALOX150101
Beta-3 adrenergic receptor0202
Androgen receptor0405
Potassium voltage-gated channel subfamily E member 10101
Cytochrome P450 3A50213
ATP-dependent translocase ABCB10101
D(1A) dopamine receptor0202
Sodium-dependent noradrenaline transporter 0202
Cruzipain0101
Mitogen-activated protein kinase 3 0101
Mu-type opioid receptor0202
Delta-type opioid receptor0202
Kappa-type opioid receptor0202
Potassium voltage-gated channel subfamily KQT member 10101
Sodium-dependent dopamine transporter 0202
TAR DNA-binding protein 431001
Sodium channel protein type 5 subunit alpha0101
Mitogen-activated protein kinase 140112
Potassium voltage-gated channel subfamily D member 30101
Chain A, Fatty acid-binding protein, adipocyte0101
acetylcholinesterase2002
Acetylcholinesterase0101
Toll-like receptor 20101
Prostaglandin G/H synthase 1 0101
Fatty acid-binding protein, adipocyte0213
Tyrosine-protein phosphatase non-receptor type 10404
Prostaglandin G/H synthase 20101
Fatty acid-binding protein 50213
Olfactory receptor 51E20011
Transient receptor potential cation channel subfamily V member 20101
aldehyde dehydrogenase 1 family, member A11001
CDGSH iron-sulfur domain-containing protein 10202
tyrosine-protein kinase Yes1001
Free fatty acid receptor 10022
Bile salt export pump0303
Peroxisome proliferator-activated receptor gamma0101
Muscarinic acetylcholine receptor M10033
Muscarinic acetylcholine receptor M30033
Muscarinic acetylcholine receptor M40033
Steryl-sulfatase0101
Muscarinic acetylcholine receptor M50033
Muscarinic acetylcholine receptor M20033
Carnitine O-palmitoyltransferase 2, mitochondrial0202
Amine oxidase [flavin-containing] B0303
Amine oxidase [flavin-containing] A 0303
Amine oxidase [flavin-containing] A0303
Carnitine O-palmitoyltransferase 2, mitochondrial0202
Amine oxidase [flavin-containing] B0606
Carnitine O-palmitoyltransferase 1, liver isoform0202
Enoyl-[acyl-carrier-protein] reductase [NADH] 0101
CDGSH iron-sulfur domain-containing protein 20202
CDGSH iron-sulfur domain-containing protein 10404
Chain A, HADH2 protein1001
Chain B, HADH2 protein1001
Chain A, 2-oxoglutarate Oxygenase2002
thyrotropin-releasing hormone receptor1001
v-jun sarcoma virus 17 oncogene homolog (avian)2002
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 11001
Cytochrome P450 2C9 0112
Catechol O-methyltransferase0011
C-C chemokine receptor type 20101
Cannabinoid receptor 20011
Mu-type opioid receptor0101
ATP-binding cassette sub-family C member 80202
ATP-sensitive inward rectifier potassium channel 110202
Sodium/bile acid cotransporter0101
Thrombin 0011
Met repressor 0022
Protein arginine N-methyltransferase 50011
Histone H3K27 methylase0001
Phenylethanolamine N-methyltransferase0012
S-adenosylmethionine decarboxylase proenzyme0102
Protein-L-isoaspartate(D-aspartate) O-methyltransferase0101
Catechol O-methyltransferase0001
Protein arginine N-methyltransferase 10101
Methylosome protein 500011
Chain A, Mineralocorticoid receptor0101
Chain A, Mineralocorticoid receptor0101
pregnane X receptor1001
activating transcription factor 62002
Histone H2A.x2002
parathyroid hormone/parathyroid hormone-related peptide receptor precursor1001
Vpr1001
Estrogen receptor0213
Glucocorticoid receptor0213
Progesterone receptor0213
Glycine receptor subunit alpha-10202
Mineralocorticoid receptor 0203
Androgen receptor0213
Glycine receptor subunit beta0202
Glycine receptor subunit alpha-20202
Glycine receptor subunit alpha-30202
Sodium-dependent serotonin transporter0101
Cytochrome P450 2C190101
Estrogen receptor beta0112
Nuclear receptor subfamily 1 group I member 20022
UDP-glucuronosyltransferase 2B70001
UDP-glucuronosyltransferase 1A40001
Serine/threonine-protein kinase mTOR0101
Peptidyl-prolyl cis-trans isomerase FKBP1A0213
Peptidyl-prolyl cis-trans isomerase FKBP1B0011
Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform0101
Peptidyl-prolyl cis-trans isomerase FKBP50101
Splicing factor 3B subunit 30101
Solute carrier organic anion transporter family member 1B10101
Chain A, TYROSYL-DNA PHOSPHODIESTERASE1001
Chain A, ATP-DEPENDENT DNA HELICASE Q11001
regulator of G-protein signaling 41001
thyroid stimulating hormone receptor2002
vitamin D3 receptor isoform VDRA1001
Polyunsaturated fatty acid lipoxygenase ALOX15B1001
UDP-glucuronosyltransferase 1-60101
UDP-glucuronosyltransferase 1A1 0001
Mitogen-activated protein kinase 10101
Indoleamine 2,3-dioxygenase 10101
5-hydroxytryptamine receptor 2B0202
Forkhead box protein M10202
Indoleamine 2,3-dioxygenase 20101
UDP-glucuronosyltransferase 1A100001
Chain A, Trp Rna-binding Attenuation Protein0011
Chain K, Trp Rna-binding Attenuation Protein0011
Chain B, tryptophanyl-tRNA synthetase0011
Chain C, Tryptophanyl-tRNA synthetase II0011
thioredoxin glutathione reductase1001
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)1001
Myeloperoxidase0101
Stromelysin-10101
Indoleamine 2,3-dioxygenase 10102
Substance-P receptor0101
Tryptophan 2,3-dioxygenase0102
SLC16A10 protein0001
Uracil nucleotide/cysteinyl leukotriene receptor0101
Tryprostatin B synthase0001
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase0011
Monocarboxylate transporter 100001
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]