Page last updated: 2024-09-27

Myositis, Orbital

Inflammation of the extraocular muscle of the eye. It is characterized by swelling which can lead to ischemia, fibrosis, or ORBITAL PSEUDOTUMOR.

Synonyms(2)

Synonym
Orbital Myositis
Myositis, Orbital

Research Excerpts

Overview

ExcerptReference
"Orbital myositis is a previously unreported complication of strabismus surgery."( Archer, SM; Wolf, AB; Yang, MB, 2007)
"Orbital myositis is an inflammatory process that primarily involves the extraocular muscles and most commonly affects young adults in the third decade of life, with a female predilection."( Costa, RM; Dumitrascu, OM; Gordon, LK, 2009)
"Orbital myositis is an extremely rare extra-intestinal manifestation of Crohn's disease."( Cheng, S; Vu, P, 2009)
"Orbital myositis is a rare extra-intestinal manifestation of inflammatory bowel disease."( Fedorak, RN; Kroeker, KI; Verma, S, 2013)

Treatment

ExcerptReference
"She was diagnosed with idiopathic orbital myositis and was successfully treated with oral corticosteroids."( Franco, J; Lee, NG, 2021)

Research

Studies (48)

TimeframeStudies, This Condition (%)All Conditions %
pre-19904 (8.33)23.3326
1990's0 (0.00)12.5806
2000's6 (12.50)18.1394
2010's29 (60.42)28.8240
2020's9 (18.75)9.53
DrugIndicatedRelationship StrengthStudiesTrials
thiamine0low10
alendronate0low20
gentamicin0low10
pamidronate0low10
prednisolone0low80
prednisone0low60
biguanides0low10
triamcinolone acetonide0low10
methylprednisolone0low100
pyridostigmine bromide0low10
vantocil0low10
propiconazole0low130
simvastatin0low10
propamidine isethionate0low10
zoledronic acid0low10
methotrexate0low10
moxifloxacin0low10
tacrolimus0low10
mercaptopurine0low10
tetracycline0low10
mysteclin f0low10
vitamin b 120low10
cyclosporine0low10
exudates0low10
acyclovir0low50
eye0low40

Protein Targets (432)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
Chain E, Purine nucleoside phosphorylase0101
Chain A, HADH2 protein4004
Chain B, HADH2 protein4004
Chain A, ATP-DEPENDENT DNA HELICASE Q11001
Chain A, Ferritin light chain6006
Thymidine kinase 0101
thioredoxin reductase4004
phosphopantetheinyl transferase5005
GLS protein2002
TDP1 protein100010
Smad33003
thyroid stimulating hormone receptor2002
EWS/FLI fusion protein7007
arylsulfatase A4004
euchromatic histone-lysine N-methyltransferase 28008
activating transcription factor 62002
Histone H2A.x7007
Bloom syndrome protein isoform 14004
hemoglobin subunit beta3003
atrial natriuretic peptide receptor 1 precursor1001
ubiquitin carboxyl-terminal hydrolase 2 isoform a1001
lamin isoform A-delta109009
Solute carrier family 22 member 1 0103
ATP-binding cassette sub-family C member 3011011
Multidrug resistance-associated protein 4011012
Solute carrier family 22 member 60001
Bile salt export pump0303
Bile salt export pump014014
Purine nucleoside phosphorylase0101
Thymidine kinase, cytosolic0001
POU domain, class 2, transcription factor 20001
Cytochrome P450 2C9 0303
Cytochrome P450 2J20303
Disintegrin and metalloproteinase domain-containing protein 171001
Purine nucleoside phosphorylase0022
Solute carrier family 22 member 60002
Thymidine kinase 0101
Solute carrier family 22 member 80003
Canalicular multispecific organic anion transporter 1011011
Thymidine kinase0101
Chain A, farnesyl pyrophosphate synthase0101
Geranylgeranyl pyrophosphate synthase0405
Farnesyl pyrophosphate synthase0606
Acetylcholinesterase0202
Hypoxanthine-guanine phosphoribosyltransferase0202
Farnesyl pyrophosphate synthase 0404
Farnesyl pyrophosphate synthase 0202
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE3003
Chain A, TYROSYL-DNA PHOSPHODIESTERASE4004
interleukin 82002
acetylcholinesterase3003
RAR-related orphan receptor gamma8008
SMAD family member 25005
ATAD5 protein, partial4004
Fumarate hydratase3003
SMAD family member 35005
GLI family zinc finger 39009
Microtubule-associated protein tau2002
AR protein130013
thioredoxin glutathione reductase4004
nuclear receptor subfamily 1, group I, member 37007
glucocorticoid receptor [Homo sapiens]130013
retinoic acid nuclear receptor alpha variant 18008
retinoid X nuclear receptor alpha7007
estrogen-related nuclear receptor alpha120012
farnesoid X nuclear receptor6006
pregnane X nuclear receptor9009
estrogen nuclear receptor alpha130013
G4004
polyprotein3003
P531001
peroxisome proliferator-activated receptor delta6006
peroxisome proliferator activated receptor gamma7007
IDH16006
aryl hydrocarbon receptor5005
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a110011
thyroid stimulating hormone receptor2002
v-jun sarcoma virus 17 oncogene homolog (avian)4004
peripheral myelin protein 22 isoform 13003
cellular tumor antigen p53 isoform a3003
thyroid hormone receptor beta isoform 27007
heat shock protein beta-14004
nuclear factor erythroid 2-related factor 2 isoform 18008
DNA polymerase iota isoform a (long)4004
geminin110011
peripheral myelin protein 223003
survival motor neuron protein isoform d4004
cytochrome P450 3A4 isoform 13003
M-phase phosphoprotein 83003
muscleblind-like protein 1 isoform 14004
muscarinic acetylcholine receptor M12002
Gamma-aminobutyric acid receptor subunit pi3003
Voltage-dependent calcium channel gamma-2 subunit6006
Interferon beta6006
HLA class I histocompatibility antigen, B alpha chain 4004
Cellular tumor antigen p53100010
Gamma-aminobutyric acid receptor subunit beta-13003
Gamma-aminobutyric acid receptor subunit delta3003
Gamma-aminobutyric acid receptor subunit gamma-23003
Glutamate receptor 26006
Gamma-aminobutyric acid receptor subunit alpha-53003
Gamma-aminobutyric acid receptor subunit alpha-33003
Gamma-aminobutyric acid receptor subunit gamma-13003
Gamma-aminobutyric acid receptor subunit alpha-23003
Gamma-aminobutyric acid receptor subunit alpha-43003
Gamma-aminobutyric acid receptor subunit gamma-33003
Gamma-aminobutyric acid receptor subunit alpha-63003
Nuclear receptor ROR-gamma3003
Gamma-aminobutyric acid receptor subunit alpha-13003
Gamma-aminobutyric acid receptor subunit beta-33003
Gamma-aminobutyric acid receptor subunit beta-23003
GABA theta subunit3003
Inositol hexakisphosphate kinase 14004
ATPase family AAA domain-containing protein 5100010
Ataxin-2110011
Gamma-aminobutyric acid receptor subunit epsilon3003
Protein-arginine deiminase type-40303
cytochrome P450 2C9, partial4004
Chain A, Beta-lactamase6006
Chain A, Putative fructose-1,6-bisphosphate aldolase2002
Chain A, JmjC domain-containing histone demethylation protein 3A3003
Chain A, 2-oxoglutarate Oxygenase2002
apical membrane antigen 1, AMA11001
aldehyde dehydrogenase 1 family, member A14004
progesterone receptor8008
cytochrome P450 2D63003
bromodomain adjacent to zinc finger domain 2B4004
vitamin D (1,25- dihydroxyvitamin D3) receptor5005
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 12002
transcriptional regulator ERG isoform 32002
urokinase-type plasminogen activator precursor3003
plasminogen precursor3003
urokinase plasminogen activator surface receptor precursor3003
histone acetyltransferase KAT2A isoform 13003
UDP-glucose 6-dehydrogenase0101
Solute carrier family 22 member 80001
Hypoxanthine-guanine phosphoribosyltransferase0001
Integrin beta-32002
Integrin alpha-IIb2002
UDP-glucose 6-dehydrogenase0101
Prostaglandin G/H synthase 10101
UDP-glucuronosyltransferase 1A1 0101
Chain B, DIHYDROFOLATE REDUCTASE0011
Chain B, DIHYDROFOLATE REDUCTASE0011
Chain B, DIHYDROFOLATE REDUCTASE0011
acid sphingomyelinase1001
dopamine D1 receptor1001
ClpP1001
15-lipoxygenase, partial1001
USP1 protein, partial2002
estrogen receptor 2 (ER beta)4004
67.9K protein1001
Thymidylate synthase 0101
alpha-galactosidase3003
Thymidylate synthase 0101
polyunsaturated fatty acid lipoxygenase ALOX121001
vitamin D3 receptor isoform VDRA5005
chromobox protein homolog 15005
nuclear factor erythroid 2-related factor 2 isoform 28008
importin subunit beta-1 isoform 11001
DNA polymerase beta2002
nuclear receptor coactivator 1 isoform 1 [Homo sapiens]0101
flap endonuclease 12002
snurportin-11001
peptidyl-prolyl cis-trans isomerase NIMA-interacting 11001
DNA polymerase eta isoform 11001
transactivating tegument protein VP16 [Human herpesvirus 1]0202
DNA polymerase kappa isoform 13003
caspase-1 isoform alpha precursor1001
nuclear receptor coactivator 3 isoform a0101
Toll-like receptor 40101
Fatty-acid amide hydrolase 10101
ATP-binding cassette sub-family C member 30102
Dihydrofolate reductase0203
Dihydrofolate reductase0203
Dihydrofolate reductase 0101
Dihydrofolate reductase0101
Dihydrofolate reductase0101
Dihydrofolate reductase0203
Thymidylate synthase0101
Tyrosine-protein kinase ABL10011
Carbonic anhydrase 20213
Thymidylate synthase0202
Bifunctional dihydrofolate reductase-thymidylate synthase0101
Thymidylate synthase0202
5-hydroxytryptamine receptor 2C0102
High mobility group protein B10011
Dihydrofolate reductase0101
Thymidylate synthase0101
Dihydrofolate reductase0224
Glucose-6-phosphate 1-dehydrogenase0101
Bifunctional dihydrofolate reductase-thymidylate synthase0101
Folate receptor beta0101
5-hydroxytryptamine receptor 2A0101
Cytochrome P450 11B1, mitochondrial 0101
Folate receptor alpha0101
Dihydrofolate reductase0202
Histidine decarboxylase0101
Trifunctional purine biosynthetic protein adenosine-30101
Cyclin-dependent kinase 20011
Bifunctional purine biosynthesis protein ATIC0202
Multidrug resistance-associated protein 1 0001
Delta-type opioid receptor0101
Mu-type opioid receptor0101
Kappa-type opioid receptor0101
Reduced folate transporter0202
Folylpolyglutamate synthase, mitochondrial0103
6-phosphogluconate dehydrogenase, decarboxylating0101
Caspase-71001
Spike glycoprotein5016
Solute carrier organic anion transporter family member 1A30001
Dihydrofolate reductase0101
Pteridine reductase 10101
Folylpolyglutamate synthase, mitochondrial0103
Bifunctional dihydrofolate reductase-thymidylate synthase0101
TAR DNA-binding protein 434004
Bifunctional dihydrofolate reductase-thymidylate synthase0101
Canalicular multispecific organic anion transporter 10102
Trifunctional purine biosynthetic protein adenosine-30101
Solute carrier family 22 member 200101
Dihydrofolate reductase 0101
Solute carrier family 22 member 60101
Dihydrofolate reductase0101
ATP-binding cassette sub-family C member 110001
Proton-coupled folate transporter0101
Multidrug resistance associated protein0102
Solute carrier organic anion transporter family member 1B30001
Solute carrier family 22 member 110002
Broad substrate specificity ATP-binding cassette transporter ABCG20102
ATP-dependent phosphofructokinase2002
hypoxia-inducible factor 1 alpha subunit4004
PPM1D protein1001
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)4004
nonstructural protein 12002
nuclear receptor subfamily 1, group I, member 24004
Nuclear receptor subfamily 1 group I member 20022
Glucocorticoid receptor010217
Glycine receptor subunit alpha-1010010
Androgen receptor0303
Glycine receptor subunit beta010010
Glycine receptor subunit alpha-2010010
Glycine receptor subunit alpha-3010010
Nuclear receptor subfamily 1 group I member 20011
Voltage-dependent L-type calcium channel subunit alpha-1C0101
Voltage-dependent L-type calcium channel subunit alpha-1F0202
Cytochrome P450 3A40303
DNA gyrase subunit B0101
DNA gyrase subunit A0102
DNA gyrase subunit B0102
DNA topoisomerase 4 subunit A0101
DNA gyrase subunit B0101
Replicase polyprotein 1ab0112
Replicase polyprotein 1ab0112
DNA topoisomerase 2-alpha0001
Potassium voltage-gated channel subfamily E member 10101
DNA gyrase subunit A0101
Voltage-dependent L-type calcium channel subunit alpha-1C0101
Potassium voltage-gated channel subfamily KQT member 10101
DNA gyrase subunit B0102
DNA gyrase subunit A0102
Voltage-dependent L-type calcium channel subunit alpha-1D 0202
Potassium voltage-gated channel subfamily H member 20102
Voltage-dependent L-type calcium channel subunit alpha-1S0202
Voltage-dependent L-type calcium channel subunit alpha-1C0202
Sodium channel protein type 5 subunit alpha0101
microphthalmia-associated transcription factor isoform 90101
Zinc finger protein mex-50001
luciferase0001
cytochrome P450 family 3 subfamily A polypeptide 45005
Fatty acid-binding protein, liver0101
Estrogen receptor0202
Progesterone receptor0203
Glucocorticoid receptor0112
Glucocorticoid receptor0011
Corticosteroid-binding globulin0101
Mineralocorticoid receptor 0213
Androgen receptor0202
Glutamine synthetase0011
Histamine H1 receptor0011
Prostaglandin G/H synthase 20202
Nociceptin receptor0011
Estrogen receptor beta0202
pregnane X receptor2002
nuclear receptor ROR-gamma isoform 15005
glp-1 receptor, partial2002
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)1001
thyroid hormone receptor beta isoform a1001
heat shock protein HSP 90-alpha isoform 20102
Polyunsaturated fatty acid lipoxygenase ALOX15B1001
Histamine H2 receptor1001
Guanine nucleotide-binding protein G1001
heat shock protein 90, putative0001
endonuclease IV1001
NS5 0011
Thrombopoietin1001
Spike glycoprotein0011
Replicase polyprotein 1ab0011
glycogen synthase kinase-3 beta isoform 10011
Transmembrane protease serine 20011
Rap guanine nucleotide exchange factor 31001
Polymerase basic protein 20011
RNA-directed RNA polymerase catalytic subunit0011
Polymerase acidic protein0011
Procathepsin L0011
Replicase polyprotein 1a0011
Replicase polyprotein 1ab0011
Adenosine receptor A30101
Adenosylhomocysteinase0002
Adenosine receptor A2a0101
Adenosine receptor A10101
Adenosine receptor A10101
Genome polyprotein0011
Angiotensin-converting enzyme 2 0011
PINK11001
regulator of G-protein signaling 41001
Parkin1001
photoreceptor-specific nuclear receptor0101
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a2002
serine/threonine-protein kinase PLK11001
DNA dC->dU-editing enzyme APOBEC-3G isoform 11001
3-hydroxy-3-methylglutaryl-coenzyme A reductase0202
ATP-dependent translocase ABCB10101
Insulin receptor 0101
Nuclear receptor subfamily 4 group A member 20011
3-hydroxy-3-methylglutaryl-coenzyme A reductase 0101
3-hydroxy-3-methylglutaryl-coenzyme A reductase0101
Sigma non-opioid intracellular receptor 10101
Solute carrier organic anion transporter family member 1B10202
UDP-glucuronosyltransferase 2B70001
Cytochrome P450 3A50101
UDP-glucuronosyltransferase 1A40001
Serine/threonine-protein kinase mTOR0101
Peptidyl-prolyl cis-trans isomerase FKBP1A0213
Peptidyl-prolyl cis-trans isomerase FKBP1B0011
Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform0101
Peptidyl-prolyl cis-trans isomerase FKBP50101
Splicing factor 3B subunit 30101
90-kda heat shock protein beta HSP90 beta, partial0101
estrogen receptor beta isoform 10101
tyrosine-protein phosphatase non-receptor type 7 isoform 20101
Dihydroxyacetone phosphate acyltransferase0001
30S ribosomal protein S60101
30S ribosomal protein S70101
50S ribosomal protein L150101
Tetracycline resistance protein, class B0001
Muscarinic acetylcholine receptor M20101
72 kDa type IV collagenase0202
Stromelysin-10101
50S ribosomal protein L100101
50S ribosomal protein L110101
50S ribosomal protein L7/L120101
50S ribosomal protein L190101
50S ribosomal protein L10101
50S ribosomal protein L200101
50S ribosomal protein L270101
50S ribosomal protein L280101
50S ribosomal protein L290101
50S ribosomal protein L310101
50S ribosomal protein L31 type B0101
50S ribosomal protein L320101
50S ribosomal protein L330101
50S ribosomal protein L340101
50S ribosomal protein L350101
50S ribosomal protein L360101
30S ribosomal protein S100101
30S ribosomal protein S110101
30S ribosomal protein S120101
30S ribosomal protein S130101
30S ribosomal protein S160101
30S ribosomal protein S180101
30S ribosomal protein S190101
30S ribosomal protein S200101
30S ribosomal protein S20101
30S ribosomal protein S30101
30S ribosomal protein S40101
30S ribosomal protein S50101
30S ribosomal protein S80101
30S ribosomal protein S90101
50S ribosomal protein L130101
50S ribosomal protein L140101
50S ribosomal protein L160101
50S ribosomal protein L230101
30S ribosomal protein S150101
Multidrug transporter MdfA0101
50S ribosomal protein L170101
50S ribosomal protein L210101
50S ribosomal protein L300101
50S ribosomal protein L60101
30S ribosomal protein S140101
30S ribosomal protein S170101
30S ribosomal protein S10101
50S ribosomal protein L180101
Alpha-1B adrenergic receptor0101
Neutrophil collagenase0202
Alpha-1D adrenergic receptor0101
Alpha-synuclein0101
Alpha-1A adrenergic receptor0101
Collagenase 30101
Cannabinoid receptor 10101
50S ribosomal protein L20101
50S ribosomal protein L30101
50S ribosomal protein L240101
50S ribosomal protein L40101
50S ribosomal protein L220101
50S ribosomal protein L50101
30S ribosomal protein S210101
50S ribosomal protein L250101
50S ribosomal protein L36 20101
Integrase 0101
P2Y purinoceptor 120101
Solute carrier family 22 member 70001
Chain A, ykoF0011
Chain B, ykoF0011
Chain A, ThiT0011
Thiamine transporter ThiT0011
Carbonic anhydrase 10202
Carbonic anhydrase 60101
Transketolase0011
Thiamine-binding periplasmic protein0011
Solute carrier family 22 member 10101
Solute carrier family 22 member 20101
NFKB1 protein, partial1001
procathepsin L isoform 1 preproprotein0101
Butyrophilin subfamily 3 member A10012
Carbonic anhydrase 120101
Matrix metalloproteinase-90101
Farnesyl diphosphate synthase0101
Matrix metalloproteinase-140101
Geranylgeranyl pyrophosphate synthase0202
Carbonic anhydrase 90101
H0101
Carbonic anhydrase 140101
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]