Page last updated: 2024-09-27

Cardiac Sinus Arrest

The omission of atrial activation that is caused by transient cessation of impulse generation at the SINOATRIAL NODE. It is characterized by a prolonged pause without P wave in an ELECTROCARDIOGRAM. Sinus arrest has been associated with sleep apnea (REM SLEEP-RELATED SINUS ARREST).

Synonyms(3)

Synonym
Sinus Arrest, Cardiac
Cardiac Sinus Arrest
Cardiac Sinus Pause

Research

Studies (20)

TimeframeStudies, This Condition (%)All Conditions %
pre-19900 (0.00)23.3326
1990's0 (0.00)12.5806
2000's3 (15.00)18.1394
2010's14 (70.00)28.8240
2020's3 (15.00)9.53
DrugIndicatedRelationship StrengthStudiesTrials
urea0low10
aspirin0low10
carbamazepine0low20
apnea0low10
papaverine0low10
piracetam0low10
prednisone0low10
lithium carbonate0low10
d,d-t80-prallethrin0low10
levobunolol0low10
fomesafen0low10
clopidogrel0low10
adenosine0low10
fluorodeoxyglucose f180low10
sertraline0low10
voriconazole0low10
rivastigmine0low10
landiolol0low10
atropine0low10
digitoxin0low10
lithium0low10
levetiracetam0low10
grayanotoxin i0low10
ticagrelor0low10
pyrethrins0low10

Protein Targets (442)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE2002
Chain A, Membrane lipoprotein tmpC0011
Chain A, Membrane lipoprotein tmpC0011
Chain A, Membrane lipoprotein tmpC0011
Chain A, Structure of PAE2307 in complex with adenosine0011
Chain B, Structure of PAE2307 in complex with adenosine0011
Chain A, ADENOSINE RECEPTOR A2A0101
Chain A, ADENOSINE RECEPTOR A2A0101
Chain A, tRNA (guanine-N(1)-)-methyltransferase0011
Chain A, Uncharacterized protein MJ08830011
AR protein8008
signal transducer and activator of transcription 6, interleukin-4 induced1001
regulator of G-protein signaling 43003
glucocorticoid receptor [Homo sapiens]6006
retinoid X nuclear receptor alpha4004
estrogen nuclear receptor alpha8008
NPYLR7B0011
arylsulfatase A4004
IDH15005
Histone H2A.x3003
glycogen synthase kinase-3 beta isoform 10011
mitogen-activated protein kinase 14004
flap endonuclease 13003
nuclear receptor ROR-gamma isoform 15005
peripheral myelin protein 223003
survival motor neuron protein isoform d2002
high affinity choline transporter 1 isoform a0101
Sodium/nucleoside cotransporter 10202
Calcium dependent protein kinase0101
Mitogen-activated protein kinase kinase kinase 70011
Sodium/nucleoside cotransporter 20202
Voltage-dependent calcium channel gamma-2 subunit2002
Rap guanine nucleotide exchange factor 33003
Purine nucleoside phosphorylase0101
Epidermal growth factor receptor0202
Phosphoglycerate kinase 1 0101
Adenosine deaminase0001
Avidin0011
Adenosine deaminase0001
Glyceraldehyde-3-phosphate dehydrogenase0202
Receptor tyrosine-protein kinase erbB-20101
Insulin receptor0001
Phosphoglycerate kinase 20101
Heat shock protein HSP 90-alpha0112
Platelet-derived growth factor receptor beta0001
Adenosine receptor A30225
Heat shock 70 kDa protein 1A 0101
Heat shock cognate 71 kDa protein0011
Fibroblast growth factor receptor 10001
Inosine-5'-monophosphate dehydrogenase 20101
Endoplasmin0112
Glutamate receptor 22002
Inosine-5'-monophosphate dehydrogenase 1 0101
Fibroblast growth factor receptor 20001
Fibroblast growth factor receptor 40001
Fibroblast growth factor receptor 30001
Streptavidin0011
Adenosylhomocysteinase0001
Adenosine receptor A10213
Adenosine receptor A30101
Adenosine receptor A2a0124
Adenosine receptor A2b0012
Adenosine receptor A2b0112
Adenylate kinase 2, mitochondrial0101
Adenosine receptor A10225
Adenosine receptor A2a0213
Adenylate kinase isoenzyme 1 0101
Phosphatidylinositol 4-kinase alpha0203
Adenosine receptor A10011
Adenosine kinase0001
Adenosine deaminase 0001
Equilibrative nucleoside transporter 20202
Phosphatidylinositol 4-kinase type 2-beta0203
Histone-lysine N-methyltransferase, H3 lysine-79 specific0101
Equilibrative nucleoside transporter 10202
Phosphatidylinositol 4-kinase type 2-alpha0203
Solute carrier family 28 member 30202
Adenosine kinase0102
Phosphatidylinositol 4-kinase beta0203
5-methylthioadenosine/S-adenosylhomocysteine deaminase0001
Adenosine transporter 10001
thioredoxin reductase5005
ATAD5 protein, partial4004
TDP1 protein8008
Microtubule-associated protein tau3003
estrogen-related nuclear receptor alpha8008
euchromatic histone-lysine N-methyltransferase 28008
Bloom syndrome protein isoform 14004
D(1A) dopamine receptor2002
lamin isoform A-delta106006
neuropeptide S receptor isoform A1001
Chain A, TYROSYL-DNA PHOSPHODIESTERASE3003
Chain A, Phospholipase A2 isoform 30011
Chain A, HADH2 protein2002
Chain B, HADH2 protein2002
Chain A, 2-oxoglutarate Oxygenase2002
GTP-binding protein (rab7)0011
ras protein, partial0011
interleukin 81001
GLS protein4004
aldehyde dehydrogenase 1 family, member A15005
thyroid stimulating hormone receptor5005
hypothetical protein, conserved1001
cytochrome P450 family 3 subfamily A polypeptide 42002
EWS/FLI fusion protein5005
retinoic acid nuclear receptor alpha variant 15005
cytochrome P450 2D61001
glucocerebrosidase1001
peroxisome proliferator-activated receptor delta3003
Rac1 protein0011
cell division cycle 42 (GTP binding protein, 25kDa), partial0011
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 11001
DNA polymerase iota isoform a (long)2002
DNA polymerase kappa isoform 12002
muscarinic acetylcholine receptor M13003
lethal factor (plasmid)2002
Prostaglandin-H2 D-isomerase0101
ATP-binding cassette sub-family C member 30808
Multidrug resistance-associated protein 40808
Solute carrier family 22 member 60101
Prostaglandin G/H synthase 1 0101
Prostaglandin G/H synthase 2 0101
Bile salt export pump0909
Carbonic anhydrase 10202
Carbonic anhydrase 20202
Fatty acid-binding protein, liver0101
Integrin beta-30101
Myeloperoxidase0101
Prostaglandin G/H synthase 10101
Seed linoleate 13S-lipoxygenase-10101
Integrin alpha-IIb0101
Glutathione hydrolase 1 proenzyme0101
Prostaglandin G/H synthase 10202
Substance-P receptor0101
Prostaglandin G/H synthase 20202
Urotensin-2 receptor0101
4-aminobutyrate aminotransferase, mitochondrial0101
Nuclear receptor ROR-gamma2002
Ras-related protein Rab-2A0011
Gamma-aminobutyric acid receptor subunit alpha-11203
Prostaglandin G/H synthase 20101
Rho-associated protein kinase 20101
Nicotinate phosphoribosyltransferase0101
Solute carrier family 22 member 200101
Solute carrier family 22 member 60101
Canalicular multispecific organic anion transporter 10808
Sigma non-opioid intracellular receptor 10415
Sigma non-opioid intracellular receptor 10112
GLI family zinc finger 35005
nuclear receptor subfamily 1, group I, member 35005
pregnane X nuclear receptor7007
cystic fibrosis transmembrane conductance regulator0101
DNA polymerase beta1001
short transient receptor potential channel 6 isoform 10011
Solute carrier family 22 member 1 0101
5-hydroxytryptamine receptor 40404
Muscarinic acetylcholine receptor M20418
Muscarinic acetylcholine receptor M40417
Muscarinic acetylcholine receptor M10215
Muscarinic acetylcholine receptor M30215
Muscarinic acetylcholine receptor M40215
Muscarinic acetylcholine receptor M50215
Muscarinic acetylcholine receptor M50417
Muscarinic acetylcholine receptor M20216
Muscarinic acetylcholine receptor M10418
Muscarinic acetylcholine receptor M10001
Muscarinic acetylcholine receptor M30215
Alpha-1D adrenergic receptor0202
5-hydroxytryptamine receptor 2C0404
Muscarinic acetylcholine receptor M40101
Histamine H2 receptor2003
5-hydroxytryptamine receptor 70101
Reverse transcriptase/RNaseH 0001
Muscarinic acetylcholine receptor0112
Chain A, Beta-lactamase4004
acetylcholinesterase2002
RAR-related orphan receptor gamma3003
USP1 protein, partial2002
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a3003
thyroid hormone receptor beta isoform a3003
nuclear factor erythroid 2-related factor 2 isoform 23003
geminin6006
Vpr1001
Bile salt export pump0101
Albumin0011
Major prion protein0011
Cellular tumor antigen p534004
Sodium channel protein type 1 subunit alpha0101
Sodium channel protein type 2 subunit alpha0202
Sodium channel protein type 3 subunit alpha0101
Cytochrome P450 2C9 0404
UDP-glucuronosyltransferase 2B70001
Cytochrome P450 2B60213
Sodium channel protein type 4 subunit alpha0204
Cytochrome P450 2J20202
Potassium voltage-gated channel subfamily H member 20606
Sodium channel protein type 9 subunit alpha0303
Frizzled-80011
P2X purinoceptor 40101
nonstructural protein 12002
chromobox protein homolog 16006
parathyroid hormone/parathyroid hormone-related peptide receptor precursor2002
Cytochrome P450 2C80101
Liver carboxylesterase 10001
Sodium-dependent serotonin transporter0718
Cytochrome P450 2C190404
Rap guanine nucleotide exchange factor 41001
P2Y purinoceptor 120303
Chain A, Cruzipain1001
SMAD family member 21001
SMAD family member 31001
STAT3, partial0101
Smad32002
estrogen receptor 2 (ER beta)2002
progesterone receptor3003
farnesoid X nuclear receptor2002
67.9K protein2002
peroxisome proliferator activated receptor gamma3003
vitamin D (1,25- dihydroxyvitamin D3) receptor4004
thyroid stimulating hormone receptor1001
activating transcription factor 61001
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a1001
v-jun sarcoma virus 17 oncogene homolog (avian)3003
nuclear receptor subfamily 1, group I, member 21001
NPC intracellular cholesterol transporter 1 precursor2002
potassium voltage-gated channel subfamily H member 2 isoform d1001
thyroid hormone receptor beta isoform 22002
ras-related protein Rab-9A3003
nuclear factor erythroid 2-related factor 2 isoform 15005
signal transducer and activator of transcription 1-alpha/beta isoform alpha0101
Interferon beta5005
Sodium/potassium-transporting ATPase subunit alpha-1 0101
Sodium/potassium-transporting ATPase subunit beta-10101
Replicase polyprotein 1ab0101
Sodium/potassium-transporting ATPase subunit alpha-30101
Sodium/potassium-transporting ATPase subunit beta-20101
Sodium/potassium-transporting ATPase subunit alpha-20101
Sodium/potassium-transporting ATPase subunit alpha-10101
Sodium/potassium-transporting ATPase subunit beta-30101
Sodium/potassium-transporting ATPase subunit gamma0101
Sodium/potassium-transporting ATPase subunit alpha-40101
Solute carrier organic anion transporter family member 4C10101
ATPase family AAA domain-containing protein 51001
Ataxin-22002
Luciferase1001
hypoxia-inducible factor 1 alpha subunit1001
chaperonin-containing TCP-1 beta subunit homolog1001
Synaptic vesicle glycoprotein 2A0202
phosphopantetheinyl transferase3003
Beta-2 adrenergic receptor0202
Beta-1 adrenergic receptor0202
Beta-3 adrenergic receptor0202
5-hydroxytryptamine receptor 1A0303
5-hydroxytryptamine receptor 1B0202
Chain A, cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A0101
glp-1 receptor, partial2002
15-lipoxygenase, partial1001
Fumarate hydratase2002
NFKB1 protein, partial1001
PPM1D protein2002
Thrombopoietin1001
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)2002
polyprotein2002
cytochrome P450 2D6 isoform 11001
hexokinase-4 isoform 11001
polyunsaturated fatty acid lipoxygenase ALOX121001
cytochrome P450 2C19 precursor1001
cytochrome P450 2C9 precursor2002
atrial natriuretic peptide receptor 1 precursor2002
glucokinase regulatory protein1001
atrial natriuretic peptide receptor 2 precursor2002
ubiquitin carboxyl-terminal hydrolase 2 isoform a1001
cytochrome P450 3A4 isoform 11001
cGMP-dependent 3',5'-cyclic phosphodiesterase0101
Gamma-aminobutyric acid receptor subunit pi1102
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A0101
cGMP-specific 3',5'-cyclic phosphodiesterase0101
3',5'-cyclic-AMP phosphodiesterase 0101
Gamma-aminobutyric acid receptor subunit beta-11102
Vascular endothelial growth factor receptor 1 0101
Gamma-aminobutyric acid receptor subunit delta1102
Gamma-aminobutyric acid receptor subunit gamma-21102
Gamma-aminobutyric acid receptor subunit alpha-51102
Gamma-aminobutyric acid receptor subunit alpha-31102
Acetylcholinesterase0202
Gamma-aminobutyric acid receptor subunit gamma-11102
Gamma-aminobutyric acid receptor subunit alpha-21102
cAMP-specific 3',5'-cyclic phosphodiesterase 4A0101
Gamma-aminobutyric acid receptor subunit alpha-41102
Gamma-aminobutyric acid receptor subunit gamma-31102
Gamma-aminobutyric acid receptor subunit alpha-61102
Serine hydroxymethyltransferase, mitochondrial0101
Vascular endothelial growth factor receptor 30101
Vascular endothelial growth factor receptor 20101
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A0101
Gamma-aminobutyric acid receptor subunit beta-31102
Gamma-aminobutyric acid receptor subunit beta-21102
Disintegrin and metalloproteinase domain-containing protein 171001
Inositol monophosphatase 12002
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B0101
cAMP-specific 3',5'-cyclic phosphodiesterase 4D0101
cGMP-inhibited 3',5'-cyclic phosphodiesterase B0202
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C0101
cGMP-inhibited 3',5'-cyclic phosphodiesterase A0202
GABA theta subunit1102
CREB-binding protein1001
Gamma-aminobutyric acid receptor subunit epsilon1102
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A 0202
Phosphodiesterase 0101
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A0102
Chain A, Putative fructose-1,6-bisphosphate aldolase1001
Gamma-aminobutyric acid 0101
endonuclease IV1001
G2002
peripheral myelin protein 22 isoform 11001
transcriptional regulator ERG isoform 31001
Gamma-aminobutyric acid receptor subunit pi0101
Gamma-aminobutyric acid receptor subunit delta0101
Voltage-dependent L-type calcium channel subunit alpha-1C0101
Voltage-dependent L-type calcium channel subunit alpha-1F0202
Dihydrofolate reductase 0101
HLA class I histocompatibility antigen, B alpha chain 2002
Gamma-aminobutyric acid receptor subunit alpha-10101
Aldo-keto reductase family 1 member B10101
Gamma-aminobutyric acid receptor subunit alpha-60101
Gamma-aminobutyric acid receptor subunit beta-10101
Gamma-aminobutyric acid receptor subunit gamma-20101
Gamma-aminobutyric acid receptor subunit gamma-20101
Gamma-aminobutyric acid receptor subunit delta0101
Gamma-aminobutyric acid receptor subunit alpha-20101
Gamma-aminobutyric acid receptor subunit alpha-30101
Gamma-aminobutyric acid receptor subunit gamma-30101
Gamma-aminobutyric acid receptor subunit beta-30101
Gamma-aminobutyric acid receptor subunit alpha-50101
Gamma-aminobutyric acid receptor subunit alpha-30101
Sodium channel protein type 1 subunit alpha0101
Gamma-aminobutyric acid receptor subunit alpha-20101
Gamma-aminobutyric acid receptor subunit beta-20101
Gamma-aminobutyric acid receptor subunit alpha-40101
Gamma-aminobutyric acid receptor subunit beta-10101
Gamma-aminobutyric acid receptor subunit alpha-10101
Gamma-aminobutyric acid receptor subunit beta-30101
Gamma-aminobutyric acid receptor subunit epsilon0101
Voltage-dependent L-type calcium channel subunit alpha-1D 0202
Voltage-dependent L-type calcium channel subunit alpha-1S0202
Voltage-dependent L-type calcium channel subunit alpha-1C0202
Sodium channel protein type 5 subunit alpha0101
Gamma-aminobutyric acid receptor subunit alpha-60101
Gamma-aminobutyric acid receptor subunit alpha-50101
Gamma-aminobutyric acid receptor subunit gamma-10101
Gamma-aminobutyric acid receptor subunit pi0101
Inositol hexakisphosphate kinase 12002
Sodium channel protein type 2 subunit alpha0101
Gamma-aminobutyric acid receptor subunit gamma-30101
Gamma-aminobutyric acid receptor subunit alpha-40101
Gamma-aminobutyric acid receptor subunit theta0101
Sodium channel protein type 3 subunit alpha0101
Gamma-aminobutyric acid receptor subunit gamma-10101
Gamma-aminobutyric acid receptor subunit theta0101
cytochrome P450 2C9, partial2002
Hsf1 protein0012
M-phase phosphoprotein 81001
histone acetyltransferase KAT2A isoform 11001
Spike glycoprotein2002
Guanine nucleotide-binding protein G1001
ATP-dependent phosphofructokinase1001
pregnane X receptor1001
thioredoxin glutathione reductase1001
vitamin D3 receptor isoform VDRA2002
Glucocorticoid receptor0213
Glycine receptor subunit alpha-10202
Glycine receptor subunit beta0202
Glycine receptor subunit alpha-20202
Glycine receptor subunit alpha-30202
Acetylcholinesterase0101
Acetylcholinesterase0101
Cholinesterase0101
Acyl-CoA desaturase 10101
Acetylcholine receptor subunit epsilon0101
Amine oxidase [flavin-containing] B0101
Amine oxidase [flavin-containing] A 0101
Acetylcholinesterase0202
Acetylcholinesterase 0101
Sodium-dependent serotonin transporter0202
Delta-type opioid receptor0101
Cholinesterase0101
Acetylcholinesterase0101
Tyrosine-protein kinase SYK0101
Beta-secretase 10101
Cholinesterase0112
Cholinesterase0101
Carboxylic ester hydrolase 0101
Carboxylic ester hydrolase 0101
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)1001
serine/threonine-protein kinase mTOR isoform 11001
histone-lysine N-methyltransferase 2A isoform 2 precursor1001
urokinase-type plasminogen activator precursor1001
plasminogen precursor1001
urokinase plasminogen activator surface receptor precursor1001
Aldo-keto reductase family 1 member B10202
ATP-dependent translocase ABCB10101
Cytochrome P450 3A40202
Alpha-2A adrenergic receptor0202
Cytochrome P450 2D60101
Transcriptional activator protein LuxR0101
Angiotensin-converting enzyme0202
Alpha-2B adrenergic receptor0202
Alpha-2C adrenergic receptor0202
D0101
D(3) dopamine receptor0101
Sodium-dependent noradrenaline transporter 0213
Sodium-dependent dopamine transporter0101
D(1B) dopamine receptor0101
5-hydroxytryptamine receptor 2A0202
D(4) dopamine receptor0101
3-oxo-5-alpha-steroid 4-dehydrogenase 20101
Melanocortin receptor 50202
5-hydroxytryptamine receptor 2B0202
D(1A) dopamine receptor1001
D(2) dopamine receptor0101
Sodium-dependent dopamine transporter 0213
Envelope glycoprotein0011
Sigma intracellular receptor 20101
Nuclear receptor subfamily 3 group C member 3 0202
Transporter0101
P2Y purinoceptor 130101
caspase 7, apoptosis-related cysteine protease1001
caspase-31001
Urease subunit alpha0101
Urease subunit beta0101
Olfactory receptor 51E20011
Sterol 14-alpha-demethylase0011
14-alpha sterol demethylase 0011
Cholesterol side-chain cleavage enzyme, mitochondrial 0011
Lanosterol 14-alpha demethylase0011
Cytochrome P450 1440011
Steroid C26-monooxygenase0011
Steroid C26-monooxygenase0011
Sterol 14-alpha demethylase0011
14-alpha sterol demethylase 0011
14-alpha sterol demethylase 0011
Cholesterol 24-hydroxylase0213
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]