substance-p--prolyl(2)-tryptophan(7-9)- and biphalin

substance-p--prolyl(2)-tryptophan(7-9)- has been researched along with biphalin* in 1 studies

Other Studies

1 other study(ies) available for substance-p--prolyl(2)-tryptophan(7-9)- and biphalin

Article	Year
Spinal co-administration of peptide substance P antagonist increases antinociceptive effect of the opioid peptide biphalin. Life sciences, 1994, Volume: 54, Issue:14 Intrathecal injection of 0.25 micrograms of undecapeptide substance P antagonist (SPA) produced transient antinociception with a peak effect at 5 min. Increasing the SPA dose resulted in neurotoxicity. Intrathecal injection of the opioid peptide biphalin (BIP) produced antinociception for over 3 hrs without neurotoxicity. Co-administration of SPA (at subtoxic doses) increased BIP's antinociceptive effect. Naltrexone reversed analgesia due to BIP alone as well as after BIP+SPA. Topics: Analgesics; Animals; Drug Synergism; Enkephalins; Injections, Spinal; Male; Naltrexone; Pain; Pain Measurement; Rats; Rats, Wistar; Substance P	1994

Article

Year

Spinal co-administration of peptide substance P antagonist increases antinociceptive effect of the opioid peptide biphalin.

Life sciences, 1994, Volume: 54, Issue:14

Intrathecal injection of 0.25 micrograms of undecapeptide substance P antagonist (SPA) produced transient antinociception with a peak effect at 5 min. Increasing the SPA dose resulted in neurotoxicity. Intrathecal injection of the opioid peptide biphalin (BIP) produced antinociception for over 3 hrs without neurotoxicity. Co-administration of SPA (at subtoxic doses) increased BIP's antinociceptive effect. Naltrexone reversed analgesia due to BIP alone as well as after BIP+SPA.

Topics: Analgesics; Animals; Drug Synergism; Enkephalins; Injections, Spinal; Male; Naltrexone; Pain; Pain Measurement; Rats; Rats, Wistar; Substance P

1994