substance-p--prolyl(2)-tryptophan(7-9)- and hydroquinone

substance-p--prolyl(2)-tryptophan(7-9)- has been researched along with hydroquinone* in 1 studies

Other Studies

1 other study(ies) available for substance-p--prolyl(2)-tryptophan(7-9)- and hydroquinone

Article	Year
Substance P mechanisms in the regulation of striated muscle microcirculation. Microvascular research, 1991, Volume: 41, Issue:1 The effects of substance P (SP) on microvessels in the cremaster of sodium pentobarbital-anesthetized male, Sprague-Dawley rats were investigated using closed-circuit television microscopy. Topically added SP (bath concentrations of 10(-13) to 10(-8) M) caused significant dilation of small arterioles. SP vasodilation was sensitive to pretreatment of the muscle tissue with SP analogues, [D-Arg1, D-Pro2, D-Trp7,9, Leu11]-substance P (APTL-SP) and [D-Pro2, D-Trp7,9]-substance P (PT-SP). Attenuation of the responses by pyrilamine suggests that part of the SP-induced dilation involves the release of histamine. The vasodilation was abolished by hydroquinone, suggesting an intermediate role for endothelium-derived relaxing factor in the response to SP. Topics: Animals; Capillaries; Endothelium, Vascular; Histamine Release; Hydroquinones; Male; Microcirculation; Muscles; Nitric Oxide; Pyrilamine; Rats; Rats, Inbred Strains; Receptors, Neurokinin-1; Receptors, Neurotransmitter; Substance P; Vasodilation	1991

Article

Year

Substance P mechanisms in the regulation of striated muscle microcirculation.

Microvascular research, 1991, Volume: 41, Issue:1

The effects of substance P (SP) on microvessels in the cremaster of sodium pentobarbital-anesthetized male, Sprague-Dawley rats were investigated using closed-circuit television microscopy. Topically added SP (bath concentrations of 10(-13) to 10(-8) M) caused significant dilation of small arterioles. SP vasodilation was sensitive to pretreatment of the muscle tissue with SP analogues, [D-Arg1, D-Pro2, D-Trp7,9, Leu11]-substance P (APTL-SP) and [D-Pro2, D-Trp7,9]-substance P (PT-SP). Attenuation of the responses by pyrilamine suggests that part of the SP-induced dilation involves the release of histamine. The vasodilation was abolished by hydroquinone, suggesting an intermediate role for endothelium-derived relaxing factor in the response to SP.

Topics: Animals; Capillaries; Endothelium, Vascular; Histamine Release; Hydroquinones; Male; Microcirculation; Muscles; Nitric Oxide; Pyrilamine; Rats; Rats, Inbred Strains; Receptors, Neurokinin-1; Receptors, Neurotransmitter; Substance P; Vasodilation

1991