substance-p--prolyl(2)-tryptophan(7-9)- and Pulmonary-Edema

substance-p--prolyl(2)-tryptophan(7-9)- has been researched along with Pulmonary-Edema* in 1 studies

Other Studies

1 other study(ies) available for substance-p--prolyl(2)-tryptophan(7-9)- and Pulmonary-Edema

ArticleYear
Capsaicin-sensitive nerves exert an inhibitory effect on the development of fibrin-induced pulmonary edema in rats.
    The American review of respiratory disease, 1989, Volume: 140, Issue:3

    This study was undertaken to evaluate the role of vagal nerves in the development of neurogenic pulmonary edema. We injected fibrinogen and thrombin into the cisterna magna of rats, a model of neurogenic pulmonary edema. When the vagal nerves were left intact, pulmonary edema occurred (fibrin-induced pulmonary edema) at a rate of 33%. Vagotomy at the midcervical portion increased the incidence of pulmonary edema to a rate of 100%, whereas pretreatment with atropine did not affect the incidence. These results suggested that vagal afferent nerves or nonadrenergic-noncholinergic efferent nerves played an important role in inhibiting the development of fibrin-induced pulmonary edema. Furthermore, in vagotomized and vagal nerve-intact rats pretreated with capsaicin, the incidence of pulmonary edema was 100%. Pretreatment with a substance P antagonist, [D-Pro2, D-Trp7,9]-SP, also increased the incidence to 100% in the vagal nerve-intact rats. On the other hand, intravenous administration of some neuropeptides that may be released from the capsaicin-sensitive nerves (e.g., substance P or calcitonin gene-related peptide) inhibited the development of pulmonary edema in vagotomized rats. We concluded that the vagal capsaicin-sensitive nerves exerted an inhibitory effect on the development of fibrin-induced pulmonary edema.

    Topics: Animals; Blood Pressure; Calcitonin Gene-Related Peptide; Capsaicin; Extracellular Space; Fibrin; Heart Rate; Lung; Male; Neuropeptides; Pulmonary Edema; Rats; Rats, Inbred Strains; Substance P; Vagotomy; Vagus Nerve

1989