Compounds > 16 alpha-ethyl-21-hydroxy-19-nor-4-pregnene-3,20-dione
Page last updated: 2024-08-03 00:49:35
16 alpha-ethyl-21-hydroxy-19-nor-4-pregnene-3,20-dione
Description
Cross-References
| ID Source | ID |
|---|
| PubMed CID | 14058554 |
| SCHEMBL ID | 17078378 |
| MeSH ID | M0073656 |
Synonyms (3)
| Synonym |
|---|
| 16 alpha-ethyl-21-hydroxy-19-nor-4-pregnene-3,20-dione |
| SCHEMBL17078378 |
| DTXSID20875414 |
Research
Studies (112)
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|
| pre-1990 | 53 (47.32) | 18.7374 |
| 1990's | 45 (40.18) | 18.2507 |
| 2000's | 12 (10.71) | 29.6817 |
| 2010's | 2 (1.79) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Study Types
| Publication Type | This drug (%) | All Drugs (%) |
|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 1 (0.86%) | 6.00% |
| Case Studies | 1 (0.86%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 114 (98.28%) | 84.16% |
Progestins activate 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (PFKFB3) in breast cancer cells.The Biochemical journal, , Mar-01, Volume: 442, Issue:2, 2012
Progestins reinitiate cell cycle progression in antiestrogen-arrested breast cancer cells through the B-isoform of progesterone receptor.Cancer research, , Sep-15, Volume: 67, Issue:18, 2007
Cyclin D1 overexpression induces progestin resistance in T-47D breast cancer cells despite p27(Kip1) association with cyclin E-Cdk2.The Journal of biological chemistry, , Dec-14, Volume: 276, Issue:50, 2001
Effect of low dose irradiation on estrogen receptor level in MCF-7 breast cancer cells.International journal of cancer, , Feb-20, Volume: 96, Issue:1, 2001
Cooperation of p27(Kip1) and p18(INK4c) in progestin-mediated cell cycle arrest in T-47D breast cancer cells.Molecular and cellular biology, , Volume: 20, Issue:7, 2000
Progestins and androgens increase expression of Spot 14 in T47-D breast tumor cells.Biochemical and biophysical research communications, , Mar-05, Volume: 269, Issue:1, 2000
Interference between progesterone and dioxin signal transduction pathways. Different mechanisms are involved in repression by the progesterone receptor A and B isoforms.The Journal of biological chemistry, , Apr-10, Volume: 273, Issue:15, 1998
Identification of PRG1, a novel progestin-responsive gene with sequence homology to 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase.Molecular endocrinology (Baltimore, Md.), , Volume: 11, Issue:4, 1997
Estrogen receptor-negative/progesterone receptor-positive Evsa-T mammary tumor cells: a model for assessing the biological property of this peculiar phenotype of breast cancers.Cancer letters, , Nov-25, Volume: 120, Issue:1, 1997
Expression of receptors for epidermal growth factor and insulin-like growth factor I by ZR-75-1 human breast cancer cell variants is inversely related: the effect of steroid hormones on insulin-like growth factor I receptor expression.British journal of cancer, , Volume: 73, Issue:4, 1996
Antagonism between estradiol and progestin on Bcl-2 expression in breast-cancer cells.International journal of cancer, , Sep-27, Volume: 68, Issue:1, 1996
Detection of HOXA1 expression in human breast cancer.Biochemical and biophysical research communications, , May-15, Volume: 222, Issue:2, 1996
Reduced levels of cathepsin D associated with tamoxifen resistance and estrogen independence in the ZR-75-1 human breast cancer cell line.Cancer letters, , Feb-06, Volume: 99, Issue:2, 1996
Effects of two classes of progestagens, pregnane and 19-nortestosterone derivatives, on cell growth of human breast tumor cells: II. T47D cell lines.The Journal of steroid biochemistry and molecular biology, , Volume: 55, Issue:3-4, 1995
Effects of two classes of progestagens, pregnane and 19-nortestosterone derivatives, on cell growth of human breast tumor cells: I. MCF-7 cell lines.The Journal of steroid biochemistry and molecular biology, , Volume: 55, Issue:3-4, 1995
Preferential stimulation of human progesterone receptor B expression by estrogen in T-47D human breast cancer cells.The Journal of biological chemistry, , Dec-22, Volume: 270, Issue:51, 1995
Inhibition by nomegestrol acetate and other synthetic progestins on proliferation and progesterone receptor content of T47-D human breast cancer cells.The Journal of steroid biochemistry and molecular biology, , Volume: 50, Issue:1-2, 1994
7 alpha-17 alpha-Dimethyl-19-nortestosterone (mibolerone) induces conformational changes in progesterone receptors distinct from those induced by ORG 2058.Steroids, , Volume: 59, Issue:6, 1994
Expression of insulin-like growth factor binding proteins by T-47D human breast cancer cells: regulation by progestins and antiestrogens.Breast cancer research and treatment, , Volume: 32, Issue:2, 1994
The relationship between affinity of progestins and antiprogestins for the progesterone receptor in breast cancer cells (ZR-PR-LT) and ability to down-regulate the receptor: evidence for heterospecific receptor modulation via the glucocorticoid receptor.European journal of cancer (Oxford, England : 1990), , Volume: 29A, Issue:12, 1993
Effects of the progestin antagonist RU 486 on T-47D breast cancer cell cycle kinetics and cell cycle regulatory genes.Biochemical and biophysical research communications, , Sep-30, Volume: 195, Issue:3, 1993
Growth factor, steroid, and steroid antagonist regulation of cyclin gene expression associated with changes in T-47D human breast cancer cell cycle progression.Molecular and cellular biology, , Volume: 13, Issue:6, 1993
The effect of progestins on prolactin receptor gene transcription in human breast cancer cells.DNA and cell biology, , Volume: 11, Issue:10, 1992
Androgen regulation of prolactin-receptor gene expression in MCF-7 and MDA-MB-453 human breast cancer cells.International journal of cancer, , Mar-12, Volume: 50, Issue:5, 1992
17 beta-hydroxysteroid dehydrogenase gene expression in human breast cancer cells: regulation of expression by a progestin.Cancer research, , Jan-15, Volume: 52, Issue:2, 1992
Progestins both stimulate and inhibit breast cancer cell cycle progression while increasing expression of transforming growth factor alpha, epidermal growth factor receptor, c-fos, and c-myc genes.Molecular and cellular biology, , Volume: 11, Issue:10, 1991
Characterization of human progesterone receptor by high performance hydrophobic interaction chromatography.Biomedical chromatography : BMC, , Volume: 5, Issue:2, 1991
Progestin regulation of estrogen receptor messenger RNA in human breast cancer cells.Molecular endocrinology (Baltimore, Md.), , Volume: 4, Issue:6, 1990
Progesterone receptor regulation by retinoic acid in the human breast cancer cell line T-47D.The Journal of biological chemistry, , Jul-25, Volume: 265, Issue:21, 1990
Modulation of laminin receptor expression by estrogen and progestins in human breast cancer cell lines.Journal of the National Cancer Institute, , May-10, Volume: 81, Issue:10, 1989
Progestin inhibition of progesterone receptor gene expression in human breast cancer cells.Molecular endocrinology (Baltimore, Md.), , Volume: 3, Issue:9, 1989
Modulation of the growth-inhibitory effects of progestins and the antiestrogen hydroxyclomiphene on human breast cancer cells by epidermal growth factor and insulin.Cancer research, , Jan-01, Volume: 49, Issue:1, 1989
Subcellular distribution of estrogen receptor and progesterone receptor with and without specific ligand.The American journal of pathology, , Volume: 135, Issue:5, 1989
Relationship of cytosolic estrogen and progesterone receptor content and the growth fraction in human mammary carcinomas.Cancer research, , Jul-15, Volume: 49, Issue:14, 1989
An improved micromethod for the determination of biochemically active estrogen and progesterone receptors in parallel to comparative histological examination of a single piece of tissue.Journal of steroid biochemistry, , Volume: 31, Issue:6, 1988
Genetic instability and the development of steroid hormone insensitivity in cultured T 47D human breast cancer cells.Cancer research, , Aug-01, Volume: 48, Issue:15, 1988
HPLC micromethod for simultaneous measurement of estradiol, progesterone, androgen and glucocorticoid receptor levels. Application to breast cancer biopsies.European journal of cancer & clinical oncology, , Volume: 23, Issue:9, 1987
Induction of progesterone receptor in an estrogen, progesterone receptor-negative breast cancer cell line.Journal of steroid biochemistry, , Volume: 24, Issue:1, 1986
A double-labeling assay for simultaneous estimation and characterization of estrogen and progesterone receptors using radioiodinated estradiol and tritiated Org 2058.Tumori, , Jun-30, Volume: 72, Issue:3, 1986
Regulation of growth hormone and epidermal growth factor receptors by progestins in breast cancer cells.Biochemical and biophysical research communications, , Sep-16, Volume: 131, Issue:2, 1985
[New method for the determination of estrogen and progesterone receptors in human breast cell lines].Revista espanola de fisiologia, , Volume: 41, Issue:4, 1985
Assay for estrogen and progesterone receptors of breast cancer cell lines in monolayer culture.European journal of cancer & clinical oncology, , Volume: 21, Issue:8, 1985
Measurement of progesterone receptors in human breast tumors using the synthetic progestin 16 alpha-ethyl-21-hydroxy-19-nor-4-pregnene-3,20-dione.Journal of steroid biochemistry, , Volume: 13, Issue:9, 1980
Oestriol receptor interactions: their biological importance and therapeutic implications.Acta endocrinologica. Supplementum, , Volume: 233, 1980
ORG-2058 as a ligand in the assay of progesterone receptor in breast cancer.Steroids, , Volume: 48, Issue:5-6
Effect of progestin treatment on estradiol-and growth factor-stimulated breast cancer cell lines.Anticancer research, , Volume: 15, Issue:6B
Binding activity of 5alpha-reduced gestagens to the progestin receptor from African elephant (Loxodonta africana).General and comparative endocrinology, , Volume: 105, Issue:2, 1997
Estrogen and progestogen receptors in the implantation sites and interembryonic segments of rat uterus endometrium and myometrium.Endocrinology, , Volume: 119, Issue:2, 1986
Estrogen and progesterone receptors in the organs of prenatal cynomolgus monkey and laboratory mouse.Biology of reproduction, , Volume: 35, Issue:3, 1986
Progestins specifically suppress alpha-lactalbumin synthesis and secretion.Journal of steroid biochemistry, , Volume: 23, Issue:6A, 1985
Progesterone receptors in mammary gland of the pregnant rat.Endocrinology, , Volume: 111, Issue:6, 1982
Progesterone receptor heterogeneity and endometrial tumour differentiation.Cancer letters, , Dec-15, Volume: 43, Issue:3, 1988
Estradiol and progesterone receptors in two cases of endometrial stromal sarcoma.Gynecologic oncology, , Volume: 18, Issue:2, 1984
Female sex steroid receptors in gynecological malignancies: clinical correlates.Journal of steroid biochemistry, , Volume: 19, Issue:1C, 1983
Progestins activate 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (PFKFB3) in breast cancer cells.The Biochemical journal, , Mar-01, Volume: 442, Issue:2, 2012
Progestins reinitiate cell cycle progression in antiestrogen-arrested breast cancer cells through the B-isoform of progesterone receptor.Cancer research, , Sep-15, Volume: 67, Issue:18, 2007
Cyclin D1 overexpression induces progestin resistance in T-47D breast cancer cells despite p27(Kip1) association with cyclin E-Cdk2.The Journal of biological chemistry, , Dec-14, Volume: 276, Issue:50, 2001
Effect of low dose irradiation on estrogen receptor level in MCF-7 breast cancer cells.International journal of cancer, , Feb-20, Volume: 96, Issue:1, 2001
Cooperation of p27(Kip1) and p18(INK4c) in progestin-mediated cell cycle arrest in T-47D breast cancer cells.Molecular and cellular biology, , Volume: 20, Issue:7, 2000
Progestins and androgens increase expression of Spot 14 in T47-D breast tumor cells.Biochemical and biophysical research communications, , Mar-05, Volume: 269, Issue:1, 2000
Interference between progesterone and dioxin signal transduction pathways. Different mechanisms are involved in repression by the progesterone receptor A and B isoforms.The Journal of biological chemistry, , Apr-10, Volume: 273, Issue:15, 1998
Identification of PRG1, a novel progestin-responsive gene with sequence homology to 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase.Molecular endocrinology (Baltimore, Md.), , Volume: 11, Issue:4, 1997
Estrogen receptor-negative/progesterone receptor-positive Evsa-T mammary tumor cells: a model for assessing the biological property of this peculiar phenotype of breast cancers.Cancer letters, , Nov-25, Volume: 120, Issue:1, 1997
Expression of receptors for epidermal growth factor and insulin-like growth factor I by ZR-75-1 human breast cancer cell variants is inversely related: the effect of steroid hormones on insulin-like growth factor I receptor expression.British journal of cancer, , Volume: 73, Issue:4, 1996
Reduced levels of cathepsin D associated with tamoxifen resistance and estrogen independence in the ZR-75-1 human breast cancer cell line.Cancer letters, , Feb-06, Volume: 99, Issue:2, 1996
Detection of HOXA1 expression in human breast cancer.Biochemical and biophysical research communications, , May-15, Volume: 222, Issue:2, 1996
Antagonism between estradiol and progestin on Bcl-2 expression in breast-cancer cells.International journal of cancer, , Sep-27, Volume: 68, Issue:1, 1996
Preferential stimulation of human progesterone receptor B expression by estrogen in T-47D human breast cancer cells.The Journal of biological chemistry, , Dec-22, Volume: 270, Issue:51, 1995
Effects of two classes of progestagens, pregnane and 19-nortestosterone derivatives, on cell growth of human breast tumor cells: I. MCF-7 cell lines.The Journal of steroid biochemistry and molecular biology, , Volume: 55, Issue:3-4, 1995
Effects of two classes of progestagens, pregnane and 19-nortestosterone derivatives, on cell growth of human breast tumor cells: II. T47D cell lines.The Journal of steroid biochemistry and molecular biology, , Volume: 55, Issue:3-4, 1995
7 alpha-17 alpha-Dimethyl-19-nortestosterone (mibolerone) induces conformational changes in progesterone receptors distinct from those induced by ORG 2058.Steroids, , Volume: 59, Issue:6, 1994
Inhibition by nomegestrol acetate and other synthetic progestins on proliferation and progesterone receptor content of T47-D human breast cancer cells.The Journal of steroid biochemistry and molecular biology, , Volume: 50, Issue:1-2, 1994
Expression of insulin-like growth factor binding proteins by T-47D human breast cancer cells: regulation by progestins and antiestrogens.Breast cancer research and treatment, , Volume: 32, Issue:2, 1994
Effects of the progestin antagonist RU 486 on T-47D breast cancer cell cycle kinetics and cell cycle regulatory genes.Biochemical and biophysical research communications, , Sep-30, Volume: 195, Issue:3, 1993
The relationship between affinity of progestins and antiprogestins for the progesterone receptor in breast cancer cells (ZR-PR-LT) and ability to down-regulate the receptor: evidence for heterospecific receptor modulation via the glucocorticoid receptor.European journal of cancer (Oxford, England : 1990), , Volume: 29A, Issue:12, 1993
Growth factor, steroid, and steroid antagonist regulation of cyclin gene expression associated with changes in T-47D human breast cancer cell cycle progression.Molecular and cellular biology, , Volume: 13, Issue:6, 1993
17 beta-hydroxysteroid dehydrogenase gene expression in human breast cancer cells: regulation of expression by a progestin.Cancer research, , Jan-15, Volume: 52, Issue:2, 1992
Androgen regulation of prolactin-receptor gene expression in MCF-7 and MDA-MB-453 human breast cancer cells.International journal of cancer, , Mar-12, Volume: 50, Issue:5, 1992
The effect of progestins on prolactin receptor gene transcription in human breast cancer cells.DNA and cell biology, , Volume: 11, Issue:10, 1992
Progestins both stimulate and inhibit breast cancer cell cycle progression while increasing expression of transforming growth factor alpha, epidermal growth factor receptor, c-fos, and c-myc genes.Molecular and cellular biology, , Volume: 11, Issue:10, 1991
Characterization of human progesterone receptor by high performance hydrophobic interaction chromatography.Biomedical chromatography : BMC, , Volume: 5, Issue:2, 1991
Progestin regulation of estrogen receptor messenger RNA in human breast cancer cells.Molecular endocrinology (Baltimore, Md.), , Volume: 4, Issue:6, 1990
Progesterone receptor regulation by retinoic acid in the human breast cancer cell line T-47D.The Journal of biological chemistry, , Jul-25, Volume: 265, Issue:21, 1990
Modulation of the growth-inhibitory effects of progestins and the antiestrogen hydroxyclomiphene on human breast cancer cells by epidermal growth factor and insulin.Cancer research, , Jan-01, Volume: 49, Issue:1, 1989
Relationship of cytosolic estrogen and progesterone receptor content and the growth fraction in human mammary carcinomas.Cancer research, , Jul-15, Volume: 49, Issue:14, 1989
Subcellular distribution of estrogen receptor and progesterone receptor with and without specific ligand.The American journal of pathology, , Volume: 135, Issue:5, 1989
Progestin inhibition of progesterone receptor gene expression in human breast cancer cells.Molecular endocrinology (Baltimore, Md.), , Volume: 3, Issue:9, 1989
Modulation of laminin receptor expression by estrogen and progestins in human breast cancer cell lines.Journal of the National Cancer Institute, , May-10, Volume: 81, Issue:10, 1989
Genetic instability and the development of steroid hormone insensitivity in cultured T 47D human breast cancer cells.Cancer research, , Aug-01, Volume: 48, Issue:15, 1988
An improved micromethod for the determination of biochemically active estrogen and progesterone receptors in parallel to comparative histological examination of a single piece of tissue.Journal of steroid biochemistry, , Volume: 31, Issue:6, 1988
HPLC micromethod for simultaneous measurement of estradiol, progesterone, androgen and glucocorticoid receptor levels. Application to breast cancer biopsies.European journal of cancer & clinical oncology, , Volume: 23, Issue:9, 1987
A double-labeling assay for simultaneous estimation and characterization of estrogen and progesterone receptors using radioiodinated estradiol and tritiated Org 2058.Tumori, , Jun-30, Volume: 72, Issue:3, 1986
Induction of progesterone receptor in an estrogen, progesterone receptor-negative breast cancer cell line.Journal of steroid biochemistry, , Volume: 24, Issue:1, 1986
Regulation of growth hormone and epidermal growth factor receptors by progestins in breast cancer cells.Biochemical and biophysical research communications, , Sep-16, Volume: 131, Issue:2, 1985
[New method for the determination of estrogen and progesterone receptors in human breast cell lines].Revista espanola de fisiologia, , Volume: 41, Issue:4, 1985
Assay for estrogen and progesterone receptors of breast cancer cell lines in monolayer culture.European journal of cancer & clinical oncology, , Volume: 21, Issue:8, 1985
Oestriol receptor interactions: their biological importance and therapeutic implications.Acta endocrinologica. Supplementum, , Volume: 233, 1980
Measurement of progesterone receptors in human breast tumors using the synthetic progestin 16 alpha-ethyl-21-hydroxy-19-nor-4-pregnene-3,20-dione.Journal of steroid biochemistry, , Volume: 13, Issue:9, 1980
ORG-2058 as a ligand in the assay of progesterone receptor in breast cancer.Steroids, , Volume: 48, Issue:5-6
Effect of progestin treatment on estradiol-and growth factor-stimulated breast cancer cell lines.Anticancer research, , Volume: 15, Issue:6B
Progestins and androgens increase expression of Spot 14 in T47-D breast tumor cells.Biochemical and biophysical research communications, , Mar-05, Volume: 269, Issue:1, 2000
[New method for the determination of estrogen and progesterone receptors in human breast cell lines].Revista espanola de fisiologia, , Volume: 41, Issue:4, 1985
Effect of progestin treatment on estradiol-and growth factor-stimulated breast cancer cell lines.Anticancer research, , Volume: 15, Issue:6B
Progesterone receptor heterogeneity and endometrial tumour differentiation.Cancer letters, , Dec-15, Volume: 43, Issue:3, 1988
Estradiol and progesterone receptors in two cases of endometrial stromal sarcoma.Gynecologic oncology, , Volume: 18, Issue:2, 1984
Female sex steroid receptors in gynecological malignancies: clinical correlates.Journal of steroid biochemistry, , Volume: 19, Issue:1C, 1983
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