Page last updated: 2024-09-03

ru-28362 and mifepristone

ru-28362 has been researched along with mifepristone in 26 studies

Compound Research Comparison

Studies
(ru-28362)
Trials
(ru-28362)
Recent Studies (post-2010)
(ru-28362)
Studies
(mifepristone)
Trials
(mifepristone)
Recent Studies (post-2010) (mifepristone)
175036,5365951,758

Protein Interaction Comparison

ProteinTaxonomyru-28362 (IC50)mifepristone (IC50)
Glucocorticoid receptor Canis lupus familiaris (dog)0.0264
Bile salt export pumpHomo sapiens (human)2.02
Estrogen receptorHomo sapiens (human)4.311
Glucocorticoid receptorHomo sapiens (human)0.0249
Prostaglandin G/H synthase 1Ovis aries (sheep)0.0003
Progesterone receptorHomo sapiens (human)0.1347
Glucocorticoid receptorRattus norvegicus (Norway rat)0.774
Glucocorticoid receptorMus musculus (house mouse)0.0022
Glycine receptor subunit alpha-1Rattus norvegicus (Norway rat)0.0022
Mineralocorticoid receptor Homo sapiens (human)2.0938
Cytochrome P450 3A4Homo sapiens (human)9.5
Coagulation factor VIIHomo sapiens (human)0.0003
Androgen receptorHomo sapiens (human)0.2988
Cytochrome P450 2C8Homo sapiens (human)1.5
Cytochrome P450 2C9 Homo sapiens (human)4.9
Steroid 17-alpha-hydroxylase/17,20 lyase Rattus norvegicus (Norway rat)0.0016
Polyunsaturated fatty acid lipoxygenase ALOX15Oryctolagus cuniculus (rabbit)0.555
Tissue factorHomo sapiens (human)0.0003
Androgen receptorRattus norvegicus (Norway rat)0.0083
5-hydroxytryptamine receptor 1ARattus norvegicus (Norway rat)0.0014
Glycine receptor subunit betaRattus norvegicus (Norway rat)0.0022
Glycine receptor subunit alpha-2Rattus norvegicus (Norway rat)0.0022
Prostaglandin G/H synthase 1Homo sapiens (human)0.0078
Glycine receptor subunit alpha-3Rattus norvegicus (Norway rat)0.0022
Substance-P receptorCavia porcellus (domestic guinea pig)0.0015
Mu-type opioid receptorHomo sapiens (human)2.457
Estrogen receptor betaHomo sapiens (human)1.528
Glucocorticoid receptorSus scrofa (pig)0.0153

Research

Studies (26)

TimeframeStudies, this research(%)All Research%
pre-19902 (7.69)18.7374
1990's20 (76.92)18.2507
2000's3 (11.54)29.6817
2010's1 (3.85)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Farnworth, P; Michel, U1
De Moraes, S; Nourani, R; Rahnemaye, F; Spadari, RC1
Funder, JW; Myles, K; Pearce, PT; Roy, LP1
de Jong, W; de Kloet, ER; van den Berg, DT; van Dijken, HH1
Agarwal, MK; Hainque, B; Moustaid, N; Quignard-Boulange, A1
King, I; Sartorelli, AC; Violette, SM1
Dixon, JE; Glembotski, CC; Shields, PP1
Asher, C; Civian, MM; Garty, H; Peterson-Yantorno, K1
Funder, JW; Provencher, PH; Saltis, J1
Briski, KP; Sylvester, PW1
Dean, RG; Edwards, GL; Martin, RJ; White, BD1
de Kloet, ER; Joëls, M1
Dayanithi, G; Gratzl, M; Link, H1
Hunt, A; Kelly, FJ; Langley, SC; Postle, AD; Rickett, GW; York, DA1
Bahn, RS; Heufelder, AE; Wenzel, BE1
Burollaud, T; Danzé, PM; Dautrevaux, M; Formstecher, P; Tbarka, N1
Husted, RF; Schmidt, TJ; Stokes, JB1
McGaugh, JL; Roozendaal, B2
Fujita, H; Maeda, N; Matsuda, S; Sakanaka, M; Tanaka, J; Toku, K1
Asselin, C; Boudreau, F; Morin, C; Provencher, PH1
McGaugh, JL; Roozendaal, B; Williams, CL1
Hattori, TA; Kawato, S; Kimoto, T; Takahashi, T; Tanabe, N; Yasumatsu, N1
Allaman, I; Magistretti, PJ; Pellerin, L1
Ghitza, UE; Li, YQ; Lu, L; Wang, XY; Zhao, M1
Dallman, MF; Ginsberg, AB; Horneman, HF; Pecoraro, NC; Warne, JP1

Other Studies

26 other study(ies) available for ru-28362 and mifepristone

ArticleYear
Follistatin steady state messenger ribonucleic acid levels in confluent cultures of a rat renal mesangial cell line are regulated by multiple factors.
    Endocrinology, 1992, Volume: 130, Issue:6

    Topics: Activins; Amino Acid Isomerases; Androstanols; Angiotensin II; Animals; Base Sequence; Carrier Proteins; Cell Line; Cells, Cultured; Cyclosporins; Dihydrotestosterone; Dinoprostone; Epidermal Growth Factor; Estradiol; Fibroblast Growth Factor 2; Follistatin; Gene Expression; Glomerular Mesangium; Glycoproteins; Inhibins; Mifepristone; Molecular Sequence Data; Oligodeoxyribonucleotides; Peptidylprolyl Isomerase; Progesterone; Rats; RNA; RNA Probes; RNA, Messenger; Somatostatin; Tretinoin

1992
Footshock stress-induced supersensitivity to isoprenaline in the isolated pacemaker of the rat: effects of the compounds RU-38486 and RU-28362.
    General pharmacology, 1992, Volume: 23, Issue:4

    Topics: Androstanols; Animals; Biological Clocks; Cytosol; Dose-Response Relationship, Drug; Electroshock; Heart Rate; Isoproterenol; Male; Mifepristone; Rats; Rats, Wistar; Receptors, Glucocorticoid; Receptors, Steroid; Stress, Psychological

1992
Apparent mineralocorticoid excess, pseudohypoaldosteronism, and urinary electrolyte excretion: toward a redefinition of mineralocorticoid action.
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 1990, Volume: 4, Issue:14

    Topics: 11-beta-Hydroxysteroid Dehydrogenases; Adrenalectomy; Aldosterone; Androstanols; Animals; Bicarbonates; Carbenoxolone; Child; Electrolytes; Female; Humans; Hydrocortisone; Hydroxysteroid Dehydrogenases; Male; Mifepristone; Mineralocorticoids; Natriuresis; Pseudohypoaldosteronism; Rats; Rats, Inbred Strains; Receptors, Mineralocorticoid; Receptors, Steroid; Spironolactone

1990
Differential central effects of mineralocorticoid and glucocorticoid agonists and antagonists on blood pressure.
    Endocrinology, 1990, Volume: 126, Issue:1

    Topics: Adrenalectomy; Aldosterone; Androstanols; Animals; Blood Pressure; Brain; Corticosterone; Glucocorticoids; Injections, Intraventricular; Male; Mifepristone; Mineralocorticoid Receptor Antagonists; Mineralocorticoids; Rats; Rats, Inbred Strains; Spironolactone

1990
Analysis of the glucocorticoid receptor during differentiation of 3T3-F442A preadipocyte cell line in culture.
    Biochemical medicine and metabolic biology, 1990, Volume: 43, Issue:2

    Topics: Adipose Tissue; Androstanols; Binding, Competitive; Cell Differentiation; Cell Line; Dexamethasone; Kinetics; Mifepristone; Receptors, Glucocorticoid

1990
Induction of the terminal differentiation of a human squamous cell carcinoma by steroids with glucocorticoid activity.
    Journal of steroid biochemistry, 1989, Volume: 33, Issue:5

    Topics: 17-alpha-Hydroxyprogesterone; Androstanols; Carcinoma, Squamous Cell; Cell Differentiation; Desoxycorticosterone; Dose-Response Relationship, Drug; Glucocorticoids; Humans; Hydrocortisone; Hydroxyprogesterones; In Vitro Techniques; Mifepristone; Mineralocorticoids; Neovascularization, Pathologic; Progesterone; Tretinoin; Tumor Cells, Cultured

1989
The secretion of atrial natriuretic factor-(99-126) by cultured cardiac myocytes is regulated by glucocorticoids.
    The Journal of biological chemistry, 1988, Sep-05, Volume: 263, Issue:25

    Topics: Amino Acids; Androstanols; Animals; Atrial Natriuretic Factor; Cells, Cultured; Chromatography, High Pressure Liquid; Culture Media; Cytoplasmic Granules; Dexamethasone; Diuretics; Estrenes; Glucocorticoids; Heart Atria; Immunohistochemistry; Immunosorbent Techniques; Mifepristone; Myocardium; Peptide Fragments; Protein Processing, Post-Translational; Radioimmunoassay; Rats; Rats, Inbred Strains

1988
Effects of corticoid agonists and antagonists on apical Na+ permeability of toad urinary bladder.
    The American journal of physiology, 1994, Volume: 266, Issue:1 Pt 2

    Topics: Adrenal Cortex Hormones; Aldosterone; Androstanols; Animals; Bufo marinus; Cell Membrane Permeability; Injections; Mifepristone; Oocytes; Receptors, Mineralocorticoid; RNA; Sodium; Sodium Channels; Urinary Bladder; Xenopus

1994
Glucocorticoids but not mineralocorticoids modulate endothelin-1 and angiotensin II binding in SHR vascular smooth muscle cells.
    The Journal of steroid biochemistry and molecular biology, 1995, Volume: 52, Issue:3

    Topics: Aldosterone; Androstanols; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Biphenyl Compounds; Cells, Cultured; Endothelin Receptor Antagonists; Endothelins; Glucocorticoids; Hypertension; Imidazoles; Losartan; Male; Mifepristone; Muscle, Smooth, Vascular; Peptides, Cyclic; Rats; Rats, Inbred SHR; Receptor, Endothelin A; Receptor, Endothelin B; Receptors, Endothelin; Receptors, Glucocorticoid; Receptors, Mineralocorticoid; Tetrazoles; Viper Venoms

1995
Antagonism of type II, but not type I glucocorticoid receptors results in elevated basal luteinizing hormone release in male rats.
    Neuroendocrinology, 1994, Volume: 60, Issue:6

    Topics: Androstanols; Animals; Canrenone; Glucocorticoids; Luteinizing Hormone; Male; Mifepristone; Mineralocorticoid Receptor Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Glucocorticoid

1994
Type II corticosteroid receptor stimulation increases NPY gene expression in basomedial hypothalamus of rats.
    The American journal of physiology, 1994, Volume: 266, Issue:5 Pt 2

    Topics: Adrenalectomy; Aldosterone; Androstanols; Animals; Blood Glucose; Drug Interactions; Gene Expression Regulation; Hypothalamus, Middle; Infusions, Parenteral; Insulin; Male; Mifepristone; Mineralocorticoid Receptor Antagonists; Neuropeptide Y; Rats; Rats, Sprague-Dawley; Receptors, Steroid; RNA, Messenger; Spironolactone

1994
Corticosteroid actions on amino acid-mediated transmission in rat CA1 hippocampal cells.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 1993, Volume: 13, Issue:9

    Topics: Action Potentials; Adrenalectomy; Aldosterone; Androstanols; Animals; Corticosterone; Electric Stimulation; Hippocampus; In Vitro Techniques; Male; Membrane Potentials; Mifepristone; Neurons; Pyramidal Tracts; Rats; Rats, Wistar; Synapses; Time Factors

1993
Glucocorticoids rapidly inhibit oxytocin-stimulated adrenocorticotropin release from rat anterior pituitary cells, without modifying intracellular calcium transients.
    Endocrinology, 1993, Volume: 132, Issue:2

    Topics: Adrenocorticotropic Hormone; Androstanols; Animals; Calcium; Cells, Cultured; Corticosterone; Female; In Vitro Techniques; Kinetics; Mifepristone; Oxytocin; Pituitary Gland, Anterior; Rats; Rats, Wistar; Time Factors

1993
Effects of the glucocorticoid agonist, RU28362, and the antagonist RU486 on lung phosphatidylcholine and antioxidant enzyme development in the genetically obese Zucker rat.
    Biochemical pharmacology, 1993, Feb-09, Volume: 45, Issue:3

    Topics: Androstanols; Animals; Body Weight; Eating; Glucocorticoids; Lung; Male; Mifepristone; Organ Size; Phospholipids; Rats; Rats, Zucker; Receptors, Glucocorticoid

1993
Glucocorticoids modulate the synthesis and expression of a 72 kDa heat shock protein in cultured Graves' retroocular fibroblasts.
    Acta endocrinologica, 1993, Volume: 128, Issue:1

    Topics: Androstanols; Blotting, Western; Cells, Cultured; Connective Tissue; Dexamethasone; Dose-Response Relationship, Drug; Eye; Fibroblasts; Fluorescent Antibody Technique; Graves Disease; Heat-Shock Proteins; Hot Temperature; Humans; Mifepristone; Receptors, Glucocorticoid

1993
Binding of RU486 and deacylcortivazol to the glucocorticoid receptor is insensitive to sulfhydryl-modifying agents.
    The Journal of steroid biochemistry and molecular biology, 1993, Volume: 44, Issue:3

    Topics: Alkylation; Androstanols; Animals; Binding, Competitive; Ethylmaleimide; Liver; Male; Maleimides; Mifepristone; Pregnatrienes; Rats; Rats, Wistar; Receptors, Glucocorticoid; Structure-Activity Relationship; Sulfhydryl Reagents; Triamcinolone Acetonide

1993
Steroid hormone stimulation of Na+ transport in A6 cells is mediated via glucocorticoid receptors.
    The American journal of physiology, 1993, Volume: 264, Issue:4 Pt 1

    Topics: Androstanols; Animals; Biological Transport, Active; Cell Line; DNA-Binding Proteins; Glucocorticoids; Kidney; Kinetics; Mifepristone; Mineralocorticoids; Nephrons; Receptors, Glucocorticoid; Sodium; Structure-Activity Relationship; Triamcinolone Acetonide; Xenopus laevis

1993
Basolateral amygdala lesions block the memory-enhancing effect of glucocorticoid administration in the dorsal hippocampus of rats.
    The European journal of neuroscience, 1997, Volume: 9, Issue:1

    Topics: Amygdala; Androstanols; Animals; Avoidance Learning; Electroshock; Glucocorticoids; Hippocampus; Hormone Antagonists; Injections, Intraventricular; Male; Maze Learning; Memory; Mifepristone; Rats; Rats, Sprague-Dawley; Receptors, Glucocorticoid

1997
Glucocorticoid receptor agonist and antagonist administration into the basolateral but not central amygdala modulates memory storage.
    Neurobiology of learning and memory, 1997, Volume: 67, Issue:2

    Topics: Amygdala; Androstanols; Animals; Male; Maze Learning; Memory; Mifepristone; Rats; Rats, Sprague-Dawley; Receptors, Glucocorticoid

1997
Glucocorticoid- and mineralocorticoid receptors in microglial cells: the two receptors mediate differential effects of corticosteroids.
    Glia, 1997, Volume: 20, Issue:1

    Topics: Adrenal Cortex Hormones; Aldosterone; Androstanols; Animals; Animals, Newborn; Cells, Cultured; Cholesterol; Corticosterone; Culture Media; Culture Media, Serum-Free; Dehydroepiandrosterone; Dexamethasone; Estradiol; Granulocyte-Macrophage Colony-Stimulating Factor; Hydrocortisone; Microglia; Mifepristone; Pregnenolone; Proliferating Cell Nuclear Antigen; Prosencephalon; Rats; Receptors, Glucocorticoid; Receptors, Mineralocorticoid; Testosterone

1997
Transcriptional regulation of pre-pro-endothelin-1 gene by glucocorticoids in vascular smooth muscle cells.
    Biochemical and biophysical research communications, 1998, Mar-17, Volume: 244, Issue:2

    Topics: Androstanols; Animals; Cells, Cultured; Cycloheximide; Dactinomycin; Endothelin-1; Endothelins; Gene Expression Regulation; Glucocorticoids; Hormone Antagonists; Mifepristone; Muscle, Smooth, Vascular; Protein Precursors; Rats; RNA, Messenger; Transcription, Genetic

1998
Glucocorticoid receptor activation in the rat nucleus of the solitary tract facilitates memory consolidation: involvement of the basolateral amygdala.
    The European journal of neuroscience, 1999, Volume: 11, Issue:4

    Topics: Amygdala; Androstanols; Animals; Avoidance Learning; Cerebellum; Dexamethasone; Dose-Response Relationship, Drug; Glucocorticoids; Hormone Antagonists; Injections, Intraventricular; Male; Memory; Mifepristone; Rats; Rats, Sprague-Dawley; Receptors, Glucocorticoid; Solitary Nucleus

1999
Corticosterone acutely prolonged N-methyl-d-aspartate receptor-mediated Ca2+ elevation in cultured rat hippocampal neurons.
    Journal of neurochemistry, 2002, Volume: 83, Issue:6

    Topics: Androstanols; Animals; Calcium; Calcium Signaling; Cells, Cultured; Corticosterone; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Fluorescent Dyes; Hippocampus; Hormone Antagonists; Membrane Potentials; Mifepristone; Mitochondria; N-Methylaspartate; Neurons; Pregnenolone; Rats; Rats, Wistar; Receptors, Glucocorticoid; Receptors, N-Methyl-D-Aspartate

2002
Glucocorticoids modulate neurotransmitter-induced glycogen metabolism in cultured cortical astrocytes.
    Journal of neurochemistry, 2004, Volume: 88, Issue:4

    Topics: Androstanols; Animals; Animals, Newborn; Astrocytes; Blotting, Northern; Carrier Proteins; Cells, Cultured; Cerebral Cortex; Cyclic AMP; Deoxyglucose; Dose-Response Relationship, Drug; Drug Interactions; Gene Expression; Glucocorticoids; Glycogen; Hormone Antagonists; Intracellular Signaling Peptides and Proteins; Lactase; Mice; Mifepristone; Neurotransmitter Agents; Norepinephrine; RNA, Messenger; Tritium

2004
Stress impairs reconsolidation of drug memory via glucocorticoid receptors in the basolateral amygdala.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2008, May-21, Volume: 28, Issue:21

    Topics: Amygdala; Analgesics, Opioid; Androstanols; Animals; Association Learning; Behavior, Animal; Conditioning, Operant; Corticosterone; Drug Administration Routes; Enzyme Inhibitors; Hormone Antagonists; Male; Memory Disorders; Metyrapone; Mifepristone; Morphine; Rats; Rats, Sprague-Dawley; Receptors, Glucocorticoid; Reward; Stress, Psychological

2008
Rapid alteration of stress-induced hypothalamic-pituitary-adrenal hormone secretion in the rat: a comparison of glucocorticoids and cannabinoids.
    Stress (Amsterdam, Netherlands), 2010, Volume: 13, Issue:3

    Topics: Adrenocorticotropic Hormone; Androstanols; Animals; Cannabinoids; Dose-Response Relationship, Drug; Feedback, Physiological; Glucocorticoids; Hormone Antagonists; Hypothalamo-Hypophyseal System; Male; Mifepristone; Paraventricular Hypothalamic Nucleus; Piperidines; Pituitary-Adrenal System; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB2; Receptors, Glutamate; Restraint, Physical; Stress, Physiological

2010