ru-28362 has been researched along with spironolactone in 15 studies
| Studies (ru-28362) | Trials (ru-28362) | Recent Studies (post-2010) (ru-28362) | Studies (spironolactone) | Trials (spironolactone) | Recent Studies (post-2010) (spironolactone) |
|---|---|---|---|---|---|
| 175 | 0 | 3 | 7,222 | 960 | 1,923 |
| Protein | Taxonomy | ru-28362 (IC50) | spironolactone (IC50) |
|---|---|---|---|
| Chain A, Mineralocorticoid receptor | Homo sapiens (human) | 0.049 | |
| Chain A, Mineralocorticoid receptor | Homo sapiens (human) | 0.049 | |
| Estrogen receptor | Homo sapiens (human) | 5.702 | |
| Glucocorticoid receptor | Homo sapiens (human) | 4.0745 | |
| Progesterone receptor | Homo sapiens (human) | 1.675 | |
| Glycine receptor subunit alpha-1 | Rattus norvegicus (Norway rat) | 1.9025 | |
| Mineralocorticoid receptor | Homo sapiens (human) | 0.0315 | |
| Androgen receptor | Homo sapiens (human) | 0.3585 | |
| Androgen receptor | Rattus norvegicus (Norway rat) | 0.406 | |
| Glycine receptor subunit beta | Rattus norvegicus (Norway rat) | 1.9025 | |
| Glycine receptor subunit alpha-2 | Rattus norvegicus (Norway rat) | 1.9025 | |
| Glycine receptor subunit alpha-3 | Rattus norvegicus (Norway rat) | 1.9025 | |
| Sodium-dependent serotonin transporter | Rattus norvegicus (Norway rat) | 6.92 | |
| Cytochrome P450 2C19 | Homo sapiens (human) | 3 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (26.67) | 18.7374 |
| 1990's | 11 (73.33) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Hayashi, T; Miyabo, S; Nakai, T | 1 |
| Fregly, MJ; Gault, TR; Sumners, C | 1 |
| Funder, JW; Myles, K; Pearce, PT; Roy, LP | 1 |
| de Jong, W; de Kloet, ER; van den Berg, DT; van Dijken, HH | 1 |
| Davda, MM; Luttge, WG; Rupp, ME | 1 |
| Binder, HJ; McGlone, F; Sandle, GI | 1 |
| Binder, HJ; Boulpaep, EL; Budinger, ME; Halevy, J; Hayslett, JP | 1 |
| Djiane, J; Houdebine, LM; Jahn, GA; Moguilewsky, M | 1 |
| Meaney, MJ; O'Donnell, D | 1 |
| Dean, RG; Edwards, GL; Martin, RJ; White, BD | 1 |
| Brooke, S; Jacobson, L; Sapolsky, R | 1 |
| Baker, ME; Rodbard, D; Rondinone, CM | 1 |
| Hastings, NB; McEwen, BS | 1 |
| Burton, G; Galigniana, MD; Lantos, CP; Monteserín, MC; Veleiro, AS; Vicent, GP | 1 |
| Fromm, M; Grotjohann, I; Schulzke, JD | 1 |
15 other study(ies) available for ru-28362 and spironolactone
| Article | Year |
|---|---|
Glucocorticoids increase Ca2+ uptake and [3H]dihydropyridine binding in A7r5 vascular smooth muscle cells.
Topics: Amiloride; Analysis of Variance; Androstanols; Animals; Calcium; Calcium Channels; Cell Count; Cell Line; Cycloheximide; Dactinomycin; Dexamethasone; Dihydropyridines; Electric Conductivity; Glucocorticoids; Indomethacin; Kinetics; Muscle, Smooth, Vascular; Potassium; Proteins; Rats; Receptors, Glucocorticoid; Spironolactone; Water | 1991 |
Potentiation of angiotensin II-induced drinking by glucocorticoids is a specific glucocorticoid type II receptor (GR)-mediated event.
Topics: Androstanols; Angiotensin II; Animals; Carbachol; Cerebral Ventricles; Dexamethasone; Dose-Response Relationship, Drug; Drinking Behavior; Drug Synergism; Injections, Intraventricular; Male; Mineralocorticoid Receptor Antagonists; Rats; Rats, Inbred Strains; Receptors, Glucocorticoid; Reference Values; Spironolactone; Time Factors | 1991 |
Apparent mineralocorticoid excess, pseudohypoaldosteronism, and urinary electrolyte excretion: toward a redefinition of mineralocorticoid action.
Topics: 11-beta-Hydroxysteroid Dehydrogenases; Adrenalectomy; Aldosterone; Androstanols; Animals; Bicarbonates; Carbenoxolone; Child; Electrolytes; Female; Humans; Hydrocortisone; Hydroxysteroid Dehydrogenases; Male; Mifepristone; Mineralocorticoids; Natriuresis; Pseudohypoaldosteronism; Rats; Rats, Inbred Strains; Receptors, Mineralocorticoid; Receptors, Steroid; Spironolactone | 1990 |
Differential central effects of mineralocorticoid and glucocorticoid agonists and antagonists on blood pressure.
Topics: Adrenalectomy; Aldosterone; Androstanols; Animals; Blood Pressure; Brain; Corticosterone; Glucocorticoids; Injections, Intraventricular; Male; Mifepristone; Mineralocorticoid Receptor Antagonists; Mineralocorticoids; Rats; Rats, Inbred Strains; Spironolactone | 1990 |
Aldosterone-stimulated down-regulation of both type I and type II adrenocorticosteroid receptors in mouse brain is mediated via type I receptors.
Topics: Aldosterone; Androstanols; Animals; Brain; Corticosterone; Dexamethasone; Female; Mice; Mice, Inbred Strains; Receptors, Corticotropin; Receptors, Pituitary Hormone; Spironolactone; Time Factors | 1989 |
Effects of corticosteroid hormones on the electrophysiology of rat distal colon: implications for Na+ and K+ transport.
Topics: Aldosterone; Amiloride; Androstanols; Animals; Biological Transport, Active; Colon; Dexamethasone; Male; Membrane Potentials; Potassium; Rats; Rats, Inbred Strains; Sodium; Spironolactone; Tetraethylammonium; Tetraethylammonium Compounds | 1989 |
Glucocorticoids have a different action than aldosterone on target tissue.
Topics: Adrenalectomy; Aldosterone; Amiloride; Androstanols; Animals; Colon; Electrophysiology; Glucocorticoids; Male; Potassium; Rats; Rats, Inbred Strains; Sodium; Spironolactone | 1988 |
Binding and action of glucocorticoids and mineralocorticoids in rabbit mammary gland. Exclusive participation of glucocorticoid type II receptors for stimulation of casein synthesis.
Topics: Aldosterone; Androstanols; Animals; Caseins; Culture Techniques; Female; Glucocorticoids; Mammary Glands, Animal; Mineralocorticoids; Rabbits; Receptors, Glucocorticoid; Spironolactone | 1987 |
Aldosterone modulates glucocorticoid receptor binding in hippocampal cell cultures via the mineralocorticoid receptor.
Topics: Aldosterone; Androstanols; Animals; Binding, Competitive; Cells, Cultured; Dexamethasone; Down-Regulation; Hippocampus; Kinetics; Rats; Receptors, Glucocorticoid; Receptors, Mineralocorticoid; Spironolactone | 1994 |
Type II corticosteroid receptor stimulation increases NPY gene expression in basomedial hypothalamus of rats.
Topics: Adrenalectomy; Aldosterone; Androstanols; Animals; Blood Glucose; Drug Interactions; Gene Expression Regulation; Hypothalamus, Middle; Infusions, Parenteral; Insulin; Male; Mifepristone; Mineralocorticoid Receptor Antagonists; Neuropeptide Y; Rats; Rats, Sprague-Dawley; Receptors, Steroid; RNA, Messenger; Spironolactone | 1994 |
Corticosterone is a preferable ligand for measuring rat brain corticosteroid receptors: competition by RU 28362 and RU 26752 for dexamethasone binding in rat hippocampal cytosol.
Topics: Androstanols; Animals; Binding, Competitive; Brain; Corticosterone; Cytosol; Dexamethasone; Hippocampus; Ligands; Male; Osmolar Concentration; Rats; Receptors, Steroid; Spironolactone | 1993 |
Aldosterone stimulated differentiation of mouse 3T3-L1 cells into adipocytes.
Topics: 3T3 Cells; Adipose Tissue; Aldosterone; Androstanols; Animals; Binding, Competitive; Cell Differentiation; Glycerolphosphate Dehydrogenase; Hydrocortisone; Mice; Receptors, Glucocorticoid; Spironolactone; Triglycerides | 1993 |
Characterization of adrenal hormone binding sites in the prairie vole.
Topics: Adrenalectomy; Adrenocorticotropic Hormone; Aldosterone; Androstanols; Animals; Arginine Vasopressin; Arvicolinae; Binding Sites; Brain; Cytosol; Dexamethasone; Hypertrophy; Kinetics; Mineralocorticoids; Rats; Receptors, Glucocorticoid; Spironolactone; Thymus Gland | 1997 |
21-Hydroxy-6,19-oxidoprogesterone: a novel synthetic steroid with specific antiglucocorticoid properties in the rat.
Topics: Aldosterone; Androstanols; Animals; Kidney; Male; Progesterone; Rats; Rats, Sprague-Dawley; Receptors, Glucocorticoid; Receptors, Mineralocorticoid; Spironolactone; Structure-Activity Relationship; Thymus Gland; Transcortin; Tritium | 1997 |
Electrogenic Na+ transport in rat late distal colon by natural and synthetic glucocorticosteroids.
Topics: Aldosterone; Androstanols; Animals; Biological Transport; Colon; Drug Combinations; Electric Conductivity; Glucocorticoids; Male; Mineralocorticoid Receptor Antagonists; Osmolar Concentration; Rats; Rats, Wistar; Sodium; Spironolactone | 1999 |