Page last updated: 2024-09-28

Masochism

Pleasure derived from being physically or psychologically abused, whether inflicted by oneself or by others. Masochism includes sexual masochism.

Synonyms(2)

Synonym
Sexual Masochism
Masochism

Research Excerpts

Overview

ExcerptReference
"Masochism is a residue of unresolved infantile conflict and is neither essentially feminine nor a valuable component of mature female function and character."( Blum, HP, 1976)

Context

ExcerptReference
"The term masochism has undergone an evaluation since first being introduced solely in relation to sexual perversion by Kraft Ebing in 1906."( Bruno, CA, 1992)

Research

Studies (101)

TimeframeStudies, This Condition (%)All Conditions %
pre-199071 (70.30)23.3326
1990's6 (5.94)12.5806
2000's14 (13.86)18.1394
2010's10 (9.90)28.8240
2020's0 (0.00)9.53
DrugIndicatedRelationship StrengthStudiesTrials
3,4-methylenedioxyamphetamine0low200
amitriptyline0low10
chlordiazepoxide0low10
diazepam0low10
haloperidol0low10
perphenazine0low10
thioridazine0low10
trifluoperazine0low10
lysergic acid diethylamide0low10
medroxyprogesterone acetate0low10
isoprene0low10
medroxyprogesterone0low30
4-methoxyamphetamine0low160
fomesafen0low10
melamine phosphate0low50
freedom0low10
17-ketosteroids0low10
vitamin k semiquinone radical0low10
humulene0low10
cyproterone0low10
id0low10
sodium ethylxanthate0low130
dicumarol0low10
eye0low10
ego0low400

Protein Targets (456)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
5-hydroxytryptamine receptor 2C07310
5-hydroxytryptamine receptor 2A07411
5-hydroxytryptamine receptor 1A011314
Sodium-dependent noradrenaline transporter 0808
Sodium-dependent dopamine transporter0314
5-hydroxytryptamine receptor 1B0729
5-hydroxytryptamine receptor 1D0325
5-hydroxytryptamine receptor 1F0325
5-hydroxytryptamine receptor 2B07310
5-hydroxytryptamine receptor 60123
Sodium-dependent serotonin transporter08210
Sodium-dependent serotonin transporter0314
5-hydroxytryptamine receptor 7 0325
5-hydroxytryptamine receptor 5A0123
5-hydroxytryptamine receptor 5B0123
5-hydroxytryptamine receptor 3A0123
Sodium-dependent dopamine transporter 0707
5-hydroxytryptamine receptor 4 0123
5-hydroxytryptamine receptor 3B0123
Chain A, HADH2 protein3003
Chain B, HADH2 protein3003
thioredoxin reductase3003
USP1 protein, partial6006
NFKB1 protein, partial4004
GLS protein4004
cytochrome P450 family 3 subfamily A polypeptide 48008
cytochrome P450 2D66006
arylsulfatase A3003
cytochrome P450 2D6 isoform 14004
D(1A) dopamine receptor5005
chromobox protein homolog 16006
atrial natriuretic peptide receptor 2 precursor4004
serine/threonine-protein kinase mTOR isoform 15005
nuclear factor erythroid 2-related factor 2 isoform 1110011
muscarinic acetylcholine receptor M14004
Solute carrier family 22 member 1 0202
Polyunsaturated fatty acid lipoxygenase ALOX15B4004
ATP-binding cassette sub-family C member 30606
Multidrug resistance-associated protein 40606
Voltage-dependent L-type calcium channel subunit alpha-1F0404
5-hydroxytryptamine receptor 40606
Bile salt export pump010010
Albumin0055
High affinity nerve growth factor receptor0123
Aldo-keto reductase family 1 member B10606
Muscarinic acetylcholine receptor M20505
Muscarinic acetylcholine receptor M40505
Muscarinic acetylcholine receptor M10404
Muscarinic acetylcholine receptor M30404
Muscarinic acetylcholine receptor M40404
Muscarinic acetylcholine receptor M50404
Muscarinic acetylcholine receptor M50606
Alpha-2A adrenergic receptor0606
Muscarinic acetylcholine receptor M20404
Muscarinic acetylcholine receptor M10606
Angiotensin-converting enzyme0909
D(2) dopamine receptor08111
Alpha-2B adrenergic receptor0606
Alpha-2C adrenergic receptor0606
Muscarinic acetylcholine receptor M30505
D(1A) dopamine receptor0607
D(1B) dopamine receptor0405
UDP-glucuronosyltransferase 1A40002
Histamine H2 receptor0808
Alpha-1D adrenergic receptor0606
5-hydroxytryptamine receptor 2A0718
5-hydroxytryptamine receptor 2C0707
Histamine H1 receptor0404
Histamine H1 receptor0909
D(3) dopamine receptor07110
Sodium channel protein type 1 subunit alpha0202
Sodium channel protein type 4 subunit alpha0202
UDP-glucuronosyltransferase 1A30001
5-hydroxytryptamine receptor 2B0707
Alpha-1A adrenergic receptor0505
Histamine H2 receptor5108
D(1A) dopamine receptor3104
5-hydroxytryptamine receptor 60606
5-hydroxytryptamine receptor 70202
Voltage-dependent N-type calcium channel subunit alpha-1B0101
Sodium channel protein type 7 subunit alpha0202
Voltage-dependent L-type calcium channel subunit alpha-1D 0404
Potassium voltage-gated channel subfamily H member 2010010
Voltage-dependent L-type calcium channel subunit alpha-1S0404
Voltage-dependent L-type calcium channel subunit alpha-1C0404
Sodium channel protein type 5 subunit alpha0303
Sodium channel protein type 9 subunit alpha0202
Sigma non-opioid intracellular receptor 10112
Nuclear receptor subfamily 3 group C member 3 0808
Canalicular multispecific organic anion transporter 10505
Sodium channel protein type 2 subunit alpha0202
Ataxin-28008
Sigma non-opioid intracellular receptor 10707
Sodium channel protein type 3 subunit alpha0202
Sodium channel protein type 11 subunit alpha0202
Sodium channel protein type 8 subunit alpha0202
Histamine H3 receptor0101
Sodium channel protein type 10 subunit alpha0202
Chain A, Ferritin light chain2002
acetylcholinesterase6006
hypoxia-inducible factor 1 alpha subunit4004
RAR-related orphan receptor gamma8008
SMAD family member 24004
SMAD family member 34004
TDP1 protein110011
GLI family zinc finger 39009
Microtubule-associated protein tau5005
AR protein140014
caspase 7, apoptosis-related cysteine protease4004
estrogen receptor 2 (ER beta)6006
nuclear receptor subfamily 1, group I, member 3110011
progesterone receptor100010
glucocorticoid receptor [Homo sapiens]9009
retinoic acid nuclear receptor alpha variant 17007
retinoid X nuclear receptor alpha8008
estrogen-related nuclear receptor alpha110011
farnesoid X nuclear receptor7007
estrogen nuclear receptor alpha140014
67.9K protein3003
peroxisome proliferator-activated receptor delta7007
peroxisome proliferator activated receptor gamma9009
vitamin D (1,25- dihydroxyvitamin D3) receptor9009
caspase-34004
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)3003
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a9009
activating transcription factor 62002
thyrotropin-releasing hormone receptor1001
v-jun sarcoma virus 17 oncogene homolog (avian)7007
vitamin D3 receptor isoform VDRA4004
thyroid hormone receptor beta isoform 2100010
heat shock protein beta-14004
mitogen-activated protein kinase 14004
nuclear receptor ROR-gamma isoform 13003
survival motor neuron protein isoform d4004
Voltage-dependent calcium channel gamma-2 subunit5005
Cellular tumor antigen p536006
Glutamate receptor 25005
Caspase-20011
Inositol monophosphatase 12002
ATPase family AAA domain-containing protein 55005
glp-1 receptor, partial5005
IDH14004
potassium voltage-gated channel subfamily H member 2 isoform d6006
geminin8008
Gamma-aminobutyric acid receptor subunit pi64111
Gamma-aminobutyric acid receptor subunit alpha-10303
Gamma-aminobutyric acid receptor subunit beta-10303
Gamma-aminobutyric acid receptor subunit alpha-20303
Gamma-aminobutyric acid receptor subunit alpha-30303
Gamma-aminobutyric acid receptor subunit alpha-10325
Gamma-aminobutyric acid receptor subunit beta-164111
Translocator protein0214
Gamma-aminobutyric acid receptor subunit delta64111
Gamma-aminobutyric acid receptor subunit gamma-20314
Gamma-aminobutyric acid receptor subunit gamma-264111
Gamma-aminobutyric acid receptor subunit alpha-564111
Gamma-aminobutyric acid receptor subunit alpha-364111
Gamma-aminobutyric acid receptor subunit alpha-40303
Gamma-aminobutyric acid receptor subunit gamma-20303
Gamma-aminobutyric acid receptor subunit gamma-164111
Gamma-aminobutyric acid receptor subunit alpha-264111
Gamma-aminobutyric acid receptor subunit alpha-464111
Gamma-aminobutyric acid receptor subunit beta-30314
Gamma-aminobutyric acid receptor subunit gamma-364111
Gamma-aminobutyric acid receptor subunit alpha-664111
Cholecystokinin receptor type A0202
Gastrin/cholecystokinin type B receptor0202
Gamma-aminobutyric acid receptor subunit alpha-50325
Gamma-aminobutyric acid receptor subunit alpha-30314
Gamma-aminobutyric acid receptor subunit alpha-20314
Gamma-aminobutyric acid receptor subunit alpha-164111
Gamma-aminobutyric acid receptor subunit beta-364111
Gamma-aminobutyric acid receptor subunit beta-264111
GABA theta subunit64111
Gamma-aminobutyric acid receptor subunit epsilon64111
nuclear receptor subfamily 1, group I, member 22002
Gamma-aminobutyric acid 0101
pregnane X nuclear receptor100010
G5005
Gamma-aminobutyric acid receptor subunit pi0202
Gamma-aminobutyric acid receptor subunit delta0202
Interferon beta6006
HLA class I histocompatibility antigen, B alpha chain 5005
Fatty acid-binding protein, liver0101
Alpha-1-acid glycoprotein 10001
Albumin0113
ATP-dependent translocase ABCB10406
Neuronal acetylcholine receptor subunit alpha-40101
Neuronal acetylcholine receptor subunit beta-20101
Gamma-aminobutyric acid receptor subunit alpha-60101
Gamma-aminobutyric acid receptor subunit beta-10202
Gamma-aminobutyric acid receptor subunit gamma-20101
Gamma-aminobutyric acid receptor subunit delta0101
Gamma-aminobutyric acid receptor subunit alpha-20101
Gamma-aminobutyric acid receptor subunit alpha-30101
Gamma-aminobutyric acid receptor subunit gamma-30101
Translocator protein0101
Translocator protein0101
Gamma-aminobutyric acid receptor subunit beta-20213
Gamma-aminobutyric acid receptor subunit alpha-40202
Gamma-aminobutyric acid receptor subunit beta-10101
Gamma-aminobutyric acid receptor subunit alpha-10101
Gamma-aminobutyric acid receptor subunit beta-30101
Gamma-aminobutyric acid receptor subunit epsilon0202
Neuronal acetylcholine receptor subunit alpha-70101
Gamma-aminobutyric acid receptor subunit alpha-60202
Gamma-aminobutyric acid receptor subunit alpha-50101
Gamma-aminobutyric acid receptor subunit gamma-10202
Gamma-aminobutyric acid receptor subunit pi0101
Sphingosine-1-phosphate lyase 10101
Inositol hexakisphosphate kinase 15005
Gamma-aminobutyric acid receptor subunit gamma-30202
Gamma-aminobutyric acid receptor subunit alpha-40101
Gamma-aminobutyric acid receptor subunit theta0101
Gamma-aminobutyric acid receptor subunit gamma-10101
Gamma-aminobutyric acid receptor subunit theta0202
cytochrome P450 2C9, partial5005
Luciferase4004
aldehyde dehydrogenase 1 family, member A15005
thyroid stimulating hormone receptor6006
Histone H2A.x5005
cellular tumor antigen p53 isoform a4004
cytochrome P450 2C19 precursor3003
cytochrome P450 2C9 precursor2002
cytochrome P450 3A4 isoform 16006
lamin isoform A-delta105005
Integrin beta-34004
NAD0101
Cholinesterase0101
Urease0101
Integrin alpha-IIb4004
Cytochrome P450 2C9 0404
NAD0102
Mitogen-activated protein kinase 10101
ATP phosphoribosyltransferase0101
Proprotein convertase subtilisin/kexin type 70101
Enoyl-[acyl-carrier-protein] reductase [NADH] 0101
Integrase 0101
G-protein coupled receptor 350112
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE3003
15-lipoxygenase, partial2002
ATAD5 protein, partial3003
Fumarate hydratase4004
Thrombopoietin3003
regulator of G-protein signaling 44004
EWS/FLI fusion protein2002
nonstructural protein 12002
polyprotein4004
glucocerebrosidase3003
euchromatic histone-lysine N-methyltransferase 26006
Adenylate cyclase type 1 0101
thyroid stimulating hormone receptor5005
peripheral myelin protein 22 isoform 12002
peripheral myelin protein 224004
transient receptor potential cation channel subfamily V member 12002
lethal factor (plasmid)3003
Cocaine esterase0101
Transient receptor potential cation channel subfamily V member 10101
Voltage-dependent L-type calcium channel subunit alpha-1C0202
UDP-glucuronosyltransferase 1A90102
Potassium channel subfamily K member 20101
Major prion protein0011
Vitamin D-binding protein0101
HLA class I histocompatibility antigen, A alpha chain 0011
Integrin beta-10101
Cytochrome P450 3A40102
5-hydroxytryptamine receptor 1A0303
Beta-2 adrenergic receptor0202
Integrin alpha-40101
Alpha-1B adrenergic receptor0404
Carbonyl reductase [NADPH] 10001
UDP-glucuronosyltransferase 2B70102
Beta-1 adrenergic receptor0101
D0303
D(3) dopamine receptor0303
Alpha-2B adrenergic receptor0202
D(2) dopamine receptor0202
D(4) dopamine receptor0518
Adenylate cyclase type 30101
Alpha-2C adrenergic receptor0202
Alpha-2A adrenergic receptor0202
Alpha-1D adrenergic receptor0404
5-hydroxytryptamine receptor 3A0101
Adenosine receptor A10101
D(1B) dopamine receptor0303
Beta-3 adrenergic receptor0101
Adenylate cyclase type 20101
Adenylate cyclase type 40101
D(4) dopamine receptor0303
C-8 sterol isomerase0202
Delta-type opioid receptor0101
Mu-type opioid receptor0101
5-hydroxytryptamine receptor 2C 0101
5-hydroxytryptamine receptor 70404
Kappa-type opioid receptor0101
Alpha-1A adrenergic receptor0101
5-hydroxytryptamine receptor 2A0101
Alpha-1B adrenergic receptor0101
Mu-type opioid receptor0213
Glutamate receptor ionotropic, NMDA 1 0101
Adenylate cyclase type 80101
Kappa-type opioid receptor0101
5-hydroxytryptamine receptor 2A0101
Cytochrome P450 2J20202
D(2) dopamine receptor0101
D(3) dopamine receptor0101
Gastrin/cholecystokinin type B receptor0101
Spike glycoprotein5005
D(2) dopamine receptor0516
AP-2 complex subunit sigma0101
N-acetyltransferase Eis0202
Glutamate receptor ionotropic, NMDA 2A 0101
Glutamate receptor ionotropic, NMDA 2B0101
Glutamate receptor ionotropic, NMDA 2C0101
5-hydroxytryptamine receptor 2B0101
Adenylate cyclase type 60101
Adenylate cyclase type 50101
TAR DNA-binding protein 431001
5-hydroxytryptamine receptor 40101
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase0202
Calcitonin gene-related peptide type 1 receptor0101
Genome polyprotein 0202
Sigma intracellular receptor 20101
Sigma intracellular receptor 20101
Zinc finger protein 6640101
Glutamate receptor ionotropic, NMDA 2D0101
Vesicular acetylcholine transporter0101
Transporter0101
Cholecystokinin receptor type A0101
Protease 0202
Adenylyl cyclase 7 0101
Glutamate receptor ionotropic, NMDA 3B0101
D0101
Transient receptor potential cation channel subfamily V member 40101
Sigma non-opioid intracellular receptor 10303
Glutamate receptor ionotropic, NMDA 3A0101
Transient receptor potential cation channel subfamily V member 20101
ATP-dependent phosphofructokinase2002
interleukin 82002
aryl hydrocarbon receptor4004
Beta-2 adrenergic receptor0101
Beta-1 adrenergic receptor0101
Catechol O-methyltransferase0101
5-hydroxytryptamine receptor 1D0101
5-hydroxytryptamine receptor 1E0101
5-hydroxytryptamine receptor 5A0101
D0101
Sodium-dependent dopamine transporter0101
Chain A, Beta-lactamase4004
GALC protein2002
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)1001
PINK12002
Parkin3003
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a3003
parathyroid hormone/parathyroid hormone-related peptide receptor precursor1001
Glucocorticoid receptor0415
Glycine receptor subunit alpha-10404
Androgen receptor0404
Glycine receptor subunit beta0404
Glycine receptor subunit alpha-20404
Glycine receptor subunit alpha-30404
Cytochrome P450 2C190202
Chain A, Cruzipain1001
pregnane X receptor2002
nuclear factor erythroid 2-related factor 2 isoform 21001
transcriptional regulator ERG isoform 32002
DNA polymerase iota isoform a (long)3003
neuropeptide S receptor isoform A2002
Estrogen receptor0112
Sex hormone-binding globulin0011
Progesterone receptor0213
Mineralocorticoid receptor 0101
Androgen receptor0224
Androgen receptor0011
Alpha-synuclein1001
Aldo-keto reductase family 1 member C30101
Nuclear receptor ROR-gamma1001
Aldo-keto reductase family 1 member C2 0101
Guanine nucleotide-binding protein G2002
Aldo-keto reductase family 1 member C10101
Estrogen receptor beta0112
Carbonic anhydrase 10101
Carbonic anhydrase 20101
Carbonic anhydrase 40101
Carbonic anhydrase0101
Sodium/iodide cotransporter0101
Carbonic anhydrase 150101
thyroid hormone receptor beta isoform a1001
Chain A, TYROSYL-DNA PHOSPHODIESTERASE2002
Chain A, JmjC domain-containing histone demethylation protein 3A2002
Chain A, ATP-DEPENDENT DNA HELICASE Q11001
endonuclease IV1001
phosphopantetheinyl transferase2002
Smad32002
apical membrane antigen 1, AMA12002
NADPH oxidase 10202
bromodomain adjacent to zinc finger domain 2B1001
Snq2p0003
Caspase-73003
NPC intracellular cholesterol transporter 1 precursor3003
caspase-33003
ubiquitin-conjugating enzyme E2 N0101
ubiquitin carboxyl-terminal hydrolase 2 isoform a1001
ras-related protein Rab-9A3003
protein AF-9 isoform a0001
bcl-2-related protein A10101
Vpr1001
M-phase phosphoprotein 83003
DNA repair protein RAD52 homolog isoform a0002
Aldehyde oxidase 10101
Retinal dehydrogenase 10101
Pleiotropic ABC efflux transporter of multiple drugs0306
Disintegrin and metalloproteinase domain-containing protein 171001
Aldehyde oxidase0103
Aldehyde oxidase 10101
Rap guanine nucleotide exchange factor 41001
Aldehyde oxidase 1 0101
atrial natriuretic peptide receptor 1 precursor1001
huntingtin isoform 21001
Epidermal growth factor receptor0101
Cytochrome P450 1A20101
Tyrosine-protein kinase Fyn0101
Tryptophan 5-hydroxylase 10101
Replicase polyprotein 1ab0101
Cytochrome P450 2D60101
Kappa-type opioid receptor0202
Proteasome subunit alpha type-60011
Cathepsin D 0101
Mucosa-associated lymphoid tissue lymphoma translocation protein 10101
Broad substrate specificity ATP-binding cassette transporter ABCG20101
Genome polyprotein 0101
DNA polymerase kappa isoform 11001
histone acetyltransferase KAT2A isoform 12002
DNA dC->dU-editing enzyme APOBEC-3G isoform 11001
Ubiquitin carboxyl-terminal hydrolase 10101
Lysozyme C-10101
Glycoprotein hormones alpha chain1001
Sarcoplasmic/endoplasmic reticulum calcium ATPase 10101
Protein kinase C alpha type0101
Beta-glucuronidase0101
Protein kinase C delta type0101
Protein kinase C epsilon type0101
Protein kinase C zeta type0101
Calmodulin-10011
Trypanothione reductase0202
Calmodulin 0011
Protein kinase C gamma type0101
Protein kinase C beta type0101
DNA-dependent protein kinase catalytic subunit0101
Protein kinase C eta type0101
Calcium-dependent protein kinase 40101
WD repeat-containing protein 480101
Emopamil-binding protein-like0101
Protein kinase C theta type0101
thioredoxin glutathione reductase1001
Rap guanine nucleotide exchange factor 31001
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]