Page last updated: 2024-09-27

Hypophysitis

Inflammation of the PITUITARY GLAND.

Synonyms(1)

Synonym
Hypophysitis

Research Excerpts

Overview

ExcerptReference
"Although hypophysitis is a rare immune-related adverse event that is associated with nivolumab therapy, clinical awareness is essential, as this condition can be life-threatening and requires prompt treatment."( Fuchigami, A; Hiyoshi, T; Sonoda, M; Takaya, K, 2017)
"Hypophysitis is a well-recognized immune-related adverse event in patients treated with immune checkpoint inhibitors for cancer."( Gallagher, EJ; Galsky, M; Leiter, A; Thapi, S, 2019)
"Immune-related hypophysitis is conventionally considered distinctive of cytotoxic T-lymphocyte antigen 4 (CTLA-4) inhibitors."( Deligiorgi, MV; Siasos, G; Trafalis, DT; Vergadis, C, 2020)
"Hypophysitis is one of the most common endocrine abnormalities."( Greener, V; Lai, ZM; Larkin, J; Morganstein, DL; Siddiqui, MS; Spain, L; Turajlic, S, 2021)
"Hypophysitis is one of the more common adverse events, usually presenting with headache, pituitary enlargement and hypopituitarism, mostly ACTH deficiency, which is usually permanent."( Brock, C; Dede, A; Larkin, J; Menon, A; Mitra, I; Morganstein, D; Nogueira, E, 2021)

Research

Studies (29)

TimeframeStudies, This Condition (%)All Conditions %
pre-19900 (0.00)23.3326
1990's0 (0.00)12.5806
2000's0 (0.00)18.1394
2010's11 (37.93)28.8240
2020's18 (62.07)9.53
DrugIndicatedRelationship StrengthStudiesTrials
prednisolone0low20
thyroxine0low20
prednisone0low20
methylprednisolone0low10
gadolinium0low10
triamcinolone0low10
fluorodeoxyglucose f180low10
oxytocin0low10
mycophenolic acid0low10
arginine vasopressin0low10
deamino arginine vasopressin0low40
axitinib0low10
trametinib0low10
plx40320low10
dabrafenib0low10
ipi-1450low10
dacarbazine0low10
leptin0low10
pyrimidinones0low10

Protein Targets (725)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
vitamin D3 receptor isoform VDRA3003
peripheral myelin protein 223003
ATP-binding cassette sub-family C member 30505
Multidrug resistance-associated protein 40505
Bile salt export pump0505
Translocator protein0011
Vasopressin V2 receptor0438
Oxytocin receptor0347
Vasopressin V1a receptor0123
Vasopressin V1a receptor0437
Vasopressin V1b receptor0336
Vasopressin V2 receptor0011
Vasopressin V1b receptor0214
Translocator protein0203
Oxytocin receptor0202
Vasopressin V2 receptor 0325
Canalicular multispecific organic anion transporter 10505
Chain A, VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 20101
Chain A, VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 20101
Chain A, VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 20101
Chain A, VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 20101
Chain A, VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 20101
Leukotriene C4 synthase0011
Luciferase2002
acetylcholinesterase3003
RAR-related orphan receptor gamma7007
SMAD family member 24004
PPM1D protein5005
SMAD family member 34004
TDP1 protein6006
GLI family zinc finger 36006
AR protein8008
caspase 7, apoptosis-related cysteine protease2002
estrogen receptor 2 (ER beta)4004
nuclear receptor subfamily 1, group I, member 35005
progesterone receptor7007
cytochrome P450 family 3 subfamily A polypeptide 46006
retinoic acid nuclear receptor alpha variant 15005
retinoid X nuclear receptor alpha4004
estrogen-related nuclear receptor alpha9009
farnesoid X nuclear receptor3003
pregnane X nuclear receptor7007
estrogen nuclear receptor alpha9009
G6006
cytochrome P450 2D62002
peroxisome proliferator-activated receptor delta4004
peroxisome proliferator activated receptor gamma5005
vitamin D (1,25- dihydroxyvitamin D3) receptor4004
caspase-32002
aryl hydrocarbon receptor4004
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a8008
Histone H2A.x3003
thyroid hormone receptor beta isoform 25005
histone deacetylase 9 isoform 31001
tyrosine-protein kinase Yes2002
nuclear factor erythroid 2-related factor 2 isoform 16006
Bone morphogenetic protein receptor type-1B0044
Cell division cycle 7-related protein kinase0033
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform0112
Serine/threonine-protein kinase PLK40246
Serine/threonine-protein kinase 250011
ATP-dependent RNA helicase DDX3X0044
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta0011
Pyridoxal kinase0044
Citron Rho-interacting kinase0044
Serine/threonine-protein kinase RIO30011
Dual specificity mitogen-activated protein kinase kinase 70011
Serine/threonine-protein kinase Chk10044
Inhibitor of nuclear factor kappa-B kinase subunit beta0011
Peripheral plasma membrane protein CASK0011
Aurora kinase A0044
Cyclin-G-associated kinase0044
Serine/threonine-protein kinase DCLK10011
Inhibitor of nuclear factor kappa-B kinase subunit alpha0011
Muscle, skeletal receptor tyrosine-protein kinase0011
Ephrin type-B receptor 60044
Peroxisomal acyl-coenzyme A oxidase 30044
Mitogen-activated protein kinase 130011
3-phosphoinositide-dependent protein kinase 10011
Mitogen-activated protein kinase kinase kinase 130011
Death-associated protein kinase 30011
Mitogen-activated protein kinase kinase kinase 70011
Receptor-interacting serine/threonine-protein kinase 20145
Mitotic checkpoint serine/threonine-protein kinase BUB10044
NUAK family SNF1-like kinase 10011
Dynamin-like 120 kDa protein, mitochondrial0044
Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma0011
Tyrosine-protein kinase JAK20044
Eukaryotic translation initiation factor 5B0033
Rho-associated protein kinase 20044
Serine/threonine-protein kinase ULK10044
Serine/threonine-protein kinase/endoribonuclease IRE10044
Ribosomal protein S6 kinase alpha-50044
U5 small nuclear ribonucleoprotein 200 kDa helicase0044
Ribosomal protein S6 kinase alpha-40044
Serine/threonine-protein kinase 160044
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma0011
Serine/threonine-protein kinase PAK 30011
Cyclin-dependent kinase-like 50033
Voltage-dependent calcium channel gamma-2 subunit4004
Serine/threonine-protein kinase 17B0011
Serine/threonine-protein kinase 100044
Serine/threonine-protein kinase D30044
Cyclin-dependent kinase 140011
Structural maintenance of chromosomes protein 20044
Mitogen-activated protein kinase kinase kinase 60044
Serine/threonine-protein kinase OSR10011
Mitogen-activated protein kinase kinase kinase kinase 40044
Serine/threonine-protein kinase LATS10044
Serine/threonine-protein kinase PAK 40044
Serine/threonine-protein kinase Chk20011
Tyrosine-protein kinase ABL10246
Epidermal growth factor receptor0145
Interferon beta8008
HLA class I histocompatibility antigen, B alpha chain 6006
RAF proto-oncogene serine/threonine-protein kinase0226
Receptor tyrosine-protein kinase erbB-20011
High affinity nerve growth factor receptor0044
Cellular tumor antigen p536006
Guanine nucleotide-binding protein G(i) subunit alpha-20044
ADP/ATP translocase 20044
Protein kinase C beta type0044
Insulin receptor0044
Tyrosine-protein kinase Lck0044
Tyrosine-protein kinase Fyn0044
Cyclin-dependent kinase 10044
Glycogen phosphorylase, liver form0044
Tyrosine-protein kinase Fes/Fps0044
Macrophage colony-stimulating factor 1 receptor0011
Adenine phosphoribosyltransferase0044
Tyrosine-protein kinase Yes0044
Tyrosine-protein kinase Lyn0044
Proto-oncogene tyrosine-protein kinase receptor Ret0044
Insulin-like growth factor 1 receptor0044
Signal recognition particle receptor subunit alpha0033
Cytochrome c1, heme protein, mitochondrial0044
Hepatocyte growth factor receptor0044
Tyrosine-protein kinase HCK0044
Cytochrome P450 3A40202
Proto-oncogene tyrosine-protein kinase ROS0011
Platelet-derived growth factor receptor beta0044
Tyrosine-protein kinase Fgr0044
Wee1-like protein kinase 20011
Uncharacterized serine/threonine-protein kinase SBK30011
Serine/threonine-protein kinase A-Raf0246
Cytochrome P450 2D60011
Mast/stem cell growth factor receptor Kit0112
Glycogen phosphorylase, brain form0044
Breakpoint cluster region protein0145
Serine/threonine-protein kinase pim-10044
Fibroblast growth factor receptor 10145
DNA topoisomerase 2-alpha0044
Cyclin-dependent kinase 40044
ADP/ATP translocase 30044
Inosine-5'-monophosphate dehydrogenase 20246
Proto-oncogene tyrosine-protein kinase Src0044
cAMP-dependent protein kinase type II-alpha regulatory subunit0044
Insulin receptor-related protein0011
Serine/threonine-protein kinase B-raf02610
Phosphorylase b kinase gamma catalytic chain, liver/testis isoform0044
Ribosyldihydronicotinamide dehydrogenase [quinone]0044
Platelet-derived growth factor receptor alpha0011
Tyrosine-protein kinase Fer0044
Protein kinase C alpha type0044
cAMP-dependent protein kinase catalytic subunit alpha0044
Vascular endothelial growth factor receptor 1 0112
General transcription and DNA repair factor IIH helicase subunit XPD0044
Glutamate receptor 24105
Interferon-induced, double-stranded RNA-activated protein kinase0011
Casein kinase II subunit alpha'0044
Ras-related protein Rab-6A0044
Serine/threonine-protein kinase MAK0011
Cyclin-dependent kinase 11B0011
Ephrin type-A receptor 10044
Fibroblast growth factor receptor 20011
Receptor tyrosine-protein kinase erbB-30011
Multifunctional protein ADE20044
Fibroblast growth factor receptor 40011
Fibroblast growth factor receptor 30011
cAMP-dependent protein kinase catalytic subunit gamma0033
cAMP-dependent protein kinase catalytic subunit beta0044
Ferrochelatase, mitochondrial0055
Ribosomal protein S6 kinase beta-10044
Tyrosine-protein kinase JAK10044
Protein kinase C eta type0011
Cyclin-dependent kinase 20044
Beta-adrenergic receptor kinase 10044
Probable ATP-dependent RNA helicase DDX60044
Activin receptor type-2A0011
Mitogen-activated protein kinase 3 0044
MAP/microtubule affinity-regulating kinase 30044
Deoxycytidine kinase0044
Mitogen-activated protein kinase 10044
Ephrin type-A receptor 20044
Ephrin type-A receptor 30011
Ephrin type-A receptor 80011
Ephrin type-B receptor 20044
Leukocyte tyrosine kinase receptor0011
Non-receptor tyrosine-protein kinase TYK20044
UMP-CMP kinase 0044
Phosphatidylethanolamine-binding protein 10044
Wee1-like protein kinase0044
Heme oxygenase 20044
Tyrosine-protein kinase receptor UFO0011
Mitogen-activated protein kinase 40011
S-adenosylmethionine synthase isoform type-20044
DnaJ homolog subfamily A member 10044
RAC-alpha serine/threonine-protein kinase0044
RAC-beta serine/threonine-protein kinase0044
G protein-coupled receptor kinase 40011
Dual specificity protein kinase TTK0033
DNA replication licensing factor MCM40044
Prostaglandin G/H synthase 20112
Myosin-100044
Tyrosine-protein kinase receptor Tie-10011
Vascular endothelial growth factor receptor 30112
Vascular endothelial growth factor receptor 20314
Dual specificity mitogen-activated protein kinase kinase 20347
Receptor-type tyrosine-protein kinase FLT30044
Bone morphogenetic protein receptor type-1A0044
Activin receptor type-1B0044
TGF-beta receptor type-10145
Serine/threonine-protein kinase receptor R30033
TGF-beta receptor type-20044
Electron transfer flavoprotein subunit beta0044
Tyrosine-protein kinase CSK0044
Glycine--tRNA ligase0044
Protein kinase C iota type0044
Exosome RNA helicase MTR40044
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform0112
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform0112
Serine/threonine-protein kinase mTOR0011
Megakaryocyte-associated tyrosine-protein kinase0011
Tyrosine-protein kinase Tec0044
Tyrosine-protein kinase TXK0011
Tyrosine-protein kinase ABL20044
Tyrosine-protein kinase FRK0044
G protein-coupled receptor kinase 60033
Tyrosine-protein kinase ZAP-700011
Tyrosine-protein kinase SYK0044
26S proteasome regulatory subunit 6B0044
Mitogen-activated protein kinase 80044
Mitogen-activated protein kinase 90044
Dual specificity mitogen-activated protein kinase kinase 40044
Dual specificity mitogen-activated protein kinase kinase 30044
Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha0044
Casein kinase I isoform alpha0044
Casein kinase I isoform delta0044
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform 0112
MAP kinase-activated protein kinase 20044
Cyclin-dependent kinase 80011
Elongation factor Tu, mitochondrial0044
Choline-phosphate cytidylyltransferase A0033
Cysteine--tRNA ligase, cytoplasmic0044
Casein kinase I isoform epsilon0044
Very long-chain specific acyl-CoA dehydrogenase, mitochondrial0044
Dual specificity protein kinase CLK10044
Dual specificity protein kinase CLK20044
Dual specificity protein kinase CLK30033
Glycogen synthase kinase-3 alpha0044
Glycogen synthase kinase-3 beta0044
Cyclin-dependent kinase 70044
Cyclin-dependent kinase 90044
Ras-related protein Rab-27A0044
Tyrosine-protein kinase Blk0011
Interleukin-1 receptor-associated kinase 10044
Ribosomal protein S6 kinase alpha-30044
Cytoplasmic tyrosine-protein kinase BMX0011
cAMP-dependent protein kinase catalytic subunit PRKX0011
Serine/threonine-protein kinase Nek20044
Serine/threonine-protein kinase Nek30044
Serine/threonine-protein kinase Nek40011
Tyrosine-protein kinase JAK30011
Dual specificity mitogen-activated protein kinase kinase 60044
Serine/threonine-protein kinase PLK10246
Death-associated protein kinase 10011
LIM domain kinase 10044
LIM domain kinase 20044
Mitogen-activated protein kinase 120011
Mitogen-activated protein kinase 100044
Tyrosine--tRNA ligase, cytoplasmic0044
5'-AMP-activated protein kinase subunit gamma-10044
5'-AMP-activated protein kinase catalytic subunit alpha-20011
Ephrin type-B receptor 30044
Ephrin type-A receptor 50044
Ephrin type-B receptor 40044
Ephrin type-B receptor 10011
Ephrin type-A receptor 40044
Adenylate kinase 2, mitochondrial0044
Adenosine kinase0044
Hormonally up-regulated neu tumor-associated kinase0011
Serine/threonine-protein kinase SIK10011
Receptor-interacting serine/threonine-protein kinase 40011
Spike glycoprotein4004
Ras-related protein Rab-100044
Cell division control protein 2 homolog0011
Actin-related protein 30044
Actin-related protein 20044
Calcium-dependent protein kinase 10011
GTP-binding nuclear protein Ran0044
Casein kinase II subunit alpha0011
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta0011
SRSF protein kinase 20011
Casein kinase I isoform gamma-20044
Mitogen-activated protein kinase kinase kinase 90011
Serine/threonine-protein kinase PknB0011
Cyclin-dependent kinase 30044
Cyclin-dependent kinase-like 10011
Cyclin-dependent kinase 60044
Cyclin-dependent-like kinase 5 0044
Cyclin-dependent kinase 160044
Cyclin-dependent kinase 170044
ATP-dependent 6-phosphofructokinase, platelet type0044
Protein kinase C epsilon type0011
Dual specificity mitogen-activated protein kinase kinase 10347
Angiopoietin-1 receptor0011
Mitogen-activated protein kinase kinase kinase 100011
DNA topoisomerase 2-beta0044
Protein kinase C theta type0044
Activin receptor type-10044
Macrophage-stimulating protein receptor0044
Focal adhesion kinase 10044
Protein kinase C zeta type0033
Protein kinase C delta type0044
Tyrosine-protein kinase BTK0044
Tyrosine-protein kinase receptor TYRO30011
Cyclin-dependent kinase 180022
Activated CDC42 kinase 10044
Epithelial discoidin domain-containing receptor 10044
Tyrosine-protein kinase ITK/TSK0011
Myotonin-protein kinase0011
Mitogen-activated protein kinase kinase kinase kinase 20044
Mitogen-activated protein kinase kinase kinase 120011
Tyrosine-protein kinase Mer0033
Serine/threonine-protein kinase 40044
5'-AMP-activated protein kinase catalytic subunit alpha-10044
Serine/threonine-protein kinase PAK 10011
Dual specificity mitogen-activated protein kinase kinase 50044
Mitogen-activated protein kinase 70044
Serine/threonine-protein kinase PAK 20044
Serine/threonine-protein kinase 30044
Mitogen-activated protein kinase kinase kinase 10044
cGMP-dependent protein kinase 20011
Integrin-linked protein kinase0044
Rho-associated protein kinase 10044
Non-receptor tyrosine-protein kinase TNK10044
Serine/threonine-protein kinase PRP4 homolog0011
Receptor-interacting serine/threonine-protein kinase 10112
Calcium/calmodulin-dependent protein kinase type II subunit beta0011
Calcium/calmodulin-dependent protein kinase type II subunit gamma0044
Calcium/calmodulin-dependent protein kinase type II subunit delta0044
Dual specificity tyrosine-phosphorylation-regulated kinase 1A0044
Activin receptor type-2B0044
Bone morphogenetic protein receptor type-20044
Protein-tyrosine kinase 60044
cGMP-dependent protein kinase 1 0044
Cyclin-dependent kinase 130044
Calcium/calmodulin-dependent protein kinase type 10011
Inhibitor of nuclear factor kappa-B kinase subunit epsilon0044
Protein-tyrosine kinase 2-beta0044
Maternal embryonic leucine zipper kinase0044
Structural maintenance of chromosomes protein 1A0044
Chromodomain-helicase-DNA-binding protein 40044
Peroxisomal acyl-coenzyme A oxidase 10044
Serine/threonine-protein kinase D10011
Serine/threonine-protein kinase 380011
Receptor tyrosine-protein kinase erbB-40011
Ribosomal protein S6 kinase alpha-20011
Ephrin type-A receptor 70033
Delta(24)-sterol reductase0044
Ribosomal protein S6 kinase alpha-10044
Dual specificity testis-specific protein kinase 10033
Myosin light chain kinase, smooth muscle0044
Mitogen-activated protein kinase 110044
Serine/threonine-protein kinase STK110044
Rhodopsin kinase GRK10011
NT-3 growth factor receptor0011
Serine/threonine-protein kinase N10044
Serine/threonine-protein kinase N20044
Mitogen-activated protein kinase 140044
Calcium/calmodulin-dependent protein kinase type IV0044
Mitogen-activated protein kinase kinase kinase 110044
BDNF/NT-3 growth factors receptor0011
Mitogen-activated protein kinase 60011
Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform0011
Discoidin domain-containing receptor 20044
AP2-associated protein kinase 10044
Myosin light chain kinase 30044
Serine/threonine-protein kinase SBK10011
Mitogen-activated protein kinase kinase kinase 190011
Putative heat shock protein HSP 90-beta 20044
Serine/threonine-protein kinase TNNI3K0011
Leucine-rich repeat serine/threonine-protein kinase 20011
Serine/threonine-protein kinase MRCK alpha0044
Serine/threonine-protein kinase MRCK gamma0044
Acyl-CoA dehydrogenase family member 100044
Serine/threonine-protein kinase Nek50011
Serine/threonine-protein kinase N30044
Serine/threonine-protein kinase ULK30044
Dual serine/threonine and tyrosine protein kinase0112
Mitogen-activated protein kinase kinase kinase 150011
Uncharacterized protein FLJ452520044
Acyl-CoA dehydrogenase family member 110044
Serine/threonine-protein kinase/endoribonuclease IRE20044
Serine/threonine-protein kinase MARK20044
ATP-dependent RNA helicase DHX300033
Serine/threonine-protein kinase TAO10044
STE20-related kinase adapter protein alpha0044
Myosin-140044
AarF domain-containing protein kinase 10044
Serine/threonine-protein kinase tousled-like 20011
Serine/threonine-protein kinase 32C0011
Serine/threonine-protein kinase pim-30011
ATP-dependent RNA helicase DDX420044
Serine/threonine-protein kinase VRK20011
Myosin light chain kinase family member 40011
Homeodomain-interacting protein kinase 10011
Calcium/calmodulin-dependent protein kinase type 1D0011
Mitogen-activated protein kinase kinase kinase kinase 30044
Cyclin-dependent kinase-like 30011
MAP kinase-activated protein kinase 50044
Serine/threonine-protein kinase BRSK20011
Serine/threonine-protein kinase NIM10011
Eukaryotic peptide chain release factor GTP-binding subunit ERF3B0044
Serine/threonine-protein kinase ULK20011
Misshapen-like kinase 10033
Serine/threonine-protein kinase DCLK20011
Calcium/calmodulin-dependent protein kinase kinase 10011
Casein kinase I isoform alpha-like0011
Homeodomain-interacting protein kinase 40011
Myosin-IIIa0011
Ankyrin repeat and protein kinase domain-containing protein 10011
Serine/threonine-protein kinase Nek110011
Atypical kinase COQ8A, mitochondrial0044
Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma0044
Mitogen-activated protein kinase 150044
Serine/threonine-protein kinase Nek90044
Serine/threonine-protein kinase BRSK10011
Serine/threonine-protein kinase 350011
Serine/threonine-protein kinase Nek70022
Rhodopsin kinase GRK70011
Serine/threonine-protein kinase 32A0011
Myosin-IIIb0011
ATP-dependent RNA helicase DDX10044
Inositol hexakisphosphate kinase 16006
Dual specificity tyrosine-phosphorylation-regulated kinase 20011
Cyclin-dependent kinase-like 20011
Mitogen-activated protein kinase kinase kinase kinase 10044
Serine/threonine-protein kinase Sgk30011
Atypical kinase COQ8B, mitochondrial0011
Aurora kinase B0044
MAP/microtubule affinity-regulating kinase 40044
Calcium/calmodulin-dependent protein kinase type 1G0011
Serine/threonine-protein kinase Nek10044
Cyclin-dependent kinase 150011
ATPase family AAA domain-containing protein 56006
PAS domain-containing serine/threonine-protein kinase0033
Calcium/calmodulin-dependent protein kinase kinase 20044
EKC/KEOPS complex subunit TP53RK0044
SRSF protein kinase 10011
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase0044
Mitogen-activated protein kinase kinase kinase 50044
Ataxin-26006
Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha0011
Mitogen-activated protein kinase kinase kinase 30044
Eukaryotic translation initiation factor 2-alpha kinase 10044
Serine/threonine-protein kinase RIO10011
MAP kinase-interacting serine/threonine-protein kinase 10011
Serine/threonine-protein kinase RIO20011
Cyclin-dependent kinase 190011
Transient receptor potential cation channel subfamily M member 60011
Testis-specific serine/threonine-protein kinase 10011
Serine/threonine-protein kinase 330011
Nucleolar GTP-binding protein 10044
Serine/threonine-protein kinase D20044
Serine/threonine-protein kinase DCLK30011
NUAK family SNF1-like kinase 20044
RNA cytidine acetyltransferase0044
Serine/threonine-protein kinase SIK20044
Myosin light chain kinase 2, skeletal/cardiac muscle0011
STE20-like serine/threonine-protein kinase 0044
Serine/threonine-protein kinase TAO30044
Homeodomain-interacting protein kinase 20011
Tyrosine-protein kinase Srms0011
Homeodomain-interacting protein kinase 30011
Serine/threonine-protein kinase PLK30213
dCTP pyrophosphatase 10044
Dual specificity protein kinase CLK40044
MAP kinase-interacting serine/threonine-protein kinase 20011
Serine/threonine-protein kinase Nek60011
Casein kinase I isoform gamma-10044
Serine/threonine-protein kinase PAK 60033
SNF-related serine/threonine-protein kinase0011
Serine/threonine-protein kinase LATS20011
Serine/threonine-protein kinase 360011
Phenylalanine--tRNA ligase beta subunit0044
BMP-2-inducible protein kinase0044
Obg-like ATPase 10044
Midasin0044
Interleukin-1 receptor-associated kinase 40044
Serine/threonine-protein kinase 32B0011
Mitogen-activated protein kinase kinase kinase 200145
Cyclin-dependent kinase 120044
Serine/threonine-protein kinase PLK20213
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 130044
Serine/threonine-protein kinase MARK10011
Serine/threonine-protein kinase pim-20044
Serine/threonine-protein kinase PAK 50011
Serine/threonine-protein kinase 260044
eIF-2-alpha kinase GCN20011
Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial0033
Serine/threonine-protein kinase NLK0044
Phosphatidylinositol 4-kinase beta0011
Serine/threonine-protein kinase 17A0011
STE20/SPS1-related proline-alanine-rich protein kinase0011
Ephrin type-A receptor 60011
5'-AMP-activated protein kinase subunit gamma-20044
Serine/threonine-protein kinase TBK10145
Septin-90044
Death-associated protein kinase 20011
Ribosomal protein S6 kinase alpha-60044
TRAF2 and NCK-interacting protein kinase0044
Serine/threonine-protein kinase tousled-like 10011
Serine/threonine-protein kinase TAO20044
Long-chain-fatty-acid--CoA ligase 50022
ALK tyrosine kinase receptor0011
SRSF protein kinase 30011
Serine/threonine-protein kinase ICK0044
Cyclin-dependent kinase 11A0011
Aurora kinase C0011
Calcium/calmodulin-dependent protein kinase type II subunit alpha0011
RAC-gamma serine/threonine-protein kinase0044
Serine/threonine-protein kinase 38-like0022
Microtubule-associated serine/threonine-protein kinase 10011
Serine/threonine-protein kinase SIK30044
Mitogen-activated protein kinase kinase kinase 20044
Thyroid hormone receptor-associated protein 30044
Dual specificity tyrosine-phosphorylation-regulated kinase 1B0044
Mitogen-activated protein kinase kinase kinase kinase 50044
Receptor-interacting serine/threonine-protein kinase 30145
Serine/threonine-protein kinase MRCK beta0044
Interleukin-1 receptor-associated kinase 30044
Serine/threonine-protein kinase 240033
Casein kinase I isoform gamma-30044
Mitogen-activated protein kinase kinase kinase 40044
cytochrome P450 2C9, partial6006
Chain A, ATP-DEPENDENT DNA HELICASE Q11001
hypoxia-inducible factor 1 alpha subunit4004
Fumarate hydratase3003
USP1 protein, partial2002
EWS/FLI fusion protein5005
glucocorticoid receptor [Homo sapiens]7007
polyprotein3003
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)1001
thyroid stimulating hormone receptor2002
activating transcription factor 63003
thyrotropin-releasing hormone receptor1001
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a2002
v-jun sarcoma virus 17 oncogene homolog (avian)4004
nuclear receptor subfamily 1, group I, member 23003
Caspase-71001
Bloom syndrome protein isoform 12002
caspase-31001
heat shock protein beta-12002
nuclear receptor ROR-gamma isoform 12002
histone acetyltransferase KAT2A isoform 11001
Cytochrome P450 26A10101
Cytochrome P450 1A20101
Retinoic acid receptor alpha0123
Retinoic acid receptor beta0123
Retinoic acid receptor gamma 0123
Retinoic acid receptor RXR-alpha0247
Retinoic acid receptor RXR-alpha0011
Retinoic acid receptor RXR-beta0112
Retinoic acid receptor RXR-beta0022
Retinoic acid receptor RXR-gamma0022
Type-1 angiotensin II receptor0011
Nuclear receptor subfamily 4 group A member 20011
Retinoic acid receptor RXR-gamma0112
Type-2 angiotensin II receptor0011
Oxysterols receptor LXR-beta0011
Retinoic acid receptor RXR-alpha0011
Oxysterols receptor LXR-alpha0011
Sigma non-opioid intracellular receptor 10101
Cytochrome P450 26B10101
Membrane-associated progesterone receptor component 10033
Pirin0202
Nuclear receptor subfamily 1 group I member 20033
GTPase KRas0202
Heat shock factor protein 10202
Cyclin-dependent kinase 100033
MAP kinase-activated protein kinase 30022
Uncharacterized aarF domain-containing protein kinase 50033
Rab-like protein 30033
Dual specificity testis-specific protein kinase 20033
Isoleucine--tRNA ligase, mitochondrial0022
Chain A, 2-oxoglutarate Oxygenase2002
interleukin 81001
aldehyde dehydrogenase 1 family, member A13003
thyroid stimulating hormone receptor1001
geminin4004
survival motor neuron protein isoform d2002
lamin isoform A-delta104004
Matrix metalloproteinase-90101
Inositol monophosphatase 11001
Isocitrate lyase0101
Phosphatidylinositol 3-kinase regulatory subunit alpha0101
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)3003
nonstructural protein 11001
bromodomain adjacent to zinc finger domain 2B1001
IDH11001
nuclear factor erythroid 2-related factor 2 isoform 25005
muscleblind-like protein 1 isoform 12002
Glucocorticoid receptor08215
Glycine receptor subunit alpha-10808
Androgen receptor0303
Glycine receptor subunit beta0808
Glycine receptor subunit alpha-20808
Glycine receptor subunit alpha-30808
Nuclear receptor subfamily 1 group I member 20011
ATP-dependent phosphofructokinase1001
Chain A, Inosine-5'-Monophosphate Dehydrogenase 20101
Chain A, HADH2 protein3003
Chain B, HADH2 protein3003
glp-1 receptor, partial2002
67.9K protein1001
euchromatic histone-lysine N-methyltransferase 23003
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 11001
urokinase-type plasminogen activator precursor1001
plasminogen precursor1001
urokinase plasminogen activator surface receptor precursor1001
cytochrome P450 3A4 isoform 12002
lethal factor (plasmid)1001
Gamma-aminobutyric acid receptor subunit pi2002
UDP-glucuronosyltransferase 1A90001
Gamma-aminobutyric acid receptor subunit beta-12002
Gamma-aminobutyric acid receptor subunit delta2002
Gamma-aminobutyric acid receptor subunit gamma-22002
Glutamate receptor 10101
Glutamate receptor 30101
Glutamate receptor 40101
Gamma-aminobutyric acid receptor subunit alpha-52002
Gamma-aminobutyric acid receptor subunit alpha-32002
Inosine-5'-monophosphate dehydrogenase 1 0202
UDP-glucuronosyltransferase 1A1 0102
Gamma-aminobutyric acid receptor subunit gamma-12002
Gamma-aminobutyric acid receptor subunit alpha-22002
Gamma-aminobutyric acid receptor subunit alpha-42002
Gamma-aminobutyric acid receptor subunit gamma-32002
Gamma-aminobutyric acid receptor subunit alpha-62002
Sodium-dependent serotonin transporter0101
Peroxisome proliferator-activated receptor gamma0033
Alpha-synuclein1001
Gamma-aminobutyric acid receptor subunit alpha-12002
Gamma-aminobutyric acid receptor subunit beta-32002
Gamma-aminobutyric acid receptor subunit beta-22002
TAR DNA-binding protein 431001
Inosine-5'-monophosphate dehydrogenase0102
GABA theta subunit2002
Gamma-aminobutyric acid receptor subunit epsilon2002
UDP-glucuronosyltransferase 1A70001
UDP-glucuronosyltransferase 1A100001
UDP-glucuronosyltransferase 1A80001
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE1001
Sodium channel protein type 1 subunit alpha0101
Sodium channel protein type 2 subunit alpha0101
Sodium channel protein type 3 subunit alpha0101
Oxytocin receptor0011
Potassium voltage-gated channel subfamily H member 20101
Chain A, AKAP9-BRAF fusion protein0101
Serine/threonine-protein kinase B-raf 0101
Dual specificity mitogen-activated protein kinase kinase 40011
Aspartyl/asparaginyl beta-hydroxylase0101
Serine/threonine-protein kinase ATR0011
luciferase0001
Fatty acid-binding protein, liver0101
Estrogen receptor0202
Progesterone receptor0203
Glucocorticoid receptor0112
Glucocorticoid receptor0011
Corticosteroid-binding globulin0101
Mineralocorticoid receptor 0213
Androgen receptor0202
Cytochrome P450 2C9 0202
Glutamine synthetase0011
Histamine H1 receptor0011
Nociceptin receptor0011
Cytochrome P450 2J20202
Estrogen receptor beta0202
Chain A, TYROSYL-DNA PHOSPHODIESTERASE1001
pregnane X receptor1001
thioredoxin glutathione reductase2002
Nuclear receptor ROR-gamma1001
Chain X, Thyroid hormone receptor beta-10011
Chain X, Thyroid hormone receptor beta-10011
thioredoxin reductase2002
apical membrane antigen 1, AMA11001
thyroid hormone receptor beta isoform a1001
serine/threonine-protein kinase PLK11001
peptidyl-prolyl cis-trans isomerase NIMA-interacting 11001
DNA polymerase eta isoform 11001
DNA polymerase kappa isoform 11001
Solute carrier organic anion transporter family member 1A40001
Solute carrier organic anion transporter family member 1A50001
Rap guanine nucleotide exchange factor 31001
Transthyretin0102
Thyroid hormone receptor alpha0011
Thyroid hormone receptor beta0011
Proliferating cell nuclear antigen0101
Malate dehydrogenase, mitochondrial0101
Solute carrier organic anion transporter family member 1A20001
Solute carrier organic anion transporter family member 1A30001
Solute carrier organic anion transporter family member 4C10101
Monocarboxylate transporter 80001
Bile acid receptor0101
Solute carrier organic anion transporter family member 1C10001
Solute carrier organic anion transporter family member 1B10001
ATP-dependent translocase ABCB10011
ATAD5 protein, partial1001
NFKB1 protein, partial1001
Smad31001
arylsulfatase A1001
peripheral myelin protein 22 isoform 11001
chromobox protein homolog 11001
procathepsin L isoform 1 preproprotein0101
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]