leptin and Hypophysitis

Leptin has a modulatory impact on the course of inflammation, affecting the expression of proinflammatory cytokines and their receptors. Pathophysiological leptin resistance identified in humans occurs typically in sheep during the long-day photoperiod. This study aimed to determine the effect of the photoperiod with relation to the leptin-modulating action on the expression of the proinflammatory cytokines and their receptors in the anterior pituitary under physiological or acute inflammation. Two in vivo experiments were conducted on 24 blackface sheep per experiment in different photoperiods. The real-time PCR analysis for the expression of the genes

Topics: Animals; Female; Gene Expression Regulation; Hypophysitis; Interleukin-1beta; Interleukin-6; Leptin; Lipopolysaccharides; Photoperiod; Pituitary Gland, Anterior; Receptors, Interleukin-1; Receptors, Interleukin-6; Receptors, Tumor Necrosis Factor, Type I; Receptors, Tumor Necrosis Factor, Type II; Sheep; Tumor Necrosis Factor-alpha