Target type: molecularfunction
Catalysis of the reaction: NADP+ + a 7-beta-hydroxysteroid = NADPH + H+ + a 7-oxosteroid. [EC:1.1.1.201, MetaCyc:1.1.1.201-RXN]
7-beta-hydroxysteroid dehydrogenase (NADP+) activity catalyzes the reversible oxidation of a hydroxyl group at the 7-beta position of a steroid molecule, using NADP+ as a cofactor. This enzyme is involved in the biosynthesis of various steroid hormones, including bile acids, androgens, and estrogens. The reaction proceeds via a hydride transfer from the substrate to the NADP+ molecule, resulting in the reduction of NADP+ to NADPH and the oxidation of the steroid molecule. The enzyme exhibits substrate specificity, primarily acting on steroid substrates with a hydroxyl group at the 7-beta position, although some variation in substrate preference may exist depending on the specific enzyme. 7-beta-hydroxysteroid dehydrogenase plays a crucial role in maintaining hormonal homeostasis and regulating steroid metabolism in the body.'
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| Protein | Definition | Taxonomy |
|---|---|---|
| Corticosteroid 11-beta-dehydrogenase isozyme 1 | An 11-beta-hydroxysteroid dehydrogenase 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P28845] | Homo sapiens (human) |
| Compound | Definition | Classes | Roles |
|---|---|---|---|
| furosemide | furosemide : A chlorobenzoic acid that is 4-chlorobenzoic acid substituted by a (furan-2-ylmethyl)amino and a sulfamoyl group at position 2 and 5 respectively. It is a diuretic used in the treatment of congestive heart failure. Furosemide: A benzoic-sulfonamide-furan. It is a diuretic with fast onset and short duration that is used for EDEMA and chronic RENAL INSUFFICIENCY. | chlorobenzoic acid; furans; sulfonamide | environmental contaminant; loop diuretic; xenobiotic |
| glycyrrhetinic acid | cyclic terpene ketone; hydroxy monocarboxylic acid; pentacyclic triterpenoid | immunomodulator; plant metabolite | |
| glycyrrhizic acid | glycyrrhizinic acid : A triterpenoid saponin that is the glucosiduronide derivative of 3beta-hydroxy-11-oxoolean-12-en-30-oic acid. | enone; glucosiduronic acid; pentacyclic triterpenoid; tricarboxylic acid; triterpenoid saponin | EC 3.4.21.5 (thrombin) inhibitor; plant metabolite |
| ursolic acid | hydroxy monocarboxylic acid; pentacyclic triterpenoid | geroprotector; plant metabolite | |
| 11-hydroxyprogesterone, (11alpha)-isomer | 11alpha-hydroxyprogesterone : A 11alpha-hydroxy steroid that is pregn-4-ene-3,20-dione substituted by a hydroxy group at position 11. | 11alpha-hydroxy steroid; 20-oxo steroid; 3-oxo-Delta(4) steroid | |
| acetylglycyrrhetinic acid | acetylglycyrrhetinic acid: RN given refers to (3beta,20beta)-isomer | triterpenoid | |
| 3-oxoglycyrrhetinic acid | pentacyclic triterpenoid | ||
| 2'-hydroxyflavanone | |||
| n-(phenylsulfonyl)benzamide | N-(phenylsulfonyl)benzamide: structure in first source | ||
| 1-adamantyl(piperidino)methanone | N-acylpiperidine | ||
| carbenoxolone | |||
| lobeline | |||
| 3-(1-adamantyl)-6,7,8,9-tetrahydro-5h-(1,2,4)triazolo(4,3-a)azepine | |||
| hylin | |||
| bvt2733 | |||
| corosolic acid | triterpenoid | metabolite | |
| mk-0916 | MK-0916: structure in first source | ||
| pf 877423 | |||
| pf 915275 | |||
| colletoic acid | colletoic acid: an 11beta-hydroxysteroid dehydrogenase type 1 inhibitor from Colletotrichum gloeosporioides; structure in first source | ||
| amg 221 | AMG 221: structure in first source |