| Assay ID | Title | Year | Journal | Article |
|---|
| AID349322 | Inhibition of human recombinant CYP2C9 | 2008 | European journal of medicinal chemistry, Aug, Volume: 43, Issue:8
| Structure-activity relationships for the inhibition of recombinant human cytochromes P450 by curcumin analogues. |
| AID1062642 | Inhibition of Wnt3A/beta-catenin signaling in HEK293 cells at 20 uM after 24 hrs by firefly/renilla dual luciferase reporter gene assay relative to vehicle-treated control | 2014 | European journal of medicinal chemistry, Jan, Volume: 71 | Functionalized curcumin analogs as potent modulators of the Wnt/β-catenin signaling pathway. |
| AID1062644 | Inhibition of Wnt3A/beta-catenin signaling in HEK293 cells at 5 uM after 24 hrs by firefly/renilla dual luciferase reporter gene assay relative to vehicle-treated control | 2014 | European journal of medicinal chemistry, Jan, Volume: 71 | Functionalized curcumin analogs as potent modulators of the Wnt/β-catenin signaling pathway. |
| AID349321 | Inhibition of human recombinant CYP3A4 | 2008 | European journal of medicinal chemistry, Aug, Volume: 43, Issue:8
| Structure-activity relationships for the inhibition of recombinant human cytochromes P450 by curcumin analogues. |
| AID1062640 | Inhibition of Wnt3A/beta-catenin signaling in HEK293 cells after 24 hrs by firefly/renilla dual luciferase reporter gene assay relative to curcumin | 2014 | European journal of medicinal chemistry, Jan, Volume: 71 | Functionalized curcumin analogs as potent modulators of the Wnt/β-catenin signaling pathway. |
| AID349319 | Stability assessed as decomposition at 25 uM and pH 7.4 after 30 mins | 2008 | European journal of medicinal chemistry, Aug, Volume: 43, Issue:8
| Structure-activity relationships for the inhibition of recombinant human cytochromes P450 by curcumin analogues. |
| AID1062641 | Inhibition of Wnt3A/beta-catenin signaling in HEK293 cells after 24 hrs by firefly/renilla dual luciferase reporter gene assay | 2014 | European journal of medicinal chemistry, Jan, Volume: 71 | Functionalized curcumin analogs as potent modulators of the Wnt/β-catenin signaling pathway. |
| AID417440 | Antiinflammatory activity in mouse J774A1 cells assessed as inhibition of LPS-induced IL6 production at 10 uM preincubated for 3 hrs before LPS challenge measured after 21 hrs by ELISA | 2009 | European journal of medicinal chemistry, Feb, Volume: 44, Issue:2
| Synthesis, crystal structure and anti-inflammatory properties of curcumin analogues. |
| AID664955 | Cytotoxicity against human PC3 cells after 72 hrs by MTT assay | 2012 | European journal of medicinal chemistry, Jul, Volume: 53 | Synthesis and evaluation of curcumin-related compounds for anticancer activity. |
| AID417439 | Antiinflammatory activity in mouse J774A1 cells assessed as inhibition of LPS-induced TNFalpha production at 10 uM preincubated for 3 hrs before LPS challenge measured after 21 hrs by ELISA | 2009 | European journal of medicinal chemistry, Feb, Volume: 44, Issue:2
| Synthesis, crystal structure and anti-inflammatory properties of curcumin analogues. |
| AID1062631 | Cytotoxicity against human U2OS cells at dual luciferase reporter gene assay EC50 after 24 hrs by MTS assay | 2014 | European journal of medicinal chemistry, Jan, Volume: 71 | Functionalized curcumin analogs as potent modulators of the Wnt/β-catenin signaling pathway. |
| AID315766 | Antiinflammatory activity in mouse J774A.1 cells assessed as inhibition of lipopolysaccharide-induced TNFalpha production pretreated for 2 hrs at 10 uM before LPS challenge | 2008 | Bioorganic & medicinal chemistry letters, Feb-15, Volume: 18, Issue:4
| Synthesis and anti-inflammatory activities of mono-carbonyl analogues of curcumin. |
| AID349320 | Inhibition of human recombinant CYP1A2 | 2008 | European journal of medicinal chemistry, Aug, Volume: 43, Issue:8
| Structure-activity relationships for the inhibition of recombinant human cytochromes P450 by curcumin analogues. |
| AID664956 | Cytotoxicity against human PANC1 cells after 72 hrs by MTT assay | 2012 | European journal of medicinal chemistry, Jul, Volume: 53 | Synthesis and evaluation of curcumin-related compounds for anticancer activity. |
| AID315767 | Antiinflammatory activity in mouse J774A.1 cells assessed as inhibition of lipopolysaccharide-induced IL6 production pretreated for 2 hrs at 10 uM before LPS challenge | 2008 | Bioorganic & medicinal chemistry letters, Feb-15, Volume: 18, Issue:4
| Synthesis and anti-inflammatory activities of mono-carbonyl analogues of curcumin. |
| AID759524 | Inhibition of 11beta-HSD1 in rat testis microsomes using [3H]-11-DHC as substrate assessed as formation of CORT at 100 uM after 60 to 90 mins by radiometric analysis relative to control | 2013 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 23, Issue:15
| Mono-carbonyl curcumin analogues as 11β-hydroxysteroid dehydrogenase 1 inhibitors. |
| AID1145209 | Antitumor activity against mouse ascites Sarcoma 180 cells allografted in ddN mouse assessed as percentage of total packed cell volume ratio at 100 mg/kg/day for 5 days administered 24 hrs after tumor inoculation measured 7th day after tumor inoculation | 1976 | Journal of medicinal chemistry, Mar, Volume: 19, Issue:3
| Structure and antitumor activity relationship of 2-arylidene-4-cyclopentene-1, 3-diones and 2-arylideneindan-1, 3-diones. |
| AID344535 | Inhibition of human recombinant CYP2C9 in presence of reduced glutathione | 2008 | European journal of medicinal chemistry, Aug, Volume: 43, Issue:8
| Structure-activity relationships for the inhibition of recombinant human cytochromes P450 by curcumin analogues. |
| AID1062639 | Inhibition of Wnt3A/beta-catenin signaling-mediated Tcf4 transcriptional activity in human U2OS cells at dual luciferase reporter gene assay EC50 after 24 hrs by FOPglow reporter gene assay | 2014 | European journal of medicinal chemistry, Jan, Volume: 71 | Functionalized curcumin analogs as potent modulators of the Wnt/β-catenin signaling pathway. |
| AID759512 | Inhibition of 11beta-HSD2 in human kidney microsomes using [3H]-cortisol as substrate assessed as formation of cortisone at 100 uM after 30 mins by radiometric analysis relative to control | 2013 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 23, Issue:15
| Mono-carbonyl curcumin analogues as 11β-hydroxysteroid dehydrogenase 1 inhibitors. |
| AID1062645 | Inhibition of Wnt3A/beta-catenin signaling in HEK293 cells at 1 uM after 24 hrs by firefly/renilla dual luciferase reporter gene assay relative to vehicle-treated control | 2014 | European journal of medicinal chemistry, Jan, Volume: 71 | Functionalized curcumin analogs as potent modulators of the Wnt/β-catenin signaling pathway. |
| AID759517 | Inhibition of human 11beta-HSD1 transfected in CHOP cells at 100 uM relative to control | 2013 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 23, Issue:15
| Mono-carbonyl curcumin analogues as 11β-hydroxysteroid dehydrogenase 1 inhibitors. |
| AID1062643 | Inhibition of Wnt3A/beta-catenin signaling in HEK293 cells at 10 uM after 24 hrs by firefly/renilla dual luciferase reporter gene assay relative to vehicle-treated control | 2014 | European journal of medicinal chemistry, Jan, Volume: 71 | Functionalized curcumin analogs as potent modulators of the Wnt/β-catenin signaling pathway. |
| AID344534 | Inhibition of human recombinant CYP1A2 in presence of reduced glutathione | 2008 | European journal of medicinal chemistry, Aug, Volume: 43, Issue:8
| Structure-activity relationships for the inhibition of recombinant human cytochromes P450 by curcumin analogues. |
| AID759519 | Inhibition of 11beta-HSD1 in Sprague-Dawley rat leydig cells at 100 uM relative to control | 2013 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 23, Issue:15
| Mono-carbonyl curcumin analogues as 11β-hydroxysteroid dehydrogenase 1 inhibitors. |
| AID344536 | Inhibition of human recombinant CYP2D6 in presence of reduced glutathione | 2008 | European journal of medicinal chemistry, Aug, Volume: 43, Issue:8
| Structure-activity relationships for the inhibition of recombinant human cytochromes P450 by curcumin analogues. |
| AID664957 | Cytotoxicity against human HT-29 cells after 72 hrs by MTT assay | 2012 | European journal of medicinal chemistry, Jul, Volume: 53 | Synthesis and evaluation of curcumin-related compounds for anticancer activity. |
| AID344533 | Inhibition of human recombinant CYP3A4 in presence of reduced glutathione | 2008 | European journal of medicinal chemistry, Aug, Volume: 43, Issue:8
| Structure-activity relationships for the inhibition of recombinant human cytochromes P450 by curcumin analogues. |
| AID759526 | Inhibition of 11beta-HSD1 in human liver microsomes using [3H]-cortisone as substrate assessed as formation of cortisol at 100 uM after 60 to 90 mins by radiometric analysis relative to control | 2013 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 23, Issue:15
| Mono-carbonyl curcumin analogues as 11β-hydroxysteroid dehydrogenase 1 inhibitors. |
| AID759513 | Inhibition of 11beta-HSD2 in rat kidney microsomes using [3H]-CORT as substrate assessed as formation of 11-DHC at 100 uM after 30 mins by radiometric analysis relative to control | 2013 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 23, Issue:15
| Mono-carbonyl curcumin analogues as 11β-hydroxysteroid dehydrogenase 1 inhibitors. |
| AID344537 | Inhibition of human recombinant CYP2B6 in presence of reduced glutathione | 2008 | European journal of medicinal chemistry, Aug, Volume: 43, Issue:8
| Structure-activity relationships for the inhibition of recombinant human cytochromes P450 by curcumin analogues. |
| AID1794808 | Fluorescence-based screening to identify small molecule inhibitors of Plasmodium falciparum apicoplast DNA polymerase (Pf-apPOL). | 2014 | Journal of biomolecular screening, Jul, Volume: 19, Issue:6
| A High-Throughput Assay to Identify Inhibitors of the Apicoplast DNA Polymerase from Plasmodium falciparum. |
| AID1794808 | Fluorescence-based screening to identify small molecule inhibitors of Plasmodium falciparum apicoplast DNA polymerase (Pf-apPOL). | | | |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |