cortisol dehydrogenase activity

Definition

Target type: molecularfunction

Catalysis of the reaction: cortisol + NADP = cortisone + NADPH + H+. [GOC:pz, PMID:16216911, RHEA:68616]

Cortisol dehydrogenase activity is a crucial enzymatic function involved in the metabolism of cortisol, a steroid hormone produced by the adrenal glands. It catalyzes the oxidation of cortisol, converting it into cortisone. This reaction is essential for maintaining hormonal balance and regulating cortisol levels in the body. Cortisol dehydrogenase activity primarily occurs in the liver, where it plays a vital role in the inactivation of cortisol. By oxidizing cortisol to cortisone, the enzyme reduces the active form of the hormone, thereby modulating its physiological effects. Cortisone, the product of this enzymatic reaction, has significantly lower biological activity compared to cortisol. This conversion process is essential for regulating various biological processes influenced by cortisol, including inflammation, immune response, blood sugar control, and stress response. The activity of cortisol dehydrogenase can be influenced by several factors, including genetic variations, medications, and certain medical conditions. Dysregulation of cortisol dehydrogenase activity can contribute to hormonal imbalances, leading to various health problems. For example, deficiencies in cortisol dehydrogenase activity can result in increased cortisol levels, potentially leading to Cushing's syndrome. Conversely, excessive activity of this enzyme can lead to decreased cortisol levels, potentially causing Addison's disease. Understanding the molecular function of cortisol dehydrogenase activity is crucial for comprehending the complex interplay of hormones in the body and for developing therapeutic strategies for conditions related to cortisol metabolism.'
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Proteins (1)

Compounds (21)