Page last updated: 2024-10-24

cortisol dehydrogenase activity

Definition

Target type: molecularfunction

Catalysis of the reaction: cortisol + NADP = cortisone + NADPH + H+. [GOC:pz, PMID:16216911, RHEA:68616]

Cortisol dehydrogenase activity is a crucial enzymatic function involved in the metabolism of cortisol, a steroid hormone produced by the adrenal glands. It catalyzes the oxidation of cortisol, converting it into cortisone. This reaction is essential for maintaining hormonal balance and regulating cortisol levels in the body. Cortisol dehydrogenase activity primarily occurs in the liver, where it plays a vital role in the inactivation of cortisol. By oxidizing cortisol to cortisone, the enzyme reduces the active form of the hormone, thereby modulating its physiological effects. Cortisone, the product of this enzymatic reaction, has significantly lower biological activity compared to cortisol. This conversion process is essential for regulating various biological processes influenced by cortisol, including inflammation, immune response, blood sugar control, and stress response. The activity of cortisol dehydrogenase can be influenced by several factors, including genetic variations, medications, and certain medical conditions. Dysregulation of cortisol dehydrogenase activity can contribute to hormonal imbalances, leading to various health problems. For example, deficiencies in cortisol dehydrogenase activity can result in increased cortisol levels, potentially leading to Cushing's syndrome. Conversely, excessive activity of this enzyme can lead to decreased cortisol levels, potentially causing Addison's disease. Understanding the molecular function of cortisol dehydrogenase activity is crucial for comprehending the complex interplay of hormones in the body and for developing therapeutic strategies for conditions related to cortisol metabolism.'
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Proteins (1)

ProteinDefinitionTaxonomy
Corticosteroid 11-beta-dehydrogenase isozyme 1An 11-beta-hydroxysteroid dehydrogenase 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P28845]Homo sapiens (human)

Compounds (21)

CompoundDefinitionClassesRoles
furosemidefurosemide : A chlorobenzoic acid that is 4-chlorobenzoic acid substituted by a (furan-2-ylmethyl)amino and a sulfamoyl group at position 2 and 5 respectively. It is a diuretic used in the treatment of congestive heart failure.

Furosemide: A benzoic-sulfonamide-furan. It is a diuretic with fast onset and short duration that is used for EDEMA and chronic RENAL INSUFFICIENCY.
chlorobenzoic acid;
furans;
sulfonamide
environmental contaminant;
loop diuretic;
xenobiotic
glycyrrhetinic acidcyclic terpene ketone;
hydroxy monocarboxylic acid;
pentacyclic triterpenoid
immunomodulator;
plant metabolite
glycyrrhizic acidglycyrrhizinic acid : A triterpenoid saponin that is the glucosiduronide derivative of 3beta-hydroxy-11-oxoolean-12-en-30-oic acid.enone;
glucosiduronic acid;
pentacyclic triterpenoid;
tricarboxylic acid;
triterpenoid saponin
EC 3.4.21.5 (thrombin) inhibitor;
plant metabolite
ursolic acidhydroxy monocarboxylic acid;
pentacyclic triterpenoid
geroprotector;
plant metabolite
11-hydroxyprogesterone, (11alpha)-isomer11alpha-hydroxyprogesterone : A 11alpha-hydroxy steroid that is pregn-4-ene-3,20-dione substituted by a hydroxy group at position 11.11alpha-hydroxy steroid;
20-oxo steroid;
3-oxo-Delta(4) steroid
acetylglycyrrhetinic acidacetylglycyrrhetinic acid: RN given refers to (3beta,20beta)-isomertriterpenoid
3-oxoglycyrrhetinic acidpentacyclic triterpenoid
2'-hydroxyflavanone
n-(phenylsulfonyl)benzamideN-(phenylsulfonyl)benzamide: structure in first source
1-adamantyl(piperidino)methanoneN-acylpiperidine
carbenoxolone
lobeline
3-(1-adamantyl)-6,7,8,9-tetrahydro-5h-(1,2,4)triazolo(4,3-a)azepine
hylin
bvt2733
corosolic acidtriterpenoidmetabolite
mk-0916MK-0916: structure in first source
pf 877423
pf 915275
colletoic acidcolletoic acid: an 11beta-hydroxysteroid dehydrogenase type 1 inhibitor from Colletotrichum gloeosporioides; structure in first source
amg 221AMG 221: structure in first source