Compounds > win 52035
Page last updated: 2024-11-04

win 52035

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

Win 52035: structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID1786
CHEMBL ID266800
CHEBI ID10028
SCHEMBL ID9705718
MeSH IDM0166076

Synonyms (28)

Synonym
5-(5-(4-(4,5-dihydro-2-oxazolyl)phenoxy)pentyl)-3-methylisoxazole
isoxazole, 5-[5-[4-(4,5-dihydro-2-oxazolyl)phenoxy]pentyl]-3-methyl-
98034-30-1
5-[5-[4-(4,5-dihydrooxazol-2-yl)phenoxy]pentyl]-3-methyl-isoxazole
C06490
5-(5-(4-(4,5-dihydro-2-oxazoly)phenoxy)pentyl)-3-methylisoxazole
win 52035
win vi
DB08720
5-(5-(4-(4,5-dihydro-2-oxazoly)phenoxy)pentyl)-3-methyl osoxazole
chebi:10028 ,
CHEMBL266800
5-{5-[4-(4,5-dihydro-2-oxazolyl)phenoxy]pentyl}-3-methylisoxazole
IWZDYGHUSXWPPM-UHFFFAOYSA-N
5-[5-[4-(4,5-dihydro-1,3-oxazol-2-yl)phenoxy]pentyl]-3-methyl-1,2-oxazole
win 52035-2
win-52035
unii-apd6gox5wk
isoxazole, 5-(5-(4-(4,5-dihydro-2-oxazolyl)phenoxy)pentyl)-3-methyl-
apd6gox5wk ,
SCHEMBL9705718
DTXSID30243387
5-{5-[4-(4,5-dihydro-1,3-oxazol-2-yl)phenoxy]pentyl}-3-methylisoxazole
win vi; win 52035
5-(5-(4-(4,5-dihydro-1,3-oxazol-2-yl)phenoxy)pentyl)-3-methyl-1,2-oxazole
Q27097905
5-(5-(4-(4,5-dihydrooxazol-2-yl)phenoxy)pentyl)-3-methylisoxazole
PD004182

Research Excerpts

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
aromatic etherAny ether in which the oxygen is attached to at least one aryl substituent.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Bioassays (65)

Assay IDTitleYearJournalArticle
AID199868Minimum inhibitory concentration against rhinovirus serotype 411989Journal of medicinal chemistry, Feb, Volume: 32, Issue:2
Synthesis and structure-activity studies of some disubstituted phenylisoxazoles against human picornavirus.
AID115948MIC at the Maximal testable level in mice was evaluated1985Journal of medicinal chemistry, Dec, Volume: 28, Issue:12
[[(4,5-Dihydro-2-oxazolyl)phenoxy]alkyl]isoxazoles. Inhibitors of picornavirus uncoating.
AID85087Tested for minimal inhibitory concentration against Human rhinovirus serotype 89 by plaque reduction assay1994Journal of medicinal chemistry, Nov-25, Volume: 37, Issue:24
An evaluation of the antirhinoviral activity of acetylfuran replacements for 3-methylisoxazoles. Are 2-acetylfurans bioisosteres for 3-methylisoxazoles?
AID228791Tested for antirhinoviral activity against the rhinovirus serotype 25; IA is inactive1987Journal of medicinal chemistry, Feb, Volume: 30, Issue:2
Structure-activity studies of 5-[[4-(4,5-dihydro-2-oxazolyl) phenoxy]alkyl]-3-methylisoxazoles: inhibitors of picornavirus uncoating.
AID222913Mean of MIC's was determined for the five types of virus like HRV-2, HRV-1A,HRV-22,HRV-41 and HRV-501987Journal of medicinal chemistry, Feb, Volume: 30, Issue:2
Structure-activity studies of 5-[[4-(4,5-dihydro-2-oxazolyl) phenoxy]alkyl]-3-methylisoxazoles: inhibitors of picornavirus uncoating.
AID199860Minimum inhibitory concentration against rhinovirus serotype 151989Journal of medicinal chemistry, Feb, Volume: 32, Issue:2
Synthesis and structure-activity studies of some disubstituted phenylisoxazoles against human picornavirus.
AID228805Tested for antirhinoviral activity against the rhinovirus serotype 891987Journal of medicinal chemistry, Feb, Volume: 30, Issue:2
Structure-activity studies of 5-[[4-(4,5-dihydro-2-oxazolyl) phenoxy]alkyl]-3-methylisoxazoles: inhibitors of picornavirus uncoating.
AID228793Tested for antirhinoviral activity against the rhinovirus serotype 301987Journal of medicinal chemistry, Feb, Volume: 30, Issue:2
Structure-activity studies of 5-[[4-(4,5-dihydro-2-oxazolyl) phenoxy]alkyl]-3-methylisoxazoles: inhibitors of picornavirus uncoating.
AID1562974Antiviral activity against Human poliovirus 22019European journal of medicinal chemistry, Sep-15, Volume: 178Back to the future: Advances in development of broad-spectrum capsid-binding inhibitors of enteroviruses.
AID85059Tested for minimal inhibitory concentration against Human rhinovirus serotype 6 by plaque reduction assay1994Journal of medicinal chemistry, Nov-25, Volume: 37, Issue:24
An evaluation of the antirhinoviral activity of acetylfuran replacements for 3-methylisoxazoles. Are 2-acetylfurans bioisosteres for 3-methylisoxazoles?
AID199869Minimum inhibitory concentration against rhinovirus serotype 501989Journal of medicinal chemistry, Feb, Volume: 32, Issue:2
Synthesis and structure-activity studies of some disubstituted phenylisoxazoles against human picornavirus.
AID84549Antirhinoviral activity calculated for mean of fifteen serotypes (HRV-1A, -1B, -2, -6, -14, -15, -21, -22, -25, -30, -41, --50, -67, -86, -89); inactive against HRV-1A, -6, -14,-671994Journal of medicinal chemistry, Nov-25, Volume: 37, Issue:24
An evaluation of the antirhinoviral activity of acetylfuran replacements for 3-methylisoxazoles. Are 2-acetylfurans bioisosteres for 3-methylisoxazoles?
AID228797Tested for antirhinoviral activity against the rhinovirus serotype 501987Journal of medicinal chemistry, Feb, Volume: 30, Issue:2
Structure-activity studies of 5-[[4-(4,5-dihydro-2-oxazolyl) phenoxy]alkyl]-3-methylisoxazoles: inhibitors of picornavirus uncoating.
AID23485Partition coefficient (logP)1987Journal of medicinal chemistry, Feb, Volume: 30, Issue:2
Structure-activity studies of 5-[[4-(4,5-dihydro-2-oxazolyl) phenoxy]alkyl]-3-methylisoxazoles: inhibitors of picornavirus uncoating.
AID228785Tested for antirhinoviral activity against the rhinovirus serotype 211987Journal of medicinal chemistry, Feb, Volume: 30, Issue:2
Structure-activity studies of 5-[[4-(4,5-dihydro-2-oxazolyl) phenoxy]alkyl]-3-methylisoxazoles: inhibitors of picornavirus uncoating.
AID23989Calculated partition coefficient (clogP)1989Journal of medicinal chemistry, Feb, Volume: 32, Issue:2
Synthesis and structure-activity studies of some disubstituted phenylisoxazoles against human picornavirus.
AID228776Tested for antirhinoviral activity against the rhinovirus serotype 151987Journal of medicinal chemistry, Feb, Volume: 30, Issue:2
Structure-activity studies of 5-[[4-(4,5-dihydro-2-oxazolyl) phenoxy]alkyl]-3-methylisoxazoles: inhibitors of picornavirus uncoating.
AID26042log (1/MIC) value of the compound1992Journal of medicinal chemistry, Mar-20, Volume: 35, Issue:6
CoMFA analysis of the interactions of antipicornavirus compounds in the binding pocket of human rhinovirus-14.
AID84914Tested for minimal inhibitory concentration against Human rhinovirus serotype 22 by plaque reduction assay1994Journal of medicinal chemistry, Nov-25, Volume: 37, Issue:24
An evaluation of the antirhinoviral activity of acetylfuran replacements for 3-methylisoxazoles. Are 2-acetylfurans bioisosteres for 3-methylisoxazoles?
AID199874Concentration required to inhibit 80 percent rhinovirus cell culture1989Journal of medicinal chemistry, Feb, Volume: 32, Issue:2
Synthesis and structure-activity studies of some disubstituted phenylisoxazoles against human picornavirus.
AID222916In vitro minimum inhibitory concentration for the inhibition of human rhinovirus-14 replication.1990Journal of medicinal chemistry, May, Volume: 33, Issue:5
A model for compounds active against human rhinovirus-14 based on X-ray crystallography data.
AID84720Compound was tested for minimum inhibitory concentration against human rhinovirus 14 (HRV14)1998Journal of medicinal chemistry, Jan-15, Volume: 41, Issue:2
Modeling RNA-ligand interactions: the Rev-binding element RNA-aminoglycoside complex.
AID85067Tested for minimal inhibitory concentration against Human rhinovirus serotype 67 by plaque reduction assay1994Journal of medicinal chemistry, Nov-25, Volume: 37, Issue:24
An evaluation of the antirhinoviral activity of acetylfuran replacements for 3-methylisoxazoles. Are 2-acetylfurans bioisosteres for 3-methylisoxazoles?
AID228799Tested for antirhinoviral activity against the rhinovirus serotype 61987Journal of medicinal chemistry, Feb, Volume: 30, Issue:2
Structure-activity studies of 5-[[4-(4,5-dihydro-2-oxazolyl) phenoxy]alkyl]-3-methylisoxazoles: inhibitors of picornavirus uncoating.
AID228783Tested for antirhinoviral activity against the rhinovirus serotype 21987Journal of medicinal chemistry, Feb, Volume: 30, Issue:2
Structure-activity studies of 5-[[4-(4,5-dihydro-2-oxazolyl) phenoxy]alkyl]-3-methylisoxazoles: inhibitors of picornavirus uncoating.
AID84924Tested for minimal inhibitory concentration against Human rhinovirus serotype 30 by plaque reduction assay1994Journal of medicinal chemistry, Nov-25, Volume: 37, Issue:24
An evaluation of the antirhinoviral activity of acetylfuran replacements for 3-methylisoxazoles. Are 2-acetylfurans bioisosteres for 3-methylisoxazoles?
AID199873Minimum inhibitory concentration against rhinovirus serotype 891989Journal of medicinal chemistry, Feb, Volume: 32, Issue:2
Synthesis and structure-activity studies of some disubstituted phenylisoxazoles against human picornavirus.
AID85043Tested for minimal inhibitory concentration against Human rhinovirus serotype 41 by plaque reduction assay; inactive1994Journal of medicinal chemistry, Nov-25, Volume: 37, Issue:24
An evaluation of the antirhinoviral activity of acetylfuran replacements for 3-methylisoxazoles. Are 2-acetylfurans bioisosteres for 3-methylisoxazoles?
AID199864Minimum inhibitory concentration against rhinovirus serotype 21.1989Journal of medicinal chemistry, Feb, Volume: 32, Issue:2
Synthesis and structure-activity studies of some disubstituted phenylisoxazoles against human picornavirus.
AID84885Tested for minimal inhibitory concentration against Human rhinovirus serotype 1A by plaque reduction assay1994Journal of medicinal chemistry, Nov-25, Volume: 37, Issue:24
An evaluation of the antirhinoviral activity of acetylfuran replacements for 3-methylisoxazoles. Are 2-acetylfurans bioisosteres for 3-methylisoxazoles?
AID199863Minimum inhibitory concentration against rhinovirus serotype 1B; IA means inactive1989Journal of medicinal chemistry, Feb, Volume: 32, Issue:2
Synthesis and structure-activity studies of some disubstituted phenylisoxazoles against human picornavirus.
AID228795Tested for antirhinoviral activity against the rhinovirus serotype 411987Journal of medicinal chemistry, Feb, Volume: 30, Issue:2
Structure-activity studies of 5-[[4-(4,5-dihydro-2-oxazolyl) phenoxy]alkyl]-3-methylisoxazoles: inhibitors of picornavirus uncoating.
AID228774Tested for antirhinoviral activity against the rhinovirus serotype 141987Journal of medicinal chemistry, Feb, Volume: 30, Issue:2
Structure-activity studies of 5-[[4-(4,5-dihydro-2-oxazolyl) phenoxy]alkyl]-3-methylisoxazoles: inhibitors of picornavirus uncoating.
AID84911Tested for minimal inhibitory concentration against Human rhinovirus serotype 21 by plaque reduction assay1994Journal of medicinal chemistry, Nov-25, Volume: 37, Issue:24
An evaluation of the antirhinoviral activity of acetylfuran replacements for 3-methylisoxazoles. Are 2-acetylfurans bioisosteres for 3-methylisoxazoles?
AID85051Tested for minimal inhibitory concentration against Human rhinovirus serotype 50 by plaque reduction assay1994Journal of medicinal chemistry, Nov-25, Volume: 37, Issue:24
An evaluation of the antirhinoviral activity of acetylfuran replacements for 3-methylisoxazoles. Are 2-acetylfurans bioisosteres for 3-methylisoxazoles?
AID199870Minimum inhibitory concentration against rhinovirus serotype 6.1989Journal of medicinal chemistry, Feb, Volume: 32, Issue:2
Synthesis and structure-activity studies of some disubstituted phenylisoxazoles against human picornavirus.
AID199855In vitro anti-rhinovirus activity was measured as maximum testable levels - highest concentration of compound which causes no apparent effect on the cell monolayers1989Journal of medicinal chemistry, Feb, Volume: 32, Issue:2
Synthesis and structure-activity studies of some disubstituted phenylisoxazoles against human picornavirus.
AID84919Tested for minimal inhibitory concentration against Human rhinovirus serotype 25 by plaque reduction assay; inactive1994Journal of medicinal chemistry, Nov-25, Volume: 37, Issue:24
An evaluation of the antirhinoviral activity of acetylfuran replacements for 3-methylisoxazoles. Are 2-acetylfurans bioisosteres for 3-methylisoxazoles?
AID199857In vitro anti-rhinovirus activity was measured as maximum testable levels - highest concentration of compound which causes no apparent effect on the cell monolayers1989Journal of medicinal chemistry, Feb, Volume: 32, Issue:2
Synthesis and structure-activity studies of some disubstituted phenylisoxazoles against human picornavirus.
AID228778Tested for antirhinoviral activity against the rhinovirus serotype 1A1987Journal of medicinal chemistry, Feb, Volume: 30, Issue:2
Structure-activity studies of 5-[[4-(4,5-dihydro-2-oxazolyl) phenoxy]alkyl]-3-methylisoxazoles: inhibitors of picornavirus uncoating.
AID89493Compound was evaluated for inhibitory effect against human Rhinovirus-141992Journal of medicinal chemistry, Mar-20, Volume: 35, Issue:6
CoMFA analysis of the interactions of antipicornavirus compounds in the binding pocket of human rhinovirus-14.
AID199861Minimum inhibitory concentration against rhinovirus serotype 1A1989Journal of medicinal chemistry, Feb, Volume: 32, Issue:2
Synthesis and structure-activity studies of some disubstituted phenylisoxazoles against human picornavirus.
AID1562980Antiviral activity against Human rhinovirus A22019European journal of medicinal chemistry, Sep-15, Volume: 178Back to the future: Advances in development of broad-spectrum capsid-binding inhibitors of enteroviruses.
AID84907Antirhinovirus activity was assessed and the maximum testable concentration that causes no apparent effects on the cell monolayers was determined against HRV-2 virus in vitro.1987Journal of medicinal chemistry, Feb, Volume: 30, Issue:2
Structure-activity studies of 5-[[4-(4,5-dihydro-2-oxazolyl) phenoxy]alkyl]-3-methylisoxazoles: inhibitors of picornavirus uncoating.
AID84894Tested for minimal inhibitory concentration against Human rhinovirus serotype 1B by plaque reduction assay; inactive1994Journal of medicinal chemistry, Nov-25, Volume: 37, Issue:24
An evaluation of the antirhinoviral activity of acetylfuran replacements for 3-methylisoxazoles. Are 2-acetylfurans bioisosteres for 3-methylisoxazoles?
AID115931In vitro antiviral activity against mice infected intracerebrally with Poliovirus type-21985Journal of medicinal chemistry, Dec, Volume: 28, Issue:12
[[(4,5-Dihydro-2-oxazolyl)phenoxy]alkyl]isoxazoles. Inhibitors of picornavirus uncoating.
AID84585Tested for in vitro antiviral activity against Human rhinovirus (HRV)-141994Journal of medicinal chemistry, Nov-25, Volume: 37, Issue:24
An evaluation of the antirhinoviral activity of acetylfuran replacements for 3-methylisoxazoles. Are 2-acetylfurans bioisosteres for 3-methylisoxazoles?
AID84723Compound was tested in vitro for minimal inhibitory constant against HRV-141994Journal of medicinal chemistry, Nov-25, Volume: 37, Issue:24
An evaluation of the antirhinoviral activity of acetylfuran replacements for 3-methylisoxazoles. Are 2-acetylfurans bioisosteres for 3-methylisoxazoles?
AID85207Negative logarithm of minimal inhibitory concentration against human rhinovirus 141993Journal of medicinal chemistry, Jan-08, Volume: 36, Issue:1
On the prediction of binding properties of drug molecules by comparative molecular field analysis.
AID23690Partition coefficient (logP)1992Journal of medicinal chemistry, Mar-20, Volume: 35, Issue:6
CoMFA analysis of the interactions of antipicornavirus compounds in the binding pocket of human rhinovirus-14.
AID228803Tested for antirhinoviral activity against the rhinovirus serotype 861987Journal of medicinal chemistry, Feb, Volume: 30, Issue:2
Structure-activity studies of 5-[[4-(4,5-dihydro-2-oxazolyl) phenoxy]alkyl]-3-methylisoxazoles: inhibitors of picornavirus uncoating.
AID199871Minimum inhibitory concentration against rhinovirus serotype 671989Journal of medicinal chemistry, Feb, Volume: 32, Issue:2
Synthesis and structure-activity studies of some disubstituted phenylisoxazoles against human picornavirus.
AID199867Minimum inhibitory concentration against rhinovirus serotype 301989Journal of medicinal chemistry, Feb, Volume: 32, Issue:2
Synthesis and structure-activity studies of some disubstituted phenylisoxazoles against human picornavirus.
AID228781Tested for antirhinoviral activity against the rhinovirus serotype 1B; IA is inactive1987Journal of medicinal chemistry, Feb, Volume: 30, Issue:2
Structure-activity studies of 5-[[4-(4,5-dihydro-2-oxazolyl) phenoxy]alkyl]-3-methylisoxazoles: inhibitors of picornavirus uncoating.
AID84721Tested for minimal inhibitory concentration against Human rhinovirus serotype 14 by plaque reduction assay1994Journal of medicinal chemistry, Nov-25, Volume: 37, Issue:24
An evaluation of the antirhinoviral activity of acetylfuran replacements for 3-methylisoxazoles. Are 2-acetylfurans bioisosteres for 3-methylisoxazoles?
AID84746Tested for minimal inhibitory concentration against Human rhinovirus serotype 15 by plaque reduction assay1994Journal of medicinal chemistry, Nov-25, Volume: 37, Issue:24
An evaluation of the antirhinoviral activity of acetylfuran replacements for 3-methylisoxazoles. Are 2-acetylfurans bioisosteres for 3-methylisoxazoles?
AID228801Tested for antirhinoviral activity against the rhinovirus serotype 671987Journal of medicinal chemistry, Feb, Volume: 30, Issue:2
Structure-activity studies of 5-[[4-(4,5-dihydro-2-oxazolyl) phenoxy]alkyl]-3-methylisoxazoles: inhibitors of picornavirus uncoating.
AID85083Tested for minimal inhibitory concentration against Human rhinovirus serotype 86 by plaque reduction assay1994Journal of medicinal chemistry, Nov-25, Volume: 37, Issue:24
An evaluation of the antirhinoviral activity of acetylfuran replacements for 3-methylisoxazoles. Are 2-acetylfurans bioisosteres for 3-methylisoxazoles?
AID84898Tested for minimal inhibitory concentration against Human rhinovirus serotype 2 by plaque reduction assay1994Journal of medicinal chemistry, Nov-25, Volume: 37, Issue:24
An evaluation of the antirhinoviral activity of acetylfuran replacements for 3-methylisoxazoles. Are 2-acetylfurans bioisosteres for 3-methylisoxazoles?
AID199856In vitro anti-rhinovirus activity was measured as mean MIC for five serotypes, HRV-1A, -2, -22, -41, and -501989Journal of medicinal chemistry, Feb, Volume: 32, Issue:2
Synthesis and structure-activity studies of some disubstituted phenylisoxazoles against human picornavirus.
AID228787Tested for antirhinoviral activity against the rhinovirus serotype 221987Journal of medicinal chemistry, Feb, Volume: 30, Issue:2
Structure-activity studies of 5-[[4-(4,5-dihydro-2-oxazolyl) phenoxy]alkyl]-3-methylisoxazoles: inhibitors of picornavirus uncoating.
AID199858In vitro antiviral activity against Rhinovirus type-21985Journal of medicinal chemistry, Dec, Volume: 28, Issue:12
[[(4,5-Dihydro-2-oxazolyl)phenoxy]alkyl]isoxazoles. Inhibitors of picornavirus uncoating.
AID84903Antirhinovirus activity was determined by the ability to inhibit the HRV-2 virus growth by 80%1987Journal of medicinal chemistry, Feb, Volume: 30, Issue:2
Structure-activity studies of 5-[[4-(4,5-dihydro-2-oxazolyl) phenoxy]alkyl]-3-methylisoxazoles: inhibitors of picornavirus uncoating.
AID222915In vitro inhibitory activity against human rhinovirus-14 was determined1990Journal of medicinal chemistry, May, Volume: 33, Issue:5
A model for compounds active against human rhinovirus-14 based on X-ray crystallography data.
AID84901Antiviral activity determined by ability to inhibit the HRV-2( human rhinovirus type -2) virus by plaque reduction assay in vitro1987Journal of medicinal chemistry, Feb, Volume: 30, Issue:2
Structure-activity studies of 5-[[4-(4,5-dihydro-2-oxazolyl) phenoxy]alkyl]-3-methylisoxazoles: inhibitors of picornavirus uncoating.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (16)

TimeframeStudies, This Drug (%)All Drugs %
pre-19904 (25.00)18.7374
1990's8 (50.00)18.2507
2000's3 (18.75)29.6817
2010's1 (6.25)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 11.56

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index11.56 (24.57)
Research Supply Index2.83 (2.92)
Research Growth Index4.40 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (11.56)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews1 (6.25%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other15 (93.75%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
sch-48973
[no description available]		3.3110
pleconaril
WIN 63843: structure given in first source		3.3110
win 53338
WIN 53338: structure given in first source. 5-{5-[2-chloro-4-(4,5-dihydro-1,3-oxazol-2-yl)phenoxy]pentyl}-3-methylisoxazole : An isoxazole compound having a methyl substituent at the 3-position and a 5-[2-chloro-4-(4,5-dihydro-1,3-oxazol-2-yl)phenoxy]pentyl substituent at the 5-position.		3.0850isoxazoles;
monochlorobenzenes		antiviral agent
win 52084
Win 52084: structure given in first source; RN given refers to (+-)-isomer; RN for cpd without isomeric designation not available 7/89		4.4770aromatic ether
pyrroles
1H-pyrrole : A tautomer of pyrrole that has the double bonds at positions 2 and 4.. pyrrole : A five-membered monocyclic heteroarene comprising one NH and four CH units which forms the parent compound of the pyrrole group of compounds. Its five-membered ring structure has three tautomers. A 'closed class'.. azole : Any monocyclic heteroarene consisting of a five-membered ring containing nitrogen. Azoles can also contain one or more other non-carbon atoms, such as nitrogen, sulfur or oxygen.		2.0110pyrrole;
secondary amine
framycetin
Framycetin: A component of NEOMYCIN that is produced by Streptomyces fradiae. On hydrolysis it yields neamine and neobiosamine B. (From Merck Index, 11th ed). framycetin : A tetracyclic antibacterial agent derived from neomycin, being a glycoside ester of neamine and neobiosamine B.		1.9910aminoglycosideallergen;
antibacterial drug;
Escherichia coli metabolite
isoxazoles
Isoxazoles: Azoles with an OXYGEN and a NITROGEN next to each other at the 1,2 positions, in contrast to OXAZOLES that have nitrogens at the 1,3 positions.. isoxazole : A monocyclic heteroarene with a structure consisting of a 5-membered ring containing three carbon atoms and an oxygen and nitrogen atom adjacent to each other. It is the parent of the class of isoxazoles.. isoxazoles : Oxazoles in which the N and O atoms are adjacent.		3.3870isoxazoles;
mancude organic heteromonocyclic parent;
monocyclic heteroarene
oxazoles
Oxazoles: Five-membered heterocyclic ring structures containing an oxygen in the 1-position and a nitrogen in the 3-position, in distinction from ISOXAZOLES where they are at the 1,2 positions.. 1,3-oxazole : A five-membered monocyclic heteroarene that is an analogue of cyclopentadiene with O in place of CH2 at position 1 and N in place of CH at position 3.. oxazole : An azole based on a five-membered heterocyclic aromatic skeleton containing one N and one O atom.		1.97101,3-oxazoles;
mancude organic heteromonocyclic parent;
monocyclic heteroarene
ribostamycin
Ribostamycin: A broad-spectrum antimicrobial isolated from Streptomyces ribosifidicus.. ribostamycin : An amino cyclitol glycoside that is 4,6-diaminocyclohexane-1,2,3-triol having a 2,6-diamino-2,6-dideoxy-alpha-D-glucosyl residue attached at position 1 and a beta-D-ribosyl residue attached at position 2. It is an antibiotic produced by Streptomyces ribosidificus (formerly S. thermoflavus).		1.9910amino cyclitol glycoside;
aminoglycoside antibiotic		antibacterial drug;
antimicrobial agent;
metabolite
sisomicin
Sisomicin: Antibiotic produced by Micromonospora inyoensis. It is closely related to gentamicin C1A, one of the components of the gentamicin complex (GENTAMICINS).		1.9910amino cyclitol glycoside;
aminoglycoside antibiotic;
beta-L-arabinoside;
monosaccharide derivative
tobramycin
Tobramycin: An aminoglycoside, broad-spectrum antibiotic produced by Streptomyces tenebrarius. It is effective against gram-negative bacteria, especially the PSEUDOMONAS species. It is a 10% component of the antibiotic complex, NEBRAMYCIN, produced by the same species.. tobramycin : A amino cyclitol glycoside that is kanamycin B lacking the 3-hydroxy substituent from the 2,6-diaminoglucose ring.		1.9910amino cyclitol glycosideantibacterial agent;
antimicrobial agent;
toxin
disoxaril
disoxaril: antipicornavirus agent		4.4770aromatic ether
neamine
neamine: fragment of NEOMYCIN B; structure in first source. neamine : 2-Deoxy-D-streptamine glycosylated at the 4-oxygen with a 6-amino-alpha-D-glucosaminyl group.		1.99102,6-dideoxy-alpha-D-glucoside;
aminoglycoside		antibacterial agent
lividomycin
[no description available]		1.9910lividomycinsmetabolite
4',6-dichloroflavan
4',6-dichloroflavan: antirhinovirus cpd; structure given in first source		1.9610
r 61837
R 61837: antirhinovirus cpd; structure given in first source		3.3110
paromomycin
Paromomycin: An aminoglycoside antibacterial and antiprotozoal agent produced by species of STREPTOMYCES.. paromomycin : An amino cyclitol glycoside that is the 1-O-(2-amino-2-deoxy-alpha-D-glucopyranoside) and the 3-O-(2,6-diamino-2,6-dideoxy-beta-L-idopyranosyl)-beta-D-ribofuranoside of 4,6-diamino-2,3-dihydroxycyclohexane (the 1R,2R,3S,4R,6S diastereoisomer). It is obtained from various Streptomyces species. A broad-spectrum antibiotic, it is used (generally as the sulfate salt) for the treatment of acute and chronic intestinal protozoal infections, but is not effective for extraintestinal protozoal infections. It is also used as a therapeutic against visceral leishmaniasis.		1.9910amino cyclitol glycoside;
aminoglycoside antibiotic		anthelminthic drug;
antibacterial drug;
antiparasitic agent;
antiprotozoal drug
bekanamycin
bekanamycin: kanendomycin is the sulfate of bekanamycin; RN given refers to parent cpd; structure		1.9910kanamycins
win 54954
Win 54954: broad-spectrum antipicornavirus drug; structure given in first source		2.6730aromatic ether
ConditionIndicatedRelationship StrengthStudiesTrials
Infections, Picornaviridae
[description not available]		01.9610