Compounds > disoxaril
Page last updated: 2024-12-06

disoxaril

Description

disoxaril: antipicornavirus agent [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID55717
CHEMBL ID283639
CHEBI ID3846
SCHEMBL ID147146
MeSH IDM0133430

Synonyms (37)

Synonym
3-methyl-5-(7-(p-2-oxazolin-2-ylphenoxy)heptyl)isoxazole
isoxazole, 5-(7-(4-(4,5-dihydro-2-oxazolyl)phenoxy)heptyl)-3-methyl-
win-51711
brn 3626820
disoxaril [usan:inn]
disoxarilum [latin]
disoxarilo [spanish]
D03874
disoxaril (usan/inn)
87495-31-6
win 51711
5-[7-[4-(4,5-dihydrooxazol-2-yl)phenoxy]heptyl]-3-methyl-isoxazole
isoxazole, 5-[7-[4-(4,5-dihydro-2-oxazolyl)phenoxy]heptyl]-3-methyl-
5-(7-(4-(4,5-dihydro-2-oxazolyl)phenoxy)heptyl)-3-methylisoxazole
compound iv
disoxaril
C06496
5-(7-(4-(4,5-dihydro-2-oxazolyl)phenoxy)heptyl)-3-methyl isoxazole
win 51,711
CHEMBL283639
chebi:3846 ,
DB08726
5-{7-[4-(4,5-dihydro-2-oxazolyl)phenoxy]heptyl}-3-methylisoxazole
FKLJPTJMIBLJAV-UHFFFAOYSA-N
5-[7-[4-(4,5-dihydro-1,3-oxazol-2-yl)phenoxy]heptyl]-3-methyl-1,2-oxazole
unii-fx8q9pi4vp
disoxarilo
fx8q9pi4vp ,
disoxarilum
disoxaril [inn]
disoxaril [usan]
SCHEMBL147146
AKOS028110949
DTXSID70236354
5-{7-[4-(4,5-dihydro-1,3-oxazol-2-yl)phenoxy]heptyl}-3-methylisoxazole
Q27097911
5-(7-(4-(4,5-dihydrooxazol-2-yl)phenoxy)heptyl)-3-methylisoxazole

Research Excerpts

Overview

Disoxaril is a hydrophobic antiviral compound that blocks picornavirus uncoating.

ExcerptReferenceRelevance
"Disoxaril is a hydrophobic antiviral compound that blocks picornavirus uncoating."( Clearance of a persistent human enterovirus infection of the mouse central nervous system by the antiviral agent disoxaril.
Guidinger, PL; Jubelt, B; McKinlay, MA; Ropka, SL; Wilson, AK, 1989)		1.21

Treatment

ExcerptReferenceRelevance
"Treatment with disoxaril (a WIN compound binding to the hydrophobic pocket within the enterovirus VP1 capsid protein) in newborn mice infected with Coxsackie B1 virus, for 10 days post virus inoculation at a daily subcutaneous dose of 25mg/kg decreased the virus titer in the mouse brain till day 7. "( Development of resistance to disoxaril in Coxsackie B1 virus-infected newborn mice.
Galabov, AS; Nikolova, I, 2003)		0.96

Dosage Studied

ExcerptRelevanceReference
" An oral four times a day dosage regimen initiated 48 h postinfection with WIN 51711 doses as low as 12."( Oral efficacy of WIN 51711 in mice infected with human poliovirus.
McKinlay, MA; Steinberg, BA, 1986)		0.27
" Oral administration of WIN 51711 twice daily beginning 72 hr after infection was the most-effective dosage regimen, with doses as low as 3 mg/kg preventing paralysis in 75% of the animals."( Use of WIN 51711 to prevent echovirus type 9-induced paralysis in suckling mice.
Benziger, DP; Frank, JA; McKinlay, MA; Steinberg, BA, 1986)		0.27
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
aromatic etherAny ether in which the oxygen is attached to at least one aryl substituent.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Bioassays (56)

Assay IDTitleYearJournalArticle
AID124292In vivo antiviral activity at 4 mg/kg oral dose in mice infected with Poliovirus1985Journal of medicinal chemistry, Dec, Volume: 28, Issue:12
[[(4,5-Dihydro-2-oxazolyl)phenoxy]alkyl]isoxazoles. Inhibitors of picornavirus uncoating.
AID111324Prevention of Echo-9-Induced Paralysis in Suckling mice with Placebo; expressed as no. nonparalyzed/total 0/301985Journal of medicinal chemistry, Dec, Volume: 28, Issue:12
[[(4,5-Dihydro-2-oxazolyl)phenoxy]alkyl]isoxazoles. Inhibitors of picornavirus uncoating.
AID84552Compound concentration which inhibits 80% of serotypes tested, was reported.1995Journal of medicinal chemistry, Mar-03, Volume: 38, Issue:5
[[[(Thienylcarbonyl)alkyl]oxy]phenyl]- and [[[(pyrrylcarbonyl)alkyl]oxy]phenyl]oxazoline derivatives with potent and selective antihuman rhinovirus activity.
AID1287134Selectivity index, ratio of CC50 for african green monkey Vero cells to EC50 for Enterovirus 712016Journal of medicinal chemistry, Mar-10, Volume: 59, Issue:5
Identification and Structure-Activity Relationships of Diarylhydrazides as Novel Potent and Selective Human Enterovirus Inhibitors.
AID342767Selectivity index, CC50 for human FL cells to IC50 for Echovirus 132008Bioorganic & medicinal chemistry, Aug-01, Volume: 16, Issue:15
Cinnamoyl- and hydroxycinnamoyl amides of glaucine and their antioxidative and antiviral activities.
AID1562980Antiviral activity against Human rhinovirus A22019European journal of medicinal chemistry, Sep-15, Volume: 178Back to the future: Advances in development of broad-spectrum capsid-binding inhibitors of enteroviruses.
AID1287145Induction of stabilization of Human enterovirus 71 capsid protein assessed as increase in temperature for achieving equal staining of viral genome at 50 ug/ml by SYBR green fluorescent assay2016Journal of medicinal chemistry, Mar-10, Volume: 59, Issue:5
Identification and Structure-Activity Relationships of Diarylhydrazides as Novel Potent and Selective Human Enterovirus Inhibitors.
AID111318Prevention of Echo-9-Induced Paralysis in Suckling mice by intraperitoneal administration at dose 10 mg/kg; expressed as no. nonparalyzed/total 19/301985Journal of medicinal chemistry, Dec, Volume: 28, Issue:12
[[(4,5-Dihydro-2-oxazolyl)phenoxy]alkyl]isoxazoles. Inhibitors of picornavirus uncoating.
AID84907Antirhinovirus activity was assessed and the maximum testable concentration that causes no apparent effects on the cell monolayers was determined against HRV-2 virus in vitro.1987Journal of medicinal chemistry, Feb, Volume: 30, Issue:2
Structure-activity studies of 5-[[4-(4,5-dihydro-2-oxazolyl) phenoxy]alkyl]-3-methylisoxazoles: inhibitors of picornavirus uncoating.
AID123023In vivo antiviral activity at 4 mg/kg oral dose in mice infected with Poliovirus; 8/201985Journal of medicinal chemistry, Dec, Volume: 28, Issue:12
[[(4,5-Dihydro-2-oxazolyl)phenoxy]alkyl]isoxazoles. Inhibitors of picornavirus uncoating.
AID1287131Cytotoxicity against african green monkey Vero cells assessed as reduction in cell viability after 24 to 36 hrs by MTS-based CPE reduction assay2016Journal of medicinal chemistry, Mar-10, Volume: 59, Issue:5
Identification and Structure-Activity Relationships of Diarylhydrazides as Novel Potent and Selective Human Enterovirus Inhibitors.
AID1287148Inhibition of human enterovirus 71 capsid assessed as reduction in viral replication at early stages infected in human RD cells at 20 ug/ml2016Journal of medicinal chemistry, Mar-10, Volume: 59, Issue:5
Identification and Structure-Activity Relationships of Diarylhydrazides as Novel Potent and Selective Human Enterovirus Inhibitors.
AID342764Selectivity index, CC50 for human FL cells to IC50 for Coxsackievirus B12008Bioorganic & medicinal chemistry, Aug-01, Volume: 16, Issue:15
Cinnamoyl- and hydroxycinnamoyl amides of glaucine and their antioxidative and antiviral activities.
AID111323Prevention of Echo-9-Induced Paralysis in Suckling mice with Placebo; Expressed as % nonparalyzed1985Journal of medicinal chemistry, Dec, Volume: 28, Issue:12
[[(4,5-Dihydro-2-oxazolyl)phenoxy]alkyl]isoxazoles. Inhibitors of picornavirus uncoating.
AID93742In vitro minimum inhibitory concentration against human rhinovirus-14 (HRV-14)1988Journal of medicinal chemistry, Mar, Volume: 31, Issue:3
Enantiomeric effects of homologues of disoxaril on the inhibitory activity against human rhinovirus-14.
AID88357In vitro concentration required to achieve 50% protection of HeLa cells from HRV-14 induced cytopathic effect1995Journal of medicinal chemistry, Mar-03, Volume: 38, Issue:5
[[[(Thienylcarbonyl)alkyl]oxy]phenyl]- and [[[(pyrrylcarbonyl)alkyl]oxy]phenyl]oxazoline derivatives with potent and selective antihuman rhinovirus activity.
AID124291In vivo antiviral activity at 32 mg/kg oral dose in mice infected with Poliovirus1985Journal of medicinal chemistry, Dec, Volume: 28, Issue:12
[[(4,5-Dihydro-2-oxazolyl)phenoxy]alkyl]isoxazoles. Inhibitors of picornavirus uncoating.
AID111208Prevention of Echo-9-Induced Paralysis in Suckling mice by intraperitoneal administration at dose 1 mg/kg; Expressed as % nonparalyzed1985Journal of medicinal chemistry, Dec, Volume: 28, Issue:12
[[(4,5-Dihydro-2-oxazolyl)phenoxy]alkyl]isoxazoles. Inhibitors of picornavirus uncoating.
AID111320Prevention of Echo-9-Induced Paralysis in Suckling mice by intraperitoneal administration at dose 3.3 mg/kg; expressed as no. nonparalyzed/total 6/301985Journal of medicinal chemistry, Dec, Volume: 28, Issue:12
[[(4,5-Dihydro-2-oxazolyl)phenoxy]alkyl]isoxazoles. Inhibitors of picornavirus uncoating.
AID1562974Antiviral activity against Human poliovirus 22019European journal of medicinal chemistry, Sep-15, Volume: 178Back to the future: Advances in development of broad-spectrum capsid-binding inhibitors of enteroviruses.
AID1287139Selectivity index, ratio of CC50 for human RD cells to EC50 for Enterovirus 712016Journal of medicinal chemistry, Mar-10, Volume: 59, Issue:5
Identification and Structure-Activity Relationships of Diarylhydrazides as Novel Potent and Selective Human Enterovirus Inhibitors.
AID342762Antiviral activity against Coxsackievirus B1 in human FL cells2008Bioorganic & medicinal chemistry, Aug-01, Volume: 16, Issue:15
Cinnamoyl- and hydroxycinnamoyl amides of glaucine and their antioxidative and antiviral activities.
AID124294In vivo antiviral activity of the compound in Placebo treated mice infected with Poliovirus1985Journal of medicinal chemistry, Dec, Volume: 28, Issue:12
[[(4,5-Dihydro-2-oxazolyl)phenoxy]alkyl]isoxazoles. Inhibitors of picornavirus uncoating.
AID123021In vivo antiviral activity at 16 mg/kg oral dose in mice infected with Poliovirus;13/201985Journal of medicinal chemistry, Dec, Volume: 28, Issue:12
[[(4,5-Dihydro-2-oxazolyl)phenoxy]alkyl]isoxazoles. Inhibitors of picornavirus uncoating.
AID111322Prevention of Echo-9-Induced Paralysis in Suckling mice by intraperitoneal administration at dose 33 mg/kg; expressed as no. nonparalyzed/total 29/301985Journal of medicinal chemistry, Dec, Volume: 28, Issue:12
[[(4,5-Dihydro-2-oxazolyl)phenoxy]alkyl]isoxazoles. Inhibitors of picornavirus uncoating.
AID124293In vivo antiviral activity at 8 mg/kg oral dose in mice infected with Poliovirus1985Journal of medicinal chemistry, Dec, Volume: 28, Issue:12
[[(4,5-Dihydro-2-oxazolyl)phenoxy]alkyl]isoxazoles. Inhibitors of picornavirus uncoating.
AID1287132Antiviral activity against Human enterovirus 71 infected in monkey African green Vero cells by MTS-based CPE reduction assay2016Journal of medicinal chemistry, Mar-10, Volume: 59, Issue:5
Identification and Structure-Activity Relationships of Diarylhydrazides as Novel Potent and Selective Human Enterovirus Inhibitors.
AID84901Antiviral activity determined by ability to inhibit the HRV-2( human rhinovirus type -2) virus by plaque reduction assay in vitro1987Journal of medicinal chemistry, Feb, Volume: 30, Issue:2
Structure-activity studies of 5-[[4-(4,5-dihydro-2-oxazolyl) phenoxy]alkyl]-3-methylisoxazoles: inhibitors of picornavirus uncoating.
AID222916In vitro minimum inhibitory concentration for the inhibition of human rhinovirus-14 replication.1990Journal of medicinal chemistry, May, Volume: 33, Issue:5
A model for compounds active against human rhinovirus-14 based on X-ray crystallography data.
AID342758Cytotoxicity against human FL cells after 24 hrs2008Bioorganic & medicinal chemistry, Aug-01, Volume: 16, Issue:15
Cinnamoyl- and hydroxycinnamoyl amides of glaucine and their antioxidative and antiviral activities.
AID111316Prevention of Echo-9-Induced Paralysis in Suckling mice by intraperitoneal administration at dose 1 mg/kg; expressed as no. nonparalyzed/total 2/301985Journal of medicinal chemistry, Dec, Volume: 28, Issue:12
[[(4,5-Dihydro-2-oxazolyl)phenoxy]alkyl]isoxazoles. Inhibitors of picornavirus uncoating.
AID123024In vivo antiviral activity at 8 mg/kg oral dose in mice infected with Poliovirus; 9/201985Journal of medicinal chemistry, Dec, Volume: 28, Issue:12
[[(4,5-Dihydro-2-oxazolyl)phenoxy]alkyl]isoxazoles. Inhibitors of picornavirus uncoating.
AID111317Prevention of Echo-9-Induced Paralysis in Suckling mice by intraperitoneal administration at dose 10 mg/kg; Expressed as % nonparalyzed1985Journal of medicinal chemistry, Dec, Volume: 28, Issue:12
[[(4,5-Dihydro-2-oxazolyl)phenoxy]alkyl]isoxazoles. Inhibitors of picornavirus uncoating.
AID124290In vivo antiviral activity at 16 mg/kg oral dose in mice infected with Poliovirus1985Journal of medicinal chemistry, Dec, Volume: 28, Issue:12
[[(4,5-Dihydro-2-oxazolyl)phenoxy]alkyl]isoxazoles. Inhibitors of picornavirus uncoating.
AID84720Compound was tested for minimum inhibitory concentration against human rhinovirus 14 (HRV14)1998Journal of medicinal chemistry, Jan-15, Volume: 41, Issue:2
Modeling RNA-ligand interactions: the Rev-binding element RNA-aminoglycoside complex.
AID1287138Cytotoxicity against human RD cells assessed as reduction in cell viability after 24 to 36 hrs by MTS-based CPE reduction assay2016Journal of medicinal chemistry, Mar-10, Volume: 59, Issue:5
Identification and Structure-Activity Relationships of Diarylhydrazides as Novel Potent and Selective Human Enterovirus Inhibitors.
AID222913Mean of MIC's was determined for the five types of virus like HRV-2, HRV-1A,HRV-22,HRV-41 and HRV-501987Journal of medicinal chemistry, Feb, Volume: 30, Issue:2
Structure-activity studies of 5-[[4-(4,5-dihydro-2-oxazolyl) phenoxy]alkyl]-3-methylisoxazoles: inhibitors of picornavirus uncoating.
AID1287137Antiviral activity against Enterovirus 71 infected in human RD cells after 24 to 36 hrs by MTS-based CPE reduction assay2016Journal of medicinal chemistry, Mar-10, Volume: 59, Issue:5
Identification and Structure-Activity Relationships of Diarylhydrazides as Novel Potent and Selective Human Enterovirus Inhibitors.
AID111319Prevention of Echo-9-Induced Paralysis in Suckling mice by intraperitoneal administration at dose 3.3 mg/kg; Expressed as % nonparalyzed1985Journal of medicinal chemistry, Dec, Volume: 28, Issue:12
[[(4,5-Dihydro-2-oxazolyl)phenoxy]alkyl]isoxazoles. Inhibitors of picornavirus uncoating.
AID342759Antiviral activity against Poliovirus type 1 Lsc-2ab in human FL cells2008Bioorganic & medicinal chemistry, Aug-01, Volume: 16, Issue:15
Cinnamoyl- and hydroxycinnamoyl amides of glaucine and their antioxidative and antiviral activities.
AID88358In vitro concentration required to achieve 50% protection of HeLa cells from HRV-2 induced cytopathic effect1995Journal of medicinal chemistry, Mar-03, Volume: 38, Issue:5
[[[(Thienylcarbonyl)alkyl]oxy]phenyl]- and [[[(pyrrylcarbonyl)alkyl]oxy]phenyl]oxazoline derivatives with potent and selective antihuman rhinovirus activity.
AID88190Compound concentration required to reduce the viability of mock-infected HeLa cells by 50%, was reported.1995Journal of medicinal chemistry, Mar-03, Volume: 38, Issue:5
[[[(Thienylcarbonyl)alkyl]oxy]phenyl]- and [[[(pyrrylcarbonyl)alkyl]oxy]phenyl]oxazoline derivatives with potent and selective antihuman rhinovirus activity.
AID111321Prevention of Echo-9-Induced Paralysis in Suckling mice by intraperitoneal administration at dose 33 mg/kg; Expressed as % nonparalyzed1985Journal of medicinal chemistry, Dec, Volume: 28, Issue:12
[[(4,5-Dihydro-2-oxazolyl)phenoxy]alkyl]isoxazoles. Inhibitors of picornavirus uncoating.
AID199858In vitro antiviral activity against Rhinovirus type-21985Journal of medicinal chemistry, Dec, Volume: 28, Issue:12
[[(4,5-Dihydro-2-oxazolyl)phenoxy]alkyl]isoxazoles. Inhibitors of picornavirus uncoating.
AID342761Selectivity index, CC50 for human FL cells to IC50 for Poliovirus type 1 Lsc-2ab2008Bioorganic & medicinal chemistry, Aug-01, Volume: 16, Issue:15
Cinnamoyl- and hydroxycinnamoyl amides of glaucine and their antioxidative and antiviral activities.
AID342769Cytotoxicity against human HeLa Ohio-1 cells2008Bioorganic & medicinal chemistry, Aug-01, Volume: 16, Issue:15
Cinnamoyl- and hydroxycinnamoyl amides of glaucine and their antioxidative and antiviral activities.
AID115931In vitro antiviral activity against mice infected intracerebrally with Poliovirus type-21985Journal of medicinal chemistry, Dec, Volume: 28, Issue:12
[[(4,5-Dihydro-2-oxazolyl)phenoxy]alkyl]isoxazoles. Inhibitors of picornavirus uncoating.
AID342770Selectivity index, CC50 for human HeLa Ohio-1 cells to IC50 for Human rhinovirus type 142008Bioorganic & medicinal chemistry, Aug-01, Volume: 16, Issue:15
Cinnamoyl- and hydroxycinnamoyl amides of glaucine and their antioxidative and antiviral activities.
AID342765Antiviral activity against Echovirus 13 in human FL cells2008Bioorganic & medicinal chemistry, Aug-01, Volume: 16, Issue:15
Cinnamoyl- and hydroxycinnamoyl amides of glaucine and their antioxidative and antiviral activities.
AID123022In vivo antiviral activity at 32 mg/kg oral dose in mice infected with Poliovirus; 15/201985Journal of medicinal chemistry, Dec, Volume: 28, Issue:12
[[(4,5-Dihydro-2-oxazolyl)phenoxy]alkyl]isoxazoles. Inhibitors of picornavirus uncoating.
AID392156Inhibition of Cryptosporidium hominis TS-DHFR by spectroscopic assay2009Bioorganic & medicinal chemistry letters, Jan-15, Volume: 19, Issue:2
Novel non-active site inhibitor of Cryptosporidium hominis TS-DHFR identified by a virtual screen.
AID123025In vivo antiviral activity of the compound in Placebo treated mice infected with Poliovirus; 4/201985Journal of medicinal chemistry, Dec, Volume: 28, Issue:12
[[(4,5-Dihydro-2-oxazolyl)phenoxy]alkyl]isoxazoles. Inhibitors of picornavirus uncoating.
AID342768Antiviral activity against Human rhinovirus type 14 in human HeLa Ohio-1 cells2008Bioorganic & medicinal chemistry, Aug-01, Volume: 16, Issue:15
Cinnamoyl- and hydroxycinnamoyl amides of glaucine and their antioxidative and antiviral activities.
AID115948MIC at the Maximal testable level in mice was evaluated1985Journal of medicinal chemistry, Dec, Volume: 28, Issue:12
[[(4,5-Dihydro-2-oxazolyl)phenoxy]alkyl]isoxazoles. Inhibitors of picornavirus uncoating.
AID85207Negative logarithm of minimal inhibitory concentration against human rhinovirus 141993Journal of medicinal chemistry, Jan-08, Volume: 36, Issue:1
On the prediction of binding properties of drug molecules by comparative molecular field analysis.
AID1562979Antiviral activity against Rhinovirus2019European journal of medicinal chemistry, Sep-15, Volume: 178Back to the future: Advances in development of broad-spectrum capsid-binding inhibitors of enteroviruses.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (55)

TimeframeStudies, This Drug (%)All Drugs %
pre-199017 (30.91)18.7374
1990's25 (45.45)18.2507
2000's9 (16.36)29.6817
2010's4 (7.27)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 17.98

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index17.98 (24.57)
Research Supply Index4.04 (2.92)
Research Growth Index4.39 (4.65)
Search Engine Demand Index15.26 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (17.98)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews2 (3.57%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other54 (96.43%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
sch-48973
[no description available]		3.3110
pleconaril
WIN 63843: structure given in first source		3.3110
win 52035
Win 52035: structure given in first source		4.4770aromatic ether
win 53338
WIN 53338: structure given in first source. 5-{5-[2-chloro-4-(4,5-dihydro-1,3-oxazol-2-yl)phenoxy]pentyl}-3-methylisoxazole : An isoxazole compound having a methyl substituent at the 3-position and a 5-[2-chloro-4-(4,5-dihydro-1,3-oxazol-2-yl)phenoxy]pentyl substituent at the 5-position.		2.8940isoxazoles;
monochlorobenzenes		antiviral agent
win 52084
Win 52084: structure given in first source; RN given refers to (+-)-isomer; RN for cpd without isomeric designation not available 7/89		4.4670aromatic ether
ciprofloxacin
Ciprofloxacin: A broad-spectrum antimicrobial carboxyfluoroquinoline.. ciprofloxacin : A quinolone that is quinolin-4(1H)-one bearing cyclopropyl, carboxylic acid, fluoro and piperazin-1-yl substituents at positions 1, 3, 6 and 7, respectively.		3.0610aminoquinoline;
cyclopropanes;
fluoroquinolone antibiotic;
N-arylpiperazine;
quinolinemonocarboxylic acid;
quinolone antibiotic;
quinolone;
zwitterion		antibacterial drug;
antiinfective agent;
antimicrobial agent;
DNA synthesis inhibitor;
EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor;
environmental contaminant;
topoisomerase IV inhibitor;
xenobiotic
guanidine
Guanidine: A strong organic base existing primarily as guanidium ions at physiological pH. It is found in the urine as a normal product of protein metabolism. It is also used in laboratory research as a protein denaturant. (From Martindale, the Extra Pharmacopoeia, 30th ed and Merck Index, 12th ed) It is also used in the treatment of myasthenia and as a fluorescent probe in HPLC.. guanidine : An aminocarboxamidine, the parent compound of the guanidines.		2.4420carboxamidine;
guanidines;
one-carbon compound
ketoconazole
1-acetyl-4-(4-{[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazine : A dioxolane that is 1,3-dioxolane which is substituted at positions 2, 2, and 4 by imidazol-1-ylmethyl, 2,4-dichlorophenyl, and [para-(4-acetylpiperazin-1-yl)phenoxy]methyl groups, respectively.		2.0510dichlorobenzene;
dioxolane;
ether;
imidazoles;
N-acylpiperazine;
N-arylpiperazine
streptonigrin
[no description available]		2.0510pyridines;
quinolone		antimicrobial agent;
antineoplastic agent
trimethoprim
Trimethoprim: A pyrimidine inhibitor of dihydrofolate reductase, it is an antibacterial related to PYRIMETHAMINE. It is potentiated by SULFONAMIDES and the TRIMETHOPRIM, SULFAMETHOXAZOLE DRUG COMBINATION is the form most often used. It is sometimes used alone as an antimalarial. TRIMETHOPRIM RESISTANCE has been reported.. trimethoprim : An aminopyrimidine antibiotic whose structure consists of pyrimidine 2,4-diamine and 1,2,3-trimethoxybenzene moieties linked by a methylene bridge.		2.0510aminopyrimidine;
methoxybenzenes		antibacterial drug;
diuretic;
drug allergen;
EC 1.5.1.3 (dihydrofolate reductase) inhibitor;
environmental contaminant;
xenobiotic
sucrose
Saccharum: A plant genus of the family POACEAE widely cultivated in the tropics for the sweet cane that is processed into sugar.		1.9610glycosyl glycosidealgal metabolite;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
osmolyte;
Saccharomyces cerevisiae metabolite;
sweetening agent
apomorphine
Apomorphine: A derivative of morphine that is a dopamine D2 agonist. It is a powerful emetic and has been used for that effect in acute poisoning. It has also been used in the diagnosis and treatment of parkinsonism, but its adverse effects limit its use.		2.1310aporphine alkaloidalpha-adrenergic drug;
antidyskinesia agent;
antiparkinson drug;
dopamine agonist;
emetic;
serotonergic drug
uridine
[no description available]		1.9610uridinesdrug metabolite;
fundamental metabolite;
human metabolite
framycetin
Framycetin: A component of NEOMYCIN that is produced by Streptomyces fradiae. On hydrolysis it yields neamine and neobiosamine B. (From Merck Index, 11th ed). framycetin : A tetracyclic antibacterial agent derived from neomycin, being a glycoside ester of neamine and neobiosamine B.		1.9910aminoglycosideallergen;
antibacterial drug;
Escherichia coli metabolite
isoxazoles
Isoxazoles: Azoles with an OXYGEN and a NITROGEN next to each other at the 1,2 positions, in contrast to OXAZOLES that have nitrogens at the 1,3 positions.. isoxazole : A monocyclic heteroarene with a structure consisting of a 5-membered ring containing three carbon atoms and an oxygen and nitrogen atom adjacent to each other. It is the parent of the class of isoxazoles.. isoxazoles : Oxazoles in which the N and O atoms are adjacent.		11.24460isoxazoles;
mancude organic heteromonocyclic parent;
monocyclic heteroarene
oxazoles
Oxazoles: Five-membered heterocyclic ring structures containing an oxygen in the 1-position and a nitrogen in the 3-position, in distinction from ISOXAZOLES where they are at the 1,2 positions.. 1,3-oxazole : A five-membered monocyclic heteroarene that is an analogue of cyclopentadiene with O in place of CH2 at position 1 and N in place of CH at position 3.. oxazole : An azole based on a five-membered heterocyclic aromatic skeleton containing one N and one O atom.		3.841201,3-oxazoles;
mancude organic heteromonocyclic parent;
monocyclic heteroarene
glaucine
glaucine: RN given refers to (+-)-isomer		2.0410aporphine alkaloid;
organic heterotetracyclic compound;
polyether;
tertiary amino compound		antibacterial agent;
antineoplastic agent;
antitussive;
muscle relaxant;
NF-kappaB inhibitor;
plant metabolite;
platelet aggregation inhibitor;
rat metabolite
ribostamycin
Ribostamycin: A broad-spectrum antimicrobial isolated from Streptomyces ribosifidicus.. ribostamycin : An amino cyclitol glycoside that is 4,6-diaminocyclohexane-1,2,3-triol having a 2,6-diamino-2,6-dideoxy-alpha-D-glucosyl residue attached at position 1 and a beta-D-ribosyl residue attached at position 2. It is an antibiotic produced by Streptomyces ribosidificus (formerly S. thermoflavus).		1.9910amino cyclitol glycoside;
aminoglycoside antibiotic		antibacterial drug;
antimicrobial agent;
metabolite
sisomicin
Sisomicin: Antibiotic produced by Micromonospora inyoensis. It is closely related to gentamicin C1A, one of the components of the gentamicin complex (GENTAMICINS).		1.9910amino cyclitol glycoside;
aminoglycoside antibiotic;
beta-L-arabinoside;
monosaccharide derivative
tobramycin
Tobramycin: An aminoglycoside, broad-spectrum antibiotic produced by Streptomyces tenebrarius. It is effective against gram-negative bacteria, especially the PSEUDOMONAS species. It is a 10% component of the antibiotic complex, NEBRAMYCIN, produced by the same species.. tobramycin : A amino cyclitol glycoside that is kanamycin B lacking the 3-hydroxy substituent from the 2,6-diaminoglucose ring.		1.9910amino cyclitol glycosideantibacterial agent;
antimicrobial agent;
toxin
ribavirin
Rebetron: Rebetron is tradename		1.98101-ribosyltriazole;
aromatic amide;
monocarboxylic acid amide;
primary carboxamide		anticoronaviral agent;
antiinfective agent;
antimetabolite;
antiviral agent;
EC 2.7.7.49 (RNA-directed DNA polymerase) inhibitor
arildone
[no description available]		2.4120methoxybenzenes
amifloxacin
amifloxacin: structure in UD		3.0610quinolines
neamine
neamine: fragment of NEOMYCIN B; structure in first source. neamine : 2-Deoxy-D-streptamine glycosylated at the 4-oxygen with a 6-amino-alpha-D-glucosaminyl group.		1.99102,6-dideoxy-alpha-D-glucoside;
aminoglycoside		antibacterial agent
lividomycin
[no description available]		1.9910lividomycinsmetabolite
oxoglaucine
1,2,9,10-tetramethoxy-7H-dibenzo(de,g)quinolin-7-one: a phosphatidylinositol 3-kinase p110alpha inhibitor that reactivates latent HIV-1; structure in first source		2.4820isoquinoline alkaloid
rmi 15731
RMI 15731: structure		3.0610
4',6-dichloroflavan
4',6-dichloroflavan: antirhinovirus cpd; structure given in first source		3.9840
r 61837
R 61837: antirhinovirus cpd; structure given in first source		3.7930
r 78206
R 78206: stabilizer of poliovirus virions & procapsids; structure given in first source		1.9710
paromomycin
Paromomycin: An aminoglycoside antibacterial and antiprotozoal agent produced by species of STREPTOMYCES.. paromomycin : An amino cyclitol glycoside that is the 1-O-(2-amino-2-deoxy-alpha-D-glucopyranoside) and the 3-O-(2,6-diamino-2,6-dideoxy-beta-L-idopyranosyl)-beta-D-ribofuranoside of 4,6-diamino-2,3-dihydroxycyclohexane (the 1R,2R,3S,4R,6S diastereoisomer). It is obtained from various Streptomyces species. A broad-spectrum antibiotic, it is used (generally as the sulfate salt) for the treatment of acute and chronic intestinal protozoal infections, but is not effective for extraintestinal protozoal infections. It is also used as a therapeutic against visceral leishmaniasis.		1.9910amino cyclitol glycoside;
aminoglycoside antibiotic		anthelminthic drug;
antibacterial drug;
antiparasitic agent;
antiprotozoal drug
ethyl-2-methylthio-4-methyl-5-pyrimidine carboxylate
[no description available]		2.4120
bekanamycin
bekanamycin: kanendomycin is the sulfate of bekanamycin; RN given refers to parent cpd; structure		1.9910kanamycins
win 54954
Win 54954: broad-spectrum antipicornavirus drug; structure given in first source		2.3820aromatic ether
betadex
beta-Cyclodextrins: Cyclic GLUCANS consisting of seven (7) glucopyranose units linked by 1,4-glycosidic bonds.		2.0310cyclodextrin
ferulic acid
ferulate : A monocarboxylic acid anion obtained by the deprotonation of the carboxy group of ferulic acid.		2.0410ferulic acidsanti-inflammatory agent;
antioxidant;
apoptosis inhibitor;
cardioprotective agent;
MALDI matrix material;
plant metabolite
2-hydroxycinnamic acid
trans-2-coumaric acid : The trans-isomer of 2-coumaric acid.. 2-coumaric acid : A monohydroxycinnamic acid in which the hydroxy substituent is located at C-2 of the phenyl ring.		2.04102-coumaric acid;
phenols		antioxidant;
metabolite
trans-4-coumaric acid
hydroxycinnamic acid : Any member of the class of cinnamic acids carrying one or more hydroxy substituents.. trans-4-coumaric acid : The trans-isomer of 4-coumaric acid.. 4-coumaric acid : A coumaric acid in which the hydroxy substituent is located at C-4 of the phenyl ring.		2.04104-coumaric acidfood component;
mouse metabolite;
plant metabolite
chalcone
trans-chalcone : The trans-isomer of chalcone.		3.9940chalconeEC 3.2.1.1 (alpha-amylase) inhibitor
sinapinic acid
sinapinic acid: a matrix for matrix-assisted laser desorption technique for protein MW determination; a constituent of propolis. trans-sinapic acid : A sinapic acid in which the double bond has trans-configuration.		2.0410sinapic acidMALDI matrix material;
plant metabolite
flavin mononucleotide
[no description available]		2.0510flavin mononucleotide;
vitamin B2		bacterial metabolite;
coenzyme;
cofactor;
human metabolite;
mouse metabolite
phenylthiourea
Phenylthiourea: Phenylthiourea is a THIOUREA derivative containing a phenyl ring. Depending on their genetic makeup, humans can find it either bitter-tasting or tasteless.. N-phenylthiourea : A member of the class of thioureas that is thiourea in which one of the hydrogens is replaced by a phenyl group. Depending on their genetic makeup, humans find it either very bitter-tasting or tasteless. This unusual property resulted in N-phenylthiourea being used in paternity testing prior to the advent of DNA testing.		2.4120thioureasEC 1.14.18.1 (tyrosinase) inhibitor
n-phenyl-n'-3-hydroxyphenylthiourea
[no description available]		2.4120
digoxin
Digoxin: A cardiotonic glycoside obtained mainly from Digitalis lanata; it consists of three sugars and the aglycone DIGOXIGENIN. Digoxin has positive inotropic and negative chronotropic activity. It is used to control ventricular rate in ATRIAL FIBRILLATION and in the management of congestive heart failure with atrial fibrillation. Its use in congestive heart failure and sinus rhythm is less certain. The margin between toxic and therapeutic doses is small. (From Martindale, The Extra Pharmacopoeia, 30th ed, p666). digoxin : A cardenolide glycoside that is digitoxin beta-hydroxylated at C-12. A cardiac glycoside extracted from the foxglove plant, Digitalis lanata, it is used to control ventricular rate in atrial fibrillation and in the management of congestive heart failure with atrial fibrillation, but the margin between toxic and therapeutic doses is small.		2.0510cardenolide glycoside;
steroid saponin		anti-arrhythmia drug;
cardiotonic drug;
EC 3.6.3.9 (Na(+)/K(+)-transporting ATPase) inhibitor;
epitope
alpha-sarcin
alpha-sarcin: basic protein 150 aa, MW 16 kDa; isolated from aspergillus giganteus; sequence similarity with ribonucleases such as RIBONUCLEASE T1; 85% identity with restrictocin; a ribotoxin cleaving the phosphodiester bond on the 3' side of G4325 in the alpha-sarcin/ricin domain of rat 28S RIBOSOMAL RNA; sometimes called a ribosome-inactivating protein but falls outside the normal definition of plant RIP that de-adenylate rRNA		1.9710
1,2-oleoylphosphatidylcholine
1,2-oleoylphosphatidylcholine: RN given refers to (Z,Z)-isomer. dioleoyl phosphatidylcholine : A phosphatidylcholine in which the phosphatidyl acyl groups are both oleoyl.		1.9710phosphatidylcholine(1+)
viroxime
[no description available]		3.2660
ro 09-0410
Ro 09-0410: structure given in first source		3.7630
oxadiazoles
Oxadiazoles: Compounds containing five-membered heteroaromatic rings containing two carbons, two nitrogens, and one oxygen atom which exist in various regioisomeric forms.		6.9810
hbbpc
[no description available]		2.4120
phosphatidylcholines
Phosphatidylcholines: Derivatives of PHOSPHATIDIC ACIDS in which the phosphoric acid is bound in ester linkage to a CHOLINE moiety.		1.97101,2-diacyl-sn-glycero-3-phosphocholine
piperidines
Piperidines: A family of hexahydropyridines.		1.9710
ConditionIndicatedRelationship StrengthStudiesTrials
Infections, Picornaviridae
[description not available]		03.2820
Coxsackie Virus Infections
[description not available]		02.7230
Enterovirus Infections
Diseases caused by ENTEROVIRUS.		02.3820
Catarrh
Inflammation of a mucous membrane with increased flow of mucous in humans or animals. Catarrh is used mostly in a historical context.		01.9610
Common Cold
A catarrhal disorder of the upper respiratory tract, which may be viral or a mixed infection. It generally involves a runny nose, nasal congestion, and sneezing.		01.9610
Disease Models, Animal
Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.		01.9710
Encephalitis, Polio
[description not available]		02.3720
Poliomyelitis
An acute infectious disease of humans, particularly children, caused by any of three serotypes of human poliovirus (POLIOVIRUS). Usually the infection is limited to the gastrointestinal tract and nasopharynx, and is often asymptomatic. The central nervous system, primarily the spinal cord, may be affected, leading to rapidly progressive paralysis, coarse FASCICULATION and hyporeflexia. Motor neurons are primarily affected. Encephalitis may also occur. The virus replicates in the nervous system, and may cause significant neuronal loss, most notably in the spinal cord. A rare related condition, nonpoliovirus poliomyelitis, may result from infections with nonpoliovirus enteroviruses. (From Adams et al., Principles of Neurology, 6th ed, pp764-5)		02.3720
HIV
Human immunodeficiency virus. A non-taxonomic and historical term referring to any of two species, specifically HIV-1 and/or HIV-2. Prior to 1986, this was called human T-lymphotropic virus type III/lymphadenopathy-associated virus (HTLV-III/LAV). From 1986-1990, it was an official species called HIV. Since 1991, HIV was no longer considered an official species name; the two species were designated HIV-1 and HIV-2.		01.9710
Palsy
[description not available]		01.9610
Echo Virus Infections
[description not available]		01.9610
Paralysis
A general term most often used to describe severe or complete loss of muscle strength due to motor system disease from the level of the cerebral cortex to the muscle fiber. This term may also occasionally refer to a loss of sensory function. (From Adams et al., Principles of Neurology, 6th ed, p45)		01.9610
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