Target type: molecularfunction
Catalysis of the reaction: retinol-[cellular-retinol-binding-protein] + phosphatidylcholine = retinyl-ester-[cellular-retinol-binding-protein] + 2-acylglycerophosphocholine. [EC:2.3.1.135, MetaCyc:2.3.1.135-RXN]
Phosphatidylcholine-retinol O-acyltransferase activity is a crucial enzyme activity in the metabolism of retinol (vitamin A). It catalyzes the transfer of a fatty acyl group from a phosphatidylcholine molecule to the hydroxyl group of retinol, producing retinyl ester. This reaction is essential for the storage and transport of retinol within the body.
Retinyl esters are the storage form of vitamin A and are found primarily in the liver. They are less toxic than retinol and are more stable in the body. When needed, retinyl esters are hydrolyzed back to retinol, which is then transported to target tissues where it can be used for a variety of functions, including vision, growth, and immune function.
The phosphatidylcholine-retinol O-acyltransferase enzyme activity is particularly important in the liver, where it plays a key role in the uptake and storage of retinol from the diet. It is also found in other tissues, such as the intestines and adipose tissue, where it contributes to the metabolism of retinol.
The specific mechanism of the reaction involves the formation of a complex between the enzyme, phosphatidylcholine, and retinol. The fatty acyl group from phosphatidylcholine is then transferred to retinol, resulting in the formation of retinyl ester and diacylglycerol.
Mutations in the gene encoding the phosphatidylcholine-retinol O-acyltransferase enzyme can lead to deficiencies in vitamin A storage and transport, which can have significant health consequences. Therefore, understanding the molecular function of this enzyme is essential for developing effective strategies for treating vitamin A deficiency.'
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Protein | Definition | Taxonomy |
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Lecithin retinol acyltransferase | A lecithin retinol acyltransferase that is encoded in the genome of human. [PRO:DNx, UniProtKB:O95237] | Homo sapiens (human) |
Lecithin retinol acyltransferase | A lecithin retinol acyltransferase that is encoded in the genome of human. [PRO:DNx, UniProtKB:O95237] | Homo sapiens (human) |
Compound | Definition | Classes | Roles |
---|---|---|---|
framycetin | framycetin : A tetracyclic antibacterial agent derived from neomycin, being a glycoside ester of neamine and neobiosamine B. Framycetin: A component of NEOMYCIN that is produced by Streptomyces fradiae. On hydrolysis it yields neamine and neobiosamine B. (From Merck Index, 11th ed) | aminoglycoside | allergen; antibacterial drug; Escherichia coli metabolite |
neamine | neamine : 2-Deoxy-D-streptamine glycosylated at the 4-oxygen with a 6-amino-alpha-D-glucosaminyl group. neamine: fragment of NEOMYCIN B; structure in first source | 2,6-dideoxy-alpha-D-glucoside; aminoglycoside | antibacterial agent |