Page last updated: 2024-09-27

Carcinoma, Skin Appendage

A malignant tumor of the skin appendages, which include the hair, nails, sebaceous glands, sweat glands, and the mammary glands. (From Dorland, 27th ed)

Synonyms(1)

Synonym
Carcinoma, Skin Appendage

Research

Studies (43)

TimeframeStudies, This Condition (%)All Conditions %
pre-19902 (4.65)23.3326
1990's5 (11.63)12.5806
2000's22 (51.16)18.1394
2010's14 (32.56)28.8240
2020's0 (0.00)9.53
DrugIndicatedRelationship StrengthStudiesTrials
aminolevulinic acid0low10
salicylic acid0medium221
iodine0low20
aspirin0low10
oxonic acid0low10
tegafur0low10
lysine0low10
methylene blue0low10
eosine yellowish-(ys)0low10
imiquimod0low10
inositol 3-phosphate0low50
bromochloroacetic acid0low60
phenylephrine hydrochloride0low50
s 1 (combination)0low10
exudates0low10

Protein Targets (401)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
Chain A, Beta-lactamase4004
bromodomain adjacent to zinc finger domain 2B2002
geminin8008
Gamma-aminobutyric acid receptor subunit rho-10101
Glutamate receptor 10101
Glutamate receptor 20101
Glutamate receptor 30101
Glutamate receptor ionotropic, kainate 30101
Solute carrier family 15 member 10101
Glutamate receptor 40101
Solute carrier family 15 member 10101
Solute carrier family 15 member 20101
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE5005
Chain A, TYROSYL-DNA PHOSPHODIESTERASE3003
Chain A, Phospholipase A2 isoform 30011
Chain A, HADH2 protein2002
Chain B, HADH2 protein2002
Chain A, 2-oxoglutarate Oxygenase5005
GTP-binding protein (rab7)0011
ras protein, partial0011
interleukin 82002
thioredoxin reductase6006
GLS protein1001
AR protein8008
aldehyde dehydrogenase 1 family, member A15005
thyroid stimulating hormone receptor2002
hypothetical protein, conserved2002
cytochrome P450 family 3 subfamily A polypeptide 44004
EWS/FLI fusion protein4004
glucocorticoid receptor [Homo sapiens]5005
retinoic acid nuclear receptor alpha variant 16006
estrogen-related nuclear receptor alpha7007
estrogen nuclear receptor alpha9009
cytochrome P450 2D63003
glucocerebrosidase2002
peroxisome proliferator-activated receptor delta5005
Rac1 protein0011
IDH16006
cell division cycle 42 (GTP binding protein, 25kDa), partial0011
euchromatic histone-lysine N-methyltransferase 26006
Bloom syndrome protein isoform 14004
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 13003
DNA polymerase iota isoform a (long)4004
DNA polymerase kappa isoform 12002
muscarinic acetylcholine receptor M12002
lethal factor (plasmid)3003
Prostaglandin-H2 D-isomerase0101
ATP-binding cassette sub-family C member 30404
Multidrug resistance-associated protein 40405
Solute carrier family 22 member 60202
Prostaglandin G/H synthase 1 0101
Prostaglandin G/H synthase 2 0101
Bile salt export pump0505
Epidermal growth factor receptor0101
Carbonic anhydrase 10404
Carbonic anhydrase 20415
Fatty acid-binding protein, liver0101
Integrin beta-31102
Myeloperoxidase0101
Prostaglandin G/H synthase 10202
Seed linoleate 13S-lipoxygenase-10101
Integrin alpha-IIb1102
Glutathione hydrolase 1 proenzyme0101
Prostaglandin G/H synthase 10303
Adenosine receptor A10101
Adenosine receptor A2a0101
Substance-P receptor0101
Prostaglandin G/H synthase 20303
Urotensin-2 receptor0101
4-aminobutyrate aminotransferase, mitochondrial0101
Nuclear receptor ROR-gamma3003
Ras-related protein Rab-2A0011
Gamma-aminobutyric acid receptor subunit alpha-12103
Prostaglandin G/H synthase 20101
Rho-associated protein kinase 20101
Nicotinate phosphoribosyltransferase0202
Solute carrier family 22 member 200303
Solute carrier family 22 member 60303
Canalicular multispecific organic anion transporter 10404
Sigma non-opioid intracellular receptor 10011
Sigma non-opioid intracellular receptor 10011
RAR-related orphan receptor gamma6006
nuclear receptor subfamily 1, group I, member 36006
thyroid stimulating hormone receptor3003
nuclear factor erythroid 2-related factor 2 isoform 18008
Cellular tumor antigen p537007
Chain A, Ferritin light chain3003
Luciferase3003
endonuclease IV1001
PAX80002
pregnane X receptor1001
hypoxia-inducible factor 1 alpha subunit3003
ATAD5 protein, partial4004
Fumarate hydratase2002
USP1 protein, partial3003
PPM1D protein3003
TDP1 protein6006
GLI family zinc finger 35005
Thrombopoietin1001
Smad32002
estrogen receptor 2 (ER beta)3003
retinoid X nuclear receptor alpha6006
farnesoid X nuclear receptor4004
pregnane X nuclear receptor5005
polyprotein2002
67.9K protein3003
peroxisome proliferator activated receptor gamma5005
vitamin D (1,25- dihydroxyvitamin D3) receptor2002
aryl hydrocarbon receptor5005
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a3003
activating transcription factor 64004
v-jun sarcoma virus 17 oncogene homolog (avian)4004
nuclear receptor subfamily 1, group I, member 22002
cytochrome P450 2D6 isoform 11001
nuclear receptor subfamily 0 group B member 10202
cellular tumor antigen p53 isoform a2002
cytochrome P450 2C19 precursor1001
cytochrome P450 2C9 precursor1001
chromobox protein homolog 15005
thyroid hormone receptor beta isoform a2002
nuclear factor erythroid 2-related factor 2 isoform 24004
thyroid hormone receptor beta isoform 24004
atrial natriuretic peptide receptor 2 precursor1001
flap endonuclease 13003
ras-related protein Rab-9A2002
steroidogenic factor 10202
peripheral myelin protein 225005
cytochrome P450 3A4 isoform 12002
muscleblind-like protein 1 isoform 13003
caspase-1 isoform alpha precursor2002
lamin isoform A-delta106006
neuropeptide S receptor isoform A2002
Gamma-aminobutyric acid receptor subunit pi2002
Solute carrier family 22 member 30101
Voltage-dependent calcium channel gamma-2 subunit5005
Interferon beta3003
Tubulin alpha-1A chain0426
Tubulin beta chain0426
Plasma kallikrein0001
Tubulin beta-4A chain0338
ATP-dependent translocase ABCB10101
Tubulin beta chain0338
ATP-dependent translocase ABCB10102
Cytochrome P450 3A40202
Tubulin alpha-3C chain0338
Serine/threonine-protein kinase pim-10101
Gamma-aminobutyric acid receptor subunit beta-12002
Gamma-aminobutyric acid receptor subunit delta2002
Gamma-aminobutyric acid receptor subunit gamma-22002
Glutamate receptor 25005
Gamma-aminobutyric acid receptor subunit alpha-52002
Gamma-aminobutyric acid receptor subunit alpha-32002
ATP-dependent translocase ABCB10101
Gamma-aminobutyric acid receptor subunit gamma-12002
Gamma-aminobutyric acid receptor subunit alpha-22002
Gamma-aminobutyric acid receptor subunit alpha-42002
Gamma-aminobutyric acid receptor subunit gamma-32002
Gamma-aminobutyric acid receptor subunit alpha-62002
Histamine H2 receptor1001
Gamma-aminobutyric acid receptor subunit beta-32002
Gamma-aminobutyric acid receptor subunit beta-22002
Tubulin alpha-1B chain0338
Tubulin alpha-4A chain0338
Tubulin beta-4B chain0338
Vesicular acetylcholine transporter0101
Tubulin beta-3 chain0338
Tubulin beta-2A chain0338
Tubulin polymerization-promoting protein0011
Tubulin beta-8 chain0338
Tubulin beta-2B chain0303
Tubulin alpha-3E chain0338
Tubulin alpha-1A chain0338
Similar to alpha-tubulin isoform 1 0202
Similar to alpha-tubulin isoform 1 0202
GABA theta subunit2002
CREB-binding protein1001
ATPase family AAA domain-containing protein 54004
Ataxin-24004
Tubulin alpha-1C chain0338
Tubulin beta-6 chain0338
Tubulin beta-2B chain0338
Gamma-aminobutyric acid receptor subunit epsilon2002
Tubulin beta-1 chain0338
ATP-dependent phosphofructokinase3003
DNA polymerase beta3003
urokinase-type plasminogen activator precursor2002
plasminogen precursor2002
urokinase plasminogen activator surface receptor precursor2002
Histamine H2 receptor0202
Alpha-1D adrenergic receptor0202
Adenosine receptor A2a0202
7,8-dihydro-8-oxoguanine triphosphatase0101
Toll-like receptor 80011
Toll-like receptor 70011
acetylcholinesterase2002
progesterone receptor4004
histone deacetylase 9 isoform 32002
Chain A, Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplast0101
Chain A, Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplast0101
potassium voltage-gated channel subfamily H member 2 isoform d3003
Glutathione reductase, mitochondrial0304
Cationic amino acid transporter 30101
Chain B, DIHYDROFOLATE REDUCTASE0011
Chain B, DIHYDROFOLATE REDUCTASE0011
Chain B, DIHYDROFOLATE REDUCTASE0011
acid sphingomyelinase1001
dopamine D1 receptor1001
ClpP1001
15-lipoxygenase, partial1001
phosphopantetheinyl transferase2002
Microtubule-associated protein tau3003
Thymidylate synthase 0101
alpha-galactosidase2002
Thymidylate synthase 0101
Histone H2A.x2002
polyunsaturated fatty acid lipoxygenase ALOX121001
vitamin D3 receptor isoform VDRA1001
transcriptional regulator ERG isoform 31001
importin subunit beta-1 isoform 11001
nuclear receptor coactivator 1 isoform 1 [Homo sapiens]0101
snurportin-11001
peptidyl-prolyl cis-trans isomerase NIMA-interacting 12002
DNA polymerase eta isoform 12002
transactivating tegument protein VP16 [Human herpesvirus 1]0101
survival motor neuron protein isoform d4004
M-phase phosphoprotein 81001
histone acetyltransferase KAT2A isoform 12002
nuclear receptor coactivator 3 isoform a0101
Toll-like receptor 40101
Fatty-acid amide hydrolase 10101
Bile salt export pump0202
ATP-binding cassette sub-family C member 30102
Dihydrofolate reductase0203
Dihydrofolate reductase0203
Dihydrofolate reductase 0101
Dihydrofolate reductase0101
Dihydrofolate reductase0101
Dihydrofolate reductase0203
Thymidylate synthase0101
Tyrosine-protein kinase ABL10011
Thymidylate synthase0202
Bifunctional dihydrofolate reductase-thymidylate synthase0101
Thymidylate synthase0202
5-hydroxytryptamine receptor 2C0102
High mobility group protein B10022
Dihydrofolate reductase0101
Thymidylate synthase0101
Dihydrofolate reductase0224
Glucose-6-phosphate 1-dehydrogenase0101
Bifunctional dihydrofolate reductase-thymidylate synthase0101
Folate receptor beta0101
5-hydroxytryptamine receptor 2A0101
Cytochrome P450 11B1, mitochondrial 0101
Folate receptor alpha0101
Dihydrofolate reductase0202
Histidine decarboxylase0101
Trifunctional purine biosynthetic protein adenosine-30101
Cyclin-dependent kinase 20011
Bifunctional purine biosynthesis protein ATIC0202
Multidrug resistance-associated protein 1 0001
Delta-type opioid receptor0101
Mu-type opioid receptor0101
Kappa-type opioid receptor0101
Reduced folate transporter0202
Folylpolyglutamate synthase, mitochondrial0103
6-phosphogluconate dehydrogenase, decarboxylating0101
Caspase-71001
Spike glycoprotein3003
Solute carrier organic anion transporter family member 1A30001
Dihydrofolate reductase0101
Pteridine reductase 10101
Folylpolyglutamate synthase, mitochondrial0103
Bifunctional dihydrofolate reductase-thymidylate synthase0101
TAR DNA-binding protein 432002
Bifunctional dihydrofolate reductase-thymidylate synthase0101
Solute carrier family 22 member 60102
Canalicular multispecific organic anion transporter 10102
Trifunctional purine biosynthetic protein adenosine-30101
Dihydrofolate reductase 0101
Solute carrier family 22 member 80102
Dihydrofolate reductase0101
ATP-binding cassette sub-family C member 110001
Proton-coupled folate transporter0101
Multidrug resistance associated protein0102
Solute carrier organic anion transporter family member 1B30001
Solute carrier family 22 member 110001
Protein-arginine deiminase type-40101
Broad substrate specificity ATP-binding cassette transporter ABCG20001
Chain E, Fibrin beta chain0101
Chain A, Putative fructose-1,6-bisphosphate aldolase1001
Chain A, JmjC domain-containing histone demethylation protein 3A1001
Chain A, ATP-DEPENDENT DNA HELICASE Q11001
T cell receptor, partial1001
luteinizing hormone receptor1001
glp-1 receptor, partial2002
integrase, partial0101
chaperonin-containing TCP-1 beta subunit homolog2002
lens epithelium-derived growth factor p750101
Caspase 6, apoptosis-related cysteine peptidase0001
SMAD family member 22002
SMAD family member 32002
TSHR protein1001
Apoptotic peptidase activating factor 10101
thioredoxin glutathione reductase1001
caspase 7, apoptosis-related cysteine protease1001
isocitrate dehydrogenase 1, partial1001
G2002
luciferase1001
caspase-31001
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a1001
serine-protein kinase ATM isoform a1001
neutrophil cytosol factor 10101
parathyroid hormone/parathyroid hormone-related peptide receptor precursor1001
caspase-9 isoform alpha precursor0101
heat shock protein beta-11001
huntingtin isoform 21001
pyruvate kinase PKM isoform a1001
mitogen-activated protein kinase 11001
caspase-3 isoform a preproprotein0101
protein AF-9 isoform a0001
histone-lysine N-methyltransferase 2A isoform 2 precursor1001
Vpr2002
replicative DNA helicase0001
recombinase A0011
POsterior Segregation0011
DNA repair protein RAD52 homolog isoform a0001
Glutathione reductase0101
Glycoprotein hormones alpha chain1001
HLA class I histocompatibility antigen, B alpha chain 2002
Albumin0001
Amyloid-beta precursor protein0101
Dihydrolipoyl dehydrogenase, mitochondrial0102
Microtubule-associated protein tau0112
Alpha-1B adrenergic receptor0101
Amine oxidase [flavin-containing] A0101
Alpha-1D adrenergic receptor0101
Sodium-dependent noradrenaline transporter 0011
Cruzipain0101
Alpha-synuclein1001
Alpha-1A adrenergic receptor0101
Guanine nucleotide-binding protein G1001
Inositol monophosphatase 11001
Thioredoxin reductase 1, cytoplasmic0102
Dihydrolipoyl dehydrogenase 0102
Inositol hexakisphosphate kinase 12002
Zinc finger protein mex-50011
cytochrome P450 2C9, partial2002
phosphoglycerate kinase1001
GALC protein1001
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)2002
beta-2 adrenergic receptor1001
lysosomal alpha-glucosidase preproprotein1001
mu-type opioid receptor isoform MOR-10011
5-hydroxytryptamine receptor 2A0011
Neuronal acetylcholine receptor subunit alpha-41001
Neuronal acetylcholine receptor subunit beta-21001
NPC intracellular cholesterol transporter 1 precursor1001
Regulatory protein E20011
Regulatory protein E20011
Regulatory protein E20011
Glucocorticoid receptor0101
Cytochrome P450 2C9 0101
Cytochrome P450 2C190101
Prostaglandin G/H synthase 20101
Calcium-activated potassium channel subunit alpha-10101
Estrogen receptor beta0001
Inhibitor of nuclear factor kappa-B kinase subunit beta0001
Polyphenol oxidase 20102
Carbonic anhydrase 120101
5'-AMP-activated protein kinase subunit beta-20001
Albumin0101
Polymerase acidic protein0011
Carbonic anhydrase 30101
Stromelysin-10011
Tyrosine-protein phosphatase YopH0101
Aldo-keto reductase family 1 member B10101
Prolyl 4-hydroxylase subunit alpha-10101
Tyrosine-protein phosphatase non-receptor type 10103
Estrogen receptor0001
Acetylcholinesterase0101
Carbonic anhydrase 40101
Carbonic anhydrase 60101
Cystathionine gamma-lyase0101
Carbonic anhydrase 5A, mitochondrial0101
Carbonic anhydrase 70101
5'-AMP-activated protein kinase subunit gamma-10001
5'-AMP-activated protein kinase catalytic subunit alpha-20001
Xanthine dehydrogenase/oxidase0101
5'-AMP-activated protein kinase catalytic subunit alpha-10001
Carbonic anhydrase 90101
Carbonic anhydrase0101
Solute carrier family 22 member 70001
Ubiquitin-like domain-containing CTD phosphatase 10101
Carbonic anhydrase 150101
Carbonic anhydrase 130101
5'-AMP-activated protein kinase subunit gamma-30001
5'-AMP-activated protein kinase subunit gamma-20001
Carbonic anhydrase 140101
Carbonic anhydrase 5B, mitochondrial0101
5'-AMP-activated protein kinase subunit beta-10001
nuclear receptor ROR-gamma isoform 11001
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]