bromochloroacetic-acid and Carcinoma--Skin-Appendage

Apocrine carcinomas are rare, the immunohistochemical characterizations that are incomplete. The purpose of this study was to determine the immunohistochemical characteristics of mucin core proteins and keratins in apocrine carcinoma, extramammary Paget's disease (EMPD) and apocrine nevus.. We report four cases of apocrine carcinomas along with immunohistochemical analyses: (i) an axillary apocrine carcinoma with an apocrine nevus, (ii) an inguinal apocrine carcinoma, (iii) a vulvar apocrine carcinoma with EMPD and (iv) an axillary apocrine carcinoma with EMPD and an apocrine nevus.. The tumor cells of apocrine carcinomas, EMPD and apocrine nevi displayed a positive reaction to MUC-1 and CK7 and a negative reaction to CK20. Apocrine carcinomas had high molecular weight (HMW) cytokeratin(+)/CK5(+)/CK14(-)/MUC5AC(-), EMPD with underlying apocrine carcinoma had HMW cytokeratin(-)/CK5(-)/CK14(-)/MUCA5AC(-) and the apocrine nevi had HMW cytokeratin(+)/CK5(+)/CK14(+)/MUCA5AC(+).. The immunohistochemical findings suggest that apocrine carcinomas, apocrine nevi and EMPD with underlying apocrine carcinomas are quite different, even though they are all derived from apocrine glands.

Topics: Adult; Aged; Aged, 80 and over; Apocrine Glands; Biomarkers, Tumor; Carcinoma, Skin Appendage; Humans; Immunohistochemistry; Keratins; Male; Mucins; Nevus; Paget Disease, Extramammary; Sweat Gland Neoplasms

The embryologic origin of the breast is related to salivary and sweats glands. Thus, breast neoplasms may show differentiation toward these tissues, although this is a rare event in humans. We report the clinicopathologic and immunohistochemical features of a 57-year-old woman presenting with a spiradenoma that originated in breast tissue and became malignant 40 years later. Some histogenetic concepts relevant to this case are discussed, along with a brief review of this neoplasm.

Topics: Adenoma, Sweat Gland; Biomarkers, Tumor; Breast Neoplasms; Carcinoma, Skin Appendage; Female; Humans; Immunohistochemistry; Keratins; Mastectomy; Middle Aged; Mucin-1; Neoplasms, Second Primary; Sweat Gland Neoplasms

Microcystic adnexal carcinoma is a rare, slowly progressing, malignant tumor of sweat gland origin.. A case of microcystic adnexal carcinoma of the breast with a history of 20 years is presented.. On initial examination, the ulcerative cutaneous mass was fixed to the underlying breast tissue and chest wall. Both the macroscopic appearance of the tumor and its location suggested a glandular breast carcinoma. However, an incisional biopsy revealed the nature of the tumor as microcystic adnexal carcinoma of the breast skin. Following the diagnosis, a wide excision of the tumor was carried out for the final treatment.. To our knowledge this is the first case of microcystic adnexal carcinoma arising in the breast skin presented in the literature.. This case demonstrates that microcystic adnexal carcinoma can occur on the breast skin and should be treated with wide excision due to its locally aggressive behavior.

Topics: Aged; Aged, 80 and over; Breast Neoplasms; Carcinoma, Skin Appendage; Diagnosis, Differential; Female; Humans; Immunohistochemistry; Keratin-7; Keratins; Skin Neoplasms; Sweat Gland Neoplasms

A 73-year-old woman had a linear yellowish plaque on the upper part of her right ear since birth. She presented because of the sudden growth of a nodule within the plaque. The plaque was waxy and yellowish, arching around the upper part of the ear. A reddish to yellowish large nodule was seen within the central part of the arc-shaped plaque; in addition, a small pigmented nodule, a small skin-colored nodule, and a few pigmented papules were observed in the anterior half of the arched plaque. Histopathologic examination revealed the large nodule to be sebaceous carcinoma, the small pigmented nodule to be trichoblastoma, the small skin-colored nodule to be sebaceoma with the features of trichoblastoma, a few pigmented papules to be superficial trichoblastomas due to primitive follicular induction, and the linear yellowish plaque to be nevus sebaceus. Although our literature search revealed scanty reports of definite cases of sebaceous carcinoma in nevus sebaceus, the presented case demonstrated the occurrence of sebaceous carcinoma in nevus sebaceus. Malignant neoplasms occurring in nevus sebaceous seem to be extremely rare, but care should be taken when a large nodule suddenly grows in a lesion of nevus sebaceus, especially in older adults. The presented case also suggested a close relation between trichoblastoma and sebaceoma. The cytokeratin staining pattern could not distinguish between sebaceous and follicular neoplasms in our case.

Topics: Aged; Carcinoma; Carcinoma, Skin Appendage; Ear Neoplasms; Ear, External; Female; Hamartoma; Humans; Immunohistochemistry; Keratins; Sebaceous Gland Neoplasms; Skin Diseases; Skin Neoplasms

We report two cases of microcystic adnexal carcinoma showing extensive sebaceous differentiation. Multiple cellular nests and strands within a moderately sclerotic stroma involving the full thickness of the dermis were observed. Clusters of basaloid cells with extensive sebaceous differentiation were present. Foci of sebaceous ductal differentiation were observed in the more superficial areas. Neither strikingly atypical cells nor mitotic figures were present. Perineural invasion was present in the deep areas of both tumors. Clinically, the lesions were solitary whitish-pink papules with a central dell on the faces of 2 men (aged 78 and 73 years old). We propose a relationship between these tumors and other cytologically bland but locally aggressive adnexal carcinomas. Sebaceous differentiation itself in a poorly circumscribed neoplasm does not indicate conventional extraocular sebaceous carcinoma. We propose a simple classification of locally aggressive adnexal carcinomas that takes into account the full range of adnexal differentiation that can occur in such lesions.

Topics: Aged; Carcinoembryonic Antigen; Carcinoma, Skin Appendage; Cell Differentiation; Elastic Tissue; Epidermis; Facial Neoplasms; Follow-Up Studies; Glycosaminoglycans; Humans; Keratins; Male; Mitosis; Neoplasm Invasiveness; Neurons; S100 Proteins; Sclerosis; Sebaceous Glands; Skin Diseases; Skin Neoplasms

Microcystic adnexal carcinoma (MAC) is known as an infiltrating but non-metastasizing tumour of the skin, that derives from sweat glands or follicular epithelium. We report on a rare case of MAC of the tongue. The patient had noticed the tumour for two years with slowly increasing dysphagia but no other symptoms of an oropharynx carcinoma. Histological and immunohistochemical analyses showed a similarity between the tumour derived from Ebner's glands of the tongue and MAC of the sweat glands.

Topics: Aged; Carcinoma, Skin Appendage; Humans; Immunoenzyme Techniques; Keratins; Magnetic Resonance Imaging; Male; Tongue Neoplasms