Page last updated: 2024-09-27

Aniridia

A congenital abnormality in which there is only a rudimentary iris. This is due to the failure of the optic cup to grow. Aniridia also occurs in a hereditary form, usually autosomal dominant.

Synonyms(1)

Synonym
Aniridia

Research Excerpts

Overview

Excerpt	Reference
"Aniridia is a panocular disorder that severely affects vision in early life."	( Marazova, K; Sahel, JA, 2014)
"Aniridia is a congenital and progressive panocular condition with poor visual prognosis that is associated with brain, olfactory, and pancreatic abnormalities."	( Gregory-Evans, CY; Gregory-Evans, K; Metcalfe, AL; Wang, X; Wasan, KM; Zhao, J, 2014)
"Aniridia is a rare panocular disorder characterized by iris hypoplasia and other associated eye anomalies."	( Dubey, SK; Mahalaxmi, N; Sundaresan, P; Vijayalakshmi, P, 2015)
"Aniridia is a condition defined by total or partial loss of the iris and leads to decreased visual quality marked by glare and photophobia."	( Firl, KC; Montezuma, SR, 2016)
"Congenital aniridia is a kind of eye disease characterized by complete or partial hypoplasia of the iris and is associated with other ocular anomalies including corneal opacity, glaucoma, and foveal hypoplasia."	( Cho, NC; Kim, JH; Kim, WJ, 2017)
"PAX6-related Aniridia is a sight-threatening disease involving progression of secondary glaucoma and aniridia related keratopathy (ARK)."	( Fries, FN; Käsmann-Kellner, B; Langenbucher, A; Latta, L; Nordström, K; Seitz, B; Stachon, T; Szentmáry, N, 2019)
"Congenital aniridia is a severe ocular abnormality characterized by incomplete formation of the iris and many other ocular complications."	( Gao, H; Liu, X; Qiu, C; Zhang, B; Zhang, Y, 2020)
"Post-traumatic aniridia is an uncommon complication of blunt ocular trauma."	( Collignon, N; Dequinze, M; Rakic, JM, 2020)
"Aniridia is a panocular inherited rare eye disease linked to heterozygous mutations on the PAX6 gene, which fail to properly produce sufficient protein essential for normal eye development and function."	( Aberdam, D; Bremond-Gignac, D; Dorot, O; Frank, E; Oved, K; Pichinuk, E; Roux, LN; Zennaro, L; Zerbib, J, 2021)
"Congenital PAX6-aniridia is a rare panocular disease resulting from limbal stem cell deficiency."	( Bleil, C; Fries, FN; Käsmann-Kellner, B; Katiyar, P; Knebel, I; Latta, L; Seitz, B; Stachon, T; Szentmáry, N; Zussy, C, 2021)
"Congenital aniridia is a pan ocular disease."	( Alió, JL; Casas-Llera, P; Ruiz-Casas, D, 2021)
"Aniridia is a panocular disease causing progressive severe visual impairment and blindness due to PAX-6 haploinsufficiency."	( Aberdam, D; Bremond-Gignac, D; Dorot, O; Oved, K; Pichinuk, E; Roux, LN; Zennaro, L, 2022)
"Aniridia is a condition characterized by defects or absence of the iris."	( Benke, E; Franke, J; Lopez, PC; Martin, S; Reitelshofer, S; Schwab, J, 2021)
"Aniridia is a pan-ocular genetic developmental eye disorder characterized by complete or partial iris and foveal hypoplasia, for which there is no treatment currently."	( Abdolkarimi, D; Cunha, DL; Lahne, M; Moosajee, M, 2022)
"Aniridia is a pan-ocular genetic developmental eye disorder characterized by complete or partial iris and foveal hypoplasia, for which there is no treatment currently."	( Abdolkarimi, D; Cunha, DL; Lahne, M; Moosajee, M, 2022)
"Aniridia is defined as missing iris tissue which can be partial, subtotal, or total."	( Pandit, R; Shah, D; Singhal, A, 2023)

Research

Studies (228)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	42 (18.42)	23.3326
1990's	31 (13.60)	12.5806
2000's	47 (20.61)	18.1394
2010's	71 (31.14)	28.8240
2020's	37 (16.23)	9.53

Drug	Relationship Strength	Studies	Trials
adenine	low	2	0
cytosine	low	2	0
thymine	low	2	0
gentamicin	low	3	0
guaifenesin	low	1	0
2-propanol	medium	162	2
ritanserin	low	1	0
triclosan	low	1	0
mitomycin	low	2	0
pilocarpine	low	1	0
serine	low	2	0
glutamine	low	2	0
physostigmine	low	1	0
threonine	low	1	0
arginine	low	2	0
perflutren	low	1	0
methylmethacrylate	low	1	0
quinoxalines	low	1	0
diadenosine tetraphosphate	low	1	0
trolamine salicylate	low	1	0
glutamic acid	low	1	0
propiconazole	low	2	0
duloxetine hydrochloride	low	1	0
5-bromo-4-chloro-3-indolyl beta-galactoside	low	1	0
antibiotic g 418	low	1	0
proline	low	1	0
tretinoin	low	2	0
keratan sulfate	low	1	0
bromochloroacetic acid	low	4	0
isomethyleugenol	low	1	0
succimer	low	1	0
phenylephrine hydrochloride	low	1	0
latanoprost	low	2	0
cysteine	low	1	0
glucoraphanin	low	1	0
oxadiazoles	low	3	0
brimonidine tartrate	low	1	0
losartan potassium	low	1	0
indocyanine green	low	2	0
c-peptide	low	1	0
p(1),p(5)-di(adenosine-5'-)pentaphosphate	low	1	0
cyclosporine	low	1	0
exudates	low	1	0
guanine	low	1	0
trypan blue	low	2	0
cytidylyl-3'-5'-guanosine	low	1	0
eye	low	18	0

Protein Targets (488)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
hypoxia-inducible factor 1 alpha subunit	4	0	0	4
RAR-related orphan receptor gamma	13	0	0	13
GLI family zinc finger 3	11	0	0	11
AR protein	14	0	0	14
aldehyde dehydrogenase 1 family, member A1	6	0	0	6
retinoic acid nuclear receptor alpha variant 1	9	0	0	9
retinoid X nuclear receptor alpha	9	0	0	9
estrogen nuclear receptor alpha	13	0	0	13
peroxisome proliferator-activated receptor delta	8	0	0	8
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	8	0	0	8
activating transcription factor 6	4	0	0	4
v-jun sarcoma virus 17 oncogene homolog (avian)	4	0	0	4
Histone H2A.x	3	0	0	3
thyroid hormone receptor beta isoform a	4	0	0	4
heat shock protein beta-1	5	0	0	5
nuclear factor erythroid 2-related factor 2 isoform 1	10	0	0	10
lamin isoform A-delta10	8	0	0	8
Voltage-dependent calcium channel gamma-2 subunit	9	0	0	9
Glutamate receptor 2	9	2	1	12
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	5	0	0	5
Chain A, MTA/SAH nucleosidase	0	1	0	1
Chain A, Ribosome-inactivating protein alpha-trichosanthin	0	0	1	1
Chain A, Ricin A chain	0	0	1	1
Chain A, Ribosome-inactivating protein 3	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
TDP1 protein	11	0	0	11
nuclear receptor subfamily 1, group I, member 3	11	0	0	11
cytochrome P450 family 3 subfamily A polypeptide 4	8	0	0	8
glucocorticoid receptor [Homo sapiens]	9	0	0	9
estrogen-related nuclear receptor alpha	12	0	0	12
pregnane X nuclear receptor	7	0	0	7
nuclear factor erythroid 2-related factor 2 isoform 2	4	0	0	4
importin subunit beta-1 isoform 1	2	0	0	2
snurportin-1	2	0	0	2
tumor susceptibility gene 101 protein	1	0	0	1
GTP-binding nuclear protein Ran isoform 1	2	0	0	2
Bile salt export pump	0	7	0	7
Cyclin-dependent kinase 1	0	1	0	1
Heat shock protein HSP 90-beta	0	1	0	1
Xanthine dehydrogenase/oxidase	0	1	0	1
TAR DNA-binding protein 43	3	0	0	3
Protein mono-ADP-ribosyltransferase PARP15	0	1	0	1
Leucine-rich repeat serine/threonine-protein kinase 2	0	2	0	2
ATPase family AAA domain-containing protein 5	6	0	0	6
Ataxin-2	7	0	0	7
30S ribosomal protein S6	0	1	0	1
30S ribosomal protein S7	0	1	0	1
50S ribosomal protein L15	0	1	0	1
50S ribosomal protein L10	0	1	0	1
50S ribosomal protein L11	0	1	0	1
50S ribosomal protein L7/L12	0	1	0	1
50S ribosomal protein L19	0	1	0	1
50S ribosomal protein L1	0	1	0	1
50S ribosomal protein L20	0	1	0	1
50S ribosomal protein L27	0	1	0	1
50S ribosomal protein L28	0	1	0	1
50S ribosomal protein L29	0	1	0	1
50S ribosomal protein L31	0	1	0	1
50S ribosomal protein L31 type B	0	1	0	1
50S ribosomal protein L32	0	1	0	1
50S ribosomal protein L33	0	1	0	1
50S ribosomal protein L34	0	1	0	1
50S ribosomal protein L35	0	1	0	1
50S ribosomal protein L36	0	1	0	1
30S ribosomal protein S10	0	1	0	1
30S ribosomal protein S11	0	1	0	1
30S ribosomal protein S12	0	1	0	1
30S ribosomal protein S13	0	1	0	1
30S ribosomal protein S16	0	1	0	1
30S ribosomal protein S18	0	1	0	1
30S ribosomal protein S19	0	1	0	1
30S ribosomal protein S20	0	1	0	1
30S ribosomal protein S2	0	1	0	1
30S ribosomal protein S3	0	1	0	1
30S ribosomal protein S4	0	1	0	1
30S ribosomal protein S5	0	1	0	1
30S ribosomal protein S8	0	1	0	1
30S ribosomal protein S9	0	1	0	1
50S ribosomal protein L13	0	1	0	1
50S ribosomal protein L14	0	1	0	1
50S ribosomal protein L16	0	1	0	1
50S ribosomal protein L23	0	1	0	1
30S ribosomal protein S15	0	1	0	1
50S ribosomal protein L17	0	1	0	1
50S ribosomal protein L21	0	1	0	1
50S ribosomal protein L30	0	1	0	1
50S ribosomal protein L6	0	1	0	1
30S ribosomal protein S14	0	1	0	1
30S ribosomal protein S17	0	1	0	1
30S ribosomal protein S1	0	1	0	1
50S ribosomal protein L18	0	1	0	1
50S ribosomal protein L2	0	1	0	1
50S ribosomal protein L3	0	1	0	1
50S ribosomal protein L24	0	1	0	1
50S ribosomal protein L4	0	1	0	1
50S ribosomal protein L22	0	1	0	1
50S ribosomal protein L5	0	1	0	1
30S ribosomal protein S21	0	1	0	1
50S ribosomal protein L25	0	1	0	1
50S ribosomal protein L36 2	0	1	0	1
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	1	1
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	1	1
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	1	1
thioredoxin reductase	8	0	0	8
phosphopantetheinyl transferase	6	0	0	6
NFKB1 protein, partial	2	0	0	2
GLS protein	8	0	0	8
thyroid stimulating hormone receptor	2	0	0	2
alpha-galactosidase	2	0	0	2
euchromatic histone-lysine N-methyltransferase 2	8	0	0	8
cytochrome P450 2C19 precursor	2	0	0	2
chromobox protein homolog 1	7	0	0	7
flap endonuclease 1	3	0	0	3
DNA polymerase iota isoform a (long)	5	0	0	5
muscarinic acetylcholine receptor M1	3	0	0	3
lethal factor (plasmid)	4	0	0	4
Cytochrome P450 3A4	0	1	1	3
Nitric oxide synthase, endothelial	0	0	0	2
Nitric oxide synthase, brain	0	0	0	1
Nitric oxide synthase, brain	0	0	0	1
Nitric oxide synthase, inducible	0	0	0	1
Nitric oxide synthase, inducible	0	0	1	3
Cationic amino acid transporter 3	0	1	0	1
ATP-dependent phosphofructokinase	5	0	0	5
thyroid stimulating hormone receptor	5	0	0	5
Cellular tumor antigen p53	9	0	0	9
Nuclear receptor ROR-gamma	1	1	1	3
IDH1	6	0	0	6
geminin	9	0	0	9
Deoxycytidine kinase	0	0	0	1
P2Y purinoceptor 4	0	0	1	1
Proto-oncogene tyrosine-protein kinase Src	0	1	0	1
P2Y purinoceptor 2	0	0	1	1
P2X purinoceptor 1	0	0	1	1
P2X purinoceptor 1	0	0	1	1
P2X purinoceptor 3	0	0	1	1
P2X purinoceptor 4	0	0	1	1
P2Y purinoceptor 12	0	1	0	1
P2X purinoceptor 2	0	0	1	1
glp-1 receptor, partial	6	0	0	6
Fumarate hydratase	4	0	0	4
Smad3	5	0	0	5
caspase 7, apoptosis-related cysteine protease	3	0	0	3
estrogen receptor 2 (ER beta)	7	0	0	7
progesterone receptor	5	0	0	5
farnesoid X nuclear receptor	7	0	0	7
cytochrome P450 2D6	6	0	0	6
polyprotein	4	0	0	4
peroxisome proliferator activated receptor gamma	8	0	0	8
vitamin D (1,25- dihydroxyvitamin D3) receptor	6	0	0	6
caspase-3	3	0	0	3
aryl hydrocarbon receptor	7	0	0	7
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	2	0	0	2
potassium voltage-gated channel subfamily H member 2 isoform d	2	0	0	2
thyroid hormone receptor beta isoform 2	7	0	0	7
urokinase-type plasminogen activator precursor	2	0	0	2
plasminogen precursor	2	0	0	2
urokinase plasminogen activator surface receptor precursor	2	0	0	2
ATP-binding cassette sub-family C member 3	0	4	0	4
Multidrug resistance-associated protein 4	0	4	0	4
Interferon beta	5	0	0	5
Alpha-synuclein	2	1	0	3
Spike glycoprotein	5	0	0	5
Canalicular multispecific organic anion transporter 1	0	3	0	3
Chain A, GLUTAMATE RECEPTOR SUBUNIT 2	0	1	0	1
Chain A, Glutamate Receptor Subunit 2	0	1	0	1
Chain B, Glutamate Receptor Subunit 2	0	1	0	1
Chain A, Slr1257 protein	0	0	1	1
Chain A, Glucosamine--fructose-6-phosphate aminotransferase [isomerizing]	0	1	0	1
regulator of G-protein signaling 4	4	0	0	4
beta-2 adrenergic receptor	3	0	0	3
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	2	0	0	2
Metabotropic glutamate receptor 8	0	2	0	2
Metabotropic glutamate receptor 6	0	1	1	3
Glutamate receptor ionotropic, NMDA 2D	0	1	0	1
Excitatory amino acid transporter 4	0	1	0	1
Glutamate receptor ionotropic, NMDA 3B	0	1	0	1
Glutathione reductase, mitochondrial	0	2	0	2
Bifunctional aspartokinase/homoserine dehydrogenase 1	0	1	0	1
Prothrombin	0	0	1	1
Carbonic anhydrase 1	0	0	0	2
Carbonic anhydrase 2	0	0	0	2
Integrin beta-3	1	0	1	2
Integrin alpha-IIb	1	0	1	2
ATP-citrate synthase	0	1	0	1
Glutamate receptor 1	0	2	1	3
Glutamate receptor 3	0	2	1	3
Glutamate receptor 4	0	2	1	3
Glutamate receptor ionotropic, kainate 1	0	2	1	3
Metabotropic glutamate receptor 1	0	1	1	2
Metabotropic glutamate receptor 2	0	0	1	1
Metabotropic glutamate receptor 3	0	0	1	1
Metabotropic glutamate receptor 4	0	1	1	2
Metabotropic glutamate receptor 5	0	0	1	1
Metabotropic glutamate receptor 6	0	0	1	1
Metabotropic glutamate receptor 7	0	0	1	1
Glutamate receptor ionotropic, NMDA 1	0	3	1	4
Glutamate receptor ionotropic, kainate 1	0	1	1	2
Metabotropic glutamate receptor 5	0	1	1	3
Glutamate receptor ionotropic, kainate 2	0	2	1	3
Glutamate receptor 1	0	2	1	3
Glutamate receptor 2	0	2	1	3
Glutamate receptor 3	0	1	1	2
Glutamate receptor ionotropic, kainate 3	0	2	0	2
Excitatory amino acid transporter 1	0	2	0	3
Excitatory amino acid transporter 2	0	2	0	3
Excitatory amino acid transporter 3	0	2	0	3
Metabotropic glutamate receptor 8	0	0	1	1
Glutamate receptor 4	0	2	1	3
Excitatory amino acid transporter 3	0	0	0	1
Glutamate racemase	0	0	0	1
Metabotropic glutamate receptor 8	0	1	1	2
Fatty-acid amide hydrolase 1	0	1	0	1
Glutamate receptor ionotropic, NMDA 2A	0	2	1	3
Glutamate receptor ionotropic, NMDA 2B	0	2	1	3
Glutamate receptor ionotropic, NMDA 2C	0	2	1	3
Glutamate receptor ionotropic, kainate 4	0	2	0	2
Glutamate carboxypeptidase 2	0	1	0	1
Glutamate receptor ionotropic, NMDA 1	0	1	0	1
Glutamate receptor ionotropic, NMDA 2A	0	1	0	1
Glutamate receptor ionotropic, kainate 2	0	1	1	2
Glutamate receptor ionotropic, kainate 3	0	1	0	1
Glutamate receptor ionotropic, NMDA 2B	0	1	0	1
Metabotropic glutamate receptor 1	0	1	1	3
Metabotropic glutamate receptor 2	0	1	1	3
Metabotropic glutamate receptor 7	0	1	1	3
Metabotropic glutamate receptor 3	0	1	1	3
Metabotropic glutamate receptor 4	0	1	1	3
Glutamate receptor ionotropic, NMDA 2C	0	1	0	1
Glutamate receptor ionotropic, kainate 5	0	1	0	1
Carbonic anhydrase-like protein, putative	0	0	0	2
Glutamate receptor ionotropic, NMDA 2D	0	2	1	3
Glutamate receptor ionotropic, kainate 5	0	2	0	2
Glutamate racemase	0	0	0	1
Prolyl 4-hydroxylase	0	1	0	1
Glutamate receptor ionotropic, NMDA 3A	0	1	0	1
Glutamate receptor ionotropic, NMDA 3B	0	2	1	3
Alpha-ketoglutarate-dependent dioxygenase FTO	0	1	0	1
Glutamate receptor ionotropic, NMDA 3A	0	2	1	3
Chain A, Glutamine Binding Protein	0	0	1	1
15-lipoxygenase, partial	2	0	0	2
arylsulfatase A	4	0	0	4
Bloom syndrome protein isoform 1	5	0	0	5
peripheral myelin protein 22 isoform 1	2	0	0	2
histone-lysine N-methyltransferase 2A isoform 2 precursor	1	0	0	1
Neutral amino acid transporter A	0	3	0	3
Asc-type amino acid transporter 1	0	1	0	1
Neutral amino acid transporter B(0)	0	3	0	3
Amino acid transporter	0	3	0	3
SMAD family member 2	5	0	0	5
SMAD family member 3	5	0	0	5
Rap guanine nucleotide exchange factor 3	1	0	0	1
Purine nucleoside phosphorylase	0	2	0	2
Hypoxanthine-guanine phosphoribosyltransferase	0	0	0	1
Ricin	0	1	0	1
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase	0	0	1	1
Purine nucleoside phosphorylase	0	0	1	2
Shiga toxin subunit A	0	1	0	1
Guanine deaminase	0	0	0	1
Chain A, Beta-lactamase	4	0	0	4
Chain A, 2-oxoglutarate Oxygenase	5	0	0	5
Microtubule-associated protein tau	4	0	0	4
mitogen-activated protein kinase 1	1	0	0	1
Solute carrier organic anion transporter family member 2A1	0	1	0	1
Type-1A angiotensin II receptor	0	1	0	1
Type-1B angiotensin II receptor	0	2	0	2
Type-2 angiotensin II receptor	0	1	0	1
cGMP-inhibited 3',5'-cyclic phosphodiesterase B	0	1	0	1
cGMP-inhibited 3',5'-cyclic phosphodiesterase A	0	1	0	1
5-hydroxytryptamine receptor 1A	0	1	0	1
Type-1 angiotensin II receptor	0	1	0	1
EWS/FLI fusion protein	2	0	0	2
67.9K protein	2	0	0	2
nuclear receptor subfamily 1, group I, member 2	2	0	0	2
Indoleamine 2,3-dioxygenase 1	0	1	0	1
Chain A, Adenosine kinase, putative	0	1	0	1
GALC protein	2	0	0	2
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	3	0	0	3
lysosomal alpha-glucosidase preproprotein	1	0	0	1
mu-type opioid receptor isoform MOR-1	0	0	1	1
Vpr	2	0	0	2
peripheral myelin protein 22	4	0	0	4
5-hydroxytryptamine receptor 2A	0	0	1	1
Neuronal acetylcholine receptor subunit alpha-4	1	0	0	1
Neuronal acetylcholine receptor subunit beta-2	1	0	0	1
Chain A, Putative fructose-1,6-bisphosphate aldolase	1	0	0	1
acetylcholinesterase	3	0	0	3
nonstructural protein 1	4	0	0	4
hexokinase-4 isoform 1	1	0	0	1
atrial natriuretic peptide receptor 1 precursor	1	0	0	1
glucokinase regulatory protein	1	0	0	1
survival motor neuron protein isoform d	3	0	0	3
M-phase phosphoprotein 8	3	0	0	3
histone acetyltransferase KAT2A isoform 1	3	0	0	3
Acetylcholinesterase	0	3	0	4
Bile salt export pump	0	1	0	1
Acetylcholinesterase	0	1	0	1
Cholinesterase	0	2	0	2
Cytochrome P450 2D6	0	1	1	2
Muscarinic acetylcholine receptor M2	0	3	0	4
Alpha-1B adrenergic receptor	0	5	1	6
Acetylcholinesterase	0	1	0	1
Acetylcholinesterase	0	1	0	2
Acetylcholinesterase	0	1	0	1
Alpha-1D adrenergic receptor	0	4	1	5
Delta-type opioid receptor	0	1	0	1
Acetylcholinesterase	0	1	0	1
Acetylcholinesterase	0	1	0	1
Alpha-1A adrenergic receptor	0	5	1	6
Cholinesterase	0	3	0	4
Cholinesterase	0	1	0	1
Acyl-CoA:cholesterol acyltransferase	0	1	0	1
Carboxylic ester hydrolase	0	1	0	1
Carboxylic ester hydrolase	0	1	0	1
cytochrome P450 2C9 precursor	2	0	0	2
cytochrome P450 3A4 isoform 1	3	0	0	3
Gamma-aminobutyric acid receptor subunit pi	3	1	0	4
Muscarinic acetylcholine receptor M2	0	1	1	2
Muscarinic acetylcholine receptor M1	0	2	0	3
Muscarinic acetylcholine receptor M3	0	2	0	3
Muscarinic acetylcholine receptor M4	0	2	0	3
Muscarinic acetylcholine receptor M5	0	2	0	3
Muscarinic acetylcholine receptor M5	0	1	0	1
Muscarinic acetylcholine receptor M1	0	1	2	3
Cytochrome P450 2A6	0	1	1	2
Muscarinic acetylcholine receptor M1	0	0	1	1
Gamma-aminobutyric acid receptor subunit beta-1	3	1	0	4
Muscarinic acetylcholine receptor DM1	0	1	0	1
Gamma-aminobutyric acid receptor subunit delta	3	1	0	4
Gamma-aminobutyric acid receptor subunit gamma-2	3	1	0	4
Gamma-aminobutyric acid receptor subunit alpha-5	3	1	0	4
Gamma-aminobutyric acid receptor subunit alpha-3	3	1	0	4
Gamma-aminobutyric acid receptor subunit gamma-1	3	1	0	4
Gamma-aminobutyric acid receptor subunit alpha-2	3	1	0	4
Gamma-aminobutyric acid receptor subunit alpha-4	3	1	0	4
Gamma-aminobutyric acid receptor subunit gamma-3	3	1	0	4
Gamma-aminobutyric acid receptor subunit alpha-6	3	1	0	4
Histamine H2 receptor	3	0	0	3
Gamma-aminobutyric acid receptor subunit alpha-1	3	1	0	4
Gamma-aminobutyric acid receptor subunit beta-3	3	1	0	4
Gamma-aminobutyric acid receptor subunit beta-2	3	1	0	4
Cytochrome P450 2A13	0	1	1	2
GABA theta subunit	3	1	0	4
Gamma-aminobutyric acid receptor subunit epsilon	3	1	0	4
Glutamate 5-kinase	0	0	0	1
Angiotensin-converting enzyme	0	1	0	1
Proton-coupled amino acid transporter 1	0	2	0	2
Chain A, Ferritin light chain	4	0	0	4
pregnane X receptor	2	0	0	2
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	1	0	0	1
vitamin D3 receptor isoform VDRA	3	0	0	3
heat shock protein HSP 90-alpha isoform 2	0	0	0	2
nuclear receptor ROR-gamma isoform 1	4	0	0	4
Polyunsaturated fatty acid lipoxygenase ALOX15B	2	0	0	2
Guanine nucleotide-binding protein G	2	0	0	2
heat shock protein 90, putative	0	0	0	2
Luciferase	2	0	0	2
G	4	0	0	4
histone deacetylase 9 isoform 3	1	0	0	1
HLA class I histocompatibility antigen, B alpha chain	4	0	0	4
Flavin reductase (NADPH)	0	0	1	1
Inositol hexakisphosphate kinase 1	4	0	0	4
cytochrome P450 2C9, partial	4	0	0	4
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	1	0	0	1
Chain A, HADH2 protein	1	0	0	1
Chain B, HADH2 protein	1	0	0	1
Chain A, JmjC domain-containing histone demethylation protein 3A	1	0	0	1
ATAD5 protein, partial	1	0	0	1
USP1 protein, partial	3	0	0	3
DNA polymerase III, partial	1	0	0	1
bromodomain adjacent to zinc finger domain 2B	2	0	0	2
cytochrome P450 2D6 isoform 1	1	0	0	1
NPC intracellular cholesterol transporter 1 precursor	1	0	0	1
cellular tumor antigen p53 isoform a	1	0	0	1
D(1A) dopamine receptor	1	0	0	1
ubiquitin-conjugating enzyme E2 N	0	1	0	1
ras-related protein Rab-9A	1	0	0	1
serine/threonine-protein kinase mTOR isoform 1	1	0	0	1
pyruvate kinase PKM isoform b	1	0	0	1
neuropeptide S receptor isoform A	1	0	0	1
5-hydroxytryptamine receptor 1A	0	0	1	1
5-hydroxytryptamine receptor 2C	0	2	1	3
Ornithine decarboxylase	1	0	0	2
5-hydroxytryptamine receptor 2A	0	2	1	3
5-hydroxytryptamine receptor 1A	0	2	0	2
Endothelin receptor type B	0	1	0	1
Diacylglycerol kinase alpha	0	1	0	1
Endothelin receptor type B	0	1	0	1
5-hydroxytryptamine receptor 2A	0	2	0	2
5-hydroxytryptamine receptor 2C	0	2	0	2
5-hydroxytryptamine receptor 2B	0	2	1	3
Histamine H1 receptor	0	1	0	1
5-hydroxytryptamine receptor 7	0	1	0	1
5-hydroxytryptamine receptor 2C	0	1	0	1
5-hydroxytryptamine receptor 7	0	1	0	1
5-hydroxytryptamine receptor 2A	0	1	0	1
5-hydroxytryptamine receptor 2B	0	3	0	3
D(1A) dopamine receptor	1	0	0	1
D(2) dopamine receptor	0	2	0	2
5-hydroxytryptamine receptor 2B	0	1	0	1
Rap guanine nucleotide exchange factor 4	1	0	0	1
DNA polymerase kappa isoform 1	2	0	0	2
Pyruvate kinase PKM	0	0	1	1
Replicase polyprotein 1ab	0	1	0	1
Replicase polyprotein 1ab	0	2	0	2
Thymidine phosphorylase	0	1	0	1
Chain A, Nuclear Receptor ROR-beta	0	1	0	1
Chain A, ATP-DEPENDENT DNA HELICASE Q1	1	0	0	1
Chain A, Cruzipain	1	0	0	1
thioredoxin glutathione reductase	1	0	0	1
Parkin	2	0	0	2
thyrotropin-releasing hormone receptor	2	0	0	2
Caspase-7	2	0	0	2
caspase-3	2	0	0	2
Ornithine decarboxylase	0	0	0	1
Amyloid-beta precursor protein	0	1	0	1
Cytochrome P450 1A2	0	0	1	1
60 kDa chaperonin	0	1	0	1
Adenosine receptor A3	0	2	0	2
Retinoic acid receptor alpha	0	2	2	7
60 kDa heat shock protein, mitochondrial	0	1	0	1
Retinoic acid receptor beta	0	2	2	7
Retinoic acid receptor alpha	0	1	2	3
Cytochrome P450 2C9	0	0	1	1
Retinoic acid receptor gamma	0	2	2	7
Alpha-1A adrenergic receptor	0	1	0	1
Retinoic acid receptor gamma	0	1	2	3
Retinoic acid receptor RXR-alpha	0	2	2	4
Retinoic acid receptor beta	0	1	2	3
Cellular retinoic acid-binding protein 2	0	0	1	1
Mitogen-activated protein kinase 1	0	1	0	1
Retinoic acid receptor RXR-alpha	0	1	2	3
Retinoic acid receptor RXR-beta	0	2	2	4
Retinoic acid receptor RXR-beta	0	1	2	3
Retinoic acid receptor RXR-gamma	0	1	2	3
Indoleamine 2,3-dioxygenase 1	0	1	0	1
Cytochrome P450 2C19	0	0	1	1
Nuclear receptor ROR-alpha	0	1	0	1
Cellular retinoic acid-binding protein 1	0	1	0	2
Retinoic acid receptor RXR-gamma	0	2	2	4
10 kDa heat shock protein, mitochondrial	0	1	0	1
Cellular retinoic acid-binding protein 1	0	0	1	1
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	0	2	1	3
Thiosulfate sulfurtransferase	0	1	0	1
60 kDa chaperonin	0	1	0	1
10 kDa chaperonin	0	1	0	1
Indoleamine 2,3-dioxygenase 2	0	1	0	1
Nuclear receptor ROR-beta	0	1	0	1
Chain A, enoyl-acyl carrier reductase	0	1	0	1
Chain C, enoyl-acyl carrier reductase	0	1	0	1
Chain A, enoyl-acyl carrier reductase	0	1	0	1
Chain C, enoyl-acyl carrier reductase	0	1	0	1
Chain A, enoyl-acyl carrier reductase	0	1	0	1
Chain C, enoyl-acyl carrier reductase	0	1	0	1
Chain A, Repressor	0	0	1	1
PINK1	1	0	0	1
3-oxoacyl-[acyl-carrier-protein] synthase 3	0	1	0	1
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	1	0	0	1
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	1	0	0	1
twin arginine protein translocation system - TatA protein	0	0	0	1
Transthyretin	0	1	1	2
Polyunsaturated fatty acid 5-lipoxygenase	0	1	0	1
Enoyl-[acyl-carrier-protein] reductase [NADH] FabI	0	1	0	1
DNA gyrase subunit A	0	1	0	1
DNA gyrase subunit B	0	1	0	1
Replicase polyprotein 1ab	0	1	0	1
Endoplasmic reticulum chaperone BiP	0	1	0	1
Carbonyl reductase [NADPH] 1	0	2	0	2
Enoyl-[acyl-carrier-protein] reductase [NADH] FabI	0	1	0	1
Enoyl-[acyl-carrier-protein] reductase [NADH] FabI	0	1	0	1
Enoyl-[acyl-carrier-protein] reductase [NADH]	0	2	0	2
Enoyl-[acyl-carrier-protein] reductase [NADH]	0	1	0	1
Enoyl-[acyl-carrier-protein] reductase [NADPH] FabI	0	2	0	2
Enoyl-acyl carrier reductase	0	1	0	1
Enoyl-acyl-carrier protein reductase	0	2	0	2
Enoyl-ACP reductase II	0	1	0	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

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