gsk0660 has been researched along with sapropterin* in 1 studies
1 other study(ies) available for gsk0660 and sapropterin
| Article | Year |
|---|---|
PPARδ agonist prevents endothelial dysfunction via induction of dihydrofolate reductase gene and activation of tetrahydrobiopterin salvage pathway.
Impaired endothelium-dependent relaxation (EDR) is a hallmark of endothelial dysfunction. A deficiency of tetrahydrobiopterin (BH. Gene expression was measured by using qRT-PCR and western blotting. Biopterins and ROS were determined by using HPLC. NO was measured with fluorescent dye and electron paramagnetic resonance spectroscopy. Vasorelaxation was measured by Multi Myograph System.. The PPARδ agonist GW501516 increased DHFR and BH. PPARδ prevented endothelial dysfunction by increasing DHFR and activating the BH Topics: Animals; Aorta; Biopterins; Cells, Cultured; Endothelium, Vascular; Gene Expression; Human Umbilical Vein Endothelial Cells; Humans; Male; Mice, Inbred C57BL; Mice, Knockout; PPAR delta; Sulfones; Tetrahydrofolate Dehydrogenase; Thiazoles; Thiophenes; Thoracic Arteries | 2019 |