linoleic acid binding

Definition

Target type: molecularfunction

Binding to linoleic acid, the 18-carbon unsaturated fatty acid (9Z,12Z)-octadeca-9,12-dienoic acid. [GOC:lp, GOC:mah]

Linoleic acid binding involves the specific recognition and interaction of a protein with the fatty acid linoleic acid. Linoleic acid, an essential omega-6 fatty acid, plays a crucial role in various cellular processes. Proteins that bind linoleic acid often possess a hydrophobic pocket or groove that complements the structure of linoleic acid, allowing for non-covalent interactions such as van der Waals forces and hydrogen bonding. These interactions are essential for the proper function of the protein. The binding of linoleic acid can trigger conformational changes in the protein, modulating its activity or influencing its interaction with other molecules. In some cases, linoleic acid binding can regulate the activity of enzymes, transcription factors, or signaling pathways. The molecular function of linoleic acid binding varies depending on the specific protein involved. However, it often contributes to processes such as lipid metabolism, cell signaling, and membrane integrity. Some examples include:

* **Lipid metabolism:** Linoleic acid is a precursor to other fatty acids and is incorporated into cell membranes. Proteins that bind linoleic acid can influence the synthesis, transport, and degradation of lipids.
* **Cell signaling:** Linoleic acid binding can activate or inhibit signaling pathways, influencing cellular responses such as proliferation, differentiation, and apoptosis.
* **Membrane integrity:** Linoleic acid is a key component of cell membranes, and its binding can influence membrane fluidity, permeability, and stability.

In summary, linoleic acid binding is a complex molecular interaction that plays a crucial role in diverse cellular processes. The specific function of linoleic acid binding is determined by the protein involved and its cellular context. '
"

Proteins (1)

Compounds (45)