Target type: cellularcomponent
The region at either end of the longest axis of a cylindrical or elongated cell, where polarized growth occurs. [GOC:mah]
The growing cell tip, also known as the apical region, is a dynamic and specialized structure essential for cell elongation and development. It is characterized by a unique cellular organization and a high concentration of specific organelles and molecules that drive growth processes. The cellular components of the growing cell tip include:
1. **Plasma membrane:** This outermost membrane of the cell encloses the cytoplasm and acts as a selective barrier, regulating the passage of molecules in and out of the cell. It plays a critical role in cell growth and development by mediating signal transduction, cell-cell interactions, and the uptake of nutrients.
2. **Cell wall:** In plant cells, a rigid cell wall surrounds the plasma membrane, providing structural support and protection. The cell wall is composed primarily of cellulose, hemicellulose, and pectin, and it exhibits a gradient of organization from the tip towards the base. The cell wall at the tip is often thinner and less rigid, allowing for expansion and growth.
3. **Cytoplasm:** This gel-like substance fills the cell and contains various organelles, including ribosomes, endoplasmic reticulum (ER), Golgi apparatus, mitochondria, and vacuoles. The cytoplasm plays a crucial role in cell metabolism, protein synthesis, and intracellular transport.
4. **Microtubules:** These hollow protein filaments form a dynamic network within the cytoplasm, providing structural support and facilitating intracellular transport. In the growing cell tip, microtubules are highly organized and play a key role in directing the growth of the cell wall and the delivery of vesicles containing cell wall material.
5. **Actin filaments:** These thin protein filaments form a dynamic network that is involved in cell shape changes, movement, and the transport of organelles. Actin filaments are particularly abundant in the growing cell tip, where they contribute to the formation of the tip-growing structure and the delivery of vesicles.
6. **Vesicles:** These small membrane-bound sacs transport molecules throughout the cell. In the growing cell tip, vesicles are filled with cell wall material, enzymes, and signaling molecules that are transported to the plasma membrane and the cell wall.
7. **Golgi apparatus:** This organelle is involved in the processing and packaging of proteins and lipids. In the growing cell tip, the Golgi apparatus plays a role in the production of cell wall materials and the modification of proteins involved in cell growth.
8. **Endoplasmic reticulum (ER):** This network of membranes is involved in protein synthesis, lipid metabolism, and calcium signaling. In the growing cell tip, the ER plays a role in the production of cell wall materials and the transport of proteins involved in cell growth.
9. **Mitochondria:** These organelles are the powerhouses of the cell, responsible for energy production through cellular respiration. In the growing cell tip, mitochondria provide the energy needed for cell growth and development.
10. **Vacuoles:** These large membrane-bound sacs store water, nutrients, and waste products. In the growing cell tip, vacuoles play a role in regulating cell turgor pressure, which is essential for cell expansion.
11. **Tip-localized proteins:** The growing cell tip is enriched in specific proteins that regulate cell growth and development. These proteins include cell wall biosynthesis enzymes, signaling molecules, and transport proteins.
The cellular components of the growing cell tip work together in a complex and coordinated manner to drive cell growth and development. This intricate organization and interplay between organelles, molecules, and processes contribute to the remarkable ability of cells to elongate and create new structures. '"
Protein | Definition | Taxonomy |
---|---|---|
Phosphatidylinositol 4-kinase type 2-alpha | A phosphatidylinositol 4-kinase type 2-alpha that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9BTU6] | Homo sapiens (human) |
Compound | Definition | Classes | Roles |
---|---|---|---|
9-ethyladenine | |||
n(6),n(6)-dimethyladenine | N(6),N(6)-dimethyladenine : A tertiary amine that is adenine substituted at N-6 by geminal methyl groups. | tertiary amine | |
1-phenyl-4-pyrazolo[3,4-d]pyrimidinamine | pyrazoles; ring assembly | ||
sq 22536 | 9-(tetrahydrofuryl)adenine : A nucleoside analogue that is adenine in which the nitrogen at position 9 has been substituted by a tetrahydrofuran-2-yl group. It is an adenylate cyclase inhibitor. | nucleoside analogue; oxolanes | EC 4.6.1.1 (adenylate cyclase) inhibitor |
adenosine diphosphate | Adenosine Diphosphate: Adenosine 5'-(trihydrogen diphosphate). An adenine nucleotide containing two phosphate groups esterified to the sugar moiety at the 5'-position. | adenosine 5'-phosphate; purine ribonucleoside 5'-diphosphate | fundamental metabolite; human metabolite |
2-aminopurine | 2-aminopurine : The parent compound of the 2-aminopurines, comprising a purine core carrying an amino substituent at the 2-position. 2-Aminopurine: A purine that is an isomer of ADENINE (6-aminopurine). aminopurine : Any purine having at least one amino substituent. | 2-aminopurines; nucleobase analogue | antimetabolite |
alpha-aminopyridine | alpha-aminopyridine: RN given refers to parent cpd; structure in Merck Index, 9th ed, #485 aminopyridine : Compounds containing a pyridine skeleton substituted by one or more amine groups. | ||
9-benzyladenine | |||
adenosine | quinquefolan B: isolated from roots of Panax quinquefolium L.; RN not in Chemline 10/87; RN from Toxlit | adenosines; purines D-ribonucleoside | analgesic; anti-arrhythmia drug; fundamental metabolite; human metabolite; vasodilator agent |
benzylaminopurine | benzylaminopurine: a plant growth regulator N-benzyladenine : A member of the class of 6-aminopurines that is adenine in which one of the hydrogens of the amino group is replaced by a benzyl group. | 6-aminopurines | cytokinin; plant metabolite |
9-methyladenine | 9-methyladenine : Adenine substituted with a methyl group at position N-9. | methyladenine | metabolite |
4-aminopyrazolo(3,4-d)pyrimidine | 4-aminopyrazolo(3,4-d)pyrimidine: adenine analog which suppresses growth of E coli & Bacillus cereus; inhibits cell growth & purine biosynthesis in rat hepatoma | ||
4-aminoquinazoline | 4-aminoquinazoline: structure in first source | ||
wortmannin | acetate ester; cyclic ketone; delta-lactone; organic heteropentacyclic compound | anticoronaviral agent; antineoplastic agent; autophagy inhibitor; EC 2.7.1.137 (phosphatidylinositol 3-kinase) inhibitor; geroprotector; Penicillium metabolite; radiosensitizing agent |