4-aminopyrazolo(3,4-d)pyrimidine and adenine

4-aminopyrazolo(3,4-d)pyrimidine has been researched along with adenine in 97 studies

Research

Studies (97)

Timeframe	Studies, this research(%)	All Research%
pre-1990	61 (62.89)	18.7374
1990's	20 (20.62)	18.2507
2000's	5 (5.15)	29.6817
2010's	11 (11.34)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Chen, ST; Choong, KF; Hsieh, JF; Wu, SH; Yang, YL	1
Dewey, VC; Kidder, GW	1
Malendowicz, LK	1
Braun, JE; Rodrigues, B; Severson, DL; Spooner, M	1
Kasprzak, A; Malendowicz, LK; Mazzocchi, G; Nussdorfer, GG; Rebuffat, P; Warchol, JB	1
Bélisle, S; Bellabarba, D; Lefebvre, A; Lehoux, JG	2
Andreis, PG; Cavallini, L; Mazzocchi, G; Meneghelli, V; Nussdorfer, GG	1
Gibori, G; Khan, I; McLean, MP; Puryear, TK	1
Berens, RL; Looker, DL; Marr, JJ	1
Belloni, AS; Mazzocchi, G; Meneghelli, V; Neri, G; Nussdorfer, GG; Rebuffat, P	1
Azhar, S; Reaven, E; Spicher, M	1
Azhar, S; Reaven, E; Stewart, D	1
Menon, KM; Talavera, F	1
Mazzocchi, G; Meneghelli, V; Nussdorfer, GG; Robba, C	2
Couture, RL; Murphy, BD; Rajkumar, K	1
Bisgaier, CL; Chanderbhan, R; Hinds, RW; Vahouny, GV	1
Murakoshi, M; Osamura, Y; Watanabe, K	3
Malendowicz, LK; Nowak, M; Paluszak, J; Torlińska, T	1
Avila, A; Avila, JL	1
van 't Hooft, FM; van Tol, A	2
Belloni, AS; Gottardo, G; Mazzocchi, G; Meneghelli, V; Nussdorfer, GG; Rebuffat, P	1
Aitken, JW; Booth, R; Stansfield, DA	1
Pittman, RC; Rinninger, F	1
Almeida, H; Magalhães, M; Magalhães, MC	1
McLean, MP; Miller, JB	1
Majchrzak, M; Malendowicz, LK; Nowak, M	1
Feingold, KR; Moser, AH	1
Adcock, CM; Schiller, CM; Shoaf, CR; Walden, R	1
Booth, R; Petrou, C; Stansfield, DA	1
Blank, MS; Catt, KJ; Ching, M; Dufau, ML	1
Azhar, S; Chen, YD; Gibori, G; Khan, I; Reaven, GM	1
Raju, K; Vijayan, E	2
Avila, A; Avila, JL; de Casanova, MA	1
Catt, KJ; Davies, TF; Katikineni, M	1
Gwynne, JT; Strauss, JF	1
Paavola, LG; Strauss, JF	1
Kumagai, A; Matsuoka, N; Mikami, K; Nishikawa, T; Saito, Y; Tamura, Y; Yoshida, S	1
Szabó, D; Szalay, KS; Tóth, IE	1
Marr, JJ	1
Avila, A; Avila, JL; Monzón, H	1
Blank, MS; Catt, KJ; Dufau, ML; Loumaye, E; Sgoutas, DS	1
Avila, A; Avila, JL; Monzón, H; Muñoz, E	1
Berens, RL; LaFon, SW; Looker, DL; Marr, JJ; Nelson, DJ	1
Suzuki, Y; Tabata, R	1
Avila, JL; Casanova, MA	1
Brown, MS; Goldstein, JL; Kovanen, PT	1
Bruot, BC; Collins, DC; Wiest, WG	1
Azhar, S; Menon, KM	1
Gwynne, JT; MacGregor, LC; Strauss, JF	1
Acs, Z; Mihály, K; Somogyi, J; Szabó, D	1
Groot, PH; Van Berkel, TJ; Van Tol, A	1
Feingold, KR; MacRae, G; Siperstein, MD; Wiley, MH	1
Krause, BR; Roheim, PS; Sloop, CH	1
Christie, MH; Gwynne, JT; Strauss, JF	1
Calvo, JC; Catt, KJ; Charreau, EH; Dufau, ML; Nozu, K; Pignataro, O	1
Ascoli, M	1
Counsell, RE; Huler, RJ; Korn, N; Schappa, LW	1
Schuler, LA; Strauss, JF; Toaff, ME	1
Feingold, KR; Funk, JL; Grunfeld, C; Moser, AH; Rapp, JH; Shigenaga, JK	1
Azhar, S; Reaven, E	1
Bouldin, TW; Goodrum, JF; Maeda, N; Popko, B; Zhang, SH	1
Aten, RF; Behrman, HR; Kolodecik, TR	1
Elias, PM; Feingold, KR; Wu-Pong, S	1
Ichii, M; Kadota, E; Minami, T; Nakagawa, H; Okazaki, Y	1
Asano, I; Minami, T; Nakagawa, H; Okazaki, Y; Yoshimoto, S	1
Minami, T; Nakagawa, H; Natsui, K; Okazaki, Y	1
Fujimoto, T; Koike, H; Ning, G; Ogawa, K	1
Goodrum, JF	1
Bertolotti, M; Spady, DK	1
Kawaki, H; Matsubara, H; Minami, T; Okazaki, Y; Tohno, S; Tohno, Y; Utsumi, M; Yamada, M; Yamagiwa, H	1
Acton, SM; Barr, HA; Davidson, KG; Nicholas, TE	1
Greene, SJ; Henson, MC; Reggio, BC; Shi, W; Swan, KF	1
Debelak, H; Seela, F	1
Brigotti, M; Carnicelli, D; Montanaro, L; Rizzi, S; Sperti, S	1
HENDERSON, JF; JUNGA, IG	2
CHENG, CC; ROBINS, RK; SUTCLIFFE, EY; ZEE-CHENG, KY	1
Chittepu, P; Seela, F	1
Choy, BS; Finck, BK; Jack, M; McDonald, JR; McIntosh, LM; Perdomo, L; Su, H	1
Bamoharram, FF	1
Pujari, SS; Seela, F	1
Bell, RL; Bouska, J; Davidsen, SK; Hu, X; Hubbard, RD; Johnson, EF; Kovar, P; Mantei, RA; Osterling, DJ; Sheppard, GS; Tucker, L; Wang, GT; Wang, J; Wilsbacher, JL; Zhang, Q	1
Akilandeswari, L; Krishnakumar, V; Nilufer, A; Prabavathi, N	1
Gupta, SK; Prasad Ojha, R; Sur, S; Tandon, V	1
CHENG, CC; HSU, TC; MILOFSKY, L; ROBINS, RK	1
Kosbar, TR; Pedersen, EB; Sofan, MA; Waly, MA	1
Cavallo, L; Chawla, M; Credendino, R; Oliva, R	1
Debelak, H; Evich, MG; Germann, MW; Seela, F; Spring-Connell, AM	1
Guo, X; Leonard, P; Seela, F; Yang, H; Zhao, H	1
Dey, AB; Estridge, TB; Fretland, AJ; Hartley, M; Jin, N; Kowala, MC; Leohr, JK; Luffer-Atlas, D; Luo, MJ; Mabry, TE; Milligan, PL; Reidy, C; Yu, X; Zhang, Y	1
DeBrota, DJ; Green, C; Leohr, JK; Luffer-Atlas, D; Luo, MJ; Mabry, TE; Suico, JG	1

Reviews

2 review(s) available for 4-aminopyrazolo(3,4-d)pyrimidine and adenine

Article	Year
The role of lipoproteins in steroidogenesis and cholesterol metabolism in steroidogenic glands. Endocrine reviews, 1982,Summer, Volume: 3, Issue:3 Topics: Adenine; Adrenal Cortex; Animals; Cattle; Cholesterol; Female; Humans; Hydroxymethylglutaryl CoA Reductases; In Vitro Techniques; Lipoproteins; Lipoproteins, LDL; Male; Mice; Ovary; Placenta; Pregnancy; Rats; Receptors, Cell Surface; Receptors, Lipoprotein; Steroids; Swine; Testis	1982
Evolution of the LDL receptor concept-from cultured cells to intact animals. Annals of the New York Academy of Sciences, 1980, Volume: 348 Topics: Adenine; Animals; Cells, Cultured; Cholesterol; Ethinyl Estradiol; Fibroblasts; Humans; Hyperlipoproteinemia Type II; Leukocytes; Lipoproteins, LDL; Receptors, Drug	1980

Article

Year

The role of lipoproteins in steroidogenesis and cholesterol metabolism in steroidogenic glands.

Endocrine reviews, 1982,Summer, Volume: 3, Issue:3

Topics: Adenine; Adrenal Cortex; Animals; Cattle; Cholesterol; Female; Humans; Hydroxymethylglutaryl CoA Reductases; In Vitro Techniques; Lipoproteins; Lipoproteins, LDL; Male; Mice; Ovary; Placenta; Pregnancy; Rats; Receptors, Cell Surface; Receptors, Lipoprotein; Steroids; Swine; Testis

1982

Evolution of the LDL receptor concept-from cultured cells to intact animals.

Annals of the New York Academy of Sciences, 1980, Volume: 348

Topics: Adenine; Animals; Cells, Cultured; Cholesterol; Ethinyl Estradiol; Fibroblasts; Humans; Hyperlipoproteinemia Type II; Leukocytes; Lipoproteins, LDL; Receptors, Drug

1980

Trials

1 trial(s) available for 4-aminopyrazolo(3,4-d)pyrimidine and adenine

Article	Year
Serum Lipid and Protein Changes in Healthy Dyslipidemic Subjects Given a Selective Inhibitor of p70 S6 Kinase-1. Journal of clinical pharmacology, 2018, Volume: 58, Issue:4 Topics: Adenine; Adult; Aged; Alanine Transaminase; Cholesterol, LDL; Cross-Over Studies; Dyslipidemias; Female; Humans; Male; Middle Aged; Protein Kinase Inhibitors; Pyrazoles; Pyrimidines; Ribosomal Protein S6 Kinases, 70-kDa; Single-Blind Method; Young Adult	2018

Article

Year

Serum Lipid and Protein Changes in Healthy Dyslipidemic Subjects Given a Selective Inhibitor of p70 S6 Kinase-1.

Journal of clinical pharmacology, 2018, Volume: 58, Issue:4

Topics: Adenine; Adult; Aged; Alanine Transaminase; Cholesterol, LDL; Cross-Over Studies; Dyslipidemias; Female; Humans; Male; Middle Aged; Protein Kinase Inhibitors; Pyrazoles; Pyrimidines; Ribosomal Protein S6 Kinases, 70-kDa; Single-Blind Method; Young Adult

2018

Other Studies

94 other study(ies) available for 4-aminopyrazolo(3,4-d)pyrimidine and adenine

Article	Year
The screening and characterization of 6-aminopurine-based xanthine oxidase inhibitors. Bioorganic & medicinal chemistry, 2007, May-15, Volume: 15, Issue:10 Topics: Allopurinol; Chromatography, High Pressure Liquid; Drug Evaluation, Preclinical; Enzyme Inhibitors; Kinetics; Magnetic Resonance Spectroscopy; Mass Spectrometry; Plant Leaves; Purines; Spectrophotometry, Ultraviolet; Structure-Activity Relationship; Triticum; Xanthine Oxidase	2007
Inhibitory action of the adenine analog, 4-aminopyrazolo(3,4-d)pyrimidine, in Crithidia fasciculata. Canadian journal of biochemistry, 1977, Volume: 55, Issue:1 Topics: Adenine; Adenine Phosphoribosyltransferase; Animals; Dose-Response Relationship, Drug; Eukaryota	1977
Comparative studies on the effect of 4-APP(4-aminopyrazolopyrimidine) on hamster and rat adrenal cortex. Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie, 1992, Volume: 44, Issue:3 Topics: Adenine; Adrenal Cortex; Adrenocorticotropic Hormone; Animals; Anticholesteremic Agents; Body Weight; Corticosterone; Cricetinae; Dose-Response Relationship, Drug; Female; Injections, Intraperitoneal; Mesocricetus; Organ Size; Rats; Rats, Inbred Strains	1992
Regulation of lipoprotein lipase activity in cardiac myocytes from control and diabetic rat hearts by plasma lipids. Canadian journal of physiology and pharmacology, 1992, Volume: 70, Issue:9 Topics: Adenine; Animals; Anticholesteremic Agents; Cells, Cultured; Diabetes Mellitus, Experimental; Heparin; Lipids; Lipoprotein Lipase; Male; Myocardium; Oleic Acid; Oleic Acids; Polyethylene Glycols; Rats; Rats, Sprague-Dawley; Triglycerides	1992
Effects of the hypocholesterolemic drug, 4-aminopyrazolo (3,4-d) pyrimidine (4-APP), on the hamster adrenal cortex. An ultrastructural and functional study. Virchows Archiv. B, Cell pathology including molecular pathology, 1991, Volume: 60, Issue:4 Topics: Adenine; Adrenal Glands; Animals; Cricetinae; Depression, Chemical; Dexamethasone; Female; Hydrocortisone; Hyperplasia; Mesocricetus; Zona Fasciculata; Zona Reticularis	1991
Effect of ACTH suppression on adrenal 3-hydroxy-3-methylglutaryl coenzyme A reductase mRNA in 4-aminopyrazolopyrimidine-treated rats. Molecular and cellular endocrinology, 1990, Feb-12, Volume: 69, Issue:1 Topics: Adenine; Adrenal Glands; Adrenocorticotropic Hormone; Aminoglutethimide; Animals; Anticholesteremic Agents; Blotting, Northern; Cholesterol; Cycloheximide; Dexamethasone; Hydroxymethylglutaryl CoA Reductases; Male; Rats; RNA, Messenger; Time Factors	1990
Lipid droplets in the secretory response of Leydig cells of normal and hCG-treated rats. Journal of submicroscopic cytology and pathology, 1990, Volume: 22, Issue:3 Topics: Adenine; Animals; Anticholesteremic Agents; Chorionic Gonadotropin; Inclusion Bodies; Leydig Cells; Lipid Metabolism; Male; Microscopy, Electron; Rats; Rats, Inbred Strains	1990
Mechanism for control of hydroxymethylglutaryl-coenzyme A reductase and cytochrome P-450 side chain cleavage message and enzyme in the corpus luteum. Endocrinology, 1990, Volume: 126, Issue:6 Topics: Adenine; Aminoglutethimide; Animals; Anticholesteremic Agents; Cholesterol; Cholesterol Esters; Cholesterol Side-Chain Cleavage Enzyme; Corpus Luteum; Estradiol; Female; Gene Expression Regulation; Hydroxymethylglutaryl CoA Reductases; Nucleic Acid Hybridization; Pregnancy; Protein Biosynthesis; Rats; Rats, Inbred Strains; RNA, Messenger	1990
Mechanisms of action of pyrazolopyrimidines in Leishmania donovani. The Journal of biological chemistry, 1986, Jul-15, Volume: 261, Issue:20 Topics: Adenine; Adenosine Triphosphate; Allopurinol; Animals; GMP Reductase; IMP Dehydrogenase; Leishmania donovani; NADH, NADPH Oxidoreductases; Protein Biosynthesis; Purine Nucleotides; Ribonucleosides; Ribonucleotides; RNA; Thionucleosides; Thionucleotides; Uridine Triphosphate	1986
Effects of 4-aminopyrazolo (3,4-d) pyrimidine on rat hepatocytes: an ultrastructural morphometric study. Histology and histopathology, 1989, Volume: 4, Issue:1 Topics: Adenine; Animals; Anticholesteremic Agents; Chemical and Drug Induced Liver Injury; Cholesterol; Endoplasmic Reticulum; Lipoproteins; Liver; Male; Microbodies; Microscopy, Electron; Rats; Rats, Inbred Strains; Staining and Labeling	1989
Hormonal regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase mRNA in the rat adrenal gland. Journal of steroid biochemistry, 1989, Volume: 34, Issue:1-6 Topics: Adenine; Adrenal Cortex Hormones; Adrenal Glands; Adrenocorticotropic Hormone; Animals; Anticholesteremic Agents; Hydroxymethylglutaryl CoA Reductases; Male; Rats; Reference Values; RNA, Messenger	1989
Microvillar channels: a unique plasma membrane compartment for concentrating lipoproteins on the surface of rat adrenal cortical cells. Journal of lipid research, 1989, Volume: 30, Issue:10 Topics: Adenine; Adrenal Cortex; Animals; Cell Membrane; Lipoproteins; Lipoproteins, HDL; Lipoproteins, LDL; Male; Microvilli; Perfusion; Rats; Rats, Inbred Strains	1989
Utilization of cholesterol-rich lipoproteins by perfused rat adrenals. Journal of lipid research, 1989, Volume: 30, Issue:11 Topics: Adenine; Adrenal Glands; Animals; Autoradiography; Cell Membrane; Cholesterol; Cholesterol, HDL; Corticosterone; Humans; Male; Microscopy, Electron; Perfusion; Rats; Rats, Inbred Strains; Tissue Distribution; Tyramine	1989
Regulation of rat luteal cell high density lipoprotein receptors: up-regulation in response to changes in intracellular cholesterol concentration. Endocrinology, 1989, Volume: 125, Issue:4 Topics: Adenine; Aminoglutethimide; Animals; Anticholesteremic Agents; Cholesterol; Corpus Luteum; Female; Intracellular Membranes; Lipoproteins, HDL; Osmolar Concentration; Ovary; Progesterone; Rats; Up-Regulation	1989
Effects of ACTH and aminoglutethimide administration on the morphological and functional responses of rat adrenal zona fasciculata to a prolonged treatment with 4-aminopyrazolo-pyrimidine. Journal of anatomy, 1987, Volume: 154 Topics: Adenine; Adrenal Cortex; Adrenocorticotropic Hormone; Aminoglutethimide; Animals; Cholesterol; Corticosterone; Male; Rats; Rats, Inbred Strains	1987
Binding of high-density lipoproteins to luteal membranes: the role of prolactin, luteinizing hormone, and circulating lipoproteins. Biology of reproduction, 1985, Volume: 32, Issue:3 Topics: Adenine; Adrenal Glands; Adrenocorticotropic Hormone; Animals; Chorionic Gonadotropin; Corpus Luteum; Drug Combinations; Female; Hypophysectomy; Iodine; Lipoproteins; Lipoproteins, HDL; Luteinizing Hormone; Membranes; Ovary; Progesterone; Prolactin; Rats; Rats, Inbred Strains; Swine; Time Factors	1985
Adrenal cholesterol esters as substrate source for steroidogenesis. Journal of steroid biochemistry, 1985, Volume: 23, Issue:6A Topics: Acetates; Adenine; Adrenal Cortex; Adrenocorticotropic Hormone; Animals; Cholesterol; Cholesterol Esters; Corticosterone; Hydrolysis; In Vitro Techniques; Lipoproteins; Male; Rats; Rats, Inbred Strains; Steroids	1985
Ultrastructural alterations in rats adrenal cortical cells produced by 4-aminopyrazolopyrimidine and ACTH administration. The Tokai journal of experimental and clinical medicine, 1985, Volume: 10, Issue:6 Topics: Adenine; Adrenal Cortex; Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Animals; Anticholesteremic Agents; Male; Microscopy, Electron; Mitochondria; Rats; Rats, Inbred Strains	1985
Adrenocortical function in 4-APP treated rats: a coupled stereological and biochemical study. Journal of steroid biochemistry, 1987, Volume: 26, Issue:4 Topics: Adenine; Adrenal Cortex; Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Animals; Anticholesteremic Agents; Cholesterol; Corticosterone; Female; Lipase; Lipoproteins, HDL; Rats; Rats, Inbred Strains	1987
Defective transport of pyrazolopyrimidine ribosides in insensitive Trypanosoma cruzi wild strains is a parasite-stage specific and reversible characteristic. Comparative biochemistry and physiology. B, Comparative biochemistry, 1987, Volume: 87, Issue:3 Topics: Adenine; Adenosine; Adenosine Kinase; Animals; Antiprotozoal Agents; Biological Transport; Drug Resistance; Formycins; Kinetics; Phosphotransferases; Pyrimidine Nucleosides; Trypanosoma cruzi	1987
Effect of 4-aminopyrazolo[3,4-d]pyrimidine on the catabolism of high-density lipoprotein apolipoprotein A-I in the rat. Biochimica et biophysica acta, 1986, Apr-15, Volume: 876, Issue:2 Topics: Adenine; Animals; Anticholesteremic Agents; Apolipoprotein A-I; Apolipoproteins A; Iodine Radioisotopes; Kinetics; Lipoproteins, HDL; Liver; Male; Rats; Rats, Inbred Strains; Tissue Distribution	1986
Effects of mevinolin, an inhibitor of cholesterol synthesis, on the morphological and functional responses of rat adrenal zona fasciculata to a prolonged treatment with 4-aminopyrazolo-pyrimidine. The Anatomical record, 1988, Volume: 221, Issue:3 Topics: Adenine; Animals; Anticholesteremic Agents; Cholesterol; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lipoproteins; Lovastatin; Male; Rats; Rats, Inbred Strains; Zona Fasciculata	1988
Luteal progesterone synthesis and high-density lipoprotein. Evidence implicating a pronase-sensitive HDL-binding site in the mechanism by which HDL supports luteal progesterone synthesis. European journal of biochemistry, 1988, Jan-15, Volume: 171, Issue:1-2 Topics: Adenine; Animals; Binding Sites; Cholesterol, HDL; Corpus Luteum; Female; In Vitro Techniques; Lipoproteins, HDL; Luteinizing Hormone; Progesterone; Pronase; Rats	1988
Regulation of the selective uptake of high density lipoprotein-associated cholesteryl esters. Journal of lipid research, 1987, Volume: 28, Issue:11 Topics: Adenine; Animals; Anticholesteremic Agents; Cells, Cultured; Cholesterol Esters; Cholesterol, HDL; Ethinyl Estradiol; Female; Fibroblasts; Humans; Lipids; Lipoproteins, HDL; Lipoproteins, LDL; Liver; Rats; Rats, Inbred Strains; Ultracentrifugation	1987
Nucleolar alterations induced by 4-aminopyrazolo(3,4-d)pyrimidine in adrenal cortex and liver cells of rat. Cell and tissue research, 1987, Volume: 248, Issue:1 Topics: Adenine; Adrenal Cortex; Animals; Anticholesteremic Agents; Cell Nucleolus; Liver; Male; Microscopy, Electron; Rats	1987
Evidence for the preferential utilization of esterified cholesterol in progesterone production by rabbit corpora lutea. Biology of reproduction, 1987, Volume: 36, Issue:3 Topics: Adenine; Animals; Cholesterol Esters; Corpus Luteum; Estradiol; Female; Hysterectomy; Lipoproteins; Models, Biological; Progesterone; Pseudopregnancy; Rabbits; Time Factors	1987
Stereologic studies on the adrenal cortex of 4-APP (4-amino-pyrazolopyrimidine)-induced lipoprotein-deficient rats. Experimental pathology, 1987, Volume: 31, Issue:3 Topics: Adenine; Adrenal Cortex; Animals; Cell Division; Cholesterol; Female; Lipoproteins; Organ Size; Rats; Rats, Inbred Strains	1987
Effect of hypocholesterolemia on cholesterol synthesis in small intestine of diabetic rats. Diabetes, 1987, Volume: 36, Issue:11 Topics: Adenine; Alkaline Phosphatase; Animals; Anticholesteremic Agents; Cholesterol; Diabetes Mellitus, Experimental; Fasting; Female; In Vitro Techniques; Intestine, Small; Rats; Rats, Inbred Strains; Reference Values; Tritium	1987
Long term effects of the hypocholesterolaemic drug 4-aminopyrazolo-pyrimidine on the zona fasciculata of the rat adrenal cortex. Journal of anatomy, 1986, Volume: 149 Topics: Adenine; Adrenal Cortex; Adrenal Glands; Animals; Anticholesteremic Agents; Cholesterol; Male; Microscopy, Electron; Rats; Rats, Inbred Strains; Time Factors	1986
Effects of adenine and its isomer 4-aminopyrazolo-[3,4-d]-pyrimidine on 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced mortality in rats. Toxicology and applied pharmacology, 1986, Jun-30, Volume: 84, Issue:2 Topics: Adenine; Administration, Oral; Animals; Body Weight; Cholesterol; Drug Interactions; Electrophoresis, Polyacrylamide Gel; Liver; Male; Polychlorinated Dibenzodioxins; Rats; Rats, Inbred F344; Triglycerides	1986
Stimulation of progesterone synthesis, in corpus luteum cells isolated from 4-amino-3,4-d-pyrazolopyrimidine-treated rats, by cholesterol presented in non-lipoprotein form. FEBS letters, 1986, Aug-18, Volume: 204, Issue:2 Topics: Adenine; Animals; Cholesterol; Cholesterol Esters; Corpus Luteum; Female; Lipoproteins, HDL; Progesterone; Rats	1986
In vivo catabolism of human low density lipoprotein in the rat is mediated by a nonsaturable, low-affinity mechanism. FEBS letters, 1985, Apr-08, Volume: 183, Issue:1 Topics: Adenine; Adrenal Glands; Animals; Cholesterol; Fasting; Half-Life; Humans; Iodine Radioisotopes; Iodobenzoates; Lipoproteins, LDL; Liver; Male; Rats; Rats, Inbred Strains; Spleen	1985
Inhibition of gonadotropin-releasing hormone release as the basis of pituitary-gonadal dysfunction during treatment with 4-aminopyrazolo-(3,4-d)-pyrimidine. Endocrinology, 1985, Volume: 116, Issue:5 Topics: Adenine; Animals; Castration; Female; Gonads; Luteinizing Hormone; Male; Naloxone; Pituitary Gland; Pituitary Hormone-Releasing Hormones; Rats; Rats, Inbred Strains	1985
Regulation of luteal cell 3-hydroxy-3-methylglutaryl coenzyme A reductase activity by estradiol. Biology of reproduction, 1985, Volume: 32, Issue:2 Topics: Adenine; Animals; Cholesterol; Cholesterol Esters; Corpus Luteum; Estradiol; Female; Hydroxymethylglutaryl CoA Reductases; NADPH-Ferrihemoprotein Reductase; Pregnancy; Rats; Testosterone	1985
Ultrastructural studies in 4-aminopyrazolopyrimidine (4-APP)-induced fatty liver. The Tokai journal of experimental and clinical medicine, 1985, Volume: 10, Issue:1 Topics: Adenine; Animals; Endoplasmic Reticulum; Fatty Liver; Golgi Apparatus; Lipids; Lipoproteins; Liver; Male; Microscopy, Electron; Mitochondria, Liver; Rats; Rats, Inbred Strains; Ribosomes	1985
Neurotensin and substance P: differential effects on plasma cholesterol levels in conscious ovariectomized rats. Regulatory peptides, 1981, Volume: 2, Issue:4 Topics: Adenine; Adrenalectomy; Animals; Castration; Cholesterol; Female; Gonadotropin-Releasing Hormone; Male; Neurotensin; Rats; Substance P	1981
Differential metabolism of allopurinol and derivatives in Trypanosoma rangeli and T. cruzi culture forms. Molecular and biochemical parasitology, 1981, Dec-31, Volume: 4, Issue:5-6 Topics: Adenine; Adenylosuccinate Synthase; Allopurinol; Animals; RNA; Trypanosoma; Trypanosoma cruzi	1981
Substance P and neurotensin: opposite effects on plasma cholesterol levels in ovariectomized conscious rats. Experientia, 1982, Jul-15, Volume: 38, Issue:7 Topics: Adenine; Animals; Anticholesteremic Agents; Castration; Cholesterol; Female; Liver; Neurotensin; Rats; Substance P	1982
Regulation of adrenal and testicular prolactin receptors by adrenocorticotropin and luteinizing hormone. Endocrinology, 1981, Volume: 108, Issue:6 Topics: 8-Bromo Cyclic Adenosine Monophosphate; Adenine; Adrenal Cortex; Adrenocorticotropic Hormone; Animals; Corticosterone; Cyclic AMP; Cycloheximide; Luteinizing Hormone; Male; Rats; Receptors, Cell Surface; Receptors, Prolactin; Testis; Testosterone	1981
Uptake of lipoproteins by in situ perfused rat ovaries: identification of binding sites for high density lipoproteins. The Journal of cell biology, 1983, Volume: 97, Issue:3 Topics: Adenine; Animals; Biological Transport; Carrier Proteins; Female; Lipoproteins, HDL; Ovary; Progestins; Rats; Receptors, Cell Surface; Receptors, Lipoprotein; RNA-Binding Proteins	1983
Regulation of cholesterol metabolism in rat adrenal glands: effect of adrenocorticotropin, cholesterol, and corticosteroids on acyl-coenzyme A synthetase and cholesterol ester hydrolases. Endocrinology, 1984, Volume: 114, Issue:1 Topics: Adenine; Adrenal Glands; Adrenocorticotropic Hormone; Animals; Anticholesteremic Agents; Carboxylic Ester Hydrolases; Cholesterol; Coenzyme A Ligases; Dexamethasone; Kinetics; Male; Rats; Rats, Inbred Strains; Sterol Esterase	1984
Correlation of lipid droplet content and steroidogenic capacity in zona glomerulosa and fasciculata cells from lipoprotein-deficient rats. Molecular and cellular endocrinology, 1984, Volume: 34, Issue:1 Topics: Adenine; Adrenal Cortex; Adrenocorticotropic Hormone; Aldosterone; Animals; Corticosterone; Hypolipoproteinemias; Lipids; Male; Microscopy, Electron; Rats	1984
Pyrazolopyrimidine metabolism in Leishmania and trypanosomes: significant differences between host and parasite. Journal of cellular biochemistry, 1983, Volume: 22, Issue:3 Topics: Adenine; Allopurinol; Animals; Formycins; Host-Parasite Interactions; Leishmania; Ribonucleosides; Thionucleosides; Trypanosoma cruzi	1983
Differences in allopurinol and 4-aminopyrazolo(3,4-d) pyrimidine metabolism in drug-sensitive and insensitive strains of Trypanosoma cruzi. Molecular and biochemical parasitology, 1984, Volume: 11 Topics: Adenine; Allopurinol; Animals; Drug Resistance, Microbial; Species Specificity; Trypanosoma cruzi	1984
Inhibition of pituitary gonadotropin secretion by 4-aminopyrazolo(3,4-d) pyrimidine. Endocrinology, 1983, Volume: 112, Issue:6 Topics: Adenine; Animals; Cholesterol; Chorionic Gonadotropin; Follicle Stimulating Hormone; Growth Hormone; Kinetics; Luteinizing Hormone; Male; Pituitary Gland; Prolactin; Rats; Testosterone; Thyrotropin	1983
Trypanosoma cruzi: 4-aminopyrazolopyrimidine in the treatment of experimental Chagas' disease. Experimental parasitology, 1983, Volume: 56, Issue:2 Topics: Adenine; Animals; Antiprotozoal Agents; Chagas Disease; Liver; Mice; Mice, Inbred C57BL; Spleen; Trypanosoma cruzi	1983
Efficacy of pyrazolopyrimidine ribonucleosides against Trypanosoma cruzi: studies in vitro and in vivo with sensitive and resistant strains. The Journal of infectious diseases, 1984, Volume: 150, Issue:4 Topics: Adenine; Allopurinol; Animals; Antiprotozoal Agents; Chagas Disease; Drug Resistance; Formycins; Inosine; Mice; Mice, Inbred DBA; Ribonucleosides; Thionucleosides; Trypanosoma cruzi	1984
Ultrastructural changes in rat adrenocortical cells produced by a 4-aminopyrazolopyrimidine (4-APP) dosage. Cell structure and function, 1984, Volume: 9, Issue:1 Topics: Adenine; Adrenal Cortex; Animals; Anticholesteremic Agents; Cytoplasm; Endoplasmic Reticulum; Lipid Metabolism; Male; Microscopy, Electron; Mitochondria; Rats; Rats, Inbred Strains	1984
Selective reduction of phosphatidylglycerol and phosphatidylcholine in pulmonary surfactant by 4-aminopyrazolo(3,4d)pyrimidine in the rat. Journal of lipid research, 1980, Volume: 21, Issue:8 Topics: Adenine; Animals; Body Weight; Cholesterol; Chromatography, Thin Layer; Fasting; Female; Gas Chromatography-Mass Spectrometry; Phosphatidylcholines; Phosphatidylglycerols; Phospholipids; Pulmonary Surfactants; Rats; Surface Tension	1980
Comparative effects of 4-aminopyrazolopyrimidine, its 2'-deoxyriboside derivative, and allopurinol on in vitro growth of American Leishmania species. Antimicrobial agents and chemotherapy, 1982, Volume: 22, Issue:3 Topics: Adenine; Allopurinol; Animals; Antiprotozoal Agents; Deoxyadenosines; Leishmania; Leishmaniasis, Mucocutaneous	1982
Effect of low density and high density lipoproteins on progesterone secretion by dispersed corpora luteal cells from rats treated with aminopyrazolo-(3,4-d)pyrimidine. Endocrinology, 1982, Volume: 110, Issue:5 Topics: Adenine; Animals; Cell Survival; Corpus Luteum; Female; Humans; In Vitro Techniques; Kinetics; Lipoproteins; Lipoproteins, HDL; Lipoproteins, LDL; Lipoproteins, VLDL; Male; Progesterone; Rats; Rats, Inbred Strains	1982
Receptor mediated gonadotropin action in gonadal tissues: relationship between blood cholesterol levels and gonadotropin stimulated steroidogenesis in isolated rat Leydig and luteal cells. Journal of steroid biochemistry, 1982, Volume: 16, Issue:2 Topics: Adenine; Animals; Cholesterol; Corpus Luteum; Female; Gonadotropins, Pituitary; Leydig Cells; Lipoproteins; Male; Polyethylene Glycols; Rats; Rats, Inbred Strains; Steroids; Time Factors	1982
Uptake of high density lipoproteins by rat ovaries in vivo and dispersed ovarian cells in vitro. Direct correlation of high density lipoprotein uptake with steroidogenic activity. Journal of steroid biochemistry, 1982, Volume: 16, Issue:4 Topics: Adenine; Animals; Binding Sites; Cell Membrane; Cholesterol; Chorionic Gonadotropin; Female; Gonadotropins, Equine; Humans; Lipoproteins, HDL; Lipoproteins, LDL; Ovary; Progestins; Rats	1982
Zonal differences in the distribution and morphology of lipid droplets using 4-amino-pyrazolo-(3,4 d) pyrimidine to lower cholesterol level in the rat adrenal. Acta biologica Academiae Scientiarum Hungaricae, 1980, Volume: 31, Issue:1-3 Topics: Adenine; Adrenal Glands; Animals; Cholesterol; Lipid Metabolism; Male; Microscopy, Electron; Rats	1980
Relative contributions of parenchymal and non-parenchymal (sinusoidal) liver cells in the uptake of chylomicron remnants. Metabolism: clinical and experimental, 1981, Volume: 30, Issue:8 Topics: Adenine; Animals; Apolipoproteins; Apolipoproteins B; Chylomicrons; Leucine; Liver; Lymph; Male; Methods; Rats; Tritium	1981
The effect of decreased plasma cholesterol concentration on circulatinga mevalonate metabolism in rats. Journal of lipid research, 1981, Volume: 22, Issue:6 Topics: Adenine; Animals; Body Weight; Cholesterol; Female; Kidney; Liver; Mevalonic Acid; Nephrectomy; Organ Size; Polyethylene Glycols; Rats	1981
Lipid absorption in unanesthetized, unrestrained rats. Effects of 4-aminopyrazolopyrimidine and ethinyl estradiol. Biochimica et biophysica acta, 1981, Jul-24, Volume: 665, Issue:1 Topics: Adenine; Animals; Cholesterol; Ethinyl Estradiol; Intestinal Absorption; Male; Rats; Tissue Distribution; Triglycerides	1981
Binding of human high density lipoproteins to membranes of luteinized rat ovaries. Journal of steroid biochemistry, 1981, Volume: 14, Issue:8 Topics: Adenine; Animals; Cell Membrane; Chorionic Gonadotropin; Corpus Luteum; Female; Gonadotropins, Equine; Humans; Kinetics; Lipoproteins, HDL; Ovary; Rats	1981
Hormonal modulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity in gonadotropin-stimulated and -desensitized testicular Leydig cells. The Journal of biological chemistry, 1981, Dec-25, Volume: 256, Issue:24 Topics: Adenine; Animals; Cholesterol; Chorionic Gonadotropin; Hydroxymethylglutaryl CoA Reductases; Kinetics; Leydig Cells; Luteinizing Hormone; Male; Pituitary Gland; Pregnenolone; Rats; Testosterone	1981
Effects of hypocholesterolemia and chronic hormonal stimulation on sterol and steroid metabolism in a Leydig cell tumor. Journal of lipid research, 1981, Volume: 22, Issue:8 Topics: Adenine; Animals; Cholesterol; Chorionic Gonadotropin; Dyslipidemias; Kinetics; Leydig Cell Tumor; Male; Mice; Mice, Inbred C57BL; Neoplasms, Experimental; Steroids; Sterols; Testicular Neoplasms	1981
Tissue distribution of high-density lipoprotein labeled with radioiodinated cholesterol. Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 1980, Volume: 21, Issue:9 Topics: Adenine; Adrenal Glands; Animals; Cholesterol; Female; Iodine Radioisotopes; Isotope Labeling; Lipoproteins, HDL; Rats; Thyroid Gland; Tissue Distribution	1980
Regulation of ovarian cholesterol metabolism: control of 3-hydroxy-3-methylglutaryl coenzyme A reductase and acyl coenzyme A:cholesterol acyltransferase. Endocrinology, 1981, Volume: 108, Issue:4 Topics: Acyltransferases; Adenine; Aminoglutethimide; Animals; Cholesterol; Chorionic Gonadotropin; Female; Gonadotropins, Equine; Hydroxymethylglutaryl CoA Reductases; Hypercholesterolemia; Kinetics; Luteinizing Hormone; Microsomes; Ovary; Progesterone; Rats; Sterol O-Acyltransferase	1981
Role for circulating lipoproteins in protection from endotoxin toxicity. Infection and immunity, 1995, Volume: 63, Issue:5 Topics: Adenine; Animals; Endotoxins; Estradiol; Humans; Hypolipidemic Agents; Lipopolysaccharides; Lipoproteins; Liver; Male; Rats; Rats, Sprague-Dawley; Shock, Septic; Tumor Necrosis Factor-alpha	1995
Effect of age on cholesterol uptake and utilization by rat adrenals: I. Internalization of lipoprotein-derived cholesteryl esters. Mechanisms of ageing and development, 1994, Nov-25, Volume: 77, Issue:1 Topics: Adenine; Adrenal Cortex; Aging; Animals; Anticholesteremic Agents; Cells, Cultured; Cholesterol; Cholesterol Esters; Cholesterol, HDL; Corticosterone; Male; Rats; Rats, Sprague-Dawley	1994
Nerve regeneration and cholesterol reutilization occur in the absence of apolipoproteins E and A-I in mice. Journal of neurochemistry, 1995, Volume: 64, Issue:1 Topics: Adenine; Animals; Anticholesteremic Agents; Apolipoprotein A-I; Apolipoproteins E; Autoradiography; Blotting, Northern; Cholesterol; Lipoproteins; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Nerve Regeneration; Sciatic Nerve	1995
Ovarian vitamin E accumulation: evidence for a role of lipoproteins. Endocrinology, 1994, Volume: 135, Issue:2 Topics: Adenine; Animals; Anticholesteremic Agents; Cholesterol Esters; Corpus Luteum; Female; Lipoproteins; Luteolysis; Ovary; Ovulation; Progesterone; Rats; Receptors, Lipoprotein; Vitamin E	1994
Influence of altered serum cholesterol levels and fasting on cutaneous cholesterol synthesis. The Journal of investigative dermatology, 1994, Volume: 102, Issue:5 Topics: Adenine; Animals; Anticholesteremic Agents; Cholesterol; Fasting; Male; Mice; Mice, Hairless; Skin; Starvation; Time Factors	1994
Nephrotoxicity induced by a single dose of adenine: effects of 4-aminopyrazolo[3,4-d]pyrimidine and allopurinol. Biological & pharmaceutical bulletin, 1994, Volume: 17, Issue:2 Topics: Adenine; Administration, Oral; Allopurinol; Animals; Blood Urea Nitrogen; Creatinine; Dose-Response Relationship, Drug; Kidney Tubules, Proximal; Male; Mice	1994
Role of metallothionein in 4-aminopyrazolo[3,4-d]pyrimidine-administered mouse pancreas. Biological & pharmaceutical bulletin, 1993, Volume: 16, Issue:11 Topics: Adenine; alpha-Amylases; Animals; Anticholesteremic Agents; Dose-Response Relationship, Drug; Insulin; Male; Metallothionein; Mice; Pancreas; Zinc	1993
The effect of 4-aminopyrazolo(3,4-d) pyrimidine on mouse plasma alpha-amylase activity. International journal of pancreatology : official journal of the International Association of Pancreatology, 1993, Volume: 13, Issue:3 Topics: Adenine; alpha-Amylases; Animals; Anticholesteremic Agents; Cholesterol; Dimethyl Sulfoxide; Lipid Peroxides; Male; Mice; Pancreas; Superoxide Dismutase	1993
Cholesterol ester in corpus luteum of rat observed by analytical color fluorescence electron microscopy. The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, 1993, Volume: 41, Issue:4 Topics: Adenine; Animals; Cholesterol Esters; Corpus Luteum; Estrus; Female; Fluorescence; Gonadotropins, Equine; Hypophysectomy; Luteinizing Hormone; Microscopy, Electron; Microscopy, Fluorescence; Pregnancy; Rats; Rats, Wistar	1993
Cholesterol synthesis in regenerating peripheral nerve is not influenced by serum cholesterol levels. Journal of neurochemistry, 1993, Volume: 60, Issue:4 Topics: Adenine; Animals; Anticholesteremic Agents; Cholesterol; Hydroxymethylglutaryl CoA Reductases; Kidney; Nerve Crush; Nerve Regeneration; Peripheral Nerves; Rats; Sciatic Nerve	1993
Effect of hypocholesterolemic doses of 17 alpha-ethinyl estradiol on cholesterol balance in liver and extrahepatic tissues. Journal of lipid research, 1996, Volume: 37, Issue:8 Topics: Adenine; Adrenal Glands; Animals; Anticholesteremic Agents; Cholesterol; Estradiol Congeners; Ethinyl Estradiol; Female; Liver; Ovary; Rats; Rats, Sprague-Dawley; Receptors, LDL; Spleen; Tissue Distribution	1996
Bindings of metallothionein to supranucleosomal fibers in mouse pancreatic nuclei after induction by 4-aminopyrazolo [3,4-D] pyrimidine. Cellular and molecular biology (Noisy-le-Grand, France), 1996, Volume: 42, Issue:8 Topics: Adenine; Animals; Cell Compartmentation; Cell Nucleus; Endoplasmic Reticulum, Rough; Enzyme Induction; Metallothionein; Mice; Mice, Inbred Strains; Microscopy, Immunoelectron; Nucleosomes; Pancreas; Protein Binding	1996
Effect of lowering serum cholesterol on the composition of surfactant in adult rat lung. The American journal of physiology, 1997, Volume: 272, Issue:1 Pt 1 Topics: Adenine; Animals; Anticholesteremic Agents; Cholesterol; In Vitro Techniques; Lipids; Lovastatin; Lung; Lung Compliance; Male; Organ Size; Phospholipids; Proteolipids; Pulmonary Surfactant-Associated Proteins; Pulmonary Surfactants; Rats; Rats, Inbred Strains; Simvastatin; Surface Tension	1997
Effects of reduced maternal lipoprotein-cholesterol availability on placental progesterone biosynthesis in the baboon. Endocrinology, 1997, Volume: 138, Issue:4 Topics: Adenine; Animals; Anticholesteremic Agents; Cholesterol, LDL; Female; Glyceraldehyde-3-Phosphate Dehydrogenases; Hydroxymethylglutaryl CoA Reductases; Papio; Placenta; Pregnancy; Progesterone; Receptors, LDL; RNA, Messenger; Sterol O-Acyltransferase; Trophoblasts	1997
The N(8)-(2'-deoxyribofuranoside) of 8-aza-7-deazaadenine: a universal nucleoside forming specific hydrogen bonds with the four canonical DNA constituents. Nucleic acids research, 2000, Sep-01, Volume: 28, Issue:17 Topics: Adenine; Base Pairing; Base Sequence; Circular Dichroism; Deoxyadenosines; DNA; Glycosylation; Half-Life; Hydrogen Bonding; Magnetic Resonance Spectroscopy; Nitrogen; Nucleic Acid Denaturation; Nucleic Acid Hybridization; Oligodeoxyribonucleotides; Spectrophotometry, Ultraviolet; Temperature; Thermodynamics	2000
A survey of adenine and 4-aminopyrazolo[3,4-d]pyrimidine (4-APP) as inhibitors of ribosome-inactivating proteins (RIPs). Life sciences, 2000, Dec-08, Volume: 68, Issue:3 Topics: Adenine; Animals; Artemia; N-Glycosyl Hydrolases; Plant Extracts; Plant Proteins; Protein Synthesis Inhibitors; Ribosome Inactivating Proteins; Ribosomes; Shiga Toxin	2000
Effects of 4-aminopyrazolo (3,4-d)pyrimidine and 1-methyl-4-aminopyrazolo(3,4-d)pyrimidine on nucleic acid purine metabolism in ascites tumors. Cancer research, 1961, Volume: 21 Topics: Adenine; Ascites; Neoplasms; Nucleic Acids; Purines; Pyrimidines	1961
The metabolism of 4-aminopyrazolo(3,4-d)pyrimidine in normal and neoplastic tissues. Cancer research, 1961, Volume: 21 Topics: Adenine; Neoplasms; Pyrimidines	1961
POTENTIAL PURINE ANTAGONISTS. 32. THE SYNTHESIS AND ANTITUMOR ACTIVITY OF CERTAIN COMPOUNDS RELATED TO 4-AMINOPYRAZOLO(3,4-D)PYRIMIDINE. Journal of medicinal and pharmaceutical chemistry, 1962, Volume: 5 Topics: Adenine; Adenocarcinoma; Antineoplastic Agents; Chemical Phenomena; Chemistry; Pharmacology; Purines; Pyrazoles; Pyrimidines; Research	1962
6-Azauracil or 8-aza-7-deazaadenine nucleosides and oligonucleotides: the effect of 2'-fluoro substituents and nucleobase nitrogens on conformation and base pairing. Organic & biomolecular chemistry, 2008, Feb-07, Volume: 6, Issue:3 Topics: Adenine; Base Pairing; Base Sequence; Crystallography, X-Ray; DNA; Hydrogen-Ion Concentration; Magnetic Resonance Spectroscopy; Nitrogen; Nucleic Acid Denaturation; Nucleosides; Oligonucleotides; Organophosphorus Compounds; RNA; Stereoisomerism; Transition Temperature; Uracil	2008
Clinical grade production and characterization of a fusion protein comprised of the chemokine CCL2-ligand genetically fused to a mutated and truncated form of the Shiga A1 subunit. Protein expression and purification, 2009, Volume: 66, Issue:2 Topics: Adenine; Amino Acid Sequence; Cell Proliferation; Cell Survival; Chemokine CCL2; Chromatography; Escherichia coli; Humans; Molecular Sequence Data; Protein Binding; Protein Synthesis Inhibitors; Recombinant Fusion Proteins; Ribosomes; Shiga Toxin	2009
Synthesis and characterization of two novel organic-inorganic compounds based on tetrahexyl and tetraheptyl ammonium ions and the Preyssler anion and their catalytic activities in the synthesis of 4-aminopyrazolo[3,4-d]- pyrimidines. Molecules (Basel, Switzerland), 2010, Apr-08, Volume: 15, Issue:4 Topics: Adenine; Catalysis; Conductometry; Potentiometry; Pyrimidines; Quaternary Ammonium Compounds; Spectrophotometry, Infrared; Spectrophotometry, Ultraviolet; Thermogravimetry; Tungsten Compounds	2010
Azide-alkyne "click" conjugation of 8-aza-7-deazaadenine-DNA: synthesis, duplex stability, and fluorogenic dye labeling. Bioconjugate chemistry, 2010, Sep-15, Volume: 21, Issue:9 Topics: Adenine; Alkynes; Azides; Base Pairing; DNA; DNA, Single-Stranded; Fluorescent Dyes; Molecular Dynamics Simulation; Nucleic Acid Denaturation; Oligonucleotides; Organophosphorus Compounds; Spectrometry, Fluorescence; Staining and Labeling; Temperature	2010
Substituted 4-amino-1H-pyrazolo[3,4-d]pyrimidines as multi-targeted inhibitors of insulin-like growth factor-1 receptor (IGF1R) and members of ErbB-family receptor kinases. Bioorganic & medicinal chemistry letters, 2010, Oct-15, Volume: 20, Issue:20 Topics: Adenine; Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; ErbB Receptors; Humans; Mice; Mice, Inbred C57BL; Neoplasms; Rats; Receptor, ErbB-2; Receptor, IGF Type 1; Structure-Activity Relationship	2010
Spectroscopic, electronic structure and natural bond analysis of 2-aminopyrimidine and 4-aminopyrazolo[3,4-d]pyrimidine: a comparative study. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 2012, Volume: 96 Topics: Adenine; Electrons; Kinetics; Magnetic Resonance Spectroscopy; Models, Molecular; Molecular Conformation; Pyrimidines; Rotation; Spectrophotometry, Ultraviolet; Spectroscopy, Fourier Transform Infrared; Spectrum Analysis, Raman; Stereoisomerism; Thermodynamics; Vibration	2012
Influence of PNA containing 8-aza-7-deazaadenine on structure stability and binding affinity of PNA·DNA duplex: insights from thermodynamics, counter ion, hydration and molecular dynamics analysis. Molecular bioSystems, 2013, Volume: 9, Issue:7 Topics: Adenine; Circular Dichroism; DNA; Hydrogen Bonding; Ions; Molecular Dynamics Simulation; Nucleic Acid Conformation; Peptide Nucleic Acids; Thermodynamics	2013
Studies on 4-aminopyrazolo(3,4-d)pyrimidine: action of derivatives and analogues on hela cells. Antibiotics & chemotherapy (Northfield, Ill.), 1959, Volume: 9, Issue:6 Topics: Adenine; HeLa Cells; Humans; Pyrimidines; Tissue Culture Techniques	1959
Anti-parallel triplexes: Synthesis of 8-aza-7-deazaadenine nucleosides with a 3-aminopropynyl side-chain and its corresponding LNA analog. Bioorganic & medicinal chemistry, 2015, May-15, Volume: 23, Issue:10 Topics: Adenine; Base Pairing; Base Sequence; Drug Stability; Hydrogen Bonding; Hydrogen-Ion Concentration; Molecular Conformation; Molecular Sequence Data; Oligonucleotides; Organophosphorus Compounds; Propylamines	2015
Structural and Energetic Impact of Non-Natural 7-Deaza-8-Azaadenine and Its 7-Substituted Derivatives on H-Bonding Potential with Uracil in RNA Molecules. The journal of physical chemistry. B, 2015, Oct-15, Volume: 119, Issue:41 Topics: Adenine; Hydrogen Bonding; Molecular Structure; RNA; Thermodynamics; Uracil	2015
Using NMR and molecular dynamics to link structure and dynamics effects of the universal base 8-aza, 7-deaza, N8 linked adenosine analog. Nucleic acids research, 2016, Oct-14, Volume: 44, Issue:18 Topics: Adenine; Base Sequence; Carbon-13 Magnetic Resonance Spectroscopy; Glycosides; Molecular Dynamics Simulation; Nuclear Magnetic Resonance, Biomolecular; Protons; Thermodynamics; Time Factors	2016
Silver-Mediated Base Pairs in DNA Incorporating Purines, 7-Deazapurines, and 8-Aza-7-deazapurines: Impact of Reduced Nucleobase Binding Sites and an Altered Glycosylation Position. Chemistry (Weinheim an der Bergstrasse, Germany), 2017, Apr-24, Volume: 23, Issue:23 Topics: Adenine; Base Pairing; Binding Sites; Circular Dichroism; DNA; Glycosylation; Nucleosides; Oligonucleotides; Purines; Silver	2017
Identification of 4-Aminopyrazolopyrimidine Metabolite That May Contribute to the Hypolipidemic Effects of LY2584702 in Long Evans Diet-Induced Obese Rats. The Journal of pharmacology and experimental therapeutics, 2017, Volume: 362, Issue:1 Topics: Adenine; Animals; Cholesterol, LDL; Cholesterol, VLDL; Gene Expression Regulation; Hep G2 Cells; Humans; Hypolipidemic Agents; Lipid Metabolism; Lipoproteins, LDL; Liver; Male; Obesity; Pyrazoles; Pyrimidines; Rats; Rats, Long-Evans; Triglycerides	2017