Adie Syndrome

A syndrome characterized by a TONIC PUPIL that occurs in combination with decreased lower extremity reflexes. The affected pupil will respond more briskly to accommodation than to light (light-near dissociation) and is supersensitive to dilute pilocarpine eye drops, which induce pupillary constriction. Pathologic features include degeneration of the ciliary ganglion and postganglionic parasympathetic fibers that innervate the pupillary constrictor muscle. (From Adams et al., Principles of Neurology, 6th ed, p279)

Synonyms(4)

Synonym
Adie Syndrome
Holmes-Adie Syndrome
Adie's Syndrome
Poorly Reacting Pupils

Research Excerpts

Overview

Excerpt	Reference
"Adie's syndrome is a disease of unknown etiology."	( Thompson, HS, 1977)

Context

Excerpt	Reference
"The pathogenesis of Adie's syndrome has so far not been definitely established."	( Vogir, R, 1976)

Treatment

Excerpt	Reference
"Our study suggests those patients with Adie's Syndrome who lack stereoacuity may benefit from long term therapy with dilute pilocarpine if their stereoacuity may benefit from long term therapy with dilute pilocarpine if their stereoacuity improves following a single drop of 0."	( Dolan, BJ; Flach, AJ, 1985)

Research

Studies (79)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	62 (78.48)	23.3326
1990's	6 (7.59)	12.5806
2000's	1 (1.27)	18.1394
2010's	7 (8.86)	28.8240
2020's	3 (3.80)	9.53

Drug	Relationship Strength	Studies	Trials
chlorine	low	1	0
creatine	low	1	0
melatonin	low	1	0
guanethidine	low	2	0
p-hydroxyamphetamine	low	1	0
2-propanol	medium	12	1
moxisylyte	low	1	0
neostigmine	low	1	0
procaine	low	2	0
tyramine	low	1	0
carbachol	low	2	0
aldosterone	low	1	0
prednisone	low	1	0
penicillin g	low	1	0
pilocarpine	low	23	0
physostigmine	low	2	0
phenylephrine	low	3	0
methacholine chloride	low	5	0
fludrocortisone	low	1	0
fomesafen	low	19	0
6-sulfatoxymelatonin	low	1	0
fluorodeoxyglucose f18	low	1	0
angiotensin ii	low	2	0
atropine	low	1	0
bradykinin	low	1	0
strychnine	low	1	0
cocaine	low	4	0
methylcellulose	low	1	0
cyclic gmp	low	2	0
eye	low	5	0

Protein Targets (436)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
hypoxia-inducible factor 1 alpha subunit	2	0	0	2
RAR-related orphan receptor gamma	4	0	0	4
GLI family zinc finger 3	6	0	0	6
AR protein	8	0	0	8
aldehyde dehydrogenase 1 family, member A1	5	0	0	5
retinoic acid nuclear receptor alpha variant 1	3	0	0	3
retinoid X nuclear receptor alpha	3	0	0	3
estrogen nuclear receptor alpha	7	0	0	7
peroxisome proliferator-activated receptor delta	1	0	0	1
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	4	0	0	4
activating transcription factor 6	1	0	0	1
v-jun sarcoma virus 17 oncogene homolog (avian)	4	0	0	4
Histone H2A.x	2	0	0	2
thyroid hormone receptor beta isoform a	2	0	0	2
heat shock protein beta-1	1	0	0	1
nuclear factor erythroid 2-related factor 2 isoform 1	4	0	0	4
lamin isoform A-delta10	6	0	0	6
Voltage-dependent calcium channel gamma-2 subunit	1	0	0	1
Glutamate receptor 2	1	0	0	1
glucocorticoid receptor [Homo sapiens]	7	0	0	7
nuclear factor erythroid 2-related factor 2 isoform 2	3	0	0	3
geminin	6	0	0	6
Sex hormone-binding globulin	0	0	1	1
Corticosteroid-binding globulin	0	1	0	1
Mineralocorticoid receptor	0	1	2	3
Androgen receptor	0	1	0	1
Mineralocorticoid receptor	0	1	0	1
Solute carrier organic anion transporter family member 1A1	0	0	0	1
Guanine nucleotide-binding protein G	2	0	0	2
glucocerebrosidase	1	0	0	1
DNA polymerase kappa isoform 1	1	0	0	1
histone acetyltransferase KAT2A isoform 1	5	0	0	5
Atrial natriuretic peptide receptor 3	0	1	0	1
Type-1A angiotensin II receptor	0	2	1	3
Type-1 angiotensin II receptor	0	0	1	1
Type-1B angiotensin II receptor	0	2	0	2
Type-1 angiotensin II receptor	0	2	2	4
Type-2 angiotensin II receptor	0	2	0	2
Type-2 angiotensin II receptor	0	2	0	2
Chain A, 2-oxoglutarate Oxygenase	5	0	0	5
nuclear receptor subfamily 1, group I, member 3	3	0	0	3
pregnane X nuclear receptor	6	0	0	6
cystic fibrosis transmembrane conductance regulator	0	1	0	1
DNA polymerase beta	2	0	0	2
short transient receptor potential channel 6 isoform 1	0	0	1	1
Solute carrier family 22 member 1	0	1	0	2
ATP-binding cassette sub-family C member 3	0	4	0	4
Multidrug resistance-associated protein 4	0	4	0	5
5-hydroxytryptamine receptor 4	0	2	0	2
Bile salt export pump	0	8	0	8
Muscarinic acetylcholine receptor M2	0	5	4	13
Muscarinic acetylcholine receptor M4	0	4	3	10
Muscarinic acetylcholine receptor M1	0	7	2	14
Muscarinic acetylcholine receptor M3	0	6	2	12
Muscarinic acetylcholine receptor M4	0	6	1	11
Muscarinic acetylcholine receptor M5	0	6	1	11
Muscarinic acetylcholine receptor M5	0	5	3	11
Muscarinic acetylcholine receptor M2	0	7	1	13
Muscarinic acetylcholine receptor M1	0	5	5	14
Muscarinic acetylcholine receptor M1	0	1	2	4
Muscarinic acetylcholine receptor M3	0	4	3	10
Alpha-1D adrenergic receptor	0	2	0	2
5-hydroxytryptamine receptor 2C	0	2	0	2
Muscarinic acetylcholine receptor M4	0	1	0	1
Histamine H2 receptor	1	0	0	2
5-hydroxytryptamine receptor 7	0	1	0	1
Reverse transcriptase/RNaseH	0	0	0	1
Muscarinic acetylcholine receptor	0	3	1	4
Canalicular multispecific organic anion transporter 1	0	4	0	4
Angiotensin-converting enzyme	0	0	0	1
B2 bradykinin receptor	0	1	0	1
B2 bradykinin receptor	0	2	1	5
B1 bradykinin receptor	0	1	0	1
Olfactory receptor 51E2	0	0	1	1
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	3	0	0	3
Chain A, Beta-lactamase	1	0	0	1
acetylcholinesterase	2	0	0	2
GALC protein	3	0	0	3
TDP1 protein	7	0	0	7
peroxisome proliferator activated receptor gamma	2	0	0	2
IDH1	2	0	0	2
thyroid stimulating hormone receptor	2	0	0	2
thyrotropin-releasing hormone receptor	2	0	0	2
Bloom syndrome protein isoform 1	4	0	0	4
chromobox protein homolog 1	3	0	0	3
Neuronal acetylcholine receptor subunit alpha-3	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-4	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-2	0	1	0	1
Neuronal acetylcholine receptor subunit beta-2	0	1	0	1
Neuronal acetylcholine receptor subunit beta-3	0	1	0	1
Neuronal acetylcholine receptor subunit beta-4	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-5	0	1	0	1
Delta-type opioid receptor	0	1	0	2
Neuronal acetylcholine receptor subunit alpha-6	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-9	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-7	0	1	0	1
Sigma non-opioid intracellular receptor 1	0	0	1	1
Muscarinic acetylcholine receptor M3	0	0	1	3
Muscarinic acetylcholine receptor M2	0	0	0	3
Neuronal acetylcholine receptor subunit alpha-10	0	1	0	1
Carbonic anhydrase 1	0	1	0	1
Carbonic anhydrase 2	0	1	0	1
Carbonic anhydrase 4	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase 15	0	1	0	1
Chain A, CHIMERA OF IG KAPPA CHAIN: HUMAN CONSTANT REGION AND MOUSE VARIABLE REGION	0	0	1	1
Chain B, CHIMERA OF IG GAMMA-1 CHAIN: HUMAN CONSTANT REGION AND MOUSE VARIABLE REGION	0	0	1	1
Chain H, Fab M82G2, Heavy chain	0	0	1	1
Chain L, Fab M82G2, Light chain	0	0	1	1
Chain H, Fab M82g2, Heavy Chain	0	0	1	1
Chain L, Fab M82g2, Light Chain	0	0	1	1
Gamma-aminobutyric acid receptor subunit pi	0	1	0	1
Gamma-aminobutyric acid receptor subunit delta	0	1	0	1
Amyloid-beta precursor protein	0	1	0	1
Fatty acid-binding protein, heart	0	1	0	1
Muscarinic acetylcholine receptor M2	0	1	0	1
5-hydroxytryptamine receptor 2C	0	2	1	3
Tryptophan 5-hydroxylase 1	0	1	0	1
5-hydroxytryptamine receptor 2A	0	2	1	3
Gamma-aminobutyric acid receptor subunit alpha-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-2	0	1	0	1
D	0	1	0	1
5-hydroxytryptamine receptor 1A	0	1	1	2
Alpha-2B adrenergic receptor	0	2	0	2
Alpha-2C adrenergic receptor	0	2	0	2
Alpha-2A adrenergic receptor	0	2	0	2
Liver carboxylesterase 1	0	0	0	1
Sodium-dependent noradrenaline transporter	0	2	0	2
Sodium-dependent dopamine transporter	0	2	0	2
cAMP-specific 3',5'-cyclic phosphodiesterase 4A	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-3	0	1	0	1
5-hydroxytryptamine receptor 1B	0	1	1	2
5-hydroxytryptamine receptor 1D	0	1	1	2
5-hydroxytryptamine receptor 1F	0	1	1	2
5-hydroxytryptamine receptor 2B	0	2	1	3
5-hydroxytryptamine receptor 6	0	1	1	2
Gamma-aminobutyric acid receptor subunit alpha-5	0	1	0	1
Sodium-dependent serotonin transporter	0	2	0	2
Sodium-dependent serotonin transporter	0	2	0	3
5-hydroxytryptamine receptor 7	0	1	1	2
Gamma-aminobutyric acid receptor subunit alpha-3	0	1	0	1
5-hydroxytryptamine receptor 5A	0	1	1	2
5-hydroxytryptamine receptor 5B	0	1	1	2
Glutamate receptor ionotropic, NMDA 1	0	1	0	1
5-hydroxytryptamine receptor 3A	0	1	1	2
Lysosomal Pro-X carboxypeptidase	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-2	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-2	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-4	0	1	0	1
D(2) dopamine receptor	0	1	0	1
Gamma-aminobutyric acid receptor subunit epsilon	0	1	0	1
Glutamate receptor ionotropic, NMDA 2A	0	1	0	1
Glutamate receptor ionotropic, NMDA 2B	0	1	0	1
Glutamate receptor ionotropic, NMDA 2C	0	1	0	1
Sodium-dependent dopamine transporter	0	2	0	2
cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	1	0	1
Potassium voltage-gated channel subfamily H member 2	0	3	0	3
Leukotriene B4 receptor 1	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	0	1	0	1
Sodium-dependent dopamine transporter	0	2	0	2
Glutamate receptor ionotropic, NMDA 2D	0	1	0	1
5-hydroxytryptamine receptor 4	0	1	1	2
Gamma-aminobutyric acid receptor subunit gamma-1	0	1	0	1
Glutamate receptor ionotropic, NMDA 3B	0	1	0	1
Sigma non-opioid intracellular receptor 1	0	2	0	2
Gamma-aminobutyric acid receptor subunit gamma-3	0	1	0	1
5-hydroxytryptamine receptor 3B	0	1	1	2
Leukotriene B4 receptor 2	0	1	0	1
Glutamate receptor ionotropic, NMDA 3A	0	1	0	1
Gamma-aminobutyric acid receptor subunit theta	0	1	0	1
Transporter	0	2	0	2
Sodium- and chloride-dependent creatine transporter 1	0	1	0	1
Proton-coupled amino acid transporter 1	0	1	0	1
Phosphodiesterase	0	1	0	1
Multidrug resistance-associated protein 5	0	0	0	1
cGMP-inhibited 3',5'-cyclic phosphodiesterase B	0	1	0	1
cGMP-inhibited 3',5'-cyclic phosphodiesterase A	0	1	0	1
progesterone receptor	3	0	0	3
aryl hydrocarbon receptor	3	0	0	3
nuclear receptor subfamily 1, group I, member 2	1	0	0	1
Interferon beta	1	0	0	1
Luciferase	1	0	0	1
estrogen-related nuclear receptor alpha	2	0	0	2
vitamin D (1,25- dihydroxyvitamin D3) receptor	2	0	0	2
USP1 protein, partial	1	0	0	1
Nitric oxide synthase, brain	0	0	0	1
Nitric oxide synthase, inducible	0	0	0	1
Chain A, JmjC domain-containing histone demethylation protein 3A	1	0	0	1
thioredoxin reductase	6	0	0	6
EWS/FLI fusion protein	3	0	0	3
euchromatic histone-lysine N-methyltransferase 2	9	0	0	9
Replicase polyprotein 1ab	0	1	0	1
CAAX prenyl protease 2 isoform 2	0	0	0	1
streptokinase A precursor	0	0	2	2
Bile salt export pump	0	2	0	2
Tubulin beta-4A chain	0	1	0	1
Tubulin beta chain	0	1	0	1
ATP-dependent translocase ABCB1	0	0	0	1
Tubulin alpha-3C chain	0	1	0	1
Spike glycoprotein	3	0	0	3
Tubulin alpha-1B chain	0	1	0	1
Tubulin alpha-4A chain	0	1	0	1
Tubulin beta-4B chain	0	1	0	1
Fatty-acid amide hydrolase 1	0	1	0	1
DNA gyrase subunit A	0	1	0	1
DNA primase	0	1	0	1
Tubulin beta-3 chain	0	1	0	1
Tubulin beta-2A chain	0	1	0	1
Tubulin beta-8 chain	0	1	0	1
Tubulin alpha-3E chain	0	1	0	1
Tubulin alpha-1A chain	0	1	0	1
Multidrug and toxin extrusion protein 1	0	1	0	1
Tubulin alpha-1C chain	0	1	0	1
Tubulin beta-6 chain	0	1	0	1
Tubulin beta-2B chain	0	1	0	1
Tubulin beta-1 chain	0	1	0	1
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	2	0	0	2
Chain A, HADH2 protein	2	0	0	2
Chain B, HADH2 protein	2	0	0	2
interleukin 8	1	0	0	1
ClpP	1	0	0	1
phosphopantetheinyl transferase	1	0	0	1
ATAD5 protein, partial	1	0	0	1
caspase 7, apoptosis-related cysteine protease	1	0	0	1
regulator of G-protein signaling 4	4	0	0	4
caspase-3	1	0	0	1
cytochrome P450 2D6 isoform 1	3	0	0	3
peripheral myelin protein 22 isoform 1	1	0	0	1
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	1	0	0	1
ras-related protein Rab-9A	2	0	0	2
cytochrome P450 3A4 isoform 1	2	0	0	2
M-phase phosphoprotein 8	2	0	0	2
muscarinic acetylcholine receptor M1	5	0	0	5
Gamma-aminobutyric acid receptor subunit pi	2	0	0	2
Cellular tumor antigen p53	2	0	0	2
Cytochrome P450 1A1	0	1	0	1
Cytochrome P450 1A2	0	1	0	1
Myeloperoxidase	0	1	0	1
Cytochrome P450 1A2	0	1	0	1
Cholinesterase	0	5	0	5
Cytochrome P450 2C11	0	1	0	1
Cytochrome P450 2D6	0	2	0	2
Aromatase	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-1	2	0	0	2
Ribosyldihydronicotinamide dehydrogenase [quinone]	0	2	0	2
Gamma-aminobutyric acid receptor subunit delta	2	0	0	2
Gamma-aminobutyric acid receptor subunit gamma-2	2	0	0	2
Gamma-aminobutyric acid receptor subunit alpha-5	2	0	0	2
Gamma-aminobutyric acid receptor subunit alpha-3	2	0	0	2
Acetylcholinesterase	0	4	0	5
Metabotropic glutamate receptor 1	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-1	2	0	0	2
Gamma-aminobutyric acid receptor subunit alpha-2	2	0	0	2
Acetylcholinesterase	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-4	2	0	0	2
Gamma-aminobutyric acid receptor subunit gamma-3	2	0	0	2
Gamma-aminobutyric acid receptor subunit alpha-6	2	0	0	2
Mu-type opioid receptor	0	1	0	1
Nociceptin receptor	0	1	0	1
Alpha-1A adrenergic receptor	0	3	0	3
Melatonin receptor type 1A	0	2	1	3
Melatonin receptor type 1C	0	0	1	1
Melatonin receptor type 1A	0	1	1	2
Melatonin receptor type 1B	0	2	1	3
Melatonin receptor type 1C	0	1	1	2
Melatonin receptor type 1B	0	1	1	2
Nuclear receptor ROR-gamma	2	0	0	2
Gamma-aminobutyric acid receptor subunit alpha-1	2	0	0	2
Gamma-aminobutyric acid receptor subunit beta-3	2	0	0	2
Gamma-aminobutyric acid receptor subunit beta-2	2	0	0	2
Nuclear factor erythroid 2-related factor 2	0	0	0	1
Cytochrome P450 1B1	0	1	0	1
Palmitoleoyl-protein carboxylesterase NOTUM	0	1	0	1
GABA theta subunit	2	0	0	2
Gamma-aminobutyric acid receptor subunit epsilon	2	0	0	2
Carboxylic ester hydrolase	0	2	0	2
Histamine H3 receptor	0	1	0	1
ATP-dependent phosphofructokinase	2	0	0	2
glp-1 receptor, partial	2	0	0	2
Microtubule-associated protein tau	1	0	0	1
cytochrome P450 family 3 subfamily A polypeptide 4	3	0	0	3
cytochrome P450 2D6	3	0	0	3
galanin receptor type 3	0	1	0	1
DNA polymerase iota isoform a (long)	1	0	0	1
survival motor neuron protein isoform d	2	0	0	2
GLS protein	5	0	0	5
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	3	0	0	3
pyruvate kinase PKM isoform b	1	0	0	1
Ornithine decarboxylase	1	0	0	1
arylsulfatase A	3	0	0	3
Acetylcholinesterase	0	3	0	4
Cholinesterase	0	3	0	4
Beta-secretase 1	0	1	2	3
Trace amine-associated receptor 1	0	0	2	2
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Metallo-beta-lactamase type 2	0	0	0	1
Metallo-beta-lactamase VIM-11	0	0	0	1
Beta-lactamase	0	0	0	1
Metallo-beta-lactamase VIM-2	0	0	0	1
Beta-lactamase	0	0	0	1
Metallo-beta-lactamase VIM-19	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Metallo-beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Solute carrier family 22 member 6	0	1	0	1
Beta-lactamase	0	0	0	1
Solute carrier family 22 member 8	0	1	0	2
Beta-lactamase	0	0	0	1
Beta-lactamase 1	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase SHV-1	0	0	0	1
Beta-lactamase SHV-1	0	0	0	1
Beta-lactamase OXA-10	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Kappa-type opioid receptor	0	0	0	1
Solute carrier family 15 member 1	0	1	0	1
Beta-lactamase TEM	0	1	0	2
Beta-lactamase	0	0	0	1
B2 metallo-beta-lactamase	0	0	0	1
Solute carrier family 15 member 2	0	1	0	1
Metallo-beta-lactamase VIM-13	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Efflux transporter	0	0	0	1
Beta-lactamase	0	0	0	1
Metallo-beta-lactamase VIM-2	0	0	0	1
Beta-lactamase Toho-1	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Class D beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Solute carrier family 15 member 2	0	1	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Metallo-b-lactamase	0	0	0	1
Beta-lactamase IMP-1	0	0	0	1
BlaVIM-1	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Solute carrier family 22 member 8	0	1	0	1
Beta-lactamase	0	0	0	1
Carbapenem-hydrolyzing beta-lactamase KPC	0	0	0	1
Beta-lactamase class B VIM-2	0	0	0	1
Beta-lactamase	0	0	0	1
Solute carrier family 22 member 8	0	1	0	2
Beta-lactamase VIM-1	0	0	0	1
dopamine D1 receptor	2	0	0	2
NFKB1 protein, partial	1	0	0	1
thyroid stimulating hormone receptor	2	0	0	2
Alpha-1B adrenergic receptor	0	0	1	1
D(1A) dopamine receptor	1	0	0	1
Beta-2 adrenergic receptor	0	0	1	1
Beta-1 adrenergic receptor	0	0	1	1
Alpha-2A adrenergic receptor	0	1	1	2
Beta-3 adrenergic receptor	0	0	1	1
POU domain, class 2, transcription factor 1	0	0	0	1
Alpha-1B adrenergic receptor	0	2	0	2
Alpha-2B adrenergic receptor	0	1	0	1
Beta-1 adrenergic receptor	0	1	0	1
Alpha-1A adrenergic receptor	0	1	1	2
Alpha-2C adrenergic receptor	0	1	1	2
Alpha-1B adrenergic receptor	0	1	0	1
Alpha-1D adrenergic receptor	0	2	0	2
Alpha-2B adrenergic receptor	0	0	0	1
Alpha-1A adrenergic receptor	0	1	1	2
Alpha-1B adrenergic receptor	0	1	1	2
Alpha-2C adrenergic receptor	0	0	0	1
Alpha-2A adrenergic receptor	0	0	0	1
Chain A, Putative fructose-1,6-bisphosphate aldolase	1	0	0	1
nonstructural protein 1	1	0	0	1
hexokinase-4 isoform 1	1	0	0	1
atrial natriuretic peptide receptor 1 precursor	1	0	0	1
glucokinase regulatory protein	1	0	0	1
peripheral myelin protein 22	1	0	0	1
Acetylcholinesterase	0	1	0	1
Acetylcholinesterase	0	1	0	1
Acetylcholinesterase	0	1	0	1
Acetylcholinesterase	0	1	0	1
Cholinesterase	0	1	0	1
Acyl-CoA:cholesterol acyltransferase	0	1	0	1
Carboxylic ester hydrolase	0	1	0	1
cytochrome P450 2C19 precursor	2	0	0	2
cytochrome P450 2C9 precursor	1	0	0	1
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	1	0	0	1
Cytochrome P450 2A6	0	1	1	2
Muscarinic acetylcholine receptor DM1	0	1	0	1
Cytochrome P450 2A13	0	1	1	2
pregnane X receptor	1	0	0	1
thioredoxin glutathione reductase	1	0	0	1
estrogen receptor 2 (ER beta)	1	0	0	1
vitamin D3 receptor isoform VDRA	1	0	0	1
thyroid hormone receptor beta isoform 2	1	0	0	1
nuclear receptor ROR-gamma isoform 1	1	0	0	1
Glucocorticoid receptor	0	2	1	3
Glycine receptor subunit alpha-1	0	3	0	3
Glycine receptor subunit beta	0	2	0	2
Glycine receptor subunit alpha-2	0	2	0	2
Glycine receptor subunit alpha-3	0	2	0	2
Gamma-aminobutyric acid receptor subunit rho-3	0	0	0	1
potassium voltage-gated channel subfamily H member 2 isoform d	1	0	0	1
Glycine receptor subunit alpha-1	0	2	0	2
Gamma-aminobutyric acid receptor subunit rho-1	0	0	0	1
Gamma-aminobutyric acid receptor subunit rho-2	0	0	0	1
Glycine receptor subunit beta	0	1	0	1
Taste receptor type 2 member 46	0	0	1	1
Taste receptor type 2 member 10	0	0	1	2
guanine nucleotide-binding protein subunit alpha-15	0	1	1	2
lethal(3)malignant brain tumor-like protein 1 isoform I	1	0	0	1
D(3) dopamine receptor isoform e	1	0	0	1
trace amine-associated receptor 1	0	1	1	2
Polyphenol oxidase 2	0	0	0	1
Phenylethanolamine N-methyltransferase	0	1	0	1
D(2) dopamine receptor	0	1	0	1
Dopamine beta-hydroxylase	0	0	0	1
Amine oxidase [flavin-containing] A	0	0	0	1
D(1A) dopamine receptor	0	1	0	2
Amine oxidase [flavin-containing] B	0	0	0	1
5-hydroxytryptamine receptor 3A	0	0	1	1
Inositol monophosphatase 1	1	0	0	1
Trace amine-associated receptor 1	0	0	1	1
Trace amine-associated receptor 1	0	0	1	1
Histamine H3 receptor	0	0	0	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

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