Page last updated: 2024-09-27

Adie Syndrome

A syndrome characterized by a TONIC PUPIL that occurs in combination with decreased lower extremity reflexes. The affected pupil will respond more briskly to accommodation than to light (light-near dissociation) and is supersensitive to dilute pilocarpine eye drops, which induce pupillary constriction. Pathologic features include degeneration of the ciliary ganglion and postganglionic parasympathetic fibers that innervate the pupillary constrictor muscle. (From Adams et al., Principles of Neurology, 6th ed, p279)

Synonyms(4)

Synonym
Adie Syndrome
Holmes-Adie Syndrome
Adie's Syndrome
Poorly Reacting Pupils

Research Excerpts

Overview

ExcerptReference
"Adie's syndrome is a disease of unknown etiology."( Thompson, HS, 1977)

Context

ExcerptReference
"The pathogenesis of Adie's syndrome has so far not been definitely established."( Vogir, R, 1976)

Treatment

ExcerptReference
"Our study suggests those patients with Adie's Syndrome who lack stereoacuity may benefit from long term therapy with dilute pilocarpine if their stereoacuity may benefit from long term therapy with dilute pilocarpine if their stereoacuity improves following a single drop of 0."( Dolan, BJ; Flach, AJ, 1985)

Research

Studies (79)

TimeframeStudies, This Condition (%)All Conditions %
pre-199062 (78.48)23.3326
1990's6 (7.59)12.5806
2000's1 (1.27)18.1394
2010's7 (8.86)28.8240
2020's3 (3.80)9.53
DrugIndicatedRelationship StrengthStudiesTrials
chlorine0low10
creatine0low10
melatonin0low10
guanethidine0low20
p-hydroxyamphetamine0low10
2-propanol0medium121
moxisylyte0low10
neostigmine0low10
procaine0low20
tyramine0low10
carbachol0low20
aldosterone0low10
prednisone0low10
penicillin g0low10
pilocarpine0low230
physostigmine0low20
phenylephrine0low30
methacholine chloride0low50
fludrocortisone0low10
fomesafen0low190
6-sulfatoxymelatonin0low10
fluorodeoxyglucose f180low10
angiotensin ii0low20
atropine0low10
bradykinin0low10
strychnine0low10
cocaine0low40
methylcellulose0low10
cyclic gmp0low20
eye0low50

Protein Targets (436)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
hypoxia-inducible factor 1 alpha subunit2002
RAR-related orphan receptor gamma4004
GLI family zinc finger 36006
AR protein8008
aldehyde dehydrogenase 1 family, member A15005
retinoic acid nuclear receptor alpha variant 13003
retinoid X nuclear receptor alpha3003
estrogen nuclear receptor alpha7007
peroxisome proliferator-activated receptor delta1001
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a4004
activating transcription factor 61001
v-jun sarcoma virus 17 oncogene homolog (avian)4004
Histone H2A.x2002
thyroid hormone receptor beta isoform a2002
heat shock protein beta-11001
nuclear factor erythroid 2-related factor 2 isoform 14004
lamin isoform A-delta106006
Voltage-dependent calcium channel gamma-2 subunit1001
Glutamate receptor 21001
glucocorticoid receptor [Homo sapiens]7007
nuclear factor erythroid 2-related factor 2 isoform 23003
geminin6006
Sex hormone-binding globulin0011
Corticosteroid-binding globulin0101
Mineralocorticoid receptor 0123
Androgen receptor0101
Mineralocorticoid receptor0101
Solute carrier organic anion transporter family member 1A10001
Guanine nucleotide-binding protein G2002
glucocerebrosidase1001
DNA polymerase kappa isoform 11001
histone acetyltransferase KAT2A isoform 15005
Atrial natriuretic peptide receptor 30101
Type-1A angiotensin II receptor 0213
Type-1 angiotensin II receptor0011
Type-1B angiotensin II receptor0202
Type-1 angiotensin II receptor0224
Type-2 angiotensin II receptor0202
Type-2 angiotensin II receptor0202
Chain A, 2-oxoglutarate Oxygenase5005
nuclear receptor subfamily 1, group I, member 33003
pregnane X nuclear receptor6006
cystic fibrosis transmembrane conductance regulator0101
DNA polymerase beta2002
short transient receptor potential channel 6 isoform 10011
Solute carrier family 22 member 1 0102
ATP-binding cassette sub-family C member 30404
Multidrug resistance-associated protein 40405
5-hydroxytryptamine receptor 40202
Bile salt export pump0808
Muscarinic acetylcholine receptor M205413
Muscarinic acetylcholine receptor M404310
Muscarinic acetylcholine receptor M107214
Muscarinic acetylcholine receptor M306212
Muscarinic acetylcholine receptor M406111
Muscarinic acetylcholine receptor M506111
Muscarinic acetylcholine receptor M505311
Muscarinic acetylcholine receptor M207113
Muscarinic acetylcholine receptor M105514
Muscarinic acetylcholine receptor M10124
Muscarinic acetylcholine receptor M304310
Alpha-1D adrenergic receptor0202
5-hydroxytryptamine receptor 2C0202
Muscarinic acetylcholine receptor M40101
Histamine H2 receptor1002
5-hydroxytryptamine receptor 70101
Reverse transcriptase/RNaseH 0001
Muscarinic acetylcholine receptor0314
Canalicular multispecific organic anion transporter 10404
Angiotensin-converting enzyme 0001
B2 bradykinin receptor0101
B2 bradykinin receptor0215
B1 bradykinin receptor0101
Olfactory receptor 51E20011
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE3003
Chain A, Beta-lactamase1001
acetylcholinesterase2002
GALC protein3003
TDP1 protein7007
peroxisome proliferator activated receptor gamma2002
IDH12002
thyroid stimulating hormone receptor2002
thyrotropin-releasing hormone receptor2002
Bloom syndrome protein isoform 14004
chromobox protein homolog 13003
Neuronal acetylcholine receptor subunit alpha-30101
Neuronal acetylcholine receptor subunit alpha-40101
Neuronal acetylcholine receptor subunit alpha-20101
Neuronal acetylcholine receptor subunit beta-20101
Neuronal acetylcholine receptor subunit beta-30101
Neuronal acetylcholine receptor subunit beta-40101
Neuronal acetylcholine receptor subunit alpha-50101
Delta-type opioid receptor0102
Neuronal acetylcholine receptor subunit alpha-60101
Neuronal acetylcholine receptor subunit alpha-90101
Neuronal acetylcholine receptor subunit alpha-70101
Sigma non-opioid intracellular receptor 10011
Muscarinic acetylcholine receptor M30013
Muscarinic acetylcholine receptor M20003
Neuronal acetylcholine receptor subunit alpha-100101
Carbonic anhydrase 10101
Carbonic anhydrase 20101
Carbonic anhydrase 40101
Carbonic anhydrase0101
Carbonic anhydrase 150101
Chain A, CHIMERA OF IG KAPPA CHAIN: HUMAN CONSTANT REGION AND MOUSE VARIABLE REGION0011
Chain B, CHIMERA OF IG GAMMA-1 CHAIN: HUMAN CONSTANT REGION AND MOUSE VARIABLE REGION0011
Chain H, Fab M82G2, Heavy chain0011
Chain L, Fab M82G2, Light chain0011
Chain H, Fab M82g2, Heavy Chain0011
Chain L, Fab M82g2, Light Chain0011
Gamma-aminobutyric acid receptor subunit pi0101
Gamma-aminobutyric acid receptor subunit delta0101
Amyloid-beta precursor protein0101
Fatty acid-binding protein, heart0101
Muscarinic acetylcholine receptor M20101
5-hydroxytryptamine receptor 2C0213
Tryptophan 5-hydroxylase 10101
5-hydroxytryptamine receptor 2A0213
Gamma-aminobutyric acid receptor subunit alpha-10101
Gamma-aminobutyric acid receptor subunit beta-10101
Gamma-aminobutyric acid receptor subunit gamma-20101
D0101
5-hydroxytryptamine receptor 1A0112
Alpha-2B adrenergic receptor0202
Alpha-2C adrenergic receptor0202
Alpha-2A adrenergic receptor0202
Liver carboxylesterase 10001
Sodium-dependent noradrenaline transporter 0202
Sodium-dependent dopamine transporter0202
cAMP-specific 3',5'-cyclic phosphodiesterase 4A0101
Gamma-aminobutyric acid receptor subunit beta-30101
5-hydroxytryptamine receptor 1B0112
5-hydroxytryptamine receptor 1D0112
5-hydroxytryptamine receptor 1F0112
5-hydroxytryptamine receptor 2B0213
5-hydroxytryptamine receptor 60112
Gamma-aminobutyric acid receptor subunit alpha-50101
Sodium-dependent serotonin transporter0202
Sodium-dependent serotonin transporter0203
5-hydroxytryptamine receptor 7 0112
Gamma-aminobutyric acid receptor subunit alpha-30101
5-hydroxytryptamine receptor 5A0112
5-hydroxytryptamine receptor 5B0112
Glutamate receptor ionotropic, NMDA 1 0101
5-hydroxytryptamine receptor 3A0112
Lysosomal Pro-X carboxypeptidase0101
Gamma-aminobutyric acid receptor subunit alpha-20101
Gamma-aminobutyric acid receptor subunit beta-20101
Gamma-aminobutyric acid receptor subunit alpha-40101
D(2) dopamine receptor0101
Gamma-aminobutyric acid receptor subunit epsilon0101
Glutamate receptor ionotropic, NMDA 2A 0101
Glutamate receptor ionotropic, NMDA 2B0101
Glutamate receptor ionotropic, NMDA 2C0101
Sodium-dependent dopamine transporter 0202
cAMP-specific 3',5'-cyclic phosphodiesterase 4B0101
cAMP-specific 3',5'-cyclic phosphodiesterase 4D0101
Potassium voltage-gated channel subfamily H member 20303
Leukotriene B4 receptor 10101
Gamma-aminobutyric acid receptor subunit alpha-60101
Sodium-dependent dopamine transporter0202
Glutamate receptor ionotropic, NMDA 2D0101
5-hydroxytryptamine receptor 4 0112
Gamma-aminobutyric acid receptor subunit gamma-10101
Glutamate receptor ionotropic, NMDA 3B0101
Sigma non-opioid intracellular receptor 10202
Gamma-aminobutyric acid receptor subunit gamma-30101
5-hydroxytryptamine receptor 3B0112
Leukotriene B4 receptor 20101
Glutamate receptor ionotropic, NMDA 3A0101
Gamma-aminobutyric acid receptor subunit theta0101
Transporter0202
Sodium- and chloride-dependent creatine transporter 10101
Proton-coupled amino acid transporter 10101
Phosphodiesterase 0101
Multidrug resistance-associated protein 50001
cGMP-inhibited 3',5'-cyclic phosphodiesterase B0101
cGMP-inhibited 3',5'-cyclic phosphodiesterase A0101
progesterone receptor3003
aryl hydrocarbon receptor3003
nuclear receptor subfamily 1, group I, member 21001
Interferon beta1001
Luciferase1001
estrogen-related nuclear receptor alpha2002
vitamin D (1,25- dihydroxyvitamin D3) receptor2002
USP1 protein, partial1001
Nitric oxide synthase, brain 0001
Nitric oxide synthase, inducible0001
Chain A, JmjC domain-containing histone demethylation protein 3A1001
thioredoxin reductase6006
EWS/FLI fusion protein3003
euchromatic histone-lysine N-methyltransferase 29009
Replicase polyprotein 1ab0101
CAAX prenyl protease 2 isoform 20001
streptokinase A precursor0022
Bile salt export pump0202
Tubulin beta-4A chain0101
Tubulin beta chain0101
ATP-dependent translocase ABCB10001
Tubulin alpha-3C chain0101
Spike glycoprotein3003
Tubulin alpha-1B chain0101
Tubulin alpha-4A chain0101
Tubulin beta-4B chain0101
Fatty-acid amide hydrolase 10101
DNA gyrase subunit A0101
DNA primase0101
Tubulin beta-3 chain0101
Tubulin beta-2A chain0101
Tubulin beta-8 chain0101
Tubulin alpha-3E chain0101
Tubulin alpha-1A chain0101
Multidrug and toxin extrusion protein 10101
Tubulin alpha-1C chain0101
Tubulin beta-6 chain0101
Tubulin beta-2B chain0101
Tubulin beta-1 chain0101
Chain A, TYROSYL-DNA PHOSPHODIESTERASE2002
Chain A, HADH2 protein2002
Chain B, HADH2 protein2002
interleukin 81001
ClpP1001
phosphopantetheinyl transferase1001
ATAD5 protein, partial1001
caspase 7, apoptosis-related cysteine protease1001
regulator of G-protein signaling 44004
caspase-31001
cytochrome P450 2D6 isoform 13003
peripheral myelin protein 22 isoform 11001
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 11001
ras-related protein Rab-9A2002
cytochrome P450 3A4 isoform 12002
M-phase phosphoprotein 82002
muscarinic acetylcholine receptor M15005
Gamma-aminobutyric acid receptor subunit pi2002
Cellular tumor antigen p532002
Cytochrome P450 1A10101
Cytochrome P450 1A2 0101
Myeloperoxidase0101
Cytochrome P450 1A20101
Cholinesterase0505
Cytochrome P450 2C11 0101
Cytochrome P450 2D60202
Aromatase0101
Gamma-aminobutyric acid receptor subunit beta-12002
Ribosyldihydronicotinamide dehydrogenase [quinone]0202
Gamma-aminobutyric acid receptor subunit delta2002
Gamma-aminobutyric acid receptor subunit gamma-22002
Gamma-aminobutyric acid receptor subunit alpha-52002
Gamma-aminobutyric acid receptor subunit alpha-32002
Acetylcholinesterase0405
Metabotropic glutamate receptor 10101
Gamma-aminobutyric acid receptor subunit gamma-12002
Gamma-aminobutyric acid receptor subunit alpha-22002
Acetylcholinesterase 0202
Gamma-aminobutyric acid receptor subunit alpha-42002
Gamma-aminobutyric acid receptor subunit gamma-32002
Gamma-aminobutyric acid receptor subunit alpha-62002
Mu-type opioid receptor0101
Nociceptin receptor0101
Alpha-1A adrenergic receptor0303
Melatonin receptor type 1A0213
Melatonin receptor type 1C0011
Melatonin receptor type 1A0112
Melatonin receptor type 1B0213
Melatonin receptor type 1C0112
Melatonin receptor type 1B0112
Nuclear receptor ROR-gamma2002
Gamma-aminobutyric acid receptor subunit alpha-12002
Gamma-aminobutyric acid receptor subunit beta-32002
Gamma-aminobutyric acid receptor subunit beta-22002
Nuclear factor erythroid 2-related factor 20001
Cytochrome P450 1B10101
Palmitoleoyl-protein carboxylesterase NOTUM0101
GABA theta subunit2002
Gamma-aminobutyric acid receptor subunit epsilon2002
Carboxylic ester hydrolase 0202
Histamine H3 receptor0101
ATP-dependent phosphofructokinase2002
glp-1 receptor, partial2002
Microtubule-associated protein tau1001
cytochrome P450 family 3 subfamily A polypeptide 43003
cytochrome P450 2D63003
galanin receptor type 30101
DNA polymerase iota isoform a (long)1001
survival motor neuron protein isoform d2002
GLS protein5005
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)3003
pyruvate kinase PKM isoform b1001
Ornithine decarboxylase1001
arylsulfatase A3003
Acetylcholinesterase0304
Cholinesterase0304
Beta-secretase 10123
Trace amine-associated receptor 10022
Beta-lactamase 0001
Beta-lactamase 0001
Beta-lactamase 0001
Beta-lactamase 0001
Beta-lactamase 0001
Beta-lactamase 0001
Beta-lactamase 0001
Beta-lactamase 0001
Beta-lactamase 0001
Metallo-beta-lactamase type 20001
Metallo-beta-lactamase VIM-11 0001
Beta-lactamase 0001
Metallo-beta-lactamase VIM-20001
Beta-lactamase 0001
Metallo-beta-lactamase VIM-19 0001
Beta-lactamase 0001
Beta-lactamase 0001
Metallo-beta-lactamase0001
Beta-lactamase 0001
Solute carrier family 22 member 60101
Beta-lactamase0001
Solute carrier family 22 member 80102
Beta-lactamase0001
Beta-lactamase 10001
Beta-lactamase0001
Beta-lactamase SHV-10001
Beta-lactamase SHV-10001
Beta-lactamase OXA-100001
Beta-lactamase0001
Beta-lactamase0001
Kappa-type opioid receptor0001
Solute carrier family 15 member 10101
Beta-lactamase TEM0102
Beta-lactamase0001
B2 metallo-beta-lactamase 0001
Solute carrier family 15 member 20101
Metallo-beta-lactamase VIM-130001
Beta-lactamase 0001
Beta-lactamase 0001
Efflux transporter 0001
Beta-lactamase 0001
Metallo-beta-lactamase VIM-20001
Beta-lactamase Toho-10001
Beta-lactamase 0001
Beta-lactamase 0001
Class D beta-lactamase0001
Beta-lactamase 0001
Solute carrier family 15 member 20101
Beta-lactamase 0001
Beta-lactamase 0001
Beta-lactamase 0001
Beta-lactamase 0001
Metallo-b-lactamase 0001
Beta-lactamase IMP-1 0001
BlaVIM-1 0001
Beta-lactamase 0001
Beta-lactamase 0001
Solute carrier family 22 member 80101
Beta-lactamase 0001
Carbapenem-hydrolyzing beta-lactamase KPC0001
Beta-lactamase class B VIM-2 0001
Beta-lactamase 0001
Solute carrier family 22 member 80102
Beta-lactamase VIM-1 0001
dopamine D1 receptor2002
NFKB1 protein, partial1001
thyroid stimulating hormone receptor2002
Alpha-1B adrenergic receptor 0011
D(1A) dopamine receptor1001
Beta-2 adrenergic receptor0011
Beta-1 adrenergic receptor0011
Alpha-2A adrenergic receptor0112
Beta-3 adrenergic receptor0011
POU domain, class 2, transcription factor 10001
Alpha-1B adrenergic receptor0202
Alpha-2B adrenergic receptor0101
Beta-1 adrenergic receptor0101
Alpha-1A adrenergic receptor0112
Alpha-2C adrenergic receptor0112
Alpha-1B adrenergic receptor0101
Alpha-1D adrenergic receptor0202
Alpha-2B adrenergic receptor0001
Alpha-1A adrenergic receptor0112
Alpha-1B adrenergic receptor0112
Alpha-2C adrenergic receptor0001
Alpha-2A adrenergic receptor0001
Chain A, Putative fructose-1,6-bisphosphate aldolase1001
nonstructural protein 11001
hexokinase-4 isoform 11001
atrial natriuretic peptide receptor 1 precursor1001
glucokinase regulatory protein1001
peripheral myelin protein 221001
Acetylcholinesterase0101
Acetylcholinesterase0101
Acetylcholinesterase0101
Acetylcholinesterase0101
Cholinesterase0101
Acyl-CoA:cholesterol acyltransferase 0101
Carboxylic ester hydrolase 0101
cytochrome P450 2C19 precursor2002
cytochrome P450 2C9 precursor1001
peptidyl-prolyl cis-trans isomerase NIMA-interacting 11001
Cytochrome P450 2A60112
Muscarinic acetylcholine receptor DM10101
Cytochrome P450 2A130112
pregnane X receptor1001
thioredoxin glutathione reductase1001
estrogen receptor 2 (ER beta)1001
vitamin D3 receptor isoform VDRA1001
thyroid hormone receptor beta isoform 21001
nuclear receptor ROR-gamma isoform 11001
Glucocorticoid receptor0213
Glycine receptor subunit alpha-10303
Glycine receptor subunit beta0202
Glycine receptor subunit alpha-20202
Glycine receptor subunit alpha-30202
Gamma-aminobutyric acid receptor subunit rho-30001
potassium voltage-gated channel subfamily H member 2 isoform d1001
Glycine receptor subunit alpha-10202
Gamma-aminobutyric acid receptor subunit rho-10001
Gamma-aminobutyric acid receptor subunit rho-20001
Glycine receptor subunit beta0101
Taste receptor type 2 member 460011
Taste receptor type 2 member 100012
guanine nucleotide-binding protein subunit alpha-150112
lethal(3)malignant brain tumor-like protein 1 isoform I1001
D(3) dopamine receptor isoform e1001
trace amine-associated receptor 10112
Polyphenol oxidase 20001
Phenylethanolamine N-methyltransferase0101
D(2) dopamine receptor0101
Dopamine beta-hydroxylase 0001
Amine oxidase [flavin-containing] A0001
D(1A) dopamine receptor0102
Amine oxidase [flavin-containing] B0001
5-hydroxytryptamine receptor 3A0011
Inositol monophosphatase 11001
Trace amine-associated receptor 10011
Trace amine-associated receptor 10011
Histamine H3 receptor0001
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]
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