cycloxaprid

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Description

cycloxaprid: a neonicotinoid insecticide; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID Source	ID
PubMed CID	58496250
SCHEMBL ID	888470
MeSH ID	M0587655

Synonyms (6)

Synonym
SCHEMBL888470
1-((6-chloropyridin-3-yl)methyl)-9-nitro-2,3,5,6,7,8-hexahydro -1h-5,8-epoxyimidazo[1,2-a]azepine
NDHXMRFNYMNBKO-UHFFFAOYSA-N
1-((6-chloropyridin-3-yl)methyl)-9-nitro-2,3,5,6,7,8-hexahydro-1h-5,8-epoxyimidazo[1,2-a]azepine
cycloxaprid
1203791-41-6

Research Excerpts

Overview

Cycloxaprid (CYC) is a promising neonicotinoid due to its insecticidal effectiveness and low cross resistance, but little is known about its fate in soils. It is currently under development in China for agricultural pest control.

Excerpt	Reference	Relevance
"Cycloxaprid is a potentially promising substitute, but its metabolism in plants is still poorly understood."	( Translocation and metabolism of the chiral neonicotinoid cycloxaprid in oilseed rape (Brassica napus L.). Cheng, X; Shao, S; Ye, Q; Yu, Z; Zhang, S; Zheng, R, 2022)	1.69
"Cycloxaprid (CYC) is a promising neonicotinoid due to its insecticidal effectiveness and low cross resistance, but little is known about its fate in soils."	( Fate of the neonicotinoid insecticide cycloxaprid in different soils under oxic conditions. Cheng, X; Wang, Y; Ye, Q; Zhang, H; Zhang, S, 2022)	1.71
"Cycloxaprid is a slow-acting and nonrepellent insecticide against S. "	( Toxicity, horizontal transfer, and physiological and behavioral effects of cycloxaprid against Solenopsis invicta (Hymenoptera: Formicidae). Cai, J; Chen, J; Chen, X; He, Y; Lu, Y; Wang, C; Wang, L; Wen, X; Xu, Z; Zhang, J; Zhang, L, 2022)	2.39
"Cycloxaprid is a novel cis-nitromethylene configuration neonicotinoid insecticide that is different from trans-configuration neonicotinoids like imidacloprid and thiamethoxam."	( Cross-Resistance and Fitness Costs of the cis-Nitromethylene Neonicotinoid Cycloxaprid Resistance in Melon Aphid, Aphis gossypii (Hemiptera: Aphididae). Chen, Z; Dong, W; Gao, X; Li, H; Liang, P; Shang, J; Shi, X; Wang, C; Yang, H; Zhang, H, 2022)	1.67
"Cycloxaprid is a novel cis-configuration neonicotinoid insecticide that is effective against a wide range of imidacloprid-resistant pests."	( Cycloxaprid: a novel cis-nitromethylene neonicotinoid insecticide to control Bemisia tabaci. Cui, L; Rui, C; Wang, L; Wang, Q; Yuan, H, 2020)	2.72
"Cycloxaprid (CYC) is a new cis-configuration neonicotinoid insecticide, which is currently under development in China for agricultural pest control. "	( Photostability study of cis-configuration neonicotinoid insecticide cycloxaprid in water. Deng, Y; Hou, S; Xu, X; Zhuang, Y, 2017)	2.13
"Cycloxaprid is a new oxabridged cis-configuration neonicotinoid insecticide, the resistance development potential and underlying resistance mechanism of which were investigated in the small brown planthopper, Laodelphax striatellus (Fallén), an important agricultural pest of rice."	( Resistance to cycloxaprid in Laodelphax striatellus is associated with altered expression of nicotinic acetylcholine receptor subunits. Fang, J; Guo, H; Han, Y; He, P; Li, Z; Liu, Z; Wang, L; Yang, Q; Zhang, Y, 2018)	2.28
"Cycloxaprid is a novel cis-configuration neonicotinoid insecticide that is effective against a wide range of insect pests, including those that are resistant to conventional neonicotinoids. "	( Sublethal effects of the novel cis-nitromethylene neonicotinoid cycloxaprid on the cotton aphid Aphis gossypii Glover (Hemiptera: Aphididae). Cui, L; Rui, C; Wang, Q; Yuan, H, 2018)	2.16
"Cycloxaprid (CYC) is a novel neonicotinoid prepared from the (nitromethylene)imidazole (NMI) analogue of imidacloprid. "	( Cycloxaprid insecticide: nicotinic acetylcholine receptor binding site and metabolism. Casida, JE; Shao, X; Swenson, TL, 2013)	3.28
"Cycloxaprid (CYC) is a novel broad-spectrum neonicotinoid insecticide that has been developed for agricultural pest control. "	( Assessment of the environmental fate of cycloxaprid in flooded and anaerobic soils by radioisotopic tracing. Fu, Q; Li, C; Li, Z; Liu, X; Shao, X; Xu, X; Ye, Q; Zhang, H, 2016)	2.14

Bioavailability

Excerpt	Reference	Relevance
"82, which suggested CYC immobilization in the soil resulted in its bioavailability being reduced which enhanced its degradation."	( Bioavailability and release of nonextractable (bound) residues of chiral cycloxaprid using geophagous earthworm Metaphire guillelmi in rice paddy soil. Li, C; Li, Z; Liu, X; Shao, X; Xu, X; Ye, Q; Zhang, H, 2015)	0.65

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (32)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	20 (62.50)	24.3611
2020's	12 (37.50)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 22.76

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

Metric	This Compound (vs All)
Research Demand Index	22.76 (24.57)
Research Supply Index	3.50 (2.92)
Research Growth Index	4.62 (4.65)
Search Engine Demand Index	23.28 (26.88)
Search Engine Supply Index	2.00 (0.95)

This Compound (22.76)

All Compounds (24.57)

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	1 (3.13%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	31 (96.88%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
chlorpyrifos Chlorpyrifos: An organothiophosphate cholinesterase inhibitor that is used as an insecticide and as an acaricide.. chlorpyrifos : An organic thiophosphate that is O,O-diethyl hydrogen phosphorothioate in which the hydrogen of the hydroxy group has been replaced by a 3,5,6-trichloropyridin-2-yl group.	2.59	2	chloropyridine; organic thiophosphate	acaricide; agrochemical; EC 3.1.1.7 (acetylcholinesterase) inhibitor; EC 3.1.1.8 (cholinesterase) inhibitor; environmental contaminant; insecticide; xenobiotic
buprofezin buprofezin: tradename - Applaud; used for the control of homopterous insect pests; structure given in first source. (E)-buprofezin : A 2-(tert-butylimino)-5-phenyl-3-(propan-2-yl)-1,3,5-thiadiazinan-4-one in which the C=N double bond has E configuration.. buprofezin : A 2-(tert-butylimino)-5-phenyl-3-(propan-2-yl)-1,3,5-thiadiazinan-4-one in which the C=N double bond has Z configuration.	7.54	2	thiadiazinane; ureas
thiamethoxam Thiamethoxam: A nitro-oxazine and thiazole derivative that is used as a broad spectrum neonicotinoid insecticide.. thiamethoxam : An oxadiazane that is tetrahydro-N-nitro-4H-1,3,5-oxadiazin-4-imine bearing (2-chloro-1,3-thiazol-5-yl)methyl and methyl substituents at positions 3 and 5 respectively.	2.41	1	1,3-thiazoles; 2-nitroguanidine derivative; organochlorine compound; oxadiazane	antifeedant; carcinogenic agent; environmental contaminant; neonicotinoid insectide; xenobiotic
nitenpyram nitenpyram: a nitromethylene neonicotinoid insecticide; structure in first source. (E)-nitenpyram : A nitenpyram in which the double bond has E configuration.. nitenpyram : A C-nitro compound consisting of 2-nitroethene-1,1-diamine where one of the nitrogens bears ethyl and (6-chloro-3-pyridinyl)methyl while the other nitrogen carries a methyl group.	2.21	1	chloropyridyl insecticide; nitenpyram
cyhalothrin cyhalothrin: acaricidal & insecticidal synthetic pyrethroid; structure given in first source. cyhalothrin : A carboxylic ester obtained by formal condensation between 3-(2-chloro-3,3,3-trifluoroprop-1-en-1-yl)-2,2-dimethylcyclopropanecarboxylic acid and cyano(3-phenoxyphenyl)methanol.	7.25	1	aromatic ether; cyclopropanecarboxylate ester; nitrile; organochlorine compound; organofluorine compound	agrochemical; pyrethroid ester acaricide; pyrethroid ester insecticide
paichongding paichongding: a neonicotinoid insecticide; structure in first source	7.6	1
pyrethrins [no description available]	2.25	1
guadipyr Guadipyr: a neonicotinoid insecticide; structure in first source	7.17	1
imidacloprid imidacloprid: systemic & contact insecticide exhibiting low mammalian toxicity; structure given in first source; it is one of the neonicotinoid insecticides, which acts as an antagonist by binding to postsynaptic nicotinic receptors in the insect central nervous system. imidacloprid : An imidazolidine that is N-nitroimidazolidin-2-imine bearing a (6-chloro-3-pyridinyl)methyl substituent at position 1.	3.58	7	imidacloprid; imidazolidines; monochloropyridine	environmental contaminant; genotoxin; neonicotinoid insectide; nicotinic acetylcholine receptor agonist; xenobiotic

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