Page last updated: 2024-09-28

Baker Cyst

A SYNOVIAL CYST located in the back of the knee, in the popliteal space arising from the semimembranous bursa or the knee joint.

Synonyms(3)

Synonym
Baker Cyst
Popliteal Cyst
Baker's Cyst

Research Excerpts

Overview

ExcerptReference
"Baker cyst is an important pathology for the differential diagnosis of popliteal neurovascular compression phenomena."( Conkling, N; Labropoulos, N; Sanchez, JE, 2011)
"Baker's cyst is a benign lesion that results from degenerative or inflammatory diseases of the knee joint."( Alpoğuz Yılmaz, Z; Genç, H; Mülkoğlu, C; Nacır, B, 2018)
"Baker's cysts are not usually subject to extensive preoperative evaluation because the cysts often disappear naturally after surgery, unaccompanied by any adverse symptoms."( Kim, YB; Lee, BI; Seo, GW; Seo, JH, 2020)

Treatment

ExcerptReference
"The presence of a Baker's cyst may diminish the therapeutic effect of intra-articular 90Y treatment to the knee joint."( Crawley, JC; Gumpel, JM; Shawe, DJ; Smith, T, 1988)
"Six patients with Baker's cysts, 3 with branchial cleft cysts, and 2 with thyroglossal duct cysts were treated with percutaneous aspiration and absolute ethanol sclerotherapy using a 7-French pigtail catheter."( Fukumoto, K; Kojima, T; Kontani, K; Murai, S; Tomonari, H; Tsujimoto, F, 1994)
"The first patient developed a popliteal cyst infected by Candida albicans after multiple intravenous antibiotic treatments."( Andréu, JL; Barbadillo, C; Cuende, E; E-Mazzucchelli, R; Isasi, C; Trujillo, A, 1993)

Research

Studies (72)

TimeframeStudies, This Condition (%)All Conditions %
pre-199012 (16.67)23.3326
1990's19 (26.39)12.5806
2000's21 (29.17)18.1394
2010's17 (23.61)28.8240
2020's3 (4.17)9.53
DrugIndicatedRelationship StrengthStudiesTrials
uric acid0low20
bupivacaine0low10
pentetic acid0low10
glyphosate0low10
ifosfamide0low10
prednisolone0low10
prednisone0low20
methylprednisolone acetate0low30
penicillin g0low10
triamcinolone acetonide0low20
phencyclidine0low10
methylprednisolone0medium52
thiazoles0low10
thioflavin t0low10
triamcinolone hexacetonide0low10
technetium0low20
gadolinium0low10
yttrium0low10
trolamine salicylate0low90
triamcinolone0low10
cephalosporin c0low10
fluorodeoxyglucose f180low10
clarithromycin0low10
yttrium radioisotopes0low30
deoxyglucose0low10
3-deoxyglucosone0low10
methotrexate0low10
clindamycin0low10
zithromax0low10
indigo carmine0low10
amphotericin b0low10
lead0low10
gadolinium dtpa0low10
yttrium silicate0low10
technetium tc 99m exametazime0low10
ro13-99040low10
phenprocoumon0low10
technetium tc 99m medronate0low10
rifampin0low10

Protein Targets (454)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
Chain A, HADH2 protein4004
Chain B, HADH2 protein4004
Chain A, Cruzipain2002
interleukin 83003
phosphopantetheinyl transferase2002
GLS protein2002
glucocorticoid receptor [Homo sapiens]9009
farnesoid X nuclear receptor2002
peroxisome proliferator-activated receptor delta6006
vitamin D (1,25- dihydroxyvitamin D3) receptor6006
tumor necrosis factor1001
vitamin D3 receptor isoform VDRA3003
nuclear factor erythroid 2-related factor 2 isoform 17007
peripheral myelin protein 223003
lamin isoform A-delta107007
Cytochrome P450 1A20101
Cytochrome P450 3A40303
Cytochrome P450 2D60202
Cytochrome P450 2C9 0404
Cytochrome P450 2C190101
Nuclear receptor ROR-gamma3003
Potassium voltage-gated channel subfamily H member 20202
Aurora kinase B0101
Broad substrate specificity ATP-binding cassette transporter ABCG20203
Potassium channel subfamily K member 30101
Potassium channel subfamily K member 30101
Potassium channel subfamily K member 20011
Potassium channel subfamily K member 90101
GLI family zinc finger 39009
cytochrome P450 family 3 subfamily A polypeptide 45005
estrogen-related nuclear receptor alpha9009
estrogen nuclear receptor alpha150015
thyroid hormone receptor beta isoform 26006
importin subunit beta-1 isoform 13003
mitogen-activated protein kinase 11001
snurportin-13003
GTP-binding nuclear protein Ran isoform 12002
urokinase-type plasminogen activator precursor2002
plasminogen precursor2002
urokinase plasminogen activator surface receptor precursor2002
geminin8008
streptokinase A precursor0033
ATP-binding cassette sub-family C member 30808
Multidrug resistance-associated protein 40809
Bile salt export pump0909
ATP-dependent translocase ABCB10101
Canalicular multispecific organic anion transporter 10808
Solute carrier organic anion transporter family member 1B30305
Solute carrier organic anion transporter family member 1B10304
Protein-arginine deiminase type-40505
Chain A, 3-phosphoshikimate 1-carboxyvinyltransferase0101
Chain A, 3-phosphoshikimate 1-carboxyvinyltransferase0101
Glutamine synthetase 0101
Cytochrome P450 71B10102
Glutamine synthetase 0101
2-dehydro-3-deoxyphosphooctonate aldolase0101
Chain A, Beta-lactamase2002
GALC protein2002
AR protein110011
EWS/FLI fusion protein3003
retinoid X nuclear receptor alpha7007
pregnane X nuclear receptor7007
chromobox protein homolog 15005
Serum paraoxonase/arylesterase 10101
Luciferase1001
retinoic acid nuclear receptor alpha variant 15005
aryl hydrocarbon receptor3003
thyroid stimulating hormone receptor2002
Histone H2A.x2002
histone deacetylase 9 isoform 31001
ATPase family AAA domain-containing protein 57007
Ataxin-27007
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE2002
Chain B, DIHYDROFOLATE REDUCTASE0011
Chain B, DIHYDROFOLATE REDUCTASE0011
Chain A, TYROSYL-DNA PHOSPHODIESTERASE3003
Chain B, DIHYDROFOLATE REDUCTASE0011
Chain A, 2-oxoglutarate Oxygenase2002
Chain A, Ferritin light chain1001
acid sphingomyelinase1001
dopamine D1 receptor1001
thioredoxin reductase2002
ClpP1001
15-lipoxygenase, partial3003
ATAD5 protein, partial3003
USP1 protein, partial3003
TDP1 protein7007
Microtubule-associated protein tau2002
aldehyde dehydrogenase 1 family, member A13003
estrogen receptor 2 (ER beta)3003
nuclear receptor subfamily 1, group I, member 32002
progesterone receptor6006
67.9K protein1001
peroxisome proliferator activated receptor gamma2002
Thymidylate synthase 0101
alpha-galactosidase1001
IDH15005
euchromatic histone-lysine N-methyltransferase 25005
Thymidylate synthase 0101
Bloom syndrome protein isoform 13003
cellular tumor antigen p53 isoform a1001
polyunsaturated fatty acid lipoxygenase ALOX121001
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 11001
nuclear factor erythroid 2-related factor 2 isoform 27007
transcriptional regulator ERG isoform 31001
DNA polymerase beta1001
nuclear receptor coactivator 1 isoform 1 [Homo sapiens]0101
flap endonuclease 12002
peptidyl-prolyl cis-trans isomerase NIMA-interacting 11001
DNA polymerase eta isoform 11001
DNA polymerase iota isoform a (long)1001
transactivating tegument protein VP16 [Human herpesvirus 1]0101
DNA polymerase kappa isoform 11001
survival motor neuron protein isoform d1001
M-phase phosphoprotein 82002
muscleblind-like protein 1 isoform 13003
histone acetyltransferase KAT2A isoform 11001
caspase-1 isoform alpha precursor1001
nuclear receptor coactivator 3 isoform a0101
Toll-like receptor 40101
Fatty-acid amide hydrolase 10101
Bile salt export pump0303
ATP-binding cassette sub-family C member 30102
Voltage-dependent calcium channel gamma-2 subunit2002
Dihydrofolate reductase0203
Dihydrofolate reductase0203
Dihydrofolate reductase 0101
Dihydrofolate reductase0101
Dihydrofolate reductase0101
Dihydrofolate reductase0203
Thymidylate synthase0101
Tyrosine-protein kinase ABL10011
Carbonic anhydrase 20011
Cellular tumor antigen p535005
Thymidylate synthase0202
Integrin beta-31001
Bifunctional dihydrofolate reductase-thymidylate synthase0101
Thymidylate synthase0202
Integrin alpha-IIb1001
5-hydroxytryptamine receptor 2C0102
High mobility group protein B10011
Dihydrofolate reductase0101
Thymidylate synthase0101
Dihydrofolate reductase0224
Glucose-6-phosphate 1-dehydrogenase0202
Bifunctional dihydrofolate reductase-thymidylate synthase0101
Folate receptor beta0101
5-hydroxytryptamine receptor 2A0101
Cytochrome P450 11B1, mitochondrial 0101
Folate receptor alpha0101
Dihydrofolate reductase0202
Histidine decarboxylase0101
Glutamate receptor 22002
Trifunctional purine biosynthetic protein adenosine-30101
Cyclin-dependent kinase 20011
Bifunctional purine biosynthesis protein ATIC0202
Multidrug resistance-associated protein 1 0001
Delta-type opioid receptor0101
Mu-type opioid receptor0101
Kappa-type opioid receptor0101
Reduced folate transporter0202
Folylpolyglutamate synthase, mitochondrial0103
6-phosphogluconate dehydrogenase, decarboxylating0101
Caspase-71001
Spike glycoprotein3003
Solute carrier organic anion transporter family member 1A30001
Dihydrofolate reductase0101
Pteridine reductase 10101
Folylpolyglutamate synthase, mitochondrial0103
Bifunctional dihydrofolate reductase-thymidylate synthase0101
TAR DNA-binding protein 433003
Bifunctional dihydrofolate reductase-thymidylate synthase0101
Solute carrier family 22 member 60002
Canalicular multispecific organic anion transporter 10102
Trifunctional purine biosynthetic protein adenosine-30101
Solute carrier family 22 member 200101
Dihydrofolate reductase 0101
Solute carrier family 22 member 80203
Solute carrier family 22 member 60101
Dihydrofolate reductase0101
ATP-binding cassette sub-family C member 110001
Proton-coupled folate transporter0101
Multidrug resistance associated protein0102
Solute carrier family 22 member 110001
ATP-dependent phosphofructokinase3003
acetylcholinesterase1001
hypoxia-inducible factor 1 alpha subunit3003
PPM1D protein2002
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)4004
nonstructural protein 12002
G1001
bromodomain adjacent to zinc finger domain 2B1001
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a7007
nuclear receptor subfamily 1, group I, member 25005
Nuclear receptor subfamily 1 group I member 20022
Interferon beta4004
HLA class I histocompatibility antigen, B alpha chain 1001
Glucocorticoid receptor010217
Glycine receptor subunit alpha-1010010
Androgen receptor0303
Glycine receptor subunit beta010010
Glycine receptor subunit alpha-2010010
Glycine receptor subunit alpha-3010010
Inositol hexakisphosphate kinase 11001
Nuclear receptor subfamily 1 group I member 20011
cytochrome P450 2C9, partial1001
Albumin0022
Stromelysin-10101
Matrilysin0101
Multidrug transporter MdfA0101
Matrix metalloproteinase-90101
Cytochrome P450 2J20303
Protein mono-ADP-ribosyltransferase PARP150101
Beta-lactamase 0001
Beta-lactamase 0001
Beta-lactamase 0001
Beta-lactamase 0001
Beta-lactamase 0001
Beta-lactamase 0001
Beta-lactamase 0001
Beta-lactamase 0001
Beta-lactamase 0001
Metallo-beta-lactamase type 20001
Metallo-beta-lactamase VIM-11 0001
Beta-lactamase 0001
Metallo-beta-lactamase VIM-20001
Beta-lactamase 0001
Metallo-beta-lactamase VIM-19 0001
Beta-lactamase 0001
Beta-lactamase 0001
Metallo-beta-lactamase0001
Beta-lactamase 0001
Solute carrier family 22 member 60101
Beta-lactamase0001
Solute carrier family 22 member 80102
Beta-lactamase0001
Beta-lactamase 10001
Beta-lactamase0001
Beta-lactamase SHV-10001
Beta-lactamase SHV-10001
Beta-lactamase OXA-100001
Beta-lactamase0001
Beta-lactamase0001
Kappa-type opioid receptor0001
Solute carrier family 15 member 10101
Beta-lactamase TEM0102
Guanine nucleotide-binding protein G1001
Beta-lactamase0001
B2 metallo-beta-lactamase 0001
Solute carrier family 15 member 20101
Metallo-beta-lactamase VIM-130001
Beta-lactamase 0001
Beta-lactamase 0001
Efflux transporter 0001
Beta-lactamase 0001
Metallo-beta-lactamase VIM-20001
Beta-lactamase Toho-10001
Beta-lactamase 0001
Beta-lactamase 0001
Class D beta-lactamase0001
Beta-lactamase 0001
Solute carrier family 15 member 20101
Beta-lactamase 0001
Beta-lactamase 0001
Beta-lactamase 0001
Beta-lactamase 0001
Metallo-b-lactamase 0001
Beta-lactamase IMP-1 0001
BlaVIM-1 0001
Beta-lactamase 0001
Beta-lactamase 0001
Beta-lactamase 0001
Carbapenem-hydrolyzing beta-lactamase KPC0001
Beta-lactamase class B VIM-2 0001
Beta-lactamase 0001
Solute carrier family 22 member 80102
Beta-lactamase VIM-1 0001
Chain A, Putative fructose-1,6-bisphosphate aldolase1001
endonuclease IV1001
RAR-related orphan receptor gamma4004
thyroid stimulating hormone receptor3003
arylsulfatase A2002
peripheral myelin protein 22 isoform 12002
cytochrome P450 2C19 precursor1001
potassium voltage-gated channel subfamily H member 2 isoform d1001
Polyunsaturated fatty acid lipoxygenase ALOX15B2002
Histamine H2 receptor2002
Chain A, Immunoglobulin0011
Chain B, Immunoglobulin0011
Glutamate receptor ionotropic, NMDA 2D0101
Glutamate receptor ionotropic, NMDA 3B0101
Muscarinic acetylcholine receptor M10011
Muscarinic acetylcholine receptor M30011
Muscarinic acetylcholine receptor M40011
Muscarinic acetylcholine receptor M50011
Muscarinic acetylcholine receptor M20011
Muscarinic acetylcholine receptor M10012
Cytochrome P450 2B60112
Sodium-dependent serotonin transporter0101
Muscarinic acetylcholine receptor M40012
Delta-type opioid receptor0001
Kappa-type opioid receptor0001
Glutamate receptor ionotropic, NMDA 1 0202
Lysosomal Pro-X carboxypeptidase0101
Mu-type opioid receptor0001
Glutamate receptor ionotropic, NMDA 2A 0202
Glutamate receptor ionotropic, NMDA 2B0202
Glutamate receptor ionotropic, NMDA 2C0203
Cholinesterase0101
Glutamate receptor ionotropic, NMDA 10202
Glutamate receptor ionotropic, NMDA 2A0202
Glutamate receptor ionotropic, NMDA 2B0202
Glutamate receptor ionotropic, NMDA 2C0101
Glutamate receptor ionotropic, NMDA 2D0202
Glutamate receptor ionotropic, NMDA 3A0101
Glutamate receptor ionotropic, NMDA 3B0202
Muscarinic acetylcholine receptor M50012
Sigma non-opioid intracellular receptor 10101
Muscarinic acetylcholine receptor M30012
Muscarinic acetylcholine receptor M20012
Sigma non-opioid intracellular receptor 10202
Glutamate receptor ionotropic, NMDA 3A0202
Gag-Pol polyprotein0101
Gag-Pol polyprotein0101
Protease 0202
luciferase0001
v-jun sarcoma virus 17 oncogene homolog (avian)2002
Fatty acid-binding protein, liver0101
Estrogen receptor0202
Progesterone receptor0203
Glucocorticoid receptor0112
Glucocorticoid receptor0011
Corticosteroid-binding globulin0101
Mineralocorticoid receptor 0213
Androgen receptor0202
Glutamine synthetase0011
Histamine H1 receptor0011
Prostaglandin G/H synthase 20101
Nociceptin receptor0011
Estrogen receptor beta0202
pregnane X receptor1001
thioredoxin glutathione reductase2002
nuclear receptor ROR-gamma isoform 12002
DNA-directed RNA polymerase subunit beta0101
Solute carrier organic anion transporter family member 1A40101
Solute carrier organic anion transporter family member 2B1 0202
NH(3)-dependent NAD(+) synthetase0101
60 kDa heat shock protein, mitochondrial0101
Polyunsaturated fatty acid lipoxygenase ALOX150101
Arylacetamide deacetylase0102
Caspase-10101
Alpha-synuclein0101
Solute carrier organic anion transporter family member 1A10101
Solute carrier organic anion transporter family member 1A20101
10 kDa heat shock protein, mitochondrial0101
Glutathione S-transferase omega-10101
DNA gyrase subunit B0101
DNA gyrase subunit A0101
Enoyl-[acyl-carrier-protein] reductase [NADH]0101
DNA-directed RNA polymerase subunit beta0101
Thiosulfate sulfurtransferase0101
Lanosterol 14-alpha demethylase0101
60 kDa chaperonin 0101
10 kDa chaperonin 0101
Amyloid-beta precursor protein0101
Cholinesterase0101
glp-1 receptor, partial2002
SMAD family member 22002
NFKB1 protein, partial1001
SMAD family member 32002
Smad31001
heat shock protein beta-12002
procathepsin L isoform 1 preproprotein0101
cytochrome P450 3A4 isoform 12002
Gamma-aminobutyric acid receptor subunit pi2002
Gamma-aminobutyric acid receptor subunit beta-12002
Gamma-aminobutyric acid receptor subunit delta2002
Gamma-aminobutyric acid receptor subunit gamma-22002
Gamma-aminobutyric acid receptor subunit alpha-52002
Gamma-aminobutyric acid receptor subunit alpha-32002
Gamma-aminobutyric acid receptor subunit gamma-12002
Gamma-aminobutyric acid receptor subunit alpha-22002
Gamma-aminobutyric acid receptor subunit alpha-42002
Gamma-aminobutyric acid receptor subunit gamma-32002
Gamma-aminobutyric acid receptor subunit alpha-62002
Gamma-aminobutyric acid receptor subunit alpha-12002
Gamma-aminobutyric acid receptor subunit beta-32002
Gamma-aminobutyric acid receptor subunit beta-22002
GABA theta subunit2002
Gamma-aminobutyric acid receptor subunit epsilon2002
cytochrome P450 2D61001
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a1001
Chain A, Glycogen phosphorylase, liver form0011
Chain A, glycogen phosphorylase, liver form0011
Chain A, Glycogen phosphorylase, liver form0011
Chain A, Glycogen phosphorylase, liver form0011
Solute carrier family 2, facilitated glucose transporter member 90112
Guanine deaminase0101
twin arginine protein translocation system - TatA protein0001
30S ribosomal protein S60101
30S ribosomal protein S70101
50S ribosomal protein L150101
50S ribosomal protein L100101
50S ribosomal protein L110101
50S ribosomal protein L7/L120101
50S ribosomal protein L190101
50S ribosomal protein L10101
50S ribosomal protein L200101
50S ribosomal protein L270101
50S ribosomal protein L280101
50S ribosomal protein L290101
50S ribosomal protein L310101
50S ribosomal protein L31 type B0101
50S ribosomal protein L320101
50S ribosomal protein L330101
50S ribosomal protein L340101
50S ribosomal protein L350101
50S ribosomal protein L360101
30S ribosomal protein S100101
30S ribosomal protein S110101
30S ribosomal protein S120101
30S ribosomal protein S130101
30S ribosomal protein S160101
30S ribosomal protein S180101
30S ribosomal protein S190101
30S ribosomal protein S200101
30S ribosomal protein S20101
30S ribosomal protein S30101
30S ribosomal protein S40101
30S ribosomal protein S50101
30S ribosomal protein S80101
30S ribosomal protein S90101
50S ribosomal protein L130101
50S ribosomal protein L140101
50S ribosomal protein L160101
50S ribosomal protein L230101
30S ribosomal protein S150101
50S ribosomal protein L170101
50S ribosomal protein L210101
50S ribosomal protein L300101
50S ribosomal protein L60101
30S ribosomal protein S140101
30S ribosomal protein S170101
30S ribosomal protein S10101
50S ribosomal protein L180101
50S ribosomal protein L20101
50S ribosomal protein L30101
50S ribosomal protein L240101
50S ribosomal protein L40101
50S ribosomal protein L220101
50S ribosomal protein L50101
30S ribosomal protein S210101
50S ribosomal protein L250101
50S ribosomal protein L36 20101
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]