netrin receptor binding

Definition

Target type: molecularfunction

Binding to a netrin receptor. [GOC:kmv, PMID:8861902, PMID:9126742]

Netrin receptors are transmembrane proteins that mediate the binding of netrin-1, a secreted protein involved in axon guidance, cell migration, and angiogenesis. The binding of netrin-1 to its receptors, such as DCC (Deleted in Colorectal Cancer) and UNC5, triggers intracellular signaling pathways that regulate cell behavior.

Netrin receptor binding activates the following molecular functions:

**1. Signal transduction:** Upon netrin-1 binding, netrin receptors initiate intracellular signaling cascades, primarily through the recruitment of adaptor proteins like SH2 and SH3 domains. These interactions activate downstream signaling pathways such as the PI3K/Akt pathway and the Rho GTPase pathway.

**2. Axon guidance:** Netrin-1 acts as a chemoattractant or chemorepellent for growing axons, guiding them towards or away from specific targets. The binding of netrin-1 to DCC promotes axon growth and guidance towards netrin-1 sources. Conversely, binding to UNC5 receptors can lead to axon repulsion, directing axons away from netrin-1.

**3. Cell migration:** Netrin receptors regulate cell migration in various developmental and physiological processes, including neuronal migration, angiogenesis, and immune cell trafficking. Netrin-1 binding can promote or inhibit cell migration depending on the specific receptor involved and the cellular context.

**4. Angiogenesis:** Netrin-1 and its receptors play a role in the formation of new blood vessels (angiogenesis). Netrin-1 can promote angiogenesis by stimulating endothelial cell proliferation and migration.

**5. Cell survival and differentiation:** Netrin receptors can also influence cell survival and differentiation through the regulation of apoptotic pathways.

Overall, netrin receptor binding serves as a crucial molecular switch that mediates diverse cellular responses, including axon guidance, cell migration, angiogenesis, and survival. The specific outcome of netrin receptor activation depends on the interplay between various factors such as the type of netrin receptor involved, the cellular context, and the presence of other signaling molecules.
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Proteins (1)

Compounds (60)