Compounds > nsc751382
Page last updated: 2024-11-13

nsc751382

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth

Cross-References

ID SourceID
PubMed CID56967399
CHEMBL ID1935538
SCHEMBL ID15942813
MeSH IDM0576701

Synonyms (6)

Synonym
chembl1935538 ,
nsc-751382
bdbm50097558
nsc751382
n-(3-((2,5-dimethylbenzyl)oxy)-4-(n-methylmethylsulfonamido)phenyl)-2,3-dihydro-1h-indene-5-carboxamide
SCHEMBL15942813

Research Excerpts

Pharmacokinetics

ExcerptReferenceRelevance
" Pharmacokinetic studies demonstrate the good bioavailability of the compound."( From COX-2 inhibitor nimesulide to potent anti-cancer agent: synthesis, in vitro, in vivo and pharmacokinetic evaluation.
Cai, X; Chennamaneni, S; Dowlati, A; Liu, L; Pink, JJ; Su, B; Xu, Y; Yi, X; Zhong, B; Zhou, A, 2012)		0.38

Bioavailability

ExcerptReferenceRelevance
" Pharmacokinetic studies demonstrate the good bioavailability of the compound."( From COX-2 inhibitor nimesulide to potent anti-cancer agent: synthesis, in vitro, in vivo and pharmacokinetic evaluation.
Cai, X; Chennamaneni, S; Dowlati, A; Liu, L; Pink, JJ; Su, B; Xu, Y; Yi, X; Zhong, B; Zhou, A, 2012)		0.38

Dosage Studied

ExcerptRelevanceReference
" Intraperitoneal injection with a dosage of 5  mg/kg/d of CSUOH0901 to nude mice suppresses HT29 colorectal xenograft growth."( From COX-2 inhibitor nimesulide to potent anti-cancer agent: synthesis, in vitro, in vivo and pharmacokinetic evaluation.
Cai, X; Chennamaneni, S; Dowlati, A; Liu, L; Pink, JJ; Su, B; Xu, Y; Yi, X; Zhong, B; Zhou, A, 2012)		0.38
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (1)

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Heat shock protein beta-1Homo sapiens (human)IC50 (µMol)0.20000.02500.09920.2000AID1231949
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (22)

Processvia Protein(s)Taxonomy
regulation of protein phosphorylationHeat shock protein beta-1Homo sapiens (human)
regulation of translational initiationHeat shock protein beta-1Homo sapiens (human)
negative regulation of protein kinase activityHeat shock protein beta-1Homo sapiens (human)
response to unfolded proteinHeat shock protein beta-1Homo sapiens (human)
response to virusHeat shock protein beta-1Homo sapiens (human)
regulation of autophagyHeat shock protein beta-1Homo sapiens (human)
positive regulation of interleukin-1 beta productionHeat shock protein beta-1Homo sapiens (human)
positive regulation of tumor necrosis factor productionHeat shock protein beta-1Homo sapiens (human)
intracellular signal transductionHeat shock protein beta-1Homo sapiens (human)
cellular response to vascular endothelial growth factor stimulusHeat shock protein beta-1Homo sapiens (human)
negative regulation of apoptotic processHeat shock protein beta-1Homo sapiens (human)
regulation of canonical NF-kappaB signal transductionHeat shock protein beta-1Homo sapiens (human)
positive regulation of blood vessel endothelial cell migrationHeat shock protein beta-1Homo sapiens (human)
positive regulation of angiogenesisHeat shock protein beta-1Homo sapiens (human)
vascular endothelial growth factor receptor signaling pathwayHeat shock protein beta-1Homo sapiens (human)
chaperone-mediated protein foldingHeat shock protein beta-1Homo sapiens (human)
platelet aggregationHeat shock protein beta-1Homo sapiens (human)
anterograde axonal protein transportHeat shock protein beta-1Homo sapiens (human)
negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathwayHeat shock protein beta-1Homo sapiens (human)
positive regulation of endothelial cell chemotaxisHeat shock protein beta-1Homo sapiens (human)
response to heatHeat shock protein beta-1Homo sapiens (human)
protein refoldingHeat shock protein beta-1Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (11)

Processvia Protein(s)Taxonomy
RNA bindingHeat shock protein beta-1Homo sapiens (human)
protein kinase C bindingHeat shock protein beta-1Homo sapiens (human)
protein bindingHeat shock protein beta-1Homo sapiens (human)
protein kinase C inhibitor activityHeat shock protein beta-1Homo sapiens (human)
protein kinase bindingHeat shock protein beta-1Homo sapiens (human)
identical protein bindingHeat shock protein beta-1Homo sapiens (human)
protein homodimerization activityHeat shock protein beta-1Homo sapiens (human)
ubiquitin bindingHeat shock protein beta-1Homo sapiens (human)
protein folding chaperoneHeat shock protein beta-1Homo sapiens (human)
RNA polymerase II-specific DNA-binding transcription factor bindingHeat shock protein beta-1Homo sapiens (human)
unfolded protein bindingHeat shock protein beta-1Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (12)

Processvia Protein(s)Taxonomy
cornified envelopeHeat shock protein beta-1Homo sapiens (human)
extracellular spaceHeat shock protein beta-1Homo sapiens (human)
nucleusHeat shock protein beta-1Homo sapiens (human)
cytoplasmHeat shock protein beta-1Homo sapiens (human)
spindleHeat shock protein beta-1Homo sapiens (human)
cytosolHeat shock protein beta-1Homo sapiens (human)
cytoskeletonHeat shock protein beta-1Homo sapiens (human)
focal adhesionHeat shock protein beta-1Homo sapiens (human)
Z discHeat shock protein beta-1Homo sapiens (human)
extracellular exosomeHeat shock protein beta-1Homo sapiens (human)
axon cytoplasmHeat shock protein beta-1Homo sapiens (human)
proteasome complexHeat shock protein beta-1Homo sapiens (human)
cytoplasmHeat shock protein beta-1Homo sapiens (human)
nucleusHeat shock protein beta-1Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (167)

Assay IDTitleYearJournalArticle
AID639276Apparent oral clearance in Sprague-Dawley rat at 20 mg/kg, ip2012European journal of medicinal chemistry, Jan, Volume: 47, Issue:1
From COX-2 inhibitor nimesulide to potent anti-cancer agent: synthesis, in vitro, in vivo and pharmacokinetic evaluation.
AID639190Growth inhibition of human ACHN cells after 48 hrs by SRB assay2012European journal of medicinal chemistry, Jan, Volume: 47, Issue:1
From COX-2 inhibitor nimesulide to potent anti-cancer agent: synthesis, in vitro, in vivo and pharmacokinetic evaluation.
AID639085Growth inhibition of human K562 cells after 48 hrs by SRB assay2012European journal of medicinal chemistry, Jan, Volume: 47, Issue:1
From COX-2 inhibitor nimesulide to potent anti-cancer agent: synthesis, in vitro, in vivo and pharmacokinetic evaluation.
AID639199Growth inhibition of human MDA-MB-231 cells after 48 hrs by SRB assay2012European journal of medicinal chemistry, Jan, Volume: 47, Issue:1
From COX-2 inhibitor nimesulide to potent anti-cancer agent: synthesis, in vitro, in vivo and pharmacokinetic evaluation.
AID638657Cell cycle arrest in human SK-BR-3 cells assessed as accumulation at G2/M phase at 0.50 uM after 3 hrs using propidium iodide staining by FACS analysis2012European journal of medicinal chemistry, Jan, Volume: 47, Issue:1
From COX-2 inhibitor nimesulide to potent anti-cancer agent: synthesis, in vitro, in vivo and pharmacokinetic evaluation.
AID638808Cell cycle arrest in human SK-BR-3 cells assessed as accumulation at S phase at 0.10 uM after 12 hrs using propidium iodide staining by FACS analysis2012European journal of medicinal chemistry, Jan, Volume: 47, Issue:1
From COX-2 inhibitor nimesulide to potent anti-cancer agent: synthesis, in vitro, in vivo and pharmacokinetic evaluation.
AID638752Cell cycle arrest in human SK-BR-3 cells assessed as accumulation at Sub-G1 phase at 5 uM after 6 hrs using propidium iodide staining by FACS analysis2012European journal of medicinal chemistry, Jan, Volume: 47, Issue:1
From COX-2 inhibitor nimesulide to potent anti-cancer agent: synthesis, in vitro, in vivo and pharmacokinetic evaluation.
AID639176Growth inhibition of human SK-MEL-2 cells after 48 hrs by SRB assay2012European journal of medicinal chemistry, Jan, Volume: 47, Issue:1
From COX-2 inhibitor nimesulide to potent anti-cancer agent: synthesis, in vitro, in vivo and pharmacokinetic evaluation.
AID638811Cell cycle arrest in human SK-BR-3 cells assessed as accumulation at G1 phase at 0.25 uM after 12 hrs using propidium iodide staining by FACS analysis2012European journal of medicinal chemistry, Jan, Volume: 47, Issue:1
From COX-2 inhibitor nimesulide to potent anti-cancer agent: synthesis, in vitro, in vivo and pharmacokinetic evaluation.
AID639088Growth inhibition of human A549 cells after 48 hrs by SRB assay2012European journal of medicinal chemistry, Jan, Volume: 47, Issue:1
From COX-2 inhibitor nimesulide to potent anti-cancer agent: synthesis, in vitro, in vivo and pharmacokinetic evaluation.
AID639179Growth inhibition of human UACC257 cells after 48 hrs by SRB assay2012European journal of medicinal chemistry, Jan, Volume: 47, Issue:1
From COX-2 inhibitor nimesulide to potent anti-cancer agent: synthesis, in vitro, in vivo and pharmacokinetic evaluation.
AID639104Growth inhibition of human SF268 cells after 48 hrs by SRB assay2012European journal of medicinal chemistry, Jan, Volume: 47, Issue:1
From COX-2 inhibitor nimesulide to potent anti-cancer agent: synthesis, in vitro, in vivo and pharmacokinetic evaluation.
AID639183Growth inhibition of human OVCAR4 cells after 48 hrs by SRB assay2012European journal of medicinal chemistry, Jan, Volume: 47, Issue:1
From COX-2 inhibitor nimesulide to potent anti-cancer agent: synthesis, in vitro, in vivo and pharmacokinetic evaluation.
AID677620Antitrypanosomal activity against bloodstream form of Trypanosoma brucei 427 after 48 hrs by MTS assay2012Bioorganic & medicinal chemistry letters, Sep-01, Volume: 22, Issue:17
Identification of selective tubulin inhibitors as potential anti-trypanosomal agents.
AID638898Cell cycle arrest in human SK-BR-3 cells assessed as accumulation at G2/M phase at 0.10 uM after 24 hrs using propidium iodide staining by FACS analysis2012European journal of medicinal chemistry, Jan, Volume: 47, Issue:1
From COX-2 inhibitor nimesulide to potent anti-cancer agent: synthesis, in vitro, in vivo and pharmacokinetic evaluation.
AID639093Growth inhibition of human NCI-H23 cells after 48 hrs by SRB assay2012European journal of medicinal chemistry, Jan, Volume: 47, Issue:1
From COX-2 inhibitor nimesulide to potent anti-cancer agent: synthesis, in vitro, in vivo and pharmacokinetic evaluation.
AID639084Growth inhibition of human HL-60(TB) cells after 48 hrs by SRB assay2012European journal of medicinal chemistry, Jan, Volume: 47, Issue:1
From COX-2 inhibitor nimesulide to potent anti-cancer agent: synthesis, in vitro, in vivo and pharmacokinetic evaluation.
AID639108Growth inhibition of human SNB75 cells after 48 hrs by SRB assay2012European journal of medicinal chemistry, Jan, Volume: 47, Issue:1
From COX-2 inhibitor nimesulide to potent anti-cancer agent: synthesis, in vitro, in vivo and pharmacokinetic evaluation.
AID639097Growth inhibition of human COLO205 cells after 48 hrs by SRB assay2012European journal of medicinal chemistry, Jan, Volume: 47, Issue:1
From COX-2 inhibitor nimesulide to potent anti-cancer agent: synthesis, in vitro, in vivo and pharmacokinetic evaluation.
AID638739Cytotoxicity against human SK-BR-3 cells after 48 hrs by MTT assay2012European journal of medicinal chemistry, Jan, Volume: 47, Issue:1
From COX-2 inhibitor nimesulide to potent anti-cancer agent: synthesis, in vitro, in vivo and pharmacokinetic evaluation.
AID638826Cell cycle arrest in human SK-BR-3 cells assessed as accumulation at Sub-G1 phase at 0.25 uM after 18 hrs using propidium iodide staining by FACS analysis2012European journal of medicinal chemistry, Jan, Volume: 47, Issue:1
From COX-2 inhibitor nimesulide to potent anti-cancer agent: synthesis, in vitro, in vivo and pharmacokinetic evaluation.
AID638901Cell cycle arrest in human SK-BR-3 cells assessed as accumulation at S phase at 0.25 uM after 24 hrs using propidium iodide staining by FACS analysis2012European journal of medicinal chemistry, Jan, Volume: 47, Issue:1
From COX-2 inhibitor nimesulide to potent anti-cancer agent: synthesis, in vitro, in vivo and pharmacokinetic evaluation.
AID639109Growth inhibition of human U251 cells after 48 hrs by SRB assay2012European journal of medicinal chemistry, Jan, Volume: 47, Issue:1
From COX-2 inhibitor nimesulide to potent anti-cancer agent: synthesis, in vitro, in vivo and pharmacokinetic evaluation.
AID639195Growth inhibition of human UO31 cells after 48 hrs by SRB assay2012European journal of medicinal chemistry, Jan, Volume: 47, Issue:1
From COX-2 inhibitor nimesulide to potent anti-cancer agent: synthesis, in vitro, in vivo and pharmacokinetic evaluation.
AID639174Growth inhibition of human M14 cells after 48 hrs by SRB assay2012European journal of medicinal chemistry, Jan, Volume: 47, Issue:1
From COX-2 inhibitor nimesulide to potent anti-cancer agent: synthesis, in vitro, in vivo and pharmacokinetic evaluation.
AID672090Inhibition of tubulin polymerization in human SKBR3 cells assessed as decrease in microtubule density at 0.5 to 1 uM after 24 hrs by fluorescence microscopic analysis2012Journal of medicinal chemistry, Apr-12, Volume: 55, Issue:7
Identification of a class of novel tubulin inhibitors.
AID639173Growth inhibition of human MALME-3M cells after 48 hrs by SRB assay2012European journal of medicinal chemistry, Jan, Volume: 47, Issue:1
From COX-2 inhibitor nimesulide to potent anti-cancer agent: synthesis, in vitro, in vivo and pharmacokinetic evaluation.
AID639197Growth inhibition of human DU145 cells after 48 hrs by SRB assay2012European journal of medicinal chemistry, Jan, Volume: 47, Issue:1
From COX-2 inhibitor nimesulide to potent anti-cancer agent: synthesis, in vitro, in vivo and pharmacokinetic evaluation.
AID638886Cell cycle arrest in human SK-BR-3 cells assessed as accumulation at G2/M phase at 0.25 uM after 18 hrs using propidium iodide staining by FACS analysis2012European journal of medicinal chemistry, Jan, Volume: 47, Issue:1
From COX-2 inhibitor nimesulide to potent anti-cancer agent: synthesis, in vitro, in vivo and pharmacokinetic evaluation.
AID638823Cell cycle arrest in human SK-BR-3 cells assessed as accumulation at G1 phase at 0.10 uM after 18 hrs using propidium iodide staining by FACS analysis2012European journal of medicinal chemistry, Jan, Volume: 47, Issue:1
From COX-2 inhibitor nimesulide to potent anti-cancer agent: synthesis, in vitro, in vivo and pharmacokinetic evaluation.
AID639091Growth inhibition of human HOP92 cells after 48 hrs by SRB assay2012European journal of medicinal chemistry, Jan, Volume: 47, Issue:1
From COX-2 inhibitor nimesulide to potent anti-cancer agent: synthesis, in vitro, in vivo and pharmacokinetic evaluation.
AID638896Cell cycle arrest in human SK-BR-3 cells assessed as accumulation at G1 phase at 0.10 uM after 24 hrs using propidium iodide staining by FACS analysis2012European journal of medicinal chemistry, Jan, Volume: 47, Issue:1
From COX-2 inhibitor nimesulide to potent anti-cancer agent: synthesis, in vitro, in vivo and pharmacokinetic evaluation.
AID639274AUC (0 to t) in Sprague-Dawley rat at 20 mg/kg, ip2012European journal of medicinal chemistry, Jan, Volume: 47, Issue:1
From COX-2 inhibitor nimesulide to potent anti-cancer agent: synthesis, in vitro, in vivo and pharmacokinetic evaluation.
AID638895Cell cycle arrest in human SK-BR-3 cells assessed as accumulation at Sub-G1 phase at 0.10 uM after 24 hrs using propidium iodide staining by FACS analysis2012European journal of medicinal chemistry, Jan, Volume: 47, Issue:1
From COX-2 inhibitor nimesulide to potent anti-cancer agent: synthesis, in vitro, in vivo and pharmacokinetic evaluation.
AID639094Growth inhibition of human NCI-H322M cells after 48 hrs by SRB assay2012European journal of medicinal chemistry, Jan, Volume: 47, Issue:1
From COX-2 inhibitor nimesulide to potent anti-cancer agent: synthesis, in vitro, in vivo and pharmacokinetic evaluation.
AID639196Growth inhibition of human PC3 cells after 48 hrs by SRB assay2012European journal of medicinal chemistry, Jan, Volume: 47, Issue:1
From COX-2 inhibitor nimesulide to potent anti-cancer agent: synthesis, in vitro, in vivo and pharmacokinetic evaluation.
AID639172Growth inhibition of human LOXIMVI cells after 48 hrs by SRB assay2012European journal of medicinal chemistry, Jan, Volume: 47, Issue:1
From COX-2 inhibitor nimesulide to potent anti-cancer agent: synthesis, in vitro, in vivo and pharmacokinetic evaluation.
AID639189Growth inhibition of human A498 cells after 48 hrs by SRB assay2012European journal of medicinal chemistry, Jan, Volume: 47, Issue:1
From COX-2 inhibitor nimesulide to potent anti-cancer agent: synthesis, in vitro, in vivo and pharmacokinetic evaluation.
AID638749Cell cycle arrest in human SK-BR-3 cells assessed as accumulation at G1 phase at 0.50 uM after 6 hrs using propidium iodide staining by FACS analysis2012European journal of medicinal chemistry, Jan, Volume: 47, Issue:1
From COX-2 inhibitor nimesulide to potent anti-cancer agent: synthesis, in vitro, in vivo and pharmacokinetic evaluation.
AID639194Growth inhibition of human TK10 cells after 48 hrs by SRB assay2012European journal of medicinal chemistry, Jan, Volume: 47, Issue:1
From COX-2 inhibitor nimesulide to potent anti-cancer agent: synthesis, in vitro, in vivo and pharmacokinetic evaluation.
AID639203Growth inhibition of human MDA-MB-468 cells after 48 hrs by SRB assay2012European journal of medicinal chemistry, Jan, Volume: 47, Issue:1
From COX-2 inhibitor nimesulide to potent anti-cancer agent: synthesis, in vitro, in vivo and pharmacokinetic evaluation.
AID639185Growth inhibition of human OVCAR8 cells after 48 hrs by SRB assay2012European journal of medicinal chemistry, Jan, Volume: 47, Issue:1
From COX-2 inhibitor nimesulide to potent anti-cancer agent: synthesis, in vitro, in vivo and pharmacokinetic evaluation.
AID639086Growth inhibition of human MOLT4 cells after 48 hrs by SRB assay2012European journal of medicinal chemistry, Jan, Volume: 47, Issue:1
From COX-2 inhibitor nimesulide to potent anti-cancer agent: synthesis, in vitro, in vivo and pharmacokinetic evaluation.
AID639201Growth inhibition of human BT549 cells after 48 hrs by SRB assay2012European journal of medicinal chemistry, Jan, Volume: 47, Issue:1
From COX-2 inhibitor nimesulide to potent anti-cancer agent: synthesis, in vitro, in vivo and pharmacokinetic evaluation.
AID639082Cell cycle arrest in human SK-BR-3 cells assessed as accumulation at G2/M phase at 5 uM after 24 hrs using propidium iodide staining by FACS analysis2012European journal of medicinal chemistry, Jan, Volume: 47, Issue:1
From COX-2 inhibitor nimesulide to potent anti-cancer agent: synthesis, in vitro, in vivo and pharmacokinetic evaluation.
AID639181Growth inhibition of human IGROV1 cells after 48 hrs by SRB assay2012European journal of medicinal chemistry, Jan, Volume: 47, Issue:1
From COX-2 inhibitor nimesulide to potent anti-cancer agent: synthesis, in vitro, in vivo and pharmacokinetic evaluation.
AID639100Growth inhibition of human HCT15 cells after 48 hrs by SRB assay2012European journal of medicinal chemistry, Jan, Volume: 47, Issue:1
From COX-2 inhibitor nimesulide to potent anti-cancer agent: synthesis, in vitro, in vivo and pharmacokinetic evaluation.
AID638885Cell cycle arrest in human SK-BR-3 cells assessed as accumulation at S phase at 0.25 uM after 18 hrs using propidium iodide staining by FACS analysis2012European journal of medicinal chemistry, Jan, Volume: 47, Issue:1
From COX-2 inhibitor nimesulide to potent anti-cancer agent: synthesis, in vitro, in vivo and pharmacokinetic evaluation.
AID638756Cell cycle arrest in human SK-BR-3 cells assessed as accumulation at Sub-G1 phase at 0.10 uM after 12 hrs using propidium iodide staining by FACS analysis2012European journal of medicinal chemistry, Jan, Volume: 47, Issue:1
From COX-2 inhibitor nimesulide to potent anti-cancer agent: synthesis, in vitro, in vivo and pharmacokinetic evaluation.
AID638825Cell cycle arrest in human SK-BR-3 cells assessed as accumulation at G2/M phase at 0.10 uM after 18 hrs using propidium iodide staining by FACS analysis2012European journal of medicinal chemistry, Jan, Volume: 47, Issue:1
From COX-2 inhibitor nimesulide to potent anti-cancer agent: synthesis, in vitro, in vivo and pharmacokinetic evaluation.
AID639202Growth inhibition of human T47D cells after 48 hrs by SRB assay2012European journal of medicinal chemistry, Jan, Volume: 47, Issue:1
From COX-2 inhibitor nimesulide to potent anti-cancer agent: synthesis, in vitro, in vivo and pharmacokinetic evaluation.
AID639178Growth inhibition of human SK-MEL-5 cells after 48 hrs by SRB assay2012European journal of medicinal chemistry, Jan, Volume: 47, Issue:1
From COX-2 inhibitor nimesulide to potent anti-cancer agent: synthesis, in vitro, in vivo and pharmacokinetic evaluation.
AID639103Growth inhibition of human SW620 cells after 48 hrs by SRB assay2012European journal of medicinal chemistry, Jan, Volume: 47, Issue:1
From COX-2 inhibitor nimesulide to potent anti-cancer agent: synthesis, in vitro, in vivo and pharmacokinetic evaluation.
AID639092Growth inhibition of human NCI-H226 cells after 48 hrs by SRB assay2012European journal of medicinal chemistry, Jan, Volume: 47, Issue:1
From COX-2 inhibitor nimesulide to potent anti-cancer agent: synthesis, in vitro, in vivo and pharmacokinetic evaluation.
AID639193Growth inhibition of human SN12C cells after 48 hrs by SRB assay2012European journal of medicinal chemistry, Jan, Volume: 47, Issue:1
From COX-2 inhibitor nimesulide to potent anti-cancer agent: synthesis, in vitro, in vivo and pharmacokinetic evaluation.
AID639272Tmax in Sprague-Dawley rat plasma at 20 mg/kg, ip2012European journal of medicinal chemistry, Jan, Volume: 47, Issue:1
From COX-2 inhibitor nimesulide to potent anti-cancer agent: synthesis, in vitro, in vivo and pharmacokinetic evaluation.
AID638746Cell cycle arrest in human SK-BR-3 cells assessed as accumulation at S phase at 0.25 uM after 6 hrs using propidium iodide staining by FACS analysis2012European journal of medicinal chemistry, Jan, Volume: 47, Issue:1
From COX-2 inhibitor nimesulide to potent anti-cancer agent: synthesis, in vitro, in vivo and pharmacokinetic evaluation.
AID639106Growth inhibition of human SF539 cells after 48 hrs by SRB assay2012European journal of medicinal chemistry, Jan, Volume: 47, Issue:1
From COX-2 inhibitor nimesulide to potent anti-cancer agent: synthesis, in vitro, in vivo and pharmacokinetic evaluation.
AID639192Growth inhibition of human RXF393 cells after 48 hrs by SRB assay2012European journal of medicinal chemistry, Jan, Volume: 47, Issue:1
From COX-2 inhibitor nimesulide to potent anti-cancer agent: synthesis, in vitro, in vivo and pharmacokinetic evaluation.
AID638748Cell cycle arrest in human SK-BR-3 cells assessed as accumulation at Sub-G1 phase at 0.50 uM after 6 hrs using propidium iodide staining by FACS analysis2012European journal of medicinal chemistry, Jan, Volume: 47, Issue:1
From COX-2 inhibitor nimesulide to potent anti-cancer agent: synthesis, in vitro, in vivo and pharmacokinetic evaluation.
AID638658Cell cycle arrest in human SK-BR-3 cells assessed as accumulation at S phase at 0.50 uM after 3 hrs using propidium iodide staining by FACS analysis2012European journal of medicinal chemistry, Jan, Volume: 47, Issue:1
From COX-2 inhibitor nimesulide to potent anti-cancer agent: synthesis, in vitro, in vivo and pharmacokinetic evaluation.
AID638750Cell cycle arrest in human SK-BR-3 cells assessed as accumulation at S phase at 0.50 uM after 6 hrs using propidium iodide staining by FACS analysis2012European journal of medicinal chemistry, Jan, Volume: 47, Issue:1
From COX-2 inhibitor nimesulide to potent anti-cancer agent: synthesis, in vitro, in vivo and pharmacokinetic evaluation.
AID639271Cmax in Sprague-Dawley rat plasma at 20 mg/kg, ip2012European journal of medicinal chemistry, Jan, Volume: 47, Issue:1
From COX-2 inhibitor nimesulide to potent anti-cancer agent: synthesis, in vitro, in vivo and pharmacokinetic evaluation.
AID639200Growth inhibition of human Hs 578T cells after 48 hrs by SRB assay2012European journal of medicinal chemistry, Jan, Volume: 47, Issue:1
From COX-2 inhibitor nimesulide to potent anti-cancer agent: synthesis, in vitro, in vivo and pharmacokinetic evaluation.
AID639107Growth inhibition of human SNB19 cells after 48 hrs by SRB assay2012European journal of medicinal chemistry, Jan, Volume: 47, Issue:1
From COX-2 inhibitor nimesulide to potent anti-cancer agent: synthesis, in vitro, in vivo and pharmacokinetic evaluation.
AID639269Toxicity in BALB/c athymic nu/nu mouse xenografted with human HT-29 cells assessed as effect on body weight at 5 mg/kg/day, ip administered 5 times per week for 3 weeks2012European journal of medicinal chemistry, Jan, Volume: 47, Issue:1
From COX-2 inhibitor nimesulide to potent anti-cancer agent: synthesis, in vitro, in vivo and pharmacokinetic evaluation.
AID639184Growth inhibition of human OVCAR5 cells after 48 hrs by SRB assay2012European journal of medicinal chemistry, Jan, Volume: 47, Issue:1
From COX-2 inhibitor nimesulide to potent anti-cancer agent: synthesis, in vitro, in vivo and pharmacokinetic evaluation.
AID638890Cell cycle arrest in human SK-BR-3 cells assessed as accumulation at G2/M phase at 0.50 uM after 18 hrs using propidium iodide staining by FACS analysis2012European journal of medicinal chemistry, Jan, Volume: 47, Issue:1
From COX-2 inhibitor nimesulide to potent anti-cancer agent: synthesis, in vitro, in vivo and pharmacokinetic evaluation.
AID639198Growth inhibition of human MCF7 cells after 48 hrs by SRB assay2012European journal of medicinal chemistry, Jan, Volume: 47, Issue:1
From COX-2 inhibitor nimesulide to potent anti-cancer agent: synthesis, in vitro, in vivo and pharmacokinetic evaluation.
AID639095Growth inhibition of human NCI-H460 cells after 48 hrs by SRB assay2012European journal of medicinal chemistry, Jan, Volume: 47, Issue:1
From COX-2 inhibitor nimesulide to potent anti-cancer agent: synthesis, in vitro, in vivo and pharmacokinetic evaluation.
AID639105Growth inhibition of human SF295 cells after 48 hrs by SRB assay2012European journal of medicinal chemistry, Jan, Volume: 47, Issue:1
From COX-2 inhibitor nimesulide to potent anti-cancer agent: synthesis, in vitro, in vivo and pharmacokinetic evaluation.
AID672089Inhibition of tubulin polymerization in human SKBR3 cells assessed as microtubule disorganization at 0.5 to 1 uM after 24 hrs by fluorescence microscopic analysis2012Journal of medicinal chemistry, Apr-12, Volume: 55, Issue:7
Identification of a class of novel tubulin inhibitors.
AID638903Cell cycle arrest in human SK-BR-3 cells assessed as accumulation at Sub-G1 phase at 0.50 uM after 24 hrs using propidium iodide staining by FACS analysis2012European journal of medicinal chemistry, Jan, Volume: 47, Issue:1
From COX-2 inhibitor nimesulide to potent anti-cancer agent: synthesis, in vitro, in vivo and pharmacokinetic evaluation.
AID638661Cell cycle arrest in human SK-BR-3 cells assessed as accumulation at G2/M phase at 0.25 uM after 3 hrs using propidium iodide staining by FACS analysis2012European journal of medicinal chemistry, Jan, Volume: 47, Issue:1
From COX-2 inhibitor nimesulide to potent anti-cancer agent: synthesis, in vitro, in vivo and pharmacokinetic evaluation.
AID638738Cell cycle arrest in human SK-BR-3 cells assessed as accumulation at Sub-G1 phase at 0.10 uM after 3 hrs using propidium iodide staining by FACS analysis2012European journal of medicinal chemistry, Jan, Volume: 47, Issue:1
From COX-2 inhibitor nimesulide to potent anti-cancer agent: synthesis, in vitro, in vivo and pharmacokinetic evaluation.
AID639102Growth inhibition of human KM12 cells after 48 hrs by SRB assay2012European journal of medicinal chemistry, Jan, Volume: 47, Issue:1
From COX-2 inhibitor nimesulide to potent anti-cancer agent: synthesis, in vitro, in vivo and pharmacokinetic evaluation.
AID677622Selectivity ratio of IC50 for human SKBR3 cells to IC50 for bloodstream form of Trypanosoma brucei 4272012Bioorganic & medicinal chemistry letters, Sep-01, Volume: 22, Issue:17
Identification of selective tubulin inhibitors as potential anti-trypanosomal agents.
AID639270Antitumor activity against human HT-29 cells xenografted in BALB/c athymic nu/nu mouse assessed as decrease in tumor weight at 5 mg/kg/day, ip administered 5 times per week for 3 weeks2012European journal of medicinal chemistry, Jan, Volume: 47, Issue:1
From COX-2 inhibitor nimesulide to potent anti-cancer agent: synthesis, in vitro, in vivo and pharmacokinetic evaluation.
AID639191Growth inhibition of human Caki1 cells after 48 hrs by SRB assay2012European journal of medicinal chemistry, Jan, Volume: 47, Issue:1
From COX-2 inhibitor nimesulide to potent anti-cancer agent: synthesis, in vitro, in vivo and pharmacokinetic evaluation.
AID639079Cell cycle arrest in human SK-BR-3 cells assessed as accumulation at Sub-G1 phase at 5 uM after 24 hrs using propidium iodide staining by FACS analysis2012European journal of medicinal chemistry, Jan, Volume: 47, Issue:1
From COX-2 inhibitor nimesulide to potent anti-cancer agent: synthesis, in vitro, in vivo and pharmacokinetic evaluation.
AID638817Cell cycle arrest in human SK-BR-3 cells assessed as accumulation at G2/M phase at 0.50 uM after 12 hrs using propidium iodide staining by FACS analysis2012European journal of medicinal chemistry, Jan, Volume: 47, Issue:1
From COX-2 inhibitor nimesulide to potent anti-cancer agent: synthesis, in vitro, in vivo and pharmacokinetic evaluation.
AID639101Growth inhibition of human HT-29 cells after 48 hrs by SRB assay2012European journal of medicinal chemistry, Jan, Volume: 47, Issue:1
From COX-2 inhibitor nimesulide to potent anti-cancer agent: synthesis, in vitro, in vivo and pharmacokinetic evaluation.
AID638899Cell cycle arrest in human SK-BR-3 cells assessed as accumulation at Sub-G1 phase at 0.25 uM after 24 hrs using propidium iodide staining by FACS analysis2012European journal of medicinal chemistry, Jan, Volume: 47, Issue:1
From COX-2 inhibitor nimesulide to potent anti-cancer agent: synthesis, in vitro, in vivo and pharmacokinetic evaluation.
AID639089Growth inhibition of human EKVX cells after 48 hrs by SRB assay2012European journal of medicinal chemistry, Jan, Volume: 47, Issue:1
From COX-2 inhibitor nimesulide to potent anti-cancer agent: synthesis, in vitro, in vivo and pharmacokinetic evaluation.
AID638893Cell cycle arrest in human SK-BR-3 cells assessed as accumulation at S phase at 5 uM after 18 hrs using propidium iodide staining by FACS analysis2012European journal of medicinal chemistry, Jan, Volume: 47, Issue:1
From COX-2 inhibitor nimesulide to potent anti-cancer agent: synthesis, in vitro, in vivo and pharmacokinetic evaluation.
AID639182Growth inhibition of human OVCAR3 cells after 48 hrs by SRB assay2012European journal of medicinal chemistry, Jan, Volume: 47, Issue:1
From COX-2 inhibitor nimesulide to potent anti-cancer agent: synthesis, in vitro, in vivo and pharmacokinetic evaluation.
AID639280Ratio of JCC76 IC50 to compound IC50 for human SK-BR-3 cells2012European journal of medicinal chemistry, Jan, Volume: 47, Issue:1
From COX-2 inhibitor nimesulide to potent anti-cancer agent: synthesis, in vitro, in vivo and pharmacokinetic evaluation.
AID1231949Inhibition of HSP27 (unknown origin) by insulin aggregation assay2015Bioorganic & medicinal chemistry, Jul-01, Volume: 23, Issue:13
In silico evaluation of human small heat shock protein HSP27: homology modeling, mutation analyses and docking studies.
AID639188Growth inhibition of human 786-0 cells after 48 hrs by SRB assay2012European journal of medicinal chemistry, Jan, Volume: 47, Issue:1
From COX-2 inhibitor nimesulide to potent anti-cancer agent: synthesis, in vitro, in vivo and pharmacokinetic evaluation.
AID638737Cell cycle arrest in human SK-BR-3 cells assessed as accumulation at G1 phase at 0.10 uM after 3 hrs using propidium iodide staining by FACS analysis2012European journal of medicinal chemistry, Jan, Volume: 47, Issue:1
From COX-2 inhibitor nimesulide to potent anti-cancer agent: synthesis, in vitro, in vivo and pharmacokinetic evaluation.
AID638743Cell cycle arrest in human SK-BR-3 cells assessed as accumulation at G2/M phase at 0.10 uM after 6 hrs using propidium iodide staining by FACS analysis2012European journal of medicinal chemistry, Jan, Volume: 47, Issue:1
From COX-2 inhibitor nimesulide to potent anti-cancer agent: synthesis, in vitro, in vivo and pharmacokinetic evaluation.
AID638821Cell cycle arrest in human SK-BR-3 cells assessed as accumulation at G2/M phase at 5 uM after 12 hrs using propidium iodide staining by FACS analysis2012European journal of medicinal chemistry, Jan, Volume: 47, Issue:1
From COX-2 inhibitor nimesulide to potent anti-cancer agent: synthesis, in vitro, in vivo and pharmacokinetic evaluation.
AID734444Antiproliferative activity against human NCI-H292 2D monolayer cells after 3 days by MTT assay2013Bioorganic & medicinal chemistry, Feb-15, Volume: 21, Issue:4
Development, validation and pilot screening of an in vitro multi-cellular three-dimensional cancer spheroid assay for anti-cancer drug testing.
AID639175Growth inhibition of human MDA-MB-435 cells after 48 hrs by SRB assay2012European journal of medicinal chemistry, Jan, Volume: 47, Issue:1
From COX-2 inhibitor nimesulide to potent anti-cancer agent: synthesis, in vitro, in vivo and pharmacokinetic evaluation.
AID639186Growth inhibition of human NCI/ADR-RES cells after 48 hrs by SRB assay2012European journal of medicinal chemistry, Jan, Volume: 47, Issue:1
From COX-2 inhibitor nimesulide to potent anti-cancer agent: synthesis, in vitro, in vivo and pharmacokinetic evaluation.
AID638810Cell cycle arrest in human SK-BR-3 cells assessed as accumulation at Sub-G1 phase at 0.25 uM after 12 hrs using propidium iodide staining by FACS analysis2012European journal of medicinal chemistry, Jan, Volume: 47, Issue:1
From COX-2 inhibitor nimesulide to potent anti-cancer agent: synthesis, in vitro, in vivo and pharmacokinetic evaluation.
AID639098Growth inhibition of human HCC2998 cells after 48 hrs by SRB assay2012European journal of medicinal chemistry, Jan, Volume: 47, Issue:1
From COX-2 inhibitor nimesulide to potent anti-cancer agent: synthesis, in vitro, in vivo and pharmacokinetic evaluation.
AID639083Growth inhibition of human CCRF-CEM cells after 48 hrs by SRB assay2012European journal of medicinal chemistry, Jan, Volume: 47, Issue:1
From COX-2 inhibitor nimesulide to potent anti-cancer agent: synthesis, in vitro, in vivo and pharmacokinetic evaluation.
AID639087Growth inhibition of human RPMI8226 cells after 48 hrs by SRB assay2012European journal of medicinal chemistry, Jan, Volume: 47, Issue:1
From COX-2 inhibitor nimesulide to potent anti-cancer agent: synthesis, in vitro, in vivo and pharmacokinetic evaluation.
AID638809Cell cycle arrest in human SK-BR-3 cells assessed as accumulation at G2/M phase at 0.10 uM after 12 hrs using propidium iodide staining by FACS analysis2012European journal of medicinal chemistry, Jan, Volume: 47, Issue:1
From COX-2 inhibitor nimesulide to potent anti-cancer agent: synthesis, in vitro, in vivo and pharmacokinetic evaluation.
AID639090Growth inhibition of human HOP62 cells after 48 hrs by SRB assay2012European journal of medicinal chemistry, Jan, Volume: 47, Issue:1
From COX-2 inhibitor nimesulide to potent anti-cancer agent: synthesis, in vitro, in vivo and pharmacokinetic evaluation.
AID638818Cell cycle arrest in human SK-BR-3 cells assessed as accumulation at Sub-G1 phase at 5 uM after 12 hrs using propidium iodide staining by FACS analysis2012European journal of medicinal chemistry, Jan, Volume: 47, Issue:1
From COX-2 inhibitor nimesulide to potent anti-cancer agent: synthesis, in vitro, in vivo and pharmacokinetic evaluation.
AID639205Cytotoxicity against human HT-29 cells after 48 hrs by MTT assay2012European journal of medicinal chemistry, Jan, Volume: 47, Issue:1
From COX-2 inhibitor nimesulide to potent anti-cancer agent: synthesis, in vitro, in vivo and pharmacokinetic evaluation.
AID639268Antitumor activity against human HT-29 cells xenografted in BALB/c athymic nu/nu mouse assessed as decrease in tumor size at 5 mg/kg/day, ip administered 5 times per week for 3 weeks2012European journal of medicinal chemistry, Jan, Volume: 47, Issue:1
From COX-2 inhibitor nimesulide to potent anti-cancer agent: synthesis, in vitro, in vivo and pharmacokinetic evaluation.
AID639204Acute toxicity in nude mouse assessed as body weight loss at 100 to 400 mg/kg administered as single dose measured after 2 weeks2012European journal of medicinal chemistry, Jan, Volume: 47, Issue:1
From COX-2 inhibitor nimesulide to potent anti-cancer agent: synthesis, in vitro, in vivo and pharmacokinetic evaluation.
AID638820Cell cycle arrest in human SK-BR-3 cells assessed as accumulation at S phase at 5 uM after 12 hrs using propidium iodide staining by FACS analysis2012European journal of medicinal chemistry, Jan, Volume: 47, Issue:1
From COX-2 inhibitor nimesulide to potent anti-cancer agent: synthesis, in vitro, in vivo and pharmacokinetic evaluation.
AID639099Growth inhibition of human HCT116 cells after 48 hrs by SRB assay2012European journal of medicinal chemistry, Jan, Volume: 47, Issue:1
From COX-2 inhibitor nimesulide to potent anti-cancer agent: synthesis, in vitro, in vivo and pharmacokinetic evaluation.
AID638900Cell cycle arrest in human SK-BR-3 cells assessed as accumulation at G1 phase at 0.25 uM after 24 hrs using propidium iodide staining by FACS analysis2012European journal of medicinal chemistry, Jan, Volume: 47, Issue:1
From COX-2 inhibitor nimesulide to potent anti-cancer agent: synthesis, in vitro, in vivo and pharmacokinetic evaluation.
AID638819Cell cycle arrest in human SK-BR-3 cells assessed as accumulation at G1 phase at 5 uM after 12 hrs using propidium iodide staining by FACS analysis2012European journal of medicinal chemistry, Jan, Volume: 47, Issue:1
From COX-2 inhibitor nimesulide to potent anti-cancer agent: synthesis, in vitro, in vivo and pharmacokinetic evaluation.
AID639180Growth inhibition of human UACC62 cells after 48 hrs by SRB assay2012European journal of medicinal chemistry, Jan, Volume: 47, Issue:1
From COX-2 inhibitor nimesulide to potent anti-cancer agent: synthesis, in vitro, in vivo and pharmacokinetic evaluation.
AID638892Cell cycle arrest in human SK-BR-3 cells assessed as accumulation at G1 phase at 5 uM after 18 hrs using propidium iodide staining by FACS analysis2012European journal of medicinal chemistry, Jan, Volume: 47, Issue:1
From COX-2 inhibitor nimesulide to potent anti-cancer agent: synthesis, in vitro, in vivo and pharmacokinetic evaluation.
AID672085Induction of Hsp27 phosphorylation in human SKBR3 cells at 0.2 to 1 uM after 24 hrs by SDS-PAGE analysis2012Journal of medicinal chemistry, Apr-12, Volume: 55, Issue:7
Identification of a class of novel tubulin inhibitors.
AID734442Ratio of IC50 for human NCI-H292 2D monolayer cells to IC50 for human NCI-H292 cells in 3D multi-cellular spheroid form2013Bioorganic & medicinal chemistry, Feb-15, Volume: 21, Issue:4
Development, validation and pilot screening of an in vitro multi-cellular three-dimensional cancer spheroid assay for anti-cancer drug testing.
AID638751Cell cycle arrest in human SK-BR-3 cells assessed as accumulation at G2/M phase at 0.50 uM after 6 hrs using propidium iodide staining by FACS analysis2012European journal of medicinal chemistry, Jan, Volume: 47, Issue:1
From COX-2 inhibitor nimesulide to potent anti-cancer agent: synthesis, in vitro, in vivo and pharmacokinetic evaluation.
AID639273Terminal half life in Sprague-Dawley rat at 20 mg/kg, ip2012European journal of medicinal chemistry, Jan, Volume: 47, Issue:1
From COX-2 inhibitor nimesulide to potent anti-cancer agent: synthesis, in vitro, in vivo and pharmacokinetic evaluation.
AID638891Cell cycle arrest in human SK-BR-3 cells assessed as accumulation at Sub-G1 phase at 5 uM after 18 hrs using propidium iodide staining by FACS analysis2012European journal of medicinal chemistry, Jan, Volume: 47, Issue:1
From COX-2 inhibitor nimesulide to potent anti-cancer agent: synthesis, in vitro, in vivo and pharmacokinetic evaluation.
AID638906Cell cycle arrest in human SK-BR-3 cells assessed as accumulation at G2/M phase at 0.50 uM after 24 hrs using propidium iodide staining by FACS analysis2012European journal of medicinal chemistry, Jan, Volume: 47, Issue:1
From COX-2 inhibitor nimesulide to potent anti-cancer agent: synthesis, in vitro, in vivo and pharmacokinetic evaluation.
AID672081Inhibition of bovine brain tubulin polymerization after 20 mins by spectrophotometric analysis2012Journal of medicinal chemistry, Apr-12, Volume: 55, Issue:7
Identification of a class of novel tubulin inhibitors.
AID638755Cell cycle arrest in human SK-BR-3 cells assessed as accumulation at G2/M phase at 5 uM after 6 hrs using propidium iodide staining by FACS analysis2012European journal of medicinal chemistry, Jan, Volume: 47, Issue:1
From COX-2 inhibitor nimesulide to potent anti-cancer agent: synthesis, in vitro, in vivo and pharmacokinetic evaluation.
AID638889Cell cycle arrest in human SK-BR-3 cells assessed as accumulation at S phase at 0.50 uM after 18 hrs using propidium iodide staining by FACS analysis2012European journal of medicinal chemistry, Jan, Volume: 47, Issue:1
From COX-2 inhibitor nimesulide to potent anti-cancer agent: synthesis, in vitro, in vivo and pharmacokinetic evaluation.
AID734441Antiproliferative activity against human NCI-H292 cells in 3D multi-cellular spheroid form at 2 uM after 15 days2013Bioorganic & medicinal chemistry, Feb-15, Volume: 21, Issue:4
Development, validation and pilot screening of an in vitro multi-cellular three-dimensional cancer spheroid assay for anti-cancer drug testing.
AID638753Cell cycle arrest in human SK-BR-3 cells assessed as accumulation at G1 phase at 5 uM after 6 hrs using propidium iodide staining by FACS analysis2012European journal of medicinal chemistry, Jan, Volume: 47, Issue:1
From COX-2 inhibitor nimesulide to potent anti-cancer agent: synthesis, in vitro, in vivo and pharmacokinetic evaluation.
AID639096Growth inhibition of human NCI-H522 cells after 48 hrs by SRB assay2012European journal of medicinal chemistry, Jan, Volume: 47, Issue:1
From COX-2 inhibitor nimesulide to potent anti-cancer agent: synthesis, in vitro, in vivo and pharmacokinetic evaluation.
AID638741Cell cycle arrest in human SK-BR-3 cells assessed as accumulation at G1 phase at 0.10 uM after 6 hrs using propidium iodide staining by FACS analysis2012European journal of medicinal chemistry, Jan, Volume: 47, Issue:1
From COX-2 inhibitor nimesulide to potent anti-cancer agent: synthesis, in vitro, in vivo and pharmacokinetic evaluation.
AID638816Cell cycle arrest in human SK-BR-3 cells assessed as accumulation at S phase at 0.50 uM after 12 hrs using propidium iodide staining by FACS analysis2012European journal of medicinal chemistry, Jan, Volume: 47, Issue:1
From COX-2 inhibitor nimesulide to potent anti-cancer agent: synthesis, in vitro, in vivo and pharmacokinetic evaluation.
AID639177Growth inhibition of human SK-MEL-28 cells after 48 hrs by SRB assay2012European journal of medicinal chemistry, Jan, Volume: 47, Issue:1
From COX-2 inhibitor nimesulide to potent anti-cancer agent: synthesis, in vitro, in vivo and pharmacokinetic evaluation.
AID638735Cell cycle arrest in human SK-BR-3 cells assessed as accumulation at G2/M phase at 0.10 uM after 3 hrs using propidium iodide staining by FACS analysis2012European journal of medicinal chemistry, Jan, Volume: 47, Issue:1
From COX-2 inhibitor nimesulide to potent anti-cancer agent: synthesis, in vitro, in vivo and pharmacokinetic evaluation.
AID638742Cell cycle arrest in human SK-BR-3 cells assessed as accumulation at S phase at 0.10 uM after 6 hrs using propidium iodide staining by FACS analysis2012European journal of medicinal chemistry, Jan, Volume: 47, Issue:1
From COX-2 inhibitor nimesulide to potent anti-cancer agent: synthesis, in vitro, in vivo and pharmacokinetic evaluation.
AID639187Growth inhibition of human SKOV3 cells after 48 hrs by SRB assay2012European journal of medicinal chemistry, Jan, Volume: 47, Issue:1
From COX-2 inhibitor nimesulide to potent anti-cancer agent: synthesis, in vitro, in vivo and pharmacokinetic evaluation.
AID638902Cell cycle arrest in human SK-BR-3 cells assessed as accumulation at G2/M phase at 0.25 uM after 24 hrs using propidium iodide staining by FACS analysis2012European journal of medicinal chemistry, Jan, Volume: 47, Issue:1
From COX-2 inhibitor nimesulide to potent anti-cancer agent: synthesis, in vitro, in vivo and pharmacokinetic evaluation.
AID638754Cell cycle arrest in human SK-BR-3 cells assessed as accumulation at S phase at 5 uM after 6 hrs using propidium iodide staining by FACS analysis2012European journal of medicinal chemistry, Jan, Volume: 47, Issue:1
From COX-2 inhibitor nimesulide to potent anti-cancer agent: synthesis, in vitro, in vivo and pharmacokinetic evaluation.
AID638663Cell cycle arrest in human SK-BR-3 cells assessed as accumulation at G1 phase at 0.25 uM after 3 hrs using propidium iodide staining by FACS analysis2012European journal of medicinal chemistry, Jan, Volume: 47, Issue:1
From COX-2 inhibitor nimesulide to potent anti-cancer agent: synthesis, in vitro, in vivo and pharmacokinetic evaluation.
AID638824Cell cycle arrest in human SK-BR-3 cells assessed as accumulation at S phase at 0.10 uM after 18 hrs using propidium iodide staining by FACS analysis2012European journal of medicinal chemistry, Jan, Volume: 47, Issue:1
From COX-2 inhibitor nimesulide to potent anti-cancer agent: synthesis, in vitro, in vivo and pharmacokinetic evaluation.
AID638659Cell cycle arrest in human SK-BR-3 cells assessed as accumulation at G1 phase at 0.50 uM after 3 hrs using propidium iodide staining by FACS analysis2012European journal of medicinal chemistry, Jan, Volume: 47, Issue:1
From COX-2 inhibitor nimesulide to potent anti-cancer agent: synthesis, in vitro, in vivo and pharmacokinetic evaluation.
AID639277Mean residence time (0 to t) in Sprague-Dawley rat at 20 mg/kg, ip2012European journal of medicinal chemistry, Jan, Volume: 47, Issue:1
From COX-2 inhibitor nimesulide to potent anti-cancer agent: synthesis, in vitro, in vivo and pharmacokinetic evaluation.
AID639081Cell cycle arrest in human SK-BR-3 cells assessed as accumulation at S phase at 5 uM after 24 hrs using propidium iodide staining by FACS analysis2012European journal of medicinal chemistry, Jan, Volume: 47, Issue:1
From COX-2 inhibitor nimesulide to potent anti-cancer agent: synthesis, in vitro, in vivo and pharmacokinetic evaluation.
AID638734Cell cycle arrest in human SK-BR-3 cells assessed as accumulation at Sub-G1 phase at 0.25 uM after 3 hrs using propidium iodide staining by FACS analysis2012European journal of medicinal chemistry, Jan, Volume: 47, Issue:1
From COX-2 inhibitor nimesulide to potent anti-cancer agent: synthesis, in vitro, in vivo and pharmacokinetic evaluation.
AID638660Cell cycle arrest in human SK-BR-3 cells assessed as accumulation at Sub-G1 phase at 0.50 uM after 3 hrs using propidium iodide staining by FACS analysis2012European journal of medicinal chemistry, Jan, Volume: 47, Issue:1
From COX-2 inhibitor nimesulide to potent anti-cancer agent: synthesis, in vitro, in vivo and pharmacokinetic evaluation.
AID672084Inhibition of tubulin polymerization in human SKBR3 cells assessed as decrease in microtubule density at 0.5 to 1 uM after 12 hrs by fluorescence microscopic analysis2012Journal of medicinal chemistry, Apr-12, Volume: 55, Issue:7
Identification of a class of novel tubulin inhibitors.
AID638822Cell cycle arrest in human SK-BR-3 cells assessed as accumulation at Sub-G1 phase at 0.10 uM after 18 hrs using propidium iodide staining by FACS analysis2012European journal of medicinal chemistry, Jan, Volume: 47, Issue:1
From COX-2 inhibitor nimesulide to potent anti-cancer agent: synthesis, in vitro, in vivo and pharmacokinetic evaluation.
AID638744Cell cycle arrest in human SK-BR-3 cells assessed as accumulation at Sub-G1 phase at 0.25 uM after 6 hrs using propidium iodide staining by FACS analysis2012European journal of medicinal chemistry, Jan, Volume: 47, Issue:1
From COX-2 inhibitor nimesulide to potent anti-cancer agent: synthesis, in vitro, in vivo and pharmacokinetic evaluation.
AID734443Antiproliferative activity against human NCI-H292 cells in 3D multi-cellular spheroid form after 7 days by inverted microscopy2013Bioorganic & medicinal chemistry, Feb-15, Volume: 21, Issue:4
Development, validation and pilot screening of an in vitro multi-cellular three-dimensional cancer spheroid assay for anti-cancer drug testing.
AID638662Cell cycle arrest in human SK-BR-3 cells assessed as accumulation at S phase at 0.25 uM after 3 hrs using propidium iodide staining by FACS analysis2012European journal of medicinal chemistry, Jan, Volume: 47, Issue:1
From COX-2 inhibitor nimesulide to potent anti-cancer agent: synthesis, in vitro, in vivo and pharmacokinetic evaluation.
AID638904Cell cycle arrest in human SK-BR-3 cells assessed as accumulation at G1 phase at 0.50 uM after 24 hrs using propidium iodide staining by FACS analysis2012European journal of medicinal chemistry, Jan, Volume: 47, Issue:1
From COX-2 inhibitor nimesulide to potent anti-cancer agent: synthesis, in vitro, in vivo and pharmacokinetic evaluation.
AID638656Cell cycle arrest in human SK-BR-3 cells assessed as accumulation at Sub-G1 phase at 5 uM after 3 hrs using propidium iodide staining by FACS analysis2012European journal of medicinal chemistry, Jan, Volume: 47, Issue:1
From COX-2 inhibitor nimesulide to potent anti-cancer agent: synthesis, in vitro, in vivo and pharmacokinetic evaluation.
AID638827Cell cycle arrest in human SK-BR-3 cells assessed as accumulation at G1 phase at 0.25 uM after 18 hrs using propidium iodide staining by FACS analysis2012European journal of medicinal chemistry, Jan, Volume: 47, Issue:1
From COX-2 inhibitor nimesulide to potent anti-cancer agent: synthesis, in vitro, in vivo and pharmacokinetic evaluation.
AID638894Cell cycle arrest in human SK-BR-3 cells assessed as accumulation at G2/M phase at 5 uM after 18 hrs using propidium iodide staining by FACS analysis2012European journal of medicinal chemistry, Jan, Volume: 47, Issue:1
From COX-2 inhibitor nimesulide to potent anti-cancer agent: synthesis, in vitro, in vivo and pharmacokinetic evaluation.
AID639275Apparent volume of distribution during terminal phase in Sprague-Dawley rat at 20 mg/kg, ip2012European journal of medicinal chemistry, Jan, Volume: 47, Issue:1
From COX-2 inhibitor nimesulide to potent anti-cancer agent: synthesis, in vitro, in vivo and pharmacokinetic evaluation.
AID639080Cell cycle arrest in human SK-BR-3 cells assessed as accumulation at G1 phase at 5 uM after 24 hrs using propidium iodide staining by FACS analysis2012European journal of medicinal chemistry, Jan, Volume: 47, Issue:1
From COX-2 inhibitor nimesulide to potent anti-cancer agent: synthesis, in vitro, in vivo and pharmacokinetic evaluation.
AID638655Cell cycle arrest in human SK-BR-3 cells assessed as accumulation at G1 phase at 5 uM after 3 hrs using propidium iodide staining by FACS analysis2012European journal of medicinal chemistry, Jan, Volume: 47, Issue:1
From COX-2 inhibitor nimesulide to potent anti-cancer agent: synthesis, in vitro, in vivo and pharmacokinetic evaluation.
AID639279Ratio of nimesulide IC50 to compound IC50 for human SK-BR-3 cells2012European journal of medicinal chemistry, Jan, Volume: 47, Issue:1
From COX-2 inhibitor nimesulide to potent anti-cancer agent: synthesis, in vitro, in vivo and pharmacokinetic evaluation.
AID638888Cell cycle arrest in human SK-BR-3 cells assessed as accumulation at G1 phase at 0.50 uM after 18 hrs using propidium iodide staining by FACS analysis2012European journal of medicinal chemistry, Jan, Volume: 47, Issue:1
From COX-2 inhibitor nimesulide to potent anti-cancer agent: synthesis, in vitro, in vivo and pharmacokinetic evaluation.
AID638887Cell cycle arrest in human SK-BR-3 cells assessed as accumulation at Sub-G1 phase at 0.50 uM after 18 hrs using propidium iodide staining by FACS analysis2012European journal of medicinal chemistry, Jan, Volume: 47, Issue:1
From COX-2 inhibitor nimesulide to potent anti-cancer agent: synthesis, in vitro, in vivo and pharmacokinetic evaluation.
AID638653Cell cycle arrest in human SK-BR-3 cells assessed as accumulation at G2/M phase at 5 uM after 3 hrs using propidium iodide staining by FACS analysis2012European journal of medicinal chemistry, Jan, Volume: 47, Issue:1
From COX-2 inhibitor nimesulide to potent anti-cancer agent: synthesis, in vitro, in vivo and pharmacokinetic evaluation.
AID638815Cell cycle arrest in human SK-BR-3 cells assessed as accumulation at G1 phase at 0.50 uM after 12 hrs using propidium iodide staining by FACS analysis2012European journal of medicinal chemistry, Jan, Volume: 47, Issue:1
From COX-2 inhibitor nimesulide to potent anti-cancer agent: synthesis, in vitro, in vivo and pharmacokinetic evaluation.
AID638745Cell cycle arrest in human SK-BR-3 cells assessed as accumulation at G1 phase at 0.25 uM after 6 hrs using propidium iodide staining by FACS analysis2012European journal of medicinal chemistry, Jan, Volume: 47, Issue:1
From COX-2 inhibitor nimesulide to potent anti-cancer agent: synthesis, in vitro, in vivo and pharmacokinetic evaluation.
AID638905Cell cycle arrest in human SK-BR-3 cells assessed as accumulation at S phase at 0.50 uM after 24 hrs using propidium iodide staining by FACS analysis2012European journal of medicinal chemistry, Jan, Volume: 47, Issue:1
From COX-2 inhibitor nimesulide to potent anti-cancer agent: synthesis, in vitro, in vivo and pharmacokinetic evaluation.
AID638812Cell cycle arrest in human SK-BR-3 cells assessed as accumulation at S phase at 0.25 uM after 12 hrs using propidium iodide staining by FACS analysis2012European journal of medicinal chemistry, Jan, Volume: 47, Issue:1
From COX-2 inhibitor nimesulide to potent anti-cancer agent: synthesis, in vitro, in vivo and pharmacokinetic evaluation.
AID638740Cell cycle arrest in human SK-BR-3 cells assessed as accumulation at Sub-G1 phase at 0.10 uM after 6 hrs using propidium iodide staining by FACS analysis2012European journal of medicinal chemistry, Jan, Volume: 47, Issue:1
From COX-2 inhibitor nimesulide to potent anti-cancer agent: synthesis, in vitro, in vivo and pharmacokinetic evaluation.
AID638736Cell cycle arrest in human SK-BR-3 cells assessed as accumulation at S phase at 0.10 uM after 3 hrs using propidium iodide staining by FACS analysis2012European journal of medicinal chemistry, Jan, Volume: 47, Issue:1
From COX-2 inhibitor nimesulide to potent anti-cancer agent: synthesis, in vitro, in vivo and pharmacokinetic evaluation.
AID638807Cell cycle arrest in human SK-BR-3 cells assessed as accumulation at G1 phase at 0.10 uM after 12 hrs using propidium iodide staining by FACS analysis2012European journal of medicinal chemistry, Jan, Volume: 47, Issue:1
From COX-2 inhibitor nimesulide to potent anti-cancer agent: synthesis, in vitro, in vivo and pharmacokinetic evaluation.
AID638814Cell cycle arrest in human SK-BR-3 cells assessed as accumulation at Sub-G1 phase at 0.50 uM after 12 hrs using propidium iodide staining by FACS analysis2012European journal of medicinal chemistry, Jan, Volume: 47, Issue:1
From COX-2 inhibitor nimesulide to potent anti-cancer agent: synthesis, in vitro, in vivo and pharmacokinetic evaluation.
AID672083Inhibition of tubulin polymerization in human SKBR3 cells assessed as microtubule disorganization at 0.5 to 1 uM after 12 hrs by fluorescence microscopic analysis2012Journal of medicinal chemistry, Apr-12, Volume: 55, Issue:7
Identification of a class of novel tubulin inhibitors.
AID638747Cell cycle arrest in human SK-BR-3 cells assessed as accumulation at G2/M phase at 0.25 uM after 6 hrs using propidium iodide staining by FACS analysis2012European journal of medicinal chemistry, Jan, Volume: 47, Issue:1
From COX-2 inhibitor nimesulide to potent anti-cancer agent: synthesis, in vitro, in vivo and pharmacokinetic evaluation.
AID638654Cell cycle arrest in human SK-BR-3 cells assessed as accumulation at S phase at 5 uM after 3 hrs using propidium iodide staining by FACS analysis2012European journal of medicinal chemistry, Jan, Volume: 47, Issue:1
From COX-2 inhibitor nimesulide to potent anti-cancer agent: synthesis, in vitro, in vivo and pharmacokinetic evaluation.
AID638813Cell cycle arrest in human SK-BR-3 cells assessed as accumulation at G2/M phase at 0.25 uM after 12 hrs using propidium iodide staining by FACS analysis2012European journal of medicinal chemistry, Jan, Volume: 47, Issue:1
From COX-2 inhibitor nimesulide to potent anti-cancer agent: synthesis, in vitro, in vivo and pharmacokinetic evaluation.
AID638897Cell cycle arrest in human SK-BR-3 cells assessed as accumulation at S phase at 0.10 uM after 24 hrs using propidium iodide staining by FACS analysis2012European journal of medicinal chemistry, Jan, Volume: 47, Issue:1
From COX-2 inhibitor nimesulide to potent anti-cancer agent: synthesis, in vitro, in vivo and pharmacokinetic evaluation.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (5)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's5 (100.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other5 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
indibulin
indibulin: Tubulin Modulator/Antineoplastic Agent; structure in first source		2.0710
nocodazole
[no description available]		2.4820aromatic ketone;
benzimidazoles;
carbamate ester;
thiophenes		antimitotic;
antineoplastic agent;
microtubule-destabilising agent;
tubulin modulator
colchicine
(S)-colchicine : A colchicine that has (S)-configuration. It is a secondary metabolite, has anti-inflammatory properties and is used to treat gout, crystal-induced joint inflammation, familial Mediterranean fever, and many other conditions.		2.0710alkaloid;
colchicine		anti-inflammatory agent;
gout suppressant;
mutagen
vinblastine
[no description available]		2.0710
paclitaxel
Taxus: Genus of coniferous yew trees or shrubs, several species of which have medicinal uses. Notable is the Pacific yew, Taxus brevifolia, which is used to make the anti-neoplastic drug taxol (PACLITAXEL).		2.0710taxane diterpenoid;
tetracyclic diterpenoid		antineoplastic agent;
human metabolite;
metabolite;
microtubule-stabilising agent
5-(5-ethyl-2-hydroxy-4-methoxyphenyl)-4-(4-methoxyphenyl)isoxazole
5-(5-ethyl-2-hydroxy-4-methoxyphenyl)-4-(4-methoxyphenyl)isoxazole: inhibits Hsp27 phosphorylation; structure in first source		2.0710
e 7010
E 7010: inhibits tubulin polymerization; structure given in first source		2.0710sulfonamide
jcc 76
[no description available]		2.9940
ConditionIndicatedRelationship StrengthStudiesTrials
African Sleeping Sickness
[description not available]		02.0710
Trypanosomiasis, African
A disease endemic among people and animals in Central Africa. It is caused by various species of trypanosomes, particularly T. gambiense and T. rhodesiense. Its second host is the TSETSE FLY. Involvement of the central nervous system produces African sleeping sickness. Nagana is a rapidly fatal trypanosomiasis of horses and other animals.		02.0710